scholarly journals Malignant Ovarian Granulosa Cell Tumour in a Ewe

2009 ◽  
Vol 78 (2) ◽  
pp. 281-285 ◽  
Author(s):  
Tanja Švara ◽  
Mitja Gombač ◽  
Polona Juntes ◽  
Milan Pogačnik
Keyword(s):  
Weight Loss ◽  
Lymph Nodes ◽  
Granulosa Cell ◽  
Rare Case ◽  
Cell Tumour ◽  
Histopathological Diagnosis ◽  
Granulosa Cell Tumour ◽  
Ovarian Granulosa Cell ◽  
Progressive Weight Loss ◽  
The Right

We describe a rare case of malignant granulosa cell tumour in an adult ewe, euthanised due to progressive weight loss. Necropsy examination revealed a neoplastic enlargement of the right ovary, multifocal neoplastic masses in the lung and spleen, and severe enlargement of mediastinal and iliacal lymph nodes. Histopathology of the right ovary revealed a malignant ovarian granulosa cell tumour with metastases to the lung, spleen, and mediastinal and iliacal lymph nodes. Immunohistochemistry confirmed histopathological diagnosis. Neoplastic cells reacted positively for CK MNF 116 and vimentin and were negative for CK 7 and desmin. To our knowledge this is the first report of a malignant granulosa cell tumour in ewe.

Endometrial mineralisation in a bitch with ovarian granulosa cell tumour and cystic endometrial hyperplasia-pyometra complex

2020 ◽  
Vol 8 (3) ◽  
pp. e000984
Author(s):  
Carmen Rodenas ◽  
Amalia Agut ◽  
Antonio Bernabe ◽  
Miguel Angel Gómez ◽  
Xiomara Lucas
Keyword(s):  
Granulosa Cell ◽  
Endometrial Hyperplasia ◽  
Abdominal Ultrasound ◽  
Serum Biochemistry ◽  
Cell Tumour ◽  
Histopathological Study ◽  
Granulosa Cell Tumour ◽  
Ovarian Granulosa Cell ◽  
One Year ◽  
The Right

Granulosa cell tumour is a common ovarian pathology in bitches. Depending on its hormonal production, this tumour often induces persistent oestrus signs and uterine disorders. Chronic treatment with progesterone contraceptives has been associated with endometrial mineralisation in bitches. The authors describe the case of a three-year-old female entire mastiff dog with a one-year history of chronic hyperoestrogenism signs and anorexia. Serum biochemistry and haematology revealed moderate leucocytosis. Abdominal ultrasound showed dilated uterine horns with anechoic fluid in the lumen, small cystic structures, and multiple stippled hyperechoic lesions with mild acoustic shadowing and comet tail artefact along the endometrial wall. Furthermore, cystic structures were observed in the right ovary. After surgery, histopathological study revealed the presence of endometrial hyperplasia-pyometra complex, endometrial mineralisation and a granulosa cell tumour. To the best of the authors’ knowledge, this is the first report of endometrial mineralisation associated with ovarian granulosa cell tumour in a bitch.

Broad ligament recurrence of ovarian granulosa cell tumour detected by touch imprint cytology

Cytopathology ◽  
2003 ◽  
Vol 14 (4) ◽  
pp. 226-227 ◽  
Author(s):  
D. Tamiolakis ◽  
J. Venizelos ◽  
D. Karamanidis ◽  
P. Prassopoulos ◽  
N. Papadopoulos
Keyword(s):  
Granulosa Cell ◽  
Broad Ligament ◽  
Cell Tumour ◽  
Imprint Cytology ◽  
Granulosa Cell Tumour ◽  
Ovarian Granulosa Cell ◽  
Touch Imprint Cytology

Ovarian granulosa cell tumour and letrozole: A case report

2015 ◽  
Vol 36 (1) ◽  
pp. 122-123 ◽  
Author(s):  
R. Yazigi ◽  
T. Rodríguez ◽  
E. Buckel ◽  
A. Wash
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Cell Tumour ◽  
Granulosa Cell Tumour ◽  
Ovarian Granulosa Cell

scholarly journals Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

2019 ◽  
Author(s):  
Ahmed Badran ◽  
Mahmoud A. Elshenawy ◽  
Hussein Soudy ◽  
Ayman Elshentenawy ◽  
Ahmed Mohieldin ◽  
...  
Keyword(s):  
Overall Survival ◽  
Adjuvant Chemotherapy ◽  
Granulosa Cell ◽  
Cell Tumour ◽  
Ca 125 ◽  
Granulosa Cell Tumour ◽  
Adult Type ◽  
Ovarian Granulosa Cell

Abstract Background: Ovarian granulosa cell tumour is rare. This study aim is to report the clinical characteristics and long-term outcomes of adult-type OGCT (AOGCT) at King Faisal Specialist Hospital and Research Centre ( KFSH&RC) and to determine the prognostic factors affecting relapse and survival. we retrospectively reviewed patients with AOGCT, from 1988 to 2014, who were treated at our institution. Baseline characteristics, pathological findings, and outcomes were analysed, and reported. RESULTS: Sixty-one patients with AOGCT were identified with a median age of 49 years. Median follow-up was 5.0 years (range 2.1 -8.2 years). 74% of patients were FIGO stage I, whereas 7% stage II, 5% stage III and unknown in 14%. The most common presenting symptoms included abdominal pain (43%) and vaginal bleeding (43%). The majority of patients (38 patients, 62%) were treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. Five (8%) patients received adjuvant chemotherapy. Sixteen patients (26%) relapsed with a median time to relapse of 5.5 years (0.7-8.1 years). Half of the recurrences (8 patients, 50%) occurred after 5 years of diagnosis. Five-year overall survival and disease-free survival were 93% and 84%, respectively. Factors associated with high risk of recurrence were presence of ascites (p=0.000) and elevated preoperative CA 125 level (p=0.048). The overall survival was significantly influenced by the menopausal status (premenopausal 100% vs. postmenopausal 84%; p=0.02), preoperative CA 125 (normal 100% vs. elevated 64%; p=0.005), Ascites (present 33% vs. absent 100%; p=0.000), and age (<55 years 100% vs. ≥ 55 years 77%; p= 0.002). CONCLUSION: This study confirms a good outcome of patients with AOGCT. They require long-term follow-up because the recurrence can occur many years post the definitive therapy. The presence of ascites and elevated preoperative CA 125 levels were associated with a higher risk of recurrence and poor prognosis. The outcome seems not to be affected by fertility-sparing surgery and/or adjuvant chemotherapy.

Endometrial Polypoid Adenomyomatosis in a Bitch with Ovarian Granulosa Cell Tumour and Pyometra

2007 ◽  
Vol 136 (1) ◽  
pp. 83-86 ◽  
Author(s):  
A. Zanghì ◽  
G. Catone ◽  
G. Marino ◽  
M. Quartuccio ◽  
P.A. Nicòtina
Keyword(s):  
Granulosa Cell ◽  
Cell Tumour ◽  
Granulosa Cell Tumour ◽  
Ovarian Granulosa Cell

scholarly journals Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat

2017 ◽  
Vol 3 (2) ◽  
pp. 205511691772270 ◽  
Author(s):  
Laura A Heaps ◽  
Christopher J Scudder ◽  
Vicky J Lipscomb ◽  
Sarah ML Steinbach ◽  
Simon L Priestnall ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Ovarian Neoplasms ◽  
Clinical Signs ◽  
Cell Tumour ◽  
Control Group ◽  
Granulosa Cell Tumour ◽  
Monitoring Tool ◽  
Case Summary ◽  
Ovarian Granulosa Cell ◽  
Before And After

Case summary A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian granulosa cell tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat’s clinical signs resolved, but 6 months later it was diagnosed as having an anaplastic astrocytoma and was euthanased. Serum anti-Müllerian hormone (AMH) concentration prior to OHE was increased vs a control group of entire and neutered female cats. Following OHE, serum AMH concentration decreased to <1% of the original value. Relevance and novel information Serum AMH measurement may represent a novel diagnostic and monitoring tool for functional ovarian neoplasms in cats.

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