scholarly journals Comparative analysis of serum calcium and magnesium as a better predictor in cases of mild and severe pre-eclampsia.

2020 ◽  
Vol 27 (08) ◽  
pp. 1722-1727
Author(s):  
Farheen Aslam ◽  
Irum Hayat ◽  
Faizan Ahmad Zakir ◽  
S. Sabahat Haider ◽  
Shams Un Nisa ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Mean Value ◽  
Control Group ◽  
Mortality And Morbidity ◽  
Nulliparous Women ◽  
Gynecology And Obstetrics ◽  
Research Population ◽  
Calcium And Magnesium

Objectives: The hypertensive disorders of pregnancy (HDP), especially severe preeclampsia are most common cause of neonatal and maternal mortality and morbidity. Alteration in metabolism of calcium and magnesium during pregnancy is considered to be one of etiological factor for pre-elampsia. Study Design: Case-control study. Settings: Departments of Pathology and Gynecology and Obstetrics, Bahawal Victoria Hospital. Period: September 2018 to June 2019. Material & Methods: To compare whether serum levels of calcium or magnesium showed significant change in mild and severe preeclamptic patients as compared to control group. Research population consisted of pregnant females that were divided into three groups. The mild and severe preeclamptic groups comprised of 55 and 26 participants respectively and 45 were included in control group. The serum calcium and magnesium levels were measured in these groups. Results: Maximum numbers of preeclamptic cases were presented at 28-32 week of gestation while severe pre-eclamptic group showed most cases in 33-36 weeks. In both groups, most of cases occurred in multiparous women as compared to nulliparous women. The normotensive group showed serum calcium and magnesium levels of 9.08±0.63 and2.12±0.22mg/dl while mild preeclamptic (mPE) had mean value of 7.91±0.64 and 1.58±0.42mg/dl and measurement were 7.67±0.48 and 1.26±0.44 in cases of severe pre eclampsia (sPE). Serum magnesium levels were significantly lower in sPE as compared to mPE (<0.0001) while difference was not statistically significant for serum calcium level (0.14). Conclusion: Both decrease level of serum calcium and magnesium might be risk factor in development of preeclampsia with more emphasis on role of low magnesium as a prognostic marker in severe preeclamptic cases.

scholarly journals Comparative Evaluation of Serum Calcium and Magnesium Level in Preeclamptic and NonPreeclamptic Women in a Tertiary Hospital in Southern Nigeria

2018 ◽  
Vol 14 (12) ◽  
pp. 437
Author(s):  
Allagoa DO. ◽  
Agbo OJ. ◽  
Orluwene CG.
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Tertiary Hospital ◽  
Magnesium Level ◽  
P Value ◽  
Serum Magnesium Level ◽  
Calcium And Magnesium

Background: Calcium and magnesium are two micronutrients whose role in the development of preeclampsia has been investigated over the years. There is paucity of studies on the role of serum levels of calcium and magnesium in the development of preeclampsia in south-south Nigeria. Objective: Our study evaluated the serum level of calcium and magnesium in preeclamptic and non preeclamptic women in a Tertiary Hospital in southsouth Nigeria. Methodology: We carried out a comparative study in which 52 preeclamptic and 52 non preeclamptic women, who satisfied the eligibility criteria, were enrolled for the study. Data entry and statistical analysis was done using statistical software (IBM SPSS® for windows version 21.0). Data were analyzed for mean and standard deviation. Comparison of serum levels of elements between the two groups was performed by student t-test, and P value < 0.05 was considered as statistically significant. Results: The serum calcium level was statistically lower in the women who developed preeclampsia compared to those who did not (8.37±0.91 mg/dl vs 9.33±1.15mg/dl, p<0.001). The serum magnesium level was not statistically different between women who had preeclampsia and those who did not (1.79±0.24mg/dl vs 1.88±0.37mg/dl, p = 0.102). The systolic and diastolic blood pressure showed a significant negative correlation with serum calcium level, unlike serum magnesiun level in those that had preeclampsia. Conclusion: This study showed that women who developed preeclampsia demonstrated reduced serum calcium level and no reduction in serum magnesium level. This study support the hypothesis that hypocalcaemia, unlike hypomagnecaemia, is a possible aetiology of preeclampsia.

scholarly journals A comparative study of serum calcium, magnesium and LDH as the best predictor for severity of pregnancy induced hypertension in the rural population

2017 ◽  
Vol 6 (10) ◽  
pp. 4652
Author(s):  
Mehul Salve ◽  
Aditi Rajgire
Keyword(s):  
Comparative Study ◽  
Serum Calcium ◽  
Magnesium Deficiency ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Calcium And Magnesium ◽  
In Pregnancy

Background: Hypertensive disorders of pregnancy are one of the commonly encountered problem by obstetrician of which, pregnancy induced hypertension leads the list. A number of dietary deficiencies or excesses have been blamed as the cause for preeclampsia over centuries. Studies have shown relationship between dietary deficiencies and incidence of preeclampsia. The lowering of serum calcium and the increase of intracellular calcium can cause an elevation of blood pressure in preeclamptic mothers. Recent investigations suggest that magnesium deficiency could play an important role in the pathogenesis of preeclampsia, particularly in regulating the tonus of arterioles and veins. The relationship of serum leptin and lactate dehydrogenase levels were increased in preeclampsia.Methods: A comparative study to evaluate the levels of serum calcium and serum magnesium and LDH in pregnancy induced hypertension and normal pregnancy and to correlate the serum levels of calcium and magnesium and LDH with the pregnancy induced hypertension.Results: The serum calcium and magnesium has significantly decreased in cases as compared to controls. Whereas the levels of LDH was significantly increased in cases compared to controls. Serum calcium decreased in severe PIH cases compared to mild PIH cases but statistically not significant. Serum magnesium in mild PIH is less compared to severe PIH cases. The decrease is not statistically significant. The increase in LDH in mild case is less compared to severe PIH case. The increase is stastically significant.Conclusion: Routine biochemical evaluation of serum concentration of calcium and magnesium early in pregnancy may be helpful in identifying at risk patients for preeclampsia. Hypocalcemia and Hypomagnesemia in patients with pregnancy induced hypertension may have a cause and effect relationship with the disorder. Amongst the biochemical markers studied LDH level was seen as the best predictor of severity of pregnancy induced hypertension.

CORRELATION OF SERUM MAGNESIUM LEVELS WITH FASTING PLASMA GLUCOSE IN TYPE 2 DIABETES MELLITUS

2021 ◽  
pp. 16-18
Author(s):  
Nishanth Kumar ◽  
Malathi R D ◽  
Ramadevi M
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Serum Magnesium ◽  
Fasting Blood Glucose ◽  
Mean Value ◽  
Control Group ◽  
Mean Values ◽  
Fasting Plasma ◽  
Increased Risk

Background: Diabetes mellitus is a metabolic disorder of multifactorial origin characterized by hyperglycemia and disturbances of glucose , fat and protein metabolism. Hypomagnesemia is been associated with chronic and uncontrolled diabetes mellitus. Magnesium deciency in diabetes is known to be associated with increased risk of microvascular and macrovascular complications. The aim of this study is to estimate fasting plasma glucose and serum magnesium levels and to assess the correlation of hypomagnesemia with abnormal fasting plasma glucose values. Material and Methods: The study was done at Government Medical College, Nizamabad. 80 subjects were recruited out of whom 40 apparently normal persons were taken as control group and the second group of 40 patients with known history of diabetes. The fasting plasma glucose(FPG) was estimated by GOD-POD method and serum Magnesium(Mg) levels were estimated using the Chemchek Mg kit which is based on Xylidyl Blue with ACTS method. Results :The mean values of fasting plasma glucose was 87.1 mg/dL in non diabetics when compared to 159.4 mg/dL in diabetics while Serum magnesium levels in control subjects had a mean value of 2.19mg/dLand 1.8mg/dLin diabetics. The data was analysed and found to be statistically signicant with a negative correlation between plasma magnesium and fasting blood glucose. Conclusion: There is signicant hypomagnesaemia which correlates increased fasting plasma glucose values in diabetics when compared to non diabetics and therefore assessing the serum magnesium levels may help in reducing risk of complications.

scholarly journals Low serum zinc and magnesium–a possible risk factor for first episode Simple febrile seizures in children between 6 months to 5 years of age

2021 ◽  
Author(s):  
Aishwarya Lakshmi L. G. ◽  
Mohanraj Kannan ◽  
Rajakumar P. G. ◽  
Selvaraj R.
Keyword(s):  
Febrile Seizure ◽  
Serum Magnesium ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Mean Value ◽  
First Episode ◽  
Control Group ◽  
Case Group ◽  
High Grade Fever ◽  
Low Serum

Background: Febrile seizure is the most common type of seizure in children. The incidence of febrile seizure is 5-10% in India. There are multiple aetiologies like high grade fever; genetic predisposition, viral infections and trace elements deficiency like iron, zinc, magnesium and calcium are postulated to be risk factors for developing febrile seizures. Recent studies had shown there is a significant association between low serum zinc, low serum magnesium levels and febrile seizures in children.Methods: This was a case control study with 40 children in each group. Children aged 6 months to 5 years with first episode of simple febrile seizures who attends the out-patient department/emergency room (OPD/ER) were included in case group consecutively and 40 children with acute febrile illness without febrile seizures were included in control group. Serum zinc and magnesium levels were estimated for all the children along with other investigations after proper consent from parents. Using statistical package for the social sciences (SPSS) software, independent sample t test was used to analysis the observations between the two groups. Normal lab reference value of serum zinc was 60-120 μg/dl and serum magnesium was 1.7-2.5 mg/dl.Results: The incidence of febrile seizure was high (37.5%) in children between 1-2 years and male (55%) children had increased incidence when compared to female children in case group. The children with febrile seizure had significantly low levels of serum zinc with mean value of 35.08 μg/dl (±8.56) when compared to control group with mean value of 70.23 μg/dl (±13.41) and serum magnesium level in case group was 1.35 mg/dl (±0.29) versus 1.68 mg/dl (±0.42) in control group, which was also statistically significant.Conclusions: The incidence of febrile seizure was high in children between 1-2 years of age with male preponderance. The serum levels of both zinc and magnesium is significantly low in children with febrile seizure pointing a need of further studies in role of supplemental zinc and magnesium in this age group to reduce the incidence of febrile seizures. 

scholarly journals Assessment of the Level of GABA and Some Trace Elements in Blood in Children who Suffer from Familial Febrile Convulsions

2014 ◽  
Vol 2 (1) ◽  
pp. 68-73 ◽  
Author(s):  
Osama N. Salah ◽  
Ehab R. Abdelraouf ◽  
Marwa H. Abdelhameed ◽  
Ahmed A. Dawood ◽  
Adel F. Hashish ◽  
...  
Keyword(s):  
Febrile Seizure ◽  
Serum Magnesium ◽  
Serum Zinc ◽  
Febrile Convulsion ◽  
Serum Levels ◽  
Serum Copper ◽  
Control Group ◽  
Protective Effects ◽  
Gamma Aminobutyric Acid ◽  
Electrolyte Disturbances

Febrile seizure is one of the most common neurological problems during childhood. The etiology and pathogenesis of febrile seizure remain unknown. However, several factors such as vitamin B6 deficiency, electrolyte disturbances, and reduction in serum zinc, selenium, magnesium levels, and low gamma - aminobutyric acid (GABA) levels are thought to play a role in the pathogenesis of febrile seizure. The present study included twenty children from 10 families, 11 were male and 9 were female. Each family has at least 2 members with a history of febrile convulsion. All cases were subjected to the following: Determination of serum levels of copper, zinc, magnesium, selenium level in serum, and plasma level of γ-aminobytaric acid (GABA). Serum levels of selenium and GABA were statistically significantly low in comparison with controls. Serum copper was statistically significantly higher in cases than controls, while serum zinc showed no significant changes in the cases of febrile convulsion compared with the control group. The mean Zn level in the serum of febrile convulsion was found to be at lower level than in the control group. The serum magnesium was significantly low in cases than controls. The logistic regression model in our study shows that Selenium and Magnesium have protective effects, while Copper has causative effect.

Clustering of serum calcium and magnesium concentrations in siblings.

1986 ◽  
Vol 32 (2) ◽  
pp. 349-350 ◽  
Author(s):  
R B Payne ◽  
D P Jones ◽  
A P Walker ◽  
R T Evans
Keyword(s):  
Serum Concentration ◽  
Total Variation ◽  
Serum Calcium ◽  
Serum Magnesium ◽  
Reference Interval ◽  
Magnesium Homeostasis ◽  
Normal Reference ◽  
Calcium And Magnesium ◽  
Altered Serum

Abstract Concentrations of both serum calcium, adjusted for albumin, and serum magnesium of siblings from 23 families were found to cluster around different concentrations within the normal reference interval. Variation between families accounted for 37% of the total variation in calcium and 28% of that in magnesium. A disturbance of serum calcium or magnesium homeostasis in an individual resulting in an altered serum concentration that remains within the reference interval might be recognized by examining values in siblings.

INSULIN EFFECTS ON CALCIUM, MAGNESIUM AND PHOSPHATE METABOLISM IN RATS

1974 ◽  
Vol 75 (4) ◽  
pp. 748-755 ◽  
Author(s):  
Erling T. Mellerup
Keyword(s):  
Serum Calcium ◽  
Indirect Effects ◽  
Serum Magnesium ◽  
Serum Phosphate ◽  
The Other ◽  
Phosphate Metabolism ◽  
Insulin Administration ◽  
Other Hand ◽  
Calcium Magnesium ◽  
Calcium And Magnesium

ABSTRACT Serum calcium as well as serum magnesium increased after insulin administration to rats. The increase in serum calcuim was followed by a decrease, which did not occur in thyroid-parathyroidectomized animals. The increase in both serum calcium and magnesium may be secondary to a diminished uptake of calcium and magnesium into bone. On the other hand this may be secondary to a decreased uptake of phosphate into bone. The decreased uptake of phosphate into bone may be secondary to the decrease in serum phosphate, which is a well-known phenomenon after insulin administration. In addition to all these indirect effects, insulin directly increased the uptake of magnesium into muscle and probably also the liver, thus counteracting the increase in serum magnesium.

scholarly journals A Study of Serum Calcium and Magnesium Levels in Idiopathic Epilepsy Patients of Hubli, Karnataka, India

2021 ◽  
Vol 8 (25) ◽  
pp. 2187-2191
Author(s):  
Chandrashekar Kachapur ◽  
Seetaram N. Kallimani ◽  
Gayathri B.H ◽  
Ishwar S. Hasabi ◽  
Zahura M. Devarhoru
Keyword(s):  
Serum Calcium ◽  
Calcium Influx ◽  
Serum Magnesium ◽  
Idiopathic Epilepsy ◽  
Total Serum ◽  
Cross Sectional ◽  
Total Serum Calcium ◽  
Study Results ◽  
Significant Difference ◽  
Calcium And Magnesium

BACKGROUND Magnesium is a potential modulator of seizure activity because of its ability to antagonize the excitatory calcium influx through N-methyl-D-aspartate (NMDA) receptor which is thought to play a role in many human forms of epilepsy. When the extracellular concentration of calcium ion falls below normal, the nervous system becomes more excitable, allowing easy initiation of action potentials. Consequently, hypocalcaemia causes seizures because of its action of increasing excitability in the brain. We wanted to estimate the serum concentration of calcium and magnesium in idiopathic epilepsy patients and its co-relation. METHODS 94 cases of idiopathic epilepsy with breakthrough seizures admitted to KIMS Hospital, Hubli, meeting the inclusion criteria were considered for the study which was for 2-years’ time period. It’s a single centred, time bound and cross sectional study. RESULTS Mean serum calcium was low 8.36 ± 0.45 mg / dL and mean serum magnesium was 1.79 ± 0.28 mg / dL. 64.9 % had total serum calcium less than 8.5 mg / dL and 44.7 % had serum magnesium of < 1.8 mg / dL. 35.1 % had both low calcium and magnesium. There was significant difference in mean serum calcium with respect to number of episodes. There was no significant difference in mean serum magnesium with respect to number of episodes. CONCLUSIONS Serum calcium and magnesium levels which play a role in seizure initiation should be measured in all idiopathic epilepsy patients with breakthrough seizures as a seizure trigger. Considering the role of calcium and magnesium in the pathophysiology of seizures and by evaluating the results from the present study, breakthrough seizure could be provoked by hypocalcaemia and hypomagnesemia. Hence they may be used for the treatment of intractable seizures. KEYWORDS Calcium, Magnesium, Idiopathic Epilepsy

scholarly journals Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

2020 ◽  
pp. 61-66
Author(s):  
Asia Parveen ◽  
Khan Farooq ◽  
Fatima Arshad ◽  
Modasrah Mazhar ◽  
Nureen Zahra ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Serum Magnesium ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Group A

Background/ Aim: Pregnancy induced hypertension (PIH) has been a leading cause of maternal mortality worldwide. It could be responsible for several complications like hemodilution, altered lipid metabolism and deficiencies of different minerals in body. Although the causes of Pregnancy induced hypertension (PIH) remains indistinct. The aim of our present study was to evaluate the changes in magnesium serum levels and lipid profile in hypertensive and normotensive pregnant women. Materials and Methods: An analytical case control study comprising 60 individuals was designed. From which 30 normotensive pregnant women served as control group (A) and 30 pregnancy induced hypertensive women served as case group (B). Patients with pre-existing hypertension were excluded. Results: The independent t-test was used for comparison of various parameters between group A and B. Triacylglycerol (TAG) and low density lipoprotein cholesterol (LDL-C) levels were significantly high in PIH (B) as compare to normotensive group (A). Mean serum values of TG were measured as (195.73 ± 70.28 vs 156.27 ± 55.60 mg dL-1) and LDL-C vs control (87.33 ± 37.74 vs 69.45 ± 28.58 mg dL-1) in PIH and normotensive groups respectively. HDL-C in PIH vs Control (47.40±1.12 vs 54.43 ±1.27 mg dL-1) and Mg+2 PIH vs control (1.36±0.07 vs 1.94±0.35 mg dL-1) were measured respectively. High density lipoprotein cholesterol (HDL-C) and magnesium Mg+2 levels were significantly reduced in PIH. Conclusion: The lower serum magnesium levels and abnormal lipids profile may indicate their possible role as risk factors in the development of PIH in pregnant women. Hence initial diagnosis of hypomagnesemia in PIH cases may help in minimizing the complications and development of new cure strategies.

scholarly journals Investigating the Relationship between Serum Level of s-Met (Soluble Hepatic Growth Factor Receptor) and Preeclampsia in the First and Second Trimesters of Pregnancy

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Farshad Naghshvar ◽  
Zhila Torabizadeh ◽  
Narges Moslemi Zadeh ◽  
Hooman Mirbaha ◽  
Parand Gheshlaghi
Keyword(s):  
Growth Factor ◽  
Serum Level ◽  
Growth Factor Receptor ◽  
Serum Levels ◽  
Severe Preeclampsia ◽  
Soluble Form ◽  
Control Group ◽  
Case Group ◽  
Mortality And Morbidity ◽  
Hepatic Growth Factor

Introduction. Preeclampsia (PE) is an important cause of mortality and morbidity for mothers, fetuses, and the newborns. Placenta plays a pivotal role in pathogenesis of PE. Hepatic growth factor (HGF) is a cytokine expressed by the mesenchymal stalk of placental villi during pregnancy and assumes a paracrine role in trophoblasts which express its receptor (c-MET). In the present study, we investigate the diagnostic value of s-Met (the soluble form of the receptor) in the first and second trimesters of pregnancy for early diagnosis of preeclampsia. Method and Materials. This is a case-control study conducted on 95 pregnant women. The serum level of s-Met was measured in the first and second trimesters, and the participants were followed until delivery. 44 individuals with preeclampsia (the case group) and 51 individuals without preeclampsia (the control group) were evaluated. Results. Serum level of s-Met in preeclamptic participants was lower than that of the control group in both the first and the second trimesters (P<0.0001). In addition, serum levels of s-Met were significantly lower during the first and second trimesters in patients with early, severe preeclampsia compared to those with late, mild preeclampsia (P<0.0001). The sensitivity and specificity of s-Met in the first and second trimesters were, respectively, (83%, 94%) and (77%, 94%) for early preeclampsia and (88%, 92%) and (86%, 98%) for severe preeclampsia. Conclusion. Considering our findings, serum level of s-Met may be used as a predictive factor for early detection of preeclampsia. Further research is required to corroborate the functional and therapeutic value of s-Met in preeclampsia.

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