scholarly journals Differential expression of the eukaryotic translation initiation factor EIF1B in the brain metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Differential Expression ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Eukaryotic Translation Initiation Factor ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation ◽  
The Brain

Metastasis to the brain is a complication of breast cancer (1, 2) with limited treatment options (3). We mined published microarray data (4, 5) to discover genes associated with brain metastases in patients with metastatic breast cancer. We identified significant differential expression of the eukaryotic translation initiation factor EIF1B in the brain metastases of patients with breast cancer as compared to primary tumors of the breast. EIF1B may be relevant to the underlying biology by which tumor cells of the breast spread to the brain.

Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging

2008 ◽  
Vol 1228 ◽  
pp. 6-13 ◽  
Author(s):  
Augusto D. Luchessi ◽  
Tavane D. Cambiaghi ◽  
Adilson S. Alves ◽  
Lucas T. Parreiras-E-Silva ◽  
Luiz R.G. Britto ◽  
...  
Keyword(s):  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Eukaryotic Translation Initiation Factor ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation ◽  
The Brain

scholarly journals Differential expression of eukaryotic translation initiation factor 4E-binding protein 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Translation Initiation ◽  
Normal Breast ◽  
Translation Initiation Factor ◽  
Differentially Expressed ◽  
Initiation Factor ◽  
Primary Tumors ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding eukaryotic translation initiation factor 4E-binding protein 2, EIF4EBP2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. EIF4EBP2 was also differentially expressed in lymph node metastasis in human breast cancer. EIF4EBP2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of EIF4EBP2 in primary tumors of the breast was correlated with recurrence-free survival in patients with luminal B and HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. EIF4EBP2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness

2019 ◽  
Vol 9 ◽  
Author(s):  
Sangita Sridharan ◽  
Megan Robeson ◽  
Diwakar Bastihalli-Tukaramrao ◽  
Cory M. Howard ◽  
Boopathi Subramaniyan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Cancer Stemness ◽  
Eukaryotic Translation Initiation Factor ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation
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