scholarly journals Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples

2018 ◽  
Vol 34 (2) ◽  
pp. 23
Author(s):  
Rogério Adelino De Sousa ◽  
Éder Tadeu Gomes Cavalheiro
Keyword(s):  
Potentiometric Titration ◽  
Confidence Level ◽  
Redox Reaction ◽  
Potentiometric Determination ◽  
Titration Method ◽  
Pharmaceutical Samples ◽  
Chromatographic Procedure ◽  
Potentiometric Titration Method

A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.

scholarly journals Potentiometric determination of Minoxidil in topical use pharmaceutical samples

2009 ◽  
Vol 34 (2) ◽  
pp. 23-27 ◽  
Author(s):  
Rogério Adelino de Sousa ◽  
Éder Tadeu Gomes Cavalheiro
Keyword(s):  
Potentiometric Titration ◽  
Confidence Level ◽  
Redox Reaction ◽  
Potentiometric Determination ◽  
Titration Method ◽  
Pharmaceutical Samples ◽  
Chromatographic Procedure ◽  
Potentiometric Titration Method

A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.

scholarly journals Analysis of alkyl ketene dimer (AKD) by potentiometric titration

1994 ◽  
Vol 72 (2) ◽  
pp. 274-278 ◽  
Author(s):  
S. Nyarku ◽  
B. Bruce Sitholé
Keyword(s):  
Potentiometric Titration ◽  
Glacial Acetic Acid ◽  
Hydrolysis Product ◽  
Organic Base ◽  
Alkyl Ketene Dimer ◽  
Titration Method ◽  
Potentiometric Titration Method ◽  
The Stability ◽  
Excess Base

A simple and precise potentiometric titration method has been developed for the determination of milligram quantities of alkyl ketene dimer (AKD) in non-aqueous solvents. It involves the addition of chloroform solutions of AKD to an excess of an organic base followed by the titration of excess base with perchloric acid in glacial acetic acid. The method was used to determine non-reacted AKD extracted from hand-sheets: our results agreed with those obtained by capillary gas chromatography. The method was also used to monitor the stability of AKD formulations. Wood resin components and stearone, a hydrolysis product of AKD, do not interfere.

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