scholarly journals Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET

2008 ◽  
Vol 50 (1) ◽  
pp. 68-71 ◽  
Author(s):  
O. Manabe ◽  
K. Yoshinaga ◽  
C. Katoh ◽  
M. Naya ◽  
R. A. deKemp ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Dynamic Pet ◽  
Flow Measurements ◽  
Blood Flow Measurements

The impact of prompt gamma compensation on myocardial blood flow measurements with rubidium-82 dynamic PET

2016 ◽  
Vol 25 (2) ◽  
pp. 596-605 ◽  
Author(s):  
Ian S. Armstrong ◽  
Matthew J. Memmott ◽  
Christine M. Tonge ◽  
Parthiban Arumugam
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Prompt Gamma ◽  
Dynamic Pet ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
The Impact ◽  
Rubidium 82

scholarly journals Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Adrian F. Ocneanu ◽  
Robert A. deKemp ◽  
Jennifer M. Renaud ◽  
Andy Adler ◽  
Rob S. B. Beanlands ◽  
...  
Keyword(s):  
Blood Flow ◽  
Kinetic Model ◽  
Myocardial Blood Flow ◽  
Input Function ◽  
Blood Pool ◽  
Flow Measurements ◽  
Flow Reserve ◽  
Arterial Blood ◽  
Spillover Correction ◽  
Blood Flow Measurements

Purpose. Myocardial blood flow (MBF) quantification with Rb82 positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic Rb82 PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: (1) blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), (2) dual spillover correction (SOC-On/Off), (3) right blood correction (RBC-On/Off), (4) arterial blood transit delay (Delay-On/Off), and (5) distribution volume (DV) constraint (Global/Regional-DV). Repeatability of MBF, stress/rest myocardial flow reserve (MFR), and stress/rest MBF difference (ΔMBF) was assessed using nonparametric reproducibility coefficients (RPCnp = 1.45 × interquartile range). Results. MBF using SOC-On, RVBC-Off, Blood-ROI, Global-DV, and Delay-Off was most repeatable for combined rest and stress: RPCnp = 0.21 mL/min/g (15.8%). Corresponding MFR and ΔMBF RPCnp were 0.42 (20.2%) and 0.24 mL/min/g (23.5%). MBF repeatability improved with SOC-On at stress (p<0.001) and tended to improve with RBC-Off at both rest and stress (p<0.08). DV and ROI did not significantly influence repeatability. The Delay-On model was overdetermined and did not reliably converge. Conclusion. MBF and MFR test-retest repeatability were the best with dual spillover correction, left atrium blood input function, and global DV.

Comparison between regional myocardial blood flow measurements and results of exercise tests

1977 ◽  
Vol 3 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Barbara H. Roberts ◽  
Peter F. Cohn ◽  
B. Leonard Holman ◽  
Douglass F. Adams ◽  
Jackie R. See
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Regional Myocardial Blood Flow ◽  
Exercise Tests ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
Regional Myocardial Blood

Increased number of myocardial blood flow measurements with radionuclide-labeled microspheres

1984 ◽  
Vol 246 (3) ◽  
pp. H418-H434 ◽  
Author(s):  
R. W. Baer ◽  
B. D. Payne ◽  
E. D. Verrier ◽  
G. J. Vlahakes ◽  
D. Molodowitch ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Least Squares ◽  
Reference Sample ◽  
Separation Technique ◽  
Fixed Amount ◽  
Flow Measurements ◽  
Coronary Pressure ◽  
Blood Flow Measurements

We evaluated the use of a least-squares radionuclide separation technique to allow an increased number of myocardial blood flow measurements with radionuclide-labeled microspheres in dogs. Two sets of labeled microspheres were studied: a set of eight labeled with 125I, 153Gd, 57Co, 51Cr, 113Sn, 85Sr, 95Nb, and 46Sc; and a set of nine in which 125I and 46Sc were replaced with 114In, 54Mn, and 65Zn. For each microsphere label the nuclide activities determined by least-squares separation compared favorably with those actually added to in vitro samples containing a fixed amount of the other nuclides in the set. For the set of eight radionuclide-labeled microspheres, myocardial flow measurements made with the least-squares separation technique and the reference sample method were usually within 15% and almost all within 20% of direct measurements of coronary venous outflow in a right heart bypass preparation. Serial left atrial injections of 15-micron microspheres totaling 48 X 10(6) caused no significant changes in systemic hemodynamics, regional myocardial flows, or coronary pressure-flow relations, whether the coronary bed was autorelating or vasodilated with chromonar. We conclude that at least nine myocardial blood flow measurements can be made in dogs with acceptable accuracy and without evidence of dysfunction due to embolization of the coronary vascular bed. With appropriate validation, this method should be applicable to other organs and animal models as well.

scholarly journals Low CT temporal sampling rates result in a substantial underestimation of myocardial blood flow measurements

2018 ◽  
Vol 35 (3) ◽  
pp. 539-547 ◽  
Author(s):  
Marly van Assen ◽  
Gert Jan Pelgrim ◽  
Emmy Slager ◽  
Sjoerd van Tuijl ◽  
U. Joseph Schoepf ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Flow Measurements ◽  
Temporal Sampling ◽  
Blood Flow Measurements
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