scholarly journals ROLE OF TISSUE, SERUM AND SALIVARY MICRO RNA 21 IN ORAL POTENTIALLY MALIGNANT DISORDERS AND ORAL CARCINOMA- A SYSTEMATIC REVIEW

2014 ◽  
Vol 5 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Peter Thomson

Oral potentially malignant disorders are mucosal diseases with a significantly increased risk of squamous carcinoma development – a lethal and deforming disease with rising incidence, especially in young people. Despite the ability to recognise pre-cancer disorders in patients, clinicians remain unable to predict individual mucosal lesion behaviour or quantify the risk of malignant transformation. No clear management guidelines exist and the available scientific literature is unable to answer the fundamental question: does early diagnosis and interventional management treat pre-cancer effectively and prevent malignant transformation?


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