scholarly journals Dynamics of IL-4 and IFN-γ cytokine profile under the influence of combined allergen-specific immunotherapy (ASIT) in patients with polynosis and combined sensitization to pollen and household allergens.

2020 ◽  
Vol 25 (1) ◽  
pp. 116-121
Author(s):  
E. M. Dytyatkovska ◽  
S. V. Biletska
Keyword(s):  
Specific Immunotherapy ◽  
Cytokine Profile ◽  
Allergen Specific Immunotherapy ◽  
Ifn Γ

scholarly journals Influence of sublingual allergen-specific immunotherapy on dynamics of immunological parameters in patients with pollinosis

2009 ◽  
Vol 6 (1) ◽  
pp. 39-44
Author(s):  
M V Manzhos ◽  
E S Fedenko ◽  
M A Myagkova ◽  
B A Molotilov ◽  
S A Shkadov ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Immunological Parameters ◽  
Allergen Specific Immunotherapy ◽  
Ige Antibodies ◽  
Ifn Γ ◽  
Cellular Tolerance ◽  
Th 1 ◽  
Healthy Persons ◽  
Immunologic Parameters

Background. To study the influence of sublingual allergen-specific immunotherapy (slASIT) on dynamics of immunologic parameters in patients with pollinosis. Materials and methods. 40 healthy persons and 25 pollinosis patients received slASIT course with mixt of autumn grasses allergen. IgA, IgM, IgG, IgE antibodies, slgA, albumin in saliva and IgA, IgM, IgG, IgE antibodies, total IgE, IFN-γ, IL-4 in serum were investigated. Results. Patients with pollinosis have infringements of both local and general immunity. SlASIT changes a profile of cytokines aside Th-1, stimulates formation of the secretory allergen-specific antibodies, reduces IgE antibodies in saliva. Conclusion. SlASIT is a highly effective method of allergic diseases treatment and it induces B-cellular and T-cellular tolerance.

scholarly journals Dynamics of the cytokine profile in achieving the therapeutic effect of allergen-specific immunotherapy in children with allergic rhinitis and bronchial asthma

2021 ◽  
Vol 66 (5) ◽  
pp. 176-182
Author(s):  
O. V. Skorokhodkina ◽  
S. A. Arkhipova ◽  
T. V. Klykova ◽  
G. M. Zaynetdinova ◽  
E. B. Kruglova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Cytokine Profile ◽  
Allergen Specific Immunotherapy ◽  
Atopic Bronchial Asthma ◽  
Regulatory T Lymphocytes ◽  
Ige Mediated ◽  
Medical University

Allergen-specific immunotherapy is a pathogenetic method for the treatment of IgE-mediated allergic diseases.Objective. To evaluate effectiveness of allergen-specific immunotherapy in 471 children with allergic rhinitis and bronchial asthma, as well to analyze the dynamics of the cytokine profile at baseline and 1 year after the start of treatment in 86 children. The research was supported by a grant from the International Scientific Council for Young Scientists of Kazan State Medical University.Results. Analysis of the data obtained demonstrated that allergen-specific immunotherapy is a highly effective method of treating children with allergic rhinitis and atopic bronchial asthma. The dynamics of the level of the studied cytokines during treatment indirectly indicates an increase in the functional activity of adaptive subpopulations of regulatory T-lymphocytes (T-reg) and B-lymphocytes (B-reg) with a decrease in the activity of Th2 lymphocytes, which may indicate the reconstruction of the immune response and possible disease-modifying effect.

Immunotheraphy in Allergic Diseases

2018 ◽  
Vol 24 (11) ◽  
pp. 1174-1194
Author(s):  
Albert Roger ◽  
Maria Basagana ◽  
Aina Teniente-Serra ◽  
Nathalie Depreux ◽  
Yanina Jurgens ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Specific Ige ◽  
World Population ◽  
Allergen Specific Immunotherapy ◽  
Routes Of Administration ◽  
Disease Modifying Therapy ◽  
History Of ◽  
Ige Mediated ◽  
Special Case

The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed or are currently under clinical trials. Besides new routes of administration, new types of allergens are being developed. The use of adjuvants may amplify the immune response towards tolerance to the antigens. In this review, we analyze different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.

Planning and approach to allergen-specific immunotherapy in polyallergic patients

Immunotherapy ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 577-585
Author(s):  
Nerin N Bahceciler ◽  
Ozel Yuruker
Keyword(s):  
Clinical Management ◽  
Respiratory Diseases ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Allergen Specific Immunotherapy ◽  
Stepwise Approach ◽  
Future Studies ◽  
Disease Modifying ◽  
Management Recommendations ◽  
Disease Modifying Treatment

Allergy immunotherapy (AIT) is currently the only disease-modifying treatment for allergic-respiratory diseases. Polysensitization may increase the severity of current disease resulting in subsequent asthma development in patients with allergic rhinitis. Due to the absence of general recommendations for the practical approach to polysensitized patients, clinical management is not standardized. The correlation between sensitizations and clinical symptoms, elimination of possible pollen cross-reactivities and principles of homologous allergen groups will guide the allergists to deduce the most relevant allergens for AIT. In the highlight of the previously proposed approach strategies to polyallergic patients, hereby we propose a revised practical stepwise approach based on the current European Medicine Agency (EMA) guidelines. However, more supporting data from well-designed, controlled, future studies are needed to improve clinical management recommendations for AIT in polyallergic patients.

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