Bupivacaine Hydrochloride Injection

2021 ◽  
Keyword(s):  
Bupivacaine Hydrochloride

The analgesic efficacy of liposomal bupivacaine compared with bupivacaine hydrochloride for the prevention of postoperative pain: a systematic review and meta-analysis with trial sequential analysis

2021 ◽  
pp. rapm-2020-102427
Author(s):  
Hanns-Christian Dinges ◽  
Thomas Wiesmann ◽  
Berit Otremba ◽  
Hinnerk Wulf ◽  
Leopold H Eberhart ◽  
...  
Keyword(s):  
Systematic Review ◽  
Postoperative Pain ◽  
Pain Score ◽  
Meta Analysis ◽  
End Points ◽  
Liposomal Bupivacaine ◽  
Bupivacaine Hydrochloride ◽  
Pain Scores ◽  
Score Difference ◽  
The Mean

Background/ImportanceLiposomal bupivacaine (LB) is a prolonged release formulation of conventional bupivacaine designed for prolonging local or peripheral regional single injection anesthesia. To this day, the benefit of the new substance on relevant end points is discussed controversial.ObjectiveThe objective was to determine whether there is a difference in postoperative pain scores and morphine consumption between patients treated with LB and bupivacaine hydrochloride in a systematic review and meta-analysis.Evidence reviewRandomized controlled trials (RCT) were identified in Embase, CENTRAL, MEDLINE and Web of Science up to May 2020. Risk of bias was assessed using Cochrane methodology. Primary end points were the mean pain score difference and the relative morphine equivalent (MEQ) consumption expressed as the ratio of means (ROM) 24 and 72 hours postoperatively.Findings23 RCTs including 1867 patients were eligible for meta-analysis. The mean pain score difference at 24 hours postoperatively was significantly lower in the LB group, at −0.37 (95% CI −0.56 to −0.19). The relative MEQ consumption after 24 hours was also significantly lower in the LB group, at 0.85 (0.82 to 0.89). At 72 hours, the pain score difference was not significant at −0.25 (−0.71 to 0.20) and the MEQ ratio was 0.85 (0.77 to 0.95).ConclusionThe beneficial effect on pain scores and opioid consumption was small but not clinically relevant, despite statistical significance. The effect was stable among all studies, indicating that it is independent of the application modality.

A Comparative Evaluation of the Anaesthetic Properties of Bupivacaine Hydrochloride and Ketamine Hydrochloride with Dextrose Given Intrathecally for Inguinal Hernia Repair - A Randomized Controlled Study in a Tertiary Centre in South Kerala

2021 ◽  
Vol 8 (41) ◽  
pp. 3520-3520
Author(s):  
Ranju Sebastian ◽  
Remani Kelan Kamalakshi ◽  
Jamsheena Muthira Parambath ◽  
Praseetha Vallomparambath Kuttiparambil
Keyword(s):  
Inguinal Hernia ◽  
Hernia Repair ◽  
Inguinal Hernia Repair ◽  
Comparative Evaluation ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Bupivacaine Hydrochloride ◽  
Randomized Controlled ◽  
Tertiary Centre ◽  
Ketamine Hydrochloride

The above article has been withdrawn on authors’ request. Original CitationSebastian R, Kamalakshi RK, Parambath JM, et al. A comparative evaluation of the anaesthetic properties of upivacaine hydrochloride and ketamine hydrochloride with dextrose given intrathecally for inguinal hernia repair – a randomized controlled study in a tertiary centre in south Kerala. J Evid Based Med Healthc 2021;8(31):2830- 2834. DOI:10.18410/jebmh/2021/518

scholarly journals ANESTESIA INALATÓRIA COM O USO DE MÁSCARA LARÍNGEA EM UM CHIMPANZÉ (Pan troglodytes)

2000 ◽  
Vol 5 (1) ◽  
Author(s):  
R. G. D´O. C. VILANI ◽  
P. D´O. C. VILANI ◽  
J. R. PACHALY ◽  
P. R. MANGINI ◽  
G. V. MACHADO ◽  
...  
Keyword(s):  
Pan Troglodytes ◽  
Minimum Alveolar Concentration ◽  
Open Circuit ◽  
Laryngeal Mask ◽  
Left Forearm ◽  
Anesthetic Induction ◽  
Adequate Ventilation ◽  
Bupivacaine Hydrochloride ◽  
Anesthetic Drugs ◽  
Effective Ventilation

Um exemplar de chimpanzé (Pan troglodytes) do sexo masculino, com idade de 5 dias e peso de 1,72 kg, foi submetido à anestesia inalatória através de uma máscara laríngea, para realização de amputação do antebraço esquerdo mutilado em função de agressão intraespecífica. A máscara laríngea auxilia na manutenção da permeabilidade das vias aéreas do paciente anestesiado, permitindo um controle seguro e eficaz da ventilação em situações distintas. O paciente sofreu indução anestésica com halotano e oxigênio, através da máscara facial classicamente empregada em pacientes humanos, sem medicação pré-anestésica. Após três minutos de administração do anestésico em concentrações crescentes até 1,5%, observou-se excelente miorrelaxamento, inclusive da musculatura da região temporo-mandibular. Foi inserida então uma máscara laríngea nº 1,5 não insuflada, que foi conectada a um circuito semi-aberto de anestesia inalatória, através do sistema de Baraka. A anestesia foi mantida com oxigênio e halotano em concentrações variáveis entre 0,3 e 0,5%. Para possibilitar redução da concentração alveolar mínima do anestésico inalatório e permitir analgesia pós-operatória, foi realizado por via supra-clavicular um bloqueio do plexo braquial, empregando-se cloridrato de bupivacaína a 0,25%, sem vasoconstritor, na dose total de 2,1 mg. Os dados vitais do paciente foram periodicamente monitorizados pela mensuração das freqüências respiratória e cardíaca através de oximetria de pulso. A anestesia prolongou-se por 120 minutos, observando-se excelente analgesia e miorrelaxamento plenamente adequado. A SpO2 se manteve constante em 100% durante todo o procedimento, e a freqüência cardíaca variou entre 94 e 100 bpm. O despertar ocorreu dois minutos após cessada a administração do anestésico inalatório, e os reflexos mostraram-se plenamente presentes em cinco minutos. A inserção da máscara laríngea ocorreu na primeira tentativa, e seu uso apresentou-se como uma excelente alternativa para adequada ventilação do paciente. Inhalatory anesthesia with laryngeal mask in a chimpanzee (Pan troglodytes) Abstract A five-day old male chimpanzee (Pan troglodytes) weighing 1,72 Kg was submitted to inhalatory anesthesia using a laryngeal mask, under the indication of amputation of the left forearm mutilated because of an intraespecific aggression. The laryngeal mask helps to maintain the air tract patency in anesthetic patients, allowing a safe and effective ventilation control in distinct situations. The patient was submitted to anesthetic induction with halothane and oxygen through the facial mask commonly used in human patients, without pre-anesthetic drugs. After three minutes of anesthetic administration in crescent concentrations until 1.5%, an excellent myorelaxation was observed, including in the temporo-mandibular muscles. A not inflated # 1.5 laryngeal mask was inserted and connected to a semi-open circuit of inhalatory anesthesia, by using the Baraka´s system. It was maintained with oxygen and halothane in variable concentrations between 0.3% and 0.5%. In order to allow a reduction in the inhalatory anesthestic´s minimum alveolar concentration and permit post-surgical analgesia there was performed a block of the brachial plexus by supra-clavicular route, using 0.25% bupivacaine hydrochloride without vasoconstritor, in a total dose of 2.1 mg. Patient’s vital sings were periodically monitored by measuring respiratory and heart rates by pulse-oximetry. The anesthesia extended by 120 minutes, providing excellent analgesia and adequate myorelaxation. The SpO2 was maintained constant in 100% during the whole procedure, and the heart rate oscillated between 94 and 100 bpm. The waken-up occurred two minutes after ceasing the administration of the inhalatory anesthetic, and all the reflexes were present within five minutes. The laryngeal mask was correctly inserted in the first trial, and its use was an excellent alternative for the patient’s adequate ventilation.

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