Severe vitamin D deficiency among pregnant women and their newborns in Turkey

BACKGROUND: Calcium and vitamin D deficiency is common among Iranian women of childbearing age and poses adverse effects on pregnancy outcomes. The aim of the current study was to determine the prevalence of vitamin D and calcium in a sample of Iranian pregnant women and to assess its correlation with the feto-maternal outcomes. METHODS: In this prospective cross-sectional study, a sample of pregnant women between 15 to 45 years who were in the third trimester were recruited from a number of hospitals in Tehran. Data were collected by the means of a self-developed questionnaire, interviews, physical examination, and paraclinical tests including measuring the serum level of calcium, vitamin D, parathormone (PTH) and phosphorous (Pi). The questionnaire obtained information on age, level of education, socio-economic status, parity, gravidity, calcium intake during pregnancy, as well as feto-maternal outcomes. RESULTS: We included a total number of 233 singleton pregnancies. Most of the subjects (58.4%) had vitamin D deficiency and 12.0% suffered from severe vitamin D deficiency. Vitamin D deficiency was adversely associated with the years of education (p= 0.007), serum level of parathormone (p< 0.001). The Metabolic Equivalent of Task (MET) (p< 0.001), the exercise sequence per week (p< 0.001), sun exposure (p< 0.001), higher rate of sunscreen usage (p= 0.011) and higher BMI (p= 0.005). Vitamin D deficiency was associated with higher rate of cesarean delivery (p= 0.024), higher rate of diastolic hypertension (p= 0.019), higher rate of neonatal jaundice (p= 0.009) and higher rate of neonatal respiratory infections (p< 0.001). Serum level of PTH was a significant risk factor for severe vitamin D deficiency while calcium D supplementation, MET and sunscreen were significant protective factors. CONCLUSION: The prevalence of vitamin D deficiency during pregnancy among Iranian women is extremely high and is associated with adverse pregnancy outcomes including cesarean delivery, neonatal jaundice and neonatal respiratory infections. Low vitamin D supplementation and sun exposure, lack of physical activity and high BMI are the etiologies. Increasing the knowledge along with vitamin D supplementation during the pregnancy is recommended in Iranian population.

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Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Public Health Nutrition ◽

10.1017/s1368980012003084 ◽

2012 ◽

Vol 16 (4) ◽

pp. 687-692 ◽

Cited By ~ 40

Author(s):

Shu Jun Song ◽

Shaoyan Si ◽

Junli Liu ◽

Xingming Chen ◽

Ling Zhou ◽

...

Keyword(s):

Vitamin D ◽

Birth Weight ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Cross Sectional Study ◽

Birth Size ◽

Vitamin D Status ◽

Cross Sectional ◽

Severe Vitamin ◽

Beijing China

AbstractObjectiveTo evaluate the prevalence of vitamin D deficiency in pregnant women and their newborns in Beijing, China and the influence of vitamin D deficiency on birth size.DesignA cross-sectional study.SettingData were collected from pregnant women who delivered during April to May 2010 at 306 Hospital of PLA in Beijing, China.SubjectsParticipants in the study were seventy healthy nulliparous pregnant women with singleton pregnancies who delivered healthy babies at full term and their newborns.ResultsSevere vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 25 nmol/l) was detected in 54·5 % of mothers and 46·6 % of newborns. Neither mothers nor newborns had serum 25(OH)D concentrations that reached the normal level (>75 nmol/l). The concentration of 25(OH)D in mothers was positively correlated with that in cord blood (r = 0·89, P < 0·001). Newborns of mothers with severe vitamin D deficiency had lower birth length and birth weight. The head circumference and birth weight were lower in vitamin D-deficient newborns.ConclusionsThe study indicates that pregnant women and neonates residing in Beijing are at high risk of vitamin D deficiency. Neonatal 25(OH)D concentrations are dependently related to maternal 25(OH)D levels. Maternal and neonatal vitamin D status influences newborn size.

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Severe Vitamin D Deficiency in Human Immunodeficiency Virus-Infected Pregnant Women is Associated with Preterm Birth

American Journal of Perinatology ◽

10.1055/s-0036-1593536 ◽

2016 ◽

Vol 34 (05) ◽

pp. 486-492 ◽

Cited By ~ 1

Author(s):

Laura Freimanis ◽

Marisa Mussi-Pinhata ◽

Rachel Cohen ◽

Jacqueline Monteiro ◽

Maria Cruz ◽

...

Keyword(s):

Vitamin D ◽

Human Immunodeficiency Virus ◽

Preterm Birth ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Severe Vitamin ◽

Immunodeficiency Virus

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Efficiency of correction of vitamin D deficiency with DeviSol Strong at the preconception stage and during pregnancy

Reproductive Endocrinology ◽

10.18370/2309-4117.2021.59.35-38 ◽

2021 ◽

pp. 35-38

Author(s):

S.O. Shurpyak ◽

V.I. Pyrohova ◽

M.I. Malachinska

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Premature Birth ◽

Comparison Group ◽

Control Group ◽

Immunochemical Method ◽

Severe Vitamin ◽

Group 2 ◽

Group 1

Research objective: to assess the course and consequences of pregnancy in women with vitamin D lack and deficit that is adjusted with DeviSol Strong at the pre-pregnancy preparation or during pregnancy.Materials and methods. The study involved 145 women aged 18 to 30 years. Experimental cohort (120 women with vitamin D deficiency) was divided into three groups: the first group – 40 pregnant women, the second group – 50 patients at the stage of pre-pregnancy preparation, comparison group – 30 pregnant women at 6–10 weeks of gestation. Control group consisted of 25 pregnant women with sufficient levels of vitamin D. 25(OH)D value in serum was determined by immunochemical method with chemiluminescent detection. DeviSol Strong dietary supplement was chosen to correct vitamin D deficiency. It was administered differently, based on 25(OH)D level.Results. Patients receiving 800 IU/day of cholecalciferol showed an increase in the vitamin D deficiency (from 46.7% to 76.7%). Vitamin D deficiency was reduced from 75.0% to 32.5% in women who received 2000 IU and 4000 IU of cholecalciferol for 3 months, the proportion of pregnant women with severe vitamin D deficiency decreased by 2,4 times. A rapid positive effect was achieved in 82.0% of pre-pregnancy patients receiving DeviSol Strong 4000 IU/day or 6000 IU/day (4000 IU + 2000 IU).Abortion risk before 12 weeks of gestation occurred in 23.3% of women in the comparison group, in 7.5% of pregnant women in group 1, in 4.0% in control group and in 2.0% in group 2. Early miscarriage occurred in 3,3% of patients in the comparison group. 13.3% of pregnant women in the comparison group, 5.0% from group 1 and 2.0% from group 2 were hospitalized with the threat of premature birth, premature birth occurred in one patient of the comparison group.Conclusions. Assessment of the first half of pregnancy with differentiated correction of vitamin D deficiency indicates the need for supplementation of cholecalciferol at the stage of pre-pregnancy preparation for prevention of gestation complications. DeviSol Strong is an effective drug for correcting vitamin D deficiency. Most effective dose in severe vitamin D deficiency is 6000 IU (4000 IU + 2000 IU), 4000 IU in lack and deficiency, which allowed achieving an adequate 25(OH)D level after 3 months in 82% of patients.

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