Lack of association between leptin, leptin receptor, adiponectin gene polymorphisms and epicardial adipose tissue, abdominal visceral fat volume and atherosclerotic burden in psoriasis patients

Introduction: Excess accumulation of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) is associated with metabolic regulatory biomarkers and an increased risk for developing type 2 diabetes, dyslipidemia and cardiovascular disease. Abdominal fat quality is related to cardiovascular disease risk factors above and beyond fat quantity. However, whether fat quality is associated with biomarkers of metabolic regulation has not been firmly established. Hypothesis: We hypothesized that SAT and VAT attenuation, an indirect measure of fat quality, would be associated with a panel of metabolic regulatory biomarkers secreted by adipose tissue or liver, independently of absolute fat volumes. Methods: We evaluated 1,829 Framingham Heart Study participants (44.9% women, mean age 45.0 years) with available data on abdominal fat attenuation and metabolic biomarkers. SAT and VAT fat attenuation was determined by multidetector computed tomography (CT) and denoted in Hounsfield units (HU). Panels of circulating biomarkers included adiponectin, leptin, leptin receptor, fatty acid binding protein-4 (FABP-4), retinol binding protein-4 (RBP-4) and fetuin-A. The relationships between SAT or VAT HU and each of the biomarkers were modeled using sex-specific linear regression model, adjusting for age, hormone replacement therapy (women), smoking status, alcohol use, and physical activity score. Biomarkers were log-transformed to normalize their distribution. Results: In both sexes, SAT and VAT attenuation were associated with all the biomarkers evaluated, except fetuin-A. Lower (i.e., more negative) attenuation of SAT and VAT was associated with lower circulating adiponectin and leptin receptor levels but higher leptin and FABP-4 levels in both women and men (all p <0.0001). SAT attenuation was inversely associated with RPB-4 levels in both sexes; whereas, the association between VAT attenuation and RPB-4 was only observed in men ( p <0.0001). In women, after additional adjustment for the respective fat volume, SAT HU retained the statistically significant associations with adiponectin, leptin, FABP, and RBP-4; and VAT HU with adiponectin only (all p <0.0001). In men, associations remained significant after additional adjustment for the respective fat volume (all p <0.005). Conclusions: Lower attenuation of abdominal fat was associated with a profile of biomarkers suggestive of greater cardiometabolic risks. These observations suggest that fat attenuation may be a valid biomarker of cardiometabolic risk. Further study is required to identify whether the quality of abdominal fat has a pathogenic impact on metabolism via its relationship with biomarkers secreted by adipose tissue or the liver.

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Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer

Scientific Reports ◽

10.1038/s41598-021-01086-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jae-Hoon Lee ◽

Soyoung Kim ◽

Hye Sun Lee ◽

Eun Jung Park ◽

Seung Hyuk Baik ◽

...

Keyword(s):

Colorectal Cancer ◽

Adipose Tissue ◽

Glucose Uptake ◽

Visceral Adipose Tissue ◽

Visceral Fat ◽

Male And Female ◽

Female Patients ◽

Pet Ct ◽

Visceral Adipose ◽

Fat Volume

AbstractThe purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients.

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CAN HIP AND WAIST CIRCUMFERENCES PREDICT HABITUAL EXERCISERS?? ABDOMINAL VISCERAL FAT VOLUME ?

Medicine & Science in Sports & Exercise ◽

10.1097/00005768-200305001-00923 ◽

2003 ◽

Vol 35 (Supplement 1) ◽

pp. S167

Author(s):

T H. Tsao ◽

S S. Hsieh ◽

C K. Chan

Keyword(s):

Visceral Fat ◽

Abdominal Visceral Fat ◽

Fat Volume

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Extension of coronary artery disease is associated with increased IL-6 and decreased adiponectin gene expression in epicardial adipose tissue

Cytokine ◽

10.1016/j.cyto.2008.05.006 ◽

2008 ◽

Vol 43 (2) ◽

pp. 174-180 ◽

Cited By ~ 76

Author(s):

Sonia Eiras ◽

Elvis Teijeira-Fernández ◽

Lilian Grigorian Shamagian ◽

Angel Luis Fernandez ◽

Angel Vazquez-Boquete ◽

...

Keyword(s):

Gene Expression ◽

Coronary Artery Disease ◽

Adipose Tissue ◽

Coronary Artery ◽

Epicardial Adipose Tissue ◽

Adiponectin Gene ◽

Artery Disease

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Epicardial adipose tissue is associated with exercise intolerance in patients with diabetes with asymptomatic left ventricular structural and functional abnormalities

European Heart Journal ◽

10.1093/eurheartj/ehab724.2644 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

Y Sugita ◽

S Sakai

Keyword(s):

Heart Failure ◽

Adipose Tissue ◽

Exercise Capacity ◽

Visceral Fat ◽

Epicardial Adipose Tissue ◽

Global Longitudinal Strain ◽

Left Ventricular ◽

Public Institution ◽

Exercise Intolerance ◽

Functional Abnormality

Abstract Background The volume of epicardial adipose tissue (EAT), which is an index of visceral fat, is high in patients with type 2 diabetes mellitus (T2DM) and may affect the myocardial performances. However, the association between EAT and left ventricular (LV) structure and function, and exercise capacity in patients with asymptomatic heart failure has not been studied. Aims To elucidate whether the volume of EAT deteriorates the exercise capacity in patients with T2DM. Methods EAT thickness and LV structural and functional abnormality components (e.g., global longitudinal strain, E/e', LV mass index, relative wall thickness) were measured with echocardiography in 176 patients with asymptomatic heart failure (Stage A and B) and 62 healthy controls (HC). To evaluate exercise capacity, peak oxygen uptake (peakVO2) was measured by using the cardiopulmonary exercise testing. Results Lipid metabolism, glucose metabolism, brain natriuretic peptide and estimated glomerular filtration rate at cystatin were worse in the heart failure (HF) group than in the HC. The EAT was significantly thicker and peakVO2 was lower in patients with LV structural and functional abnormalities than in individuals without these abnormalities (p<0.001). As the number of LV structural and functional abnormality components increased, the thickness of the EAT increased and peakVO2 decreased (p<0.001). The EAT thickness (β=−0.207) was negatively correlated with peakVO2, even after adjusting for multivariates (R2=0.724). Conclusions In patients with T2DM with asymptomatic heart failure, EAT is associated with LV structural and functional abnormalities. It also suggests that increase of visceral fat around myocardium contributes to exercise intolerance. FUNDunding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): National University Corporation Tsukuba University of Technology education and research Grant

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Association of Epicardial Fat Volume With Increased Risk of Obstructive Coronary Artery Disease in Chinese Patients With Suspected Coronary Artery Disease

Journal of the American Heart Association ◽

10.1161/jaha.120.018080 ◽

2021 ◽

Author(s):

Wenji Yu ◽

Bao Liu ◽

Feifei Zhang ◽

Jianfeng Wang ◽

Xiaoliang Shao ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Adipose Tissue ◽

Coronary Artery ◽

Epicardial Adipose Tissue ◽

Chinese Patients ◽

Epicardial Fat Volume ◽

Traditional Risk Factors ◽

Artery Disease ◽

Fat Volume

Background Epicardial adipose tissue may be associated with the pathogenesis of coronary artery disease (CAD), but its effect on obstructive CAD risk is uncertain. Therefore, we aimed to examine the relationship between epicardial adipose tissue and obstructive CAD in Chinese patients with suspected CAD. Methods and Results The present study enrolled 194 consecutive inpatients with suspected CAD who underwent both noncontrast computed tomography and coronary angiography. We measured epicardial fat volume (EFV) and evaluated its association with obstructive CAD, which was defined as coronary stenosis severity ≥70%. Overall, 44.3% patients had obstructive CAD and tend to have higher EFV. Age, body mass index, triglycerides, incidence of hypertension, and hyperlipidemia were higher across tertiles of EFV ( P for trend <0.05). In univariate regression analysis, a per‐SD increase in EFV was independently associated with obstructive CAD (odds ratio [OR], 2.31; 95% CI, 1.61–3.32; P <0.001). Consistent with these findings, EFV was still significantly related to obstructive CAD as continuous variable after adjustment for all traditional risk factors and coronary artery calcium (OR per SD, 2.82; 95% CI, 1.68–4.74; P <0.001). Generalized additive model indicated that EFV was linearly associated with risk of obstructive CAD. E ‐value analysis suggested robustness to unmeasured confounding. Conclusions Our results suggested that in Chinese patients with suspected CAD, EFV was significantly and positively associated with the risk of obstructive CAD, independent of traditional risk factors and coronary artery calcium.

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