Validation of Liquid Chromatographic Method of Assay for Acetaminophen, Butalbital and Caffeine in Solid Dosage Forms

1987 ◽  
Vol 13 (15) ◽  
pp. 2811-2821 ◽  
Author(s):  
Aqeel A. Fatmi ◽  
Gregory V. Williams
Keyword(s):  
Chromatographic Method ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

Liquid Chromatographic Determination of Levodopa, Levodopa-Carbidopa, and Related Impurities in Solid Dosage Forms

1986 ◽  
Vol 69 (1) ◽  
pp. 169-173 ◽  
Author(s):  
Susan Ting
Keyword(s):  
Chromatographic Determination ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Reverse Phase ◽  
Solid Dosage ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Determination ◽  
Phase Liquid ◽  
Liquid Chromatographic

Abstract A rapid reverse phase liquid chromatographic method was developed for the determination of levodopa and levodopa-carbidopa in tablets and capsules. The method also separates these drugs from 3-(3,4,6- trihydroxyphenyl)alanine and methoxytyrosine, impurities of levodopa, and from methyldopa and 3-O-methylcarbidopa, impurities of carbidopa. The mobile phase was 3% acetic acid and the detection wavelength was 280 nm. The method was linear over the concentration range 0.05-0.40 mg levodopa/mL, 0.01-0.06 mg carbidopa/mL, 0.9- 12.8 μg 3-(3,4,6-trihydroxyphenyl)alanine/mL, 0.7-3.1 μg methyldopa/ mL, 5-20 μg methoxytyrosine/mL, and 0.5-3.3 μg 3-O-methylcarbidopa/ mL. Mean recoveries (%) for spiked commercial tablets were: levodopa 100.3, carbidopa 100.4, 3-(3,4,6-trihydroxyphenyl) alanine 99.1, methoxytyrosine 100.0, methyldopa 100.0, and 3-O-methylcarbidopa 99.4.

Gas Chromatographic Separation and Quantitative Estimation of Barbiturate Mixtures in Solid Dosage Forms

1968 ◽  
Vol 51 (3) ◽  
pp. 619-621
Author(s):  
John L Allen
Keyword(s):  
Chromatographic Separation ◽  
Chromatographic Method ◽  
Quantitative Estimation ◽  
Collaborative Study ◽  
Internal Standard ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Gas Chromatographic Method ◽  
Gas Chromatographic Separation

Abstract A gas chromatographic method has been described for the analysis of mixed barbiturates in solid dosage forms. Analysis on a 10% SE-30 column gave good separations for butabarbital, amobarbital, secobarbital, pentobarbital, and/or phenobarbital; amobarbital is not separated adequately from pentobarbital. An internal standard, mephobarbital, is used to minimize injection errors. The method gives both good quantitative and qualitative results on the barbiturates investigated. Two synthetic tablet mixtures were analyzed by this procedure and recoveries were 98—103%. It is recommended that the method be subjected to collaborative study.

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