A comparative study between olive oil and Nigella Sativa oil in treatment of hyperlipidemia induced in male albino mice

2014 ◽  
Vol 38 (2) ◽  
pp. 123-127
Author(s):  
Lubna Ahmed Kafi
Keyword(s):  
Olive Oil ◽  
Nigella Sativa ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Positive Control ◽  
Negative Control ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Nigella Sativa Oil

     This study was conducted on 20 adult mice which were divided randomly in to 4 equal groups. The first group served as negative control (NC) that received the diluent (sun flower oil), while hyperlipidemia was induced in the other three groups, the second group received the diluent and considered as positive control (PC), while group three and four were treated with olive oil (OO) or Nigella sativa oil (NSO) at a dose of 0.4ml/kg BW orally, respectively for two months. At the end of experiment and fasting overnight, lipid profile which included (total cholesterol TC, triglyceride TG, high density lipoprotein cholesterol HDL-C, low density lipoprotein cholesterol LDL-C and very low density lipoprotein cholesterol VLDL-C) were measured. The results indicated significant (P<0.05) improvement in all these parameters as compare to the positive control, while the value of HDL-C was significantly higher in the olive oil treated group as compared with all groups including negative control group.

scholarly journals Antiatherogenic Potential ofNigella sativaSeeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Ghanya Al-Naqeep ◽  
Adel S. Al-Zubairi ◽  
Maznah Ismail ◽  
Zulkhairi Hj Amom ◽  
Norhaizan Mohd Esa
Keyword(s):  
Nigella Sativa ◽  
Middle Eastern ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Positive Control ◽  
Plaque Formation ◽  
Lipoprotein Cholesterol ◽  
Herbaceous Plant ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Nigella sativaor Black seed (N. sativaL.) is traditionally used for several ailments in many Middle Eastern countries. It is an annual herbaceous plant that belongs to the Ranuculacea family with many beneficial properties as antitumor, antidiabetic, antihypertensive, antioxidative and antibacterial. This work attempted to study the effect ofN. sativaseeds powder and oil on atherosclerosis in diet-induced hypercholesterolemic (HC) rabbits in comparison with simvastatin (ST). Twenty-five adult New Zealand male white rabbits, weighing 1.5–2.5 kg, were divided into five groups; normal group (NC,n=5) and four hypercholesterolemic groups (n=20): a positive control (PC) and three HC groups force fed diet supplemented with 1000 mg Kg−1body weight ofN. sativapowder (NSP), 500 mg Kg−1bodyN. sativaoil (NSO) and 10 mg Kg−1ST for 8 weeks. Feeding HC rabbits withN. sativaeither in powder or oil forms was shown to significantly reduce (P<.05) total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels and enhance high-density lipoprotein cholesterol (HDL) levels after treatment for 2, 4, 6 and 8 weeks compared to the PC group. Plaque formation was significantly inhibited while the intima: media ratio was significantly reduced in the NSP and NSO supplemented groups compared to the PC group. In conclusion, treatment of HC rabbits withN. sativaseeds powder or oil showed hypocholesterolemic and antiatherogenic cardioprotective properties.

Effect of Honey & Olive Oil Supplemented Bio-Yoghurt Feeding on Lipid Profile, Blood Glucose and Hematological Parameters in Rats

2019 ◽  
Vol 15 (2) ◽  
pp. 140-147
Author(s):  
Magdy M. Ismail ◽  
El-Tahra M. Ammar ◽  
Abd El-Wahab E. Khalil ◽  
Mohamed Z. Eid
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Olive Oil ◽  
Body Weight Gain ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background and Objective: Yoghurt, especially bio-yoghurt has long been recognized as a product with many health benefits for consumers. Also, honey and olive oil have considerable nutritional and health effects. So, the effect of administration of yoghurt made using ABT culture and fortified with honey (2 and 6%), olive oil (1 and 4%) or honey + olive oil (2+1 and 6+4% respectively) on some biological and hematological properties of rats was investigated.Methods:The body weight gain, serum lipid level, blood glucose level, serum creatinine level, Glutamic Oxaloacetic Transaminase (GOT) activity, Glutamic Pyruvic Transaminase (GPT) activity, leukocytes and lymphocytes counts of rats were evaluated.Results:Blending of bio-yoghurt with rats&#039; diet improved body weight gain. Concentrations of Total plasma Cholesterol (TC), High-Density Lipoprotein cholesterol (HDL), Low-Density Lipoprotein cholesterol (LDL), Very Low-Density Lipoprotein cholesterol (VLDL) and Triglycerides (TG) significantly lowered in plasma of rats fed bio-yoghurt. Levels of TC, LDL, VLDL, and TG also decreased in rat groups feed bio-yoghurt supplemented with honey and olive oil. LDL concentrations were reduced by 10.32, 18.51, 34.17, 22.48, 43.30% in plasma of rats fed classic starter yoghurt, ABT yoghurt, ABT yoghurt contained 6% honey, ABT yoghurt contained 4% olive oil and ABT yoghurt contained 6% honey + 4% olive oil respectively. The blood glucose, serum creatinine, GOT and GPT values of rats decreased while white blood cells and lymphocytes counts increased by feeding bioyoghurt contained honey and olive oil.Conclusion:The findings enhanced the multiple therapeutic effects of bio-yoghurt supplemented with honey and olive oil.

scholarly journals Antidiabetic Efficacy of Nigella sativa Linn. in Alloxan-induced Diabetic Rabbits

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Ikram F ◽  
Hussain F
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Nigella Sativa ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Β Cells ◽  
Diabetic Rabbits

Introduction: Diabetes mellitus (DM) is the most common metabolic disease worldwide. Multiple medications and side effects, the most significant and prevalent themes in diabetes mellitus ultimately determine novel directions and avenues in drug discovery. The present study was conducted to investigate antidiabetic efficacy of extracts of Nigella sativa Linn. seeds (NS). Methods: Alloxan-induced diabetic rabbits (n = 28) were divided into four groups, including diabetic control. Two groups were treated with NS methanol (NSM) and ethanol (NSE) extracts, and one group were given glibenclamide. Serum glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) were measured by kit methods. Results: NS demonstrated hypoglycaemic and hypolipidaemic activities. Although NS treatments decreased blood glucose, TC, TG and LDL-C and increased HDL-C in diabetic groups, it was unable to normalize all the parameters. NS extracts did not regenerate β-cells of islet of the pancreas. Glibenclamide showed significant (P<0.05) decline in hyperglycaemia and hyperlipidaemia as well as prominent renewal of β-cells of islets of Langerhans. Few surviving beta cells of islet of the pancreas were apparent in NSM treated group. Standard drug glibenclamide showed a significant decline in hyperglycaemia and hyperlipidaemia as well as prominent renewal of beta cells. Conclusion: N. sativa L. extracts have curative effects in terms of diabetes-induced disturbances of glucose and lipids. Further investigations are suggested to ascertain the therapeutic role of NS on islet histopathology in diabetes mellitus.

Effects of Nigella Sativa (Black seeds) Supplementation on Plasma Lipid Profile in Human Subjects – A review

2021 ◽  
Vol 02 ◽  
Author(s):  
Naina Mohamed Pakkir Maideen
Keyword(s):  
Nigella Sativa ◽  
Human Subjects ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Lifestyle Changes ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Black Seeds

: Dyslipidemia is the major risk factor for atherosclerotic cardiovascular disease (ASCVD), cerebrovascular disease and peripheral artery disease (PAD). It is characterized by higher plasma concentrations of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c), apolipoprotein B (apoB), very low density lipoprotein-cholesterol (VLDL-c), triglycerides (TGs) and low levels of high density lipoprotein-cholesterol (HDL-c). Herbal medicines are preferred by many across the globe particularly to manage chronic conditions such as dyslipidemia, hypertension, type 2 diabetes, cancer, and plenty of others. Nigella sativa (Black seeds or Black cumin seeds) is a miracle herb employed within the management of many sicknesses for centuries. Hence, this review focuses on the ameliorative effects of N. sativa on the plasma lipid concentrations of human subjects. Numerous randomized controlled clinical trials (RCTs) and different clinical studies demonstrated that N. sativa possess potential anti-dyslipidemic activity. The patients with dyslipidemia may well be benefited by using N. sativa along with healthy lifestyle changes and statin and other antihyperlipidemic medications as adjuvant therapy if needed.

scholarly journals Hypocholesterolaemic and Anti-Atherogenic Effects of Palm-Based Oils (NoveLin I and NoveLin II) in Cholesterol-Fed Rabbits

2020 ◽  
Vol 17 (9) ◽  
pp. 3226
Author(s):  
Che Anishas Che Idris ◽  
Siew Wai Lin ◽  
Ahmad Faizal Abdull Razis
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Olive Oil ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Equal Distribution

NoveLin I and NoveLin II are palm-based oils. NoveLin I has an equal distribution of saturated, monounsaturated and polyunsaturated fatty acids, whereas NoveLin II has a moderate level of monounsaturated fatty acids, and a lower content of saturated and polyunsaturated fatty acids. However, their hypocholesterolaemic and anti-atherogenic effects have not been studied. Therefore, this study aimed to assess the hypocholesterolaemic and anti-atherogenic effects of these oils. Forty male New Zealand White rabbits were divided into four groups and fed with diets containing 35% energy fat with added 0.15% (w/w) dietary cholesterol. Group 1, as the control group (CNO) was fed with a diet containing coconut oil, group 2 and 3 were fed with diets containing either NoveLin I or NoveLin II, and group 4, was fed with diet containing olive oil (OLV) for 100 days. Our results demonstrated that both NoveLin groups have significantly lower total cholesterol and low-density lipoprotein–cholesterol (LDL–C) compared to CNO group and are comparable to the OLV group. Low density lipoprotein–cholesterol/high density lipoprotein-cholesterol (LDL/HDL–C) ratio was significantly lower after the NoveLin II diet but attained significance only in comparison to NoveLin I and CNO groups. Aortic fibrous plaque score was significantly lower in both NoveLin groups compared to CNO group. Our findings suggest that despite the high-fat cholesterol diet, NoveLin II oil resulted in atherogenic effects comparable to olive oil.

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