Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity

2010 ◽  
Vol 43 (8) ◽  
pp. 617-649 ◽  
Author(s):  
Giovanni Musso ◽  
Roberto Gambino ◽  
Maurizio Cassader ◽  
Gianfranco Pagano
Keyword(s):  
Liver Disease ◽  
Natural History ◽  
Diagnostic Accuracy ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
History Of ◽  
Alcoholic Fatty Liver Disease

scholarly journals Natural History of Non-Alcoholic Fatty Liver Disease: A Study With Paired Liver Biopsies

2020 ◽  
Vol 10 (3) ◽  
pp. 245-254 ◽  
Author(s):  
Yala K. Reddy ◽  
Hemnishil K. Marella ◽  
Yu Jiang ◽  
Surosree Ganguli ◽  
Peter Snell ◽  
...  
Keyword(s):  
Liver Disease ◽  
Natural History ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
History Of ◽  
Liver Biopsies ◽  
Alcoholic Fatty Liver Disease

Epidemiology and natural history of non-alcoholic fatty liver disease

Metabolism ◽  
2016 ◽  
Vol 65 (8) ◽  
pp. 1017-1025 ◽  
Author(s):  
Yousef Fazel ◽  
Aaron B. Koenig ◽  
Mehmet Sayiner ◽  
Zachary D. Goodman ◽  
Zobair M. Younossi
Keyword(s):  
Liver Disease ◽  
Natural History ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
History Of ◽  
Alcoholic Fatty Liver Disease

scholarly journals Systematic review and meta-analysis: non-invasive detection of non-alcoholic fatty liver disease related fibrosis in the obese

2017 ◽  
Vol 19 (2) ◽  
pp. 281-294 ◽  
Author(s):  
G. J. Ooi ◽  
S. Mgaieth ◽  
G. D. Eslick ◽  
P. R. Burton ◽  
W. W. Kemp ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

scholarly journals Systematic Review with Meta-Analysis: Diagnostic Accuracy of Pro-C3 for Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1920
Author(s):  
Anne Linde Mak ◽  
Jenny Lee ◽  
Anne-Marieke van Dijk ◽  
Yasaman Vali ◽  
Guruprasad P. Aithal ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Advanced Fibrosis ◽  
Inclusion Criteria ◽  
Alcoholic Fatty Liver ◽  
Significant Fibrosis ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

The prevalence and severity of non-alcoholic fatty liver disease (NAFLD) is increasing, yet adequately validated tests for care paths are limited and non-invasive markers of disease progression are urgently needed. The aim of this work was to summarize the performance of Pro-C3, a biomarker of active fibrogenesis, in detecting significant fibrosis (F ≥ 2), advanced fibrosis (F ≥ 3), cirrhosis (F4) and non-alcoholic steatohepatitis (NASH) in patients with NAFLD. A sensitive search of five databases was performed in July 2021. Studies reporting Pro-C3 measurements and liver histology in adults with NAFLD without co-existing liver diseases were eligible. Meta-analysis was conducted by applying a bivariate random effects model to produce summary estimates of Pro-C3 accuracy. From 35 evaluated reports, eight studies met our inclusion criteria; 1568 patients were included in our meta-analysis of significant fibrosis and 2058 in that of advanced fibrosis. The area under the summary curve was 0.81 (95% CI 0.77–0.84) in detecting significant fibrosis and 0.79 (95% CI 0.73–0.82) for advanced fibrosis. Our results support Pro-C3 as an important candidate biomarker for non-invasive assessment of liver fibrosis in NAFLD. Further direct comparisons with currently recommended non-invasive tests will demonstrate whether Pro-C3 panels can outperform these tests, and improve care paths for patients with NAFLD.

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