scholarly journals Choice of calcium channel blockers in arterial hypertension. Pharmacokinetic and pharmacodynamic mechanisms of high selectivity and superlative action of lercanidipine

2017 ◽  
Vol 19 (12) ◽  
pp. 59-65
Keyword(s):  
Arterial Hypertension ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
High Selectivity ◽  
Channel Blockers

Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels

2014 ◽  
Vol 22 (24) ◽  
pp. 6899-6907 ◽  
Author(s):  
Takashi Ogiyama ◽  
Makoto Inoue ◽  
Shugo Honda ◽  
Hiroyoshi Yamada ◽  
Toshihiro Watanabe ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
High Selectivity ◽  
Channel Blockers ◽  
Orally Active

scholarly journals Impact of antihypertensive therapy on the functional state of the pituitary-gonadal system in patients with arterial hypertension

2005 ◽  
Vol 11 (1) ◽  
pp. 34-38 ◽  
Author(s):  
N. V. Ivanov
Keyword(s):  
Arterial Hypertension ◽  
Calcium Channel ◽  
Antihypertensive Therapy ◽  
Calcium Channel Blockers ◽  
Ace Inhibitors ◽  
Antihypertensive Agents ◽  
Free Testosterone ◽  
Blood Levels ◽  
Channel Blockers ◽  
The Impact

The aim of the study was to evaluate the impact of antihypertensive therapy with slow calcium-channel blockers, angiotensin-converting enzyme (ACE) inhibitors, and ß-adrenergic receptor blockers on the metabolism and blood levels of major adrenal androgens and gonads, as well as the insulin resistance in males with arterial hypertension (AH) Ninety-one patients with AH and 15 age-matched healthy male controls were examined The hypertensive males treated with slow calcium-channel blockers or ACE inhibitors were found to have a lower level of insulin and higher levels of dehydroepiandrosterone sulfate and free testosterone on the 30th day of treatment Those on blockers were observed to have a higher level of insulin and lower levels of major adrenal and testicular androgens as compared with their baseline levels Therapy did not alter the levels of gonadotropic hormones, estradiol, and cortisol and they did not differ in the compared groups The family history of AH has a modulating effect on a hormonal response in males with AH treated with antihypertensive agents

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