scholarly journals Efficacy of fine needle aspiration cytology in diagnosis of common diseases of thyroid using histopathology as gold standard

2020 ◽  
Vol 13 (1) ◽  
pp. 08-11
Author(s):  
Manish Kumar ◽  
◽  
Manjeet Singh ◽  
Keyword(s):  
Fine Needle Aspiration ◽  
Gold Standard ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Common Diseases ◽  
Needle Aspiration Cytology

scholarly journals Significance of Quadruple assessment of breast lump–A hospital based study

2014 ◽  
Vol 4 (8) ◽  
pp. 630-634
Author(s):  
MK Shrestha ◽  
D Ghartimagar ◽  
A Ghosh ◽  
E Shrestha ◽  
P Bolar
Keyword(s):  
Breast Cancer ◽  
Sensitivity And Specificity ◽  
Fine Needle Aspiration ◽  
Gold Standard ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: Approximately 10% of breast masses are breast cancer. It is important for women with a breast lump to receive appropriate evaluation. Mammography has been the “gold standard” in breast cancer detection for >40 years. Ultrasonography is non-invasive easily available, cheaper and accurate tool while Fine needle aspiration cytology has a high diagnostic accuracy rate in hands of experienced cytopathologist. Materials and methods: This was a retrospective and prospective study of 173 women attending radiology department in Manipal Teaching Hospital, Pokhara for mammography during a period of 18 months from January 2011 to June 2012.The age ranged from 20yrs to 75yrs. BIRADS score was given for both mammography and sonomammography. All malignant and suspicious cases had undergone fine needle aspiration cytology. Cytology reports were correlated with imaging study. Results: The most common age group for the breast lump was 40-49 years showing 65(37.57%) cases. Most lumps were seen on the left side 54.3% (94/ 173) cases and were seen in upper outer quadrant of the breast (74 cases). 11 cases each were given the BIRADS score of 4 in both mammography and sonomammography. Sensitivity and specificity of mammography and sonomammography were compared to cytologyreports. The sensitivity for mammogram was 73.7% while specificity was 96.3%. The sensitivity and specificity for sonomammogram was 78.9% and 95% respectively. Conclusion: Quadruple assessment i.e. clinical assessment, mammography, sonomammography and cytological study are the new “gold standard” in the investigation of breast disease. DOI: http://dx.doi.org/10.3126/jpn.v4i8.11499 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 630-634

scholarly journals Correlation of Fine Needle Aspiration Cytology and Histopathology of the Neck Swellings Presenting at National Academy of Medical Sciences, Kathmandu, Nepal

2017 ◽  
Vol 2 (2) ◽  
pp. 206-210
Author(s):  
Harihar Devkota ◽  
YC Sibakoti ◽  
S Menyangbo ◽  
S Basnet ◽  
MK Jha ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Gold Standard ◽  
Fine Needle Aspiration Cytology ◽  
Calculated Data ◽  
Needle Aspiration ◽  
Invasive Technique ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Neck Masses ◽  
Needle Aspiration Cytology

IntroductionNeck masses are frequently found in clinical practice. A spectrum of pathological lesions ranging from inflammation to benign and highly malignant manifestation is observed. Fine needle aspiration cytology (FNAC) of neck masses is a quick, easy, safe and cheap technique in the diagnosis which has been a well-accepted procedure in diagnosing various swellings. Histopathology is a gold standard technique in diagnosing any swelling which also provide detail architecture, however it also requires OT setings, more manpower, expensive, time consuming, more traumatic and can sometimes become difficult.ObjectiveThe objective of our study was to evaluate the frequencies of neck swellings and how efficacy FNAC is in diagnosing neck masses by correlating the gold standard histopathological examination.MethodologyA Hospital based descriptive cross sectional prospective study was conducted in 50 patients with neck swellings presenting in the surgery OPD and admitied patient for some other reasons. FNAC and histopathological examinations were done from those lesions and were compared. The sensitivity, specificity and accuracy rates were calculated. Data entry and analysis was performed using SPSS.ResultsA total of 50 patient were subjected to both FNAC and histopathology examination (HPE). Out of 50 cases, 25 were male and 25 were female. The age ranged from 16 to 82 years. Lymph nodes 22 (44%) was the most common case, followed by thyroid 17 (34%), salivary glands 10 (20%) and soft issue 1 (2%).Among all Tubercular lymphadenitis (18%) followed by papillary carcinoma of thyroid (14%),metastatic carcinoma of lymph node, NHL, and pleomorphic adenoma 10% each. The sensitivity of FNAC in diagnosing neck masses is 90.08%, specificity is of 98.53%, and diagnostic accuracy is of 87.64%.ConclusionFNAC is a simple, fast, inexpensive, and minimally invasive technique which can be used as the first line investigation in diagnosing neck swellings.Birat Journal of Health SciencesVol.2/No.1/Issue 2/ Jan - April 2017, page: 206-210

Evaluation of Ultrasound-Guided Fine-Needle Aspiration Cytology of Ovarian Masses with Histopathological Correlation

2015 ◽  
Vol 59 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Subrata Pal ◽  
Srabani Chakrabarti ◽  
Debasis Deuoghuria ◽  
Jyoti Prakash Phukan ◽  
Anuradha Sinha ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Gold Standard ◽  
Fine Needle Aspiration Cytology ◽  
Imaging Techniques ◽  
Needle Aspiration ◽  
Safe Procedure ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Ovarian Masses

Background: Preoperative cytodiagnosis of ovarian masses is a difficult process, and sampling of pelvic masses is quite easier after the improvement of imaging techniques. Though histopathology is the gold standard, fine-needle aspiration cytology (FNAC) under ultrasound (US) guidance can be a valuable tool for pre-operative diagnosis of ovarian lesions, especially in the hands of an experienced pathologist. Objective: The present study was performed to evaluate the role of US-guided FNAC in pre-operative cytological diagnosis of ovarian masses in comparison with histopathology, and to assess the pitfalls and limitations of cytological interpretation. Materials and Methods: This study was conducted over a 2-year period on 70 cases of ovarian masses, which were evaluated by US-guided FNAC. Sensitivity, specificity and diagnostic efficacy were calculated using histopathology as gold standard. Results: On cytological evaluation, non-neoplastic cysts, and benign and malignant ovarian tumours were diagnosed in 8, 18 and 40 cases, respectively. On histopathology, 62 cases were concordant with cytology. Sensitivity and specificity were 95.23 and 95.83%, respectively, in the present study. Diagnostic accuracy was 93.94% in respect to the correct diagnosis. Cytohistological discrepancies and limitations of the study are discussed. Conclusion: US-guided FNAC has proved as a quick, economic and safe procedure in diagnosing ovarian masses with brilliant accuracy.

scholarly journals A comparative study of free-hand fine needle aspiration cytology and ultrasound guided fi ne needle aspiration cytology in the diagnosis of thyroid swellings at BP Koirala Institute of Health Sciences- a tertiary care centre in Nepal

2015 ◽  
Vol 12 (2) ◽  
pp. 78-86
Author(s):  
M Agarwal ◽  
A K Sinha ◽  
C S Agrawal ◽  
S Bhandary ◽  
A Tiwari ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Gold Standard ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Diagnostic Reliability ◽  
Fine Needle ◽  
Definitive Therapy ◽  
Needle Aspiration Cytology

Background: Thyroid lesions are commonly encountered in clinical practice and it  is mandatory to know and record the nature of pathology prior to definitive therapy.  Fine needle aspiration cytology (FNAC) is a time tested, cheap, reliable and safe  method to establish a cytological diagnosis of the nature of the disease. Ultrasound  guided FNAC has the potential to reduce inadequacy rates and is regarded as  the optimal cytological method for diagnosis. Objective: To compare the results  of free-hand and ultrasound-guided FNAC of thyroid swellings and to find out  the diagnostic reliability of free-hand FNAC and ultrasound-guided FNAC using  histological diagnosis as the gold standard. Methods: Fifty-five patients with thyroid  swelling who were subjected to free-hand and ultrasound-guided FNACs and who  subsequently underwent surgery over one year were studied. Results: Ultrasound  guided FNAC results revealed 72.75 % benign lesions and 25.45 % of malignant  lesions, and free hand FNAC revealed 52.73 % benign and 16.36% malignant cases.  A 14.55 % inadequacy rate was seen in the free hand group. Histological gold  standard diagnosis comprised of 60 % benign and 40 % malignant cases. Sensitivity  and specificity of free-hand and ultrasound guided FNAC in diagnosing malignancy  of the thyroid were 56.25% and 100%; and 63.64% and 96.97% respectively.  Conclusion: Free hand FNAC of thyroid swellings is more convenient and cost  effective as compared to ultrasound guided FNAC. However, the diagnostic yield  in ultrasound guided FNAC is significantly more in terms of accuracy especially in  cystic and tiny lesions.Health Renaissance 2014;12(2): pp. 78-86

Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm

2014 ◽  
Vol 19 (2) ◽  
pp. 110-118
Author(s):  
Mohammad Amzad Hossain ◽  
Md Zahedul Alam ◽  
Md Rojibul Haque ◽  
Md Nazmul Haque ◽  
KM Nurul Alam ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Preoperative Diagnostic ◽  
Needle Aspiration Cytology

Objective: To evaluate the role of Fine Needle Aspiration Cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Methods: This cross sectional study on 50 cases was conducted in the Department of Otolaryngology and Head-Neck Surgery of Sir Salimullah Medical College Mitford Hospital and Dhaka Medical College Hospital from January’2009 to June 2010. Results: Fine needle aspiration cytology findings of our all 50 cases were compared with postoperative histopathological reports. Out of the 50 cases, in 36(72%) cases of benign neoplasm and 7(14%) cases of malignant neoplasm, pre-operative FNAC findings and post operative histopathological findings were same. In 7 cases, FNAC and post operative histopathological findings did not matched. These were 2 (4%) false positive and 5 (10%) false negative result.In our study sensitivity of FNAC for reporting malignancy was 58.33%, specificity to rule out malignancy was 94.73% and overall accuracy in detecting malignant tumour was 86%. Positive predictive value and negative value were 77.77% and 87.80% respectively. It can be concluded that fine needle aspiration cytology is a safe, cheap and useful preoperative diagnostic tool in the diagnosis of malignancy in parotid and submandibular gland, but as fine needle aspiration cytology partly depends on operator skill, it may give false negative and false positive result. Conclusion: FNAC is a useful preoperative diagnostic tool for malignant parotid and submandibular glands with high specificity and sensitivity. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2): 110-118

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