Repeatability of SphygmoCor pulse wave analysis in assessing arterial wave reflection in pregnancy using applanation tonometry

2014 ◽  
Vol 33 (3) ◽  
pp. 322-332 ◽  
Author(s):  
Michael A. Crilly ◽  
Kirsty M. Orme ◽  
Joan Henderson ◽  
Angela J. Allan ◽  
Sohinee Bhattacharya
2021 ◽  
Vol 9 (18) ◽  
Author(s):  
Junjing Su ◽  
Ulf Simonsen ◽  
Soren Mellemkjaer ◽  
Luke S. Howard ◽  
Charlotte Manisty ◽  
...  

Author(s):  
Frederik Trinkmann ◽  
Urs Benck ◽  
Julian Halder ◽  
Alexandra Semmelweis ◽  
Joachim Saur ◽  
...  

Abstract Background Central blood pressure becomes increasingly accepted as an important diagnostic and therapeutic parameter in the management of cardiovascular disease. This led to development of several non-invasive techniques most commonly based on peripheral pulse wave analysis. Accuracy of widespread applanation tonometry can be affected by calibration and operator training. To overcome this, we aimed to evaluate a novel device (VascAssist 2) using automated oscillometric radial pulse wave analysis and a refined multi-compartment model of the arterial tree. Methods 225 patients were prospectively enrolled. Invasive aortic root measurements served as reference in MEASURE-cBP 1 (n=106) whereas an applanation tonometry device (SphygmoCor) was used in MEASURE-cBP 2 (n=119). Results In MEASURE-cBP 1, we found a mean overestimation for systolic values of 4±12 mmHg (3±10%) and 6±10 mmHg (9±14%) for diastolic values. Diabetes mellitus and low blood pressure were associated with larger variation. In MEASURE-cBP 2, mean overestimation of systolic values was 4±4 mmHg (4±4%) and 1±4 mmHg (1±7%) of diastolic values. Arrhythmia was significantly more frequent in invalid measurements (61 vs. 18%, p<0.0001) which were most often due to a low quality index of SphygmoCor. Accuracy did not differ between patients with arrhythmia and sinus rhythm in MEASURE-cBP 1. Conclusions Central blood pressure estimates using VascAssist 2 can be considered at least as accurate as available techniques, even including diabetic patients. In direct comparison, automated measurement considerably facilitates application not requiring operator training and can be reliably applied even in patients with arrhythmias.


2004 ◽  
Vol 287 (3) ◽  
pp. H1262-H1268 ◽  
Author(s):  
Brian A. Mullan ◽  
Ciaran N. Ennis ◽  
Howard J. P. Fee ◽  
Ian S. Young ◽  
David R. McCance

Mortality increases when acute coronary syndromes are complicated by stress-induced hyperglycemia. Early pulse wave reflection can augment central aortic systolic blood pressure and increase left ventricular strain. Altered pulse wave reflection may contribute to the increase in cardiac risk during acute hyperglycemia. Chronic ascorbic acid (AA) supplementation has recently been shown to reduce pulse wave reflection in diabetes. We investigated the in vivo effects of acute hyperglycemia, with and without AA pretreatment, on pulse wave reflection and arterial hemodynamics. Healthy male volunteers were studied. Peripheral blood pressure (BP) was measured at the brachial artery, and the SphygmoCor pulse wave analysis system was used to derive central BP, the aortic augmentation index (AIx; measure of systemic arterial stiffness), and the time to pulse wave refection ( Tr; measure of aortic distensibility) from noninvasively obtained radial artery pulse pressure (PP) waveforms. Hemodynamics were recorded at baseline and then every 30 min during a 120-min systemic hyperglycemic clamp (14 mmol/l). The subjects, studied on two separate occasions, were randomized in a double-blind, crossover manner to placebo or 2 g intravenous AA before the initiation of hyperglycemia. During hyperglycemia, AIx increased and Tr decreased. Hyperglycemia did not change peripheral PP but did magnify central aortic PP and diminished the normal physiological amplification of PP from the aorta to the periphery. Pulse wave reflection, as assessed from peripheral pulse wave analysis, is enhanced during acute hyperglycemia. Pretreatment with AA prevented the hyperglycemia-induced hemodynamic changes. By protecting hemodynamics during acute hyperglycemia, AA may have therapeutic use.


2002 ◽  
Vol 103 (1) ◽  
pp. 59-65 ◽  
Author(s):  
M. Tessa SAVAGE ◽  
Charles J. FERRO ◽  
Sarah J. PINDER ◽  
Charles R.V. TOMSON

Arterial stiffness potently predicts mortality in dialysis patients. Pulse-wave analysis permits the non-invasive assessment of indices of arterial stiffness and the central pressure waveform by applanation tonometry. The aim of this study was to assess the reproducibility of pulse-wave analysis in patients with chronic renal failure. A total of 188 subjects (23 healthy controls, along with 71 pre-dialysis, 67 dialysis and 27 transplant patients) took part. Duplicate measurements were recorded of brachial blood pressure using the semi-automated Omron 705 device and of the radial artery pressure waveform using applanation tonometry. The central pressure aortic waveform was then obtained by application of a transfer function incorporated into the SphygmoCor software. Central aortic mean blood pressure (MBP), indices of arterial stiffness [augmentation index (AIx) and time to reflection (TR)] and the subendocardial viability ratio (SEVR) were analysed for intra-observer, inter-observer and long-term reproducibility using Bland-Altman plots. The mean (±S.D.) intra-observer difference was 0±4% for AIx, 0±20 ms for TR, 0±3 mmHg for aortic MBP and 0±18% for the SEVR. Inter-observer mean differences were 0±3% for AIx, 1±7ms for TR, 1±4mmHg for aortic MBP and 1±9% for the SEVR. For the long-term study, the mean differences were -1±9% for AIx, -2±13mmHg for aortic MBP, -2±12ms for TR and 1±29% for the SEVR. Pulse-wave analysis showed excellent reproducibility in all the studies, and is therefore suitable for use in all patients with chronic renal failure. Further prospective and interventional studies are now required to assess whether AIx and TR are important prognostic indices of cardiovascular events, and therefore relevant surrogate indices of arterial stiffness in this susceptible population.


2007 ◽  
Vol 25 (8) ◽  
pp. 1678-1686 ◽  
Author(s):  
Theodore G Papaioannou ◽  
Emmanouil N Karatzis ◽  
Kalliopi N Karatzi ◽  
Elias J Gialafos ◽  
Athanassios D Protogerou ◽  
...  

2003 ◽  
Vol 18 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Theodoros G. Papaioannou ◽  
Kimon S. Stamatelopoulos ◽  
Elias Gialafos ◽  
Charalambos Vlachopoulos ◽  
Emmanouil Karatzis ◽  
...  

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