scholarly journals Pre-emptive analgesia VS Prophylactic analgesia and its influence on postoperative pain in postoperative laparoscopic cholecystectomy patients

2020 ◽  
Vol 1 (2) ◽  
pp. 038-043
Author(s):  
María Fernanda Maya Guerrero ◽  
Fabiola María Nuccio Giordano ◽  
Bernardo José Gutiérrez Sougarret ◽  
Alejandro Díaz Girón Gidi
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Postoperative Pain ◽  
Total Dose ◽  
Pain Control ◽  
Randomized Study ◽  
Pain Scale ◽  
Postoperative Pain Control ◽  
Double Blind ◽  
The Moment

Introduction: There are no studies on the use of dexketoprofen for postoperative pain control in patients undergoing laparoscopic cholecystectomy. Purpose: To assess if the timing of dexketoprofen administration influences the intensity of postoperative pain in patients undergoing laparoscopic cholecystectomy. Materials and methods used: Experimental, longitudinal, double-blind, randomized study. 50 mg of dexketoprofen diluted in 50 ml of 0.9% saline was administered to 50 patients divided into two groups: Pre-operative group: the substance was administered one hour before the beginning of surgery. Trans-operative group: the substance was administered at the moment when the gallbladder was separated from the liver base. The Numerical Pain Scale was evaluated and the number of doses and the total dose of tramadol that the patients received as analgesic rescue was quantified. Results: Administration of dexketoprofen before starting laparoscopic cholecystectomy tends to reduce the intensity of postoperative pain without being statistically significant. Conclusion: The timing of dexketoprofen administration has no impact on postoperative pain in patients operated for laparoscopic cholecystectomy.

scholarly journals Bayesian inference for causal mechanisms with application to a randomized study for postoperative pain control

Biostatistics ◽  
2017 ◽  
Vol 18 (4) ◽  
pp. 605-617 ◽  
Author(s):  
Michela Baccini ◽  
Alessandra Mattei ◽  
Fabrizia Mealli
Keyword(s):  
Postoperative Pain ◽  
Mediation Analysis ◽  
Pain Control ◽  
Randomized Study ◽  
Double Blind Study ◽  
Principal Stratification ◽  
Self Administration ◽  
Postoperative Pain Control ◽  
Double Blind ◽  
Effect Of Treatment

SUMMARY We conduct principal stratification and mediation analysis to investigate to what extent the positive overall effect of treatment on postoperative pain control is mediated by postoperative self administration of intra-venous analgesia by patients in a prospective, randomized, double-blind study. Using the Bayesian approach for inference, we estimate both associative and dissociative principal strata effects arising in principal stratification, as well as natural effects from mediation analysis. We highlight that principal stratification and mediation analysis focus on different causal estimands, answer different causal questions, and involve different sets of structural assumptions.

A prospective randomized double-blind controlled trial to evaluate the efficacy of an analgesic epidural paste following lumbar decompressive surgery

1999 ◽  
Vol 90 (2) ◽  
pp. 191-197 ◽  
Author(s):  
R. John Hurlbert ◽  
Nicholas Theodore ◽  
Janine B. Drabier ◽  
Andrea M. Magwood ◽  
Volker K. H. Sonntag
Keyword(s):  
Postoperative Pain ◽  
Pain Control ◽  
Short Form ◽  
Health Perception ◽  
Decompressive Surgery ◽  
Postoperative Pain Control ◽  
Double Blind ◽  
Content Type ◽  
Active Paste ◽  
Fine Print

Object. Pain control can often be improved by local (as opposed to systemic) application of analgesic and/or anesthetic medication. The purpose of this study was to evaluate the efficacy of a single-dose epidural analgesic “paste” in the control of postoperative pain in patients who have undergone lumbar decompressive surgery. Methods. Sixty patients undergoing routine elective lumbar decompressive surgery were randomized in a double-blind fashion to one of two groups: those receiving active paste or placebo paste. The paste was applied to the exposed dura at the time of surgery, just prior to wound closure. Patients received follow-up care in the hospital and at home for 3 months postsurgery. Several outcome measures were studied to ascertain differences in pain control and to ensure comparability between groups. Patients who received active paste demonstrated significantly lower pain scores compared with those who received placebo paste for up to 6 weeks postoperatively. General health perception indexed by the Short Form 36 was also significantly better in patients who received active paste for up to 6 weeks. In-hospital and outpatient oral narcotic consumption was significantly lower in the active paste-treated group. Inpatient straight leg raising scores were improved in those patients who received active compared with control paste. Conclusions. Application of an analgesic paste directly to the epidural space during lumbar decompressive surgery significantly improves postoperative pain control, reduces prescribed analgesic drug consumption, and improves overall health perception for up to 6 weeks following surgery. The authors conclude that this postoperative pain control strategy is both effective and safe and may provide a new standard of pain management in patients undergoing lumbar discectomy or laminectomy.

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