scholarly journals A Possible Relationship Between Toxicity and Carcinogenicity

1986 ◽  
Vol 5 (2) ◽  
pp. 137-151 ◽  
Author(s):  
L. Zeise ◽  
E. A.C. Crouch ◽  
R. Wilson

Carcinogenic response is compared to noncarcinogenic toxicity in that group of chemicals tested by the National Cancer Institute (NCI) and National Toxicology Program (NTP) between 1976 and 1982 and reported in the Carcinogenesis Technical Report Series. A positive finding of carcinogenicity in the bioassay is correlated with the degree of noncarcinogenic chronic toxicity of the dose applied. Comparisons of acute toxicity (LD50) with carcinogenic potency show that they are correlated, but the correlation may in part be an artifact, since doses used in the NCI/NTP carcinogenesis bioassays are toxic and because reliable measures of potency can only be derived for positive carcinogenic responses. The high correlations for certain classes of chemicals and the relationship of chronic toxicity to positive carcinogenic finding suggest that these relationships are more than spurious. Since toxicities in different species are highly correlated, these findings imply that carcinogenicities in different species are also correlated.

1969 ◽  
Vol 25 (3) ◽  
pp. 711-714 ◽  
Author(s):  
Russell G. Geen ◽  
Robert George

A self-report inventory made up of items from the Buss-Durkee manifest aggressiveness scales, the Marlowe-Crowne Social Desirability Scale, and the Masculinity-Femininity scale of the Guilford-Zimmerman Temperament Survey was administered to 72 men along with a test of verbal associations to aggressive and neutral cue words. The number of aggressive associations made to aggressive cue words was highly correlated with over-all manifest aggressiveness and with two of the aggressiveness subscales. The results were discussed in terms of the relationship of aggressiveness habit strength to verbal behavior.


1971 ◽  
Vol 29 (3_suppl) ◽  
pp. 1035-1039
Author(s):  
Logan Wright

A comparison was made of two sociometric measures of personality integration. Contrary to prediction, the more brief, 6-item PIRT scale was significantly more reliable ( r11 = .84) than the lengthier 30-item ESD scale ( r11 = .74). Also contrary to prediction, neither test was more highly correlated than the other (and therefore more valid) with any of 8 construct-validity measures. It was concluded that the PIRT was the more functional measure and therefore recommended for use in future personality integration research. Earlier results concerning the relationship of personality integration to self-concept and environmental contact, as well as locus of control and locus of evaluation in college-age females, were replicated.


1994 ◽  
Vol 369 ◽  
Author(s):  
D. Knödler ◽  
P. Pendzig ◽  
W. Dieterich

AbstractA lattice-gas model is presented, where ions are diffusing in an energy landscape due to immobile, randomly placed counterions. All Coulombic interactions are taken into account.By Monte Carlo simulations we obtain the ac-conductivity, which shows strong dispersion in the form of power-laws. In a separate study we investigate a restricted model, where long-range diffusion is suppressed. These calculations suggest that the response at high frequencies can be interpreted in terms of highly correlated, local motions of dipolar character. Conductivity exponents n1 near unity or even exceeding unity arefound in that regime. We discuss the relationship of these results to experiments on ionic transport in alkali-doped network glasses.


2017 ◽  
Vol 13 (10) ◽  
pp. 105
Author(s):  
Ruzhdie Bici ◽  
Ahmet Mancellari

There exist different methods and definition how to measure poverty. It can be measured by income or consumption, objectively or as a perception of individuals for their socio-economic situation.The objective and subjective poverty are highly correlated and both are influenced by socioeconomic factors. Till now, it is the objective poverty mostly considered while the subjective one has been analyzed only as a part of it. Assessments of the subjective poverty are more scarce, especially in the case of transition countries. Different studies proposed advantages and disadvantages of using each method. The significance of different factors shows the characteristics and the trend of monetary or subjective poverty. The national poverty is Albania is calculated through monetary poverty. There are a set of influenced factors related with household composition, geographic division, education and other socio-economic indicators. In this paper we analyze the perception of individuals for the poverty, the relationship of this perception with the objective poverty, and the socio-demographic factors that influence the probability of being poor. There are used the data from the Albanian Living Standard Measurement Survey (LSMS).


2005 ◽  
Vol 63 (2a) ◽  
pp. 207-212 ◽  
Author(s):  
Jerson Laks ◽  
Elienai Maria Rubim Batista ◽  
Elza Rocha Lima Guilherme ◽  
Ana Lúcia Barros Contino ◽  
Maria Eliete Vieira Faria ◽  
...  

The study aims to evaluate the prevalence of cognitive/functional impairment in community-dwelling elderly above 60 years of age (n= 870; m=297, f=573) and the relationship of age, gender, and functional impairment with cognitive impairment using Mini-Mental State Examination (MMSE) and Pfeffer Functional Activities Questionnaire (PFAQ). Chi-square and Student's tests were used to compare cognitive and functional deficits. Linear regression assessed MMSE/PFAQ relationship. Stratified analysis assessed confounding factors. Logistic regression assessed the relationship among age/gender/functional status with cognitive impairment (p<0.05). Prevalence of cognitive/functional impairment was 19.2%. Functional and cognitive impairment are negatively correlated (Pearson= 0.737), despite educational level (illiterate/literate: OR=15.60; p=0/OR = 16.40; p=0). Age and gender (female) were associated with cognitive/functional impairment. Functional impairment is highly correlated to cognitive impairment. Family/health professionals may recognize functional impairment more easily than cognitive impairment. Thus, the use in combination of cognitive and functional scales is important when screening for dementia.


2009 ◽  
Vol 297 (4) ◽  
pp. H1421-H1428 ◽  
Author(s):  
Jason Ng ◽  
Sri Sundaram ◽  
Alan H. Kadish ◽  
Jeffrey J. Goldberger

Although frequency-domain analysis of heart rate variability (HRV) has been performed in the setting of exercise and recovery from exercise, the relationship of specific frequency components to sympathetic and parasympathetic inputs has not been validated in this setting. The aim of this study is to evaluate the relationship of frequency components of HRV to sympathetic and parasympathetic modulation in the setting of recovery after exercise using selective autonomic blockade. Normal subjects ( n = 27, 17 men, 53 ± 7 yr old) underwent bicycle stress testing on four separate days. On day 1, a baseline study without autonomic blockade was performed. On days 2 through 4, either β-adrenergic, parasympathetic, or double blockade was administered during exercise and completed 3 min before recovery. Continuous ECG was recorded for 5 min starting from the end of exercise. Time- and frequency-domain measures of HRV were computed for each of the five 1-min segments of RR intervals. Parasympathetic blockade significantly decreased all the HRV measures compared with baseline ( P < 0.02 for all). Root mean square of successive differences of RR intervals (rMSSD) was increased by β-adrenergic blockade ( P < 0.0002). All the HRV measures except rMSSD showed increases with time after the first minute of recovery. The low frequency-to-high frequency ratio did not respond to autonomic blockade or to recovery time, consistent with the expected changes in sympathovagal influence. Root mean square (detrended SD) and rMSSD were highly correlated with the square root of the total power ( r = 0.96) and high-frequency power ( r = 0.95), respectively. Although there are marked reductions in the frequency-domain measures in recovery versus rest, the fluctuations in the low- and high-frequency bands respond to autonomic blockade in the expected fashion. Time-domain measures of HRV were highly correlated with frequency-domain measures and therefore provide a computationally more efficient assessment of autonomic influences during recovery from exercise that is less susceptible to anomalies of frequency-domain analysis.


2001 ◽  
Vol 88 (1) ◽  
pp. 189-200 ◽  
Author(s):  
Sonja M. Ramirez ◽  
Hillel Glover ◽  
Carroll Ohlde ◽  
Richard Mercer ◽  
Cary Hamlin ◽  
...  

The present study assessed the relationship between numbing and three associated conditions of alexithymia, apathy, and depression, utilizing data collected on 353 Vietnam combat veterans diagnosed with Posttraumatic Stress Disorder from in- and out-patient settings and an outreach center at various Department of Veterans Affairs Medical Centers. All subjects completed four self-report measures: the Glover Numbing Scale©, the Beck Depression Inventory, the Apathy Evaluation Scale, and the Toronto Alexithymia Scale–20. The correlation matrix indicated that scores on the four measures were moderately to highly correlated. Principal components analysis with a varimax rotation indicated a five-factor solution that provided evidence for the factorial validity of each of the constructs assessed. Results of the factor analysis of items from the four measures were consistent with numbing being a separate and distinct construct from alexithymia, apathy, and depression. In general, results indicated that all constructs measured were separate and distinct from one another.


1970 ◽  
Vol 10 (44) ◽  
pp. 350 ◽  
Author(s):  
JR Syme

A study has been made of a Mexican semi-dwarf wheat (Lerma Rojo X Norim 10- Brevor 14) Andes3, local accession number WW 15. In 53 trials, over two seasons and a wide range of conditions, this has shown a marked grain yield superiority over other Mexican and Australian varieties when grown in high yielding environments. Nine varieties in five trials were sampled at maturity. Varietal grain yield was highly correlated with harvest index and with the number of grains set relative to straw and chaff weight. WW 15 excelled in both ratios, and combined a dense ear population with many grains per ear.


1991 ◽  
Vol 116 (3) ◽  
pp. 565-568 ◽  
Author(s):  
Shawn A. Mehlenbacher ◽  
Anna M. Voordeckers

The relationship between dormancy of seeds and buds of apple (Malus × domestica Borkh.) might provide breeders with an early opportunity to select for delayed development. Seeds of late-flowering genotypes require much longer exposure to chilling temperatures than those of early flowering” genotypes, and they germinate over a much longer period. In three progenies that exhibit much variation for the two traits, seed germination time was correlated with time of leafing-out of the resulting seedlings, and could be used to select for delayed budbreak. However, selection would be ineffective when little genetic variation for seed germination and budbreak is present. Leafing-out ratings in the nursery in the 2nd year were highly correlated with those in the 3rd year, indicating that selection for late leafing in the nursery during the 2nd year would be more effective than selection based on seed dormancy, especially in progenies exhibiting little genetic variability for this trait. Breeders can effectively use both relationships by first eliminating early germinating seeds and then eliminating early leafing seedlings.


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