Gelatin promotes murine fibrosarcoma L929 cell detachment and protects the cells from TNFα-induced cytotoxicity

2016 ◽  
Vol 57 (4) ◽  
pp. 262-269 ◽  
Author(s):  
Hong-Ju Wang ◽  
Meng-Qi Li ◽  
Wei Liu ◽  
Guo-Dong Yao ◽  
Ming-Yu Xia ◽  
...  
Keyword(s):  
L929 Cell ◽  
Cell Detachment ◽  
Murine Fibrosarcoma

Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin

Phytomedicine ◽  
2010 ◽  
Vol 18 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Zi-ting Zhang ◽  
Hao Peng ◽  
Chun-yang Li ◽  
Jun-jie Liu ◽  
Ting-Ting Zhou ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
L929 Cell ◽  
Ophiopogon Japonicus ◽  
Murine Fibrosarcoma ◽  
Dependent Pathway

scholarly journals Pseudolaric Acid B Induced Cell Cycle Arrest, Autophagy and Senescence in Murine Fibrosarcoma L929 Cell

2013 ◽  
Vol 10 (6) ◽  
pp. 707-718 ◽  
Author(s):  
Jing hua Yu ◽  
Chun yu Liu ◽  
Gui bin Zheng ◽  
Li Ying Zhang ◽  
Ming hui Yan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
L929 Cell ◽  
Pseudolaric Acid B ◽  
Cycle Arrest ◽  
Murine Fibrosarcoma

Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras–Raf and PI3K–Akt signaling pathways

Biochimie ◽  
2010 ◽  
Vol 92 (12) ◽  
pp. 1934-1938 ◽  
Author(s):  
Bo Liu ◽  
Jin-ming Wu ◽  
Jing Li ◽  
Jun-jie Liu ◽  
Wen-wen Li ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Cell Apoptosis ◽  
L929 Cell ◽  
Akt Signaling ◽  
Murine Fibrosarcoma

scholarly journals Self-Targeting of Carbon Dots into the Cell Nucleus: Diverse Mechanisms of Toxicity in NIH/3T3 and L929 Cells

2021 ◽  
Vol 22 (11) ◽  
pp. 5608
Author(s):  
Markéta Havrdová ◽  
Iztok Urbančič ◽  
Kateřina Bartoň Tománková ◽  
Lukáš Malina ◽  
Janez Štrancar ◽  
...  
Keyword(s):  
Dna Damage ◽  
Carbon Dots ◽  
L929 Cell ◽  
Fluorescent Properties ◽  
Cell Cycle Profile ◽  
Mechanisms Of Toxicity ◽  
3T3 Fibroblasts ◽  
Nih 3T3 ◽  
Positively Charged ◽  
Endocytic Pathways

It is important to understand the nanomaterials intracellular trafficking and distribution and investigate their targeting into the nuclear area in the living cells. In our previous study, we firstly observed penetration of nonmodified positively charged carbon dots decorated with quaternary ammonium groups (QCDs) into the nucleus of mouse NIH/3T3 fibroblasts. Thus, in this work, we focused on deeper study of QCDs distribution inside two healthy mouse NIH/3T3 and L929 cell lines by fluorescence microspectroscopy and performed a comprehensive cytotoxic and DNA damage measurements. Real-time penetration of QCDs across the plasma cell membrane was recorded, concentration dependent uptake was determined and endocytic pathways were characterized. We found out that the QCDs concentration of 200 µg/mL is close to saturation and subsequently, NIH/3T3 had a different cell cycle profile, however, no significant changes in viability (not even in the case with QCDs in the nuclei) and DNA damage. In the case of L929, the presence of QCDs in the nucleus evoked a cellular death. Intranuclear environment of NIH/3T3 cells affected fluorescent properties of QCDs and evoked fluorescence blue shifts. Studying the intracellular interactions with CDs is essential for development of future applications such as DNA sensing, because CDs as DNA probes have not yet been developed.

Sign in / Sign up

Export Citation Format

Share Document