scholarly journals Efficacy of Azoles Antifungals in Treatment of Pityriasis Versicolor

2022 ◽  
Vol 19 (1) ◽  
pp. 43-46
Author(s):  
Smita Jha
Keyword(s):  
Adverse Effects ◽  
Pityriasis Versicolor ◽  
Limited Disease ◽  
Oral Fluconazole ◽  
Medical College ◽  
Group I ◽  
Oral Itraconazole ◽  
Group Ii ◽  
200Mg Daily ◽  
Different Doses

Introduction: Pityriasis versicolor is superficial fungal infection. Topical drugs are often effective in treatment of limited disease while systemic drugs are more suitable in extensive cases. The systemic triazole drugs, itraconazole and fluconazole have shown promising results at different doses. Aims: To assess the efficacy and safety of oral fluconazole combined with ketoconazole shampoo and oral itraconazole in the treatment of Pityriasis versicolor. Methods: The study was conducted at department of Dermatology at Nepalgunj Medical College from March 2019 to February 2020. Total 100 patients of both genders with Pityriasis versicolor were randomly allocated into two groups with 50 patients in each group. Patients in Group I received oral fluconazole 300mg a week for two consecutive weeks along with ketoconazole 2% shampoo twice weekly for two weeks while those in Group II received  itraconazole 200mg daily for one week. Efficacy was assessed in terms of negative fungal hyphae. The drug is considered safe if no patients were withdrawn for clinical adverse effects or laboratory abnormalities. Results: In this study age ranged from 18 to 50 years with mean age of 31.1 years in Group I and 31.92 years in Group II. Efficacy was seen in 78% of Group I patients as compared to 54% in Group II patients at two weeks and 94% in Group I and 90% in Group II at four weeks. No significant adverse effects were reported in any of the group. Conclusion: Fluconazole along with ketoconazole shampoo is more effective than itraconazole in treatment of pityriasis versicolor with minimal side effects, at lesser cost.

scholarly journals TO STUDY THE ONSET AND PROGRESSION OF AIRWAY ABNORMALITY IN TERMS OF ALTERATION IN PFT IN ASYMPTOMATIC SMOKERS.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Hitesh Kumar Solanki ◽  
Dr. Omnath P Yadav ◽  
Dr. Anita J Gojiya
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Young Smokers ◽  
The Mean ◽  
Group Ii

The study was conducted in department of physiology, B J Medical College, Ahmedabad from Mar. 2012 to Feb. 2013. This was a cross-sectional study to evaluate the effect of smoking on lung   function and serum lipids in asymptomatic smokers   and comparable non   smokers. The mean of the various spirometric parameters were calculated of the subjects for both the groups. The mean FVC in group I and group II was 2.60 ± 0.62 L and 4.10 ± 0.64L respectively. The mean FEV1 in group I was 1.91 ± 0.57L and     3.19 ± 0.77L in group II Group I had mean FEF25% - 75% and PEFR of 1.98 ± 0.67L/sec and 4.50 ± 1.57L/sec respectively. Group II had mean FEF25 – 75% of 4.22 ± 1.23L/sec and a mean PEFR of 7.22 ± 1.42L/sec. In young smokers and asymptomatic, still the spirometric values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All he spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. Keywords: Progression, PFT, Asymptomatic & Smokers

scholarly journals Remifentanil and Propofol Sedation for Retrobulbar Nerve Block

2002 ◽  
Vol 30 (4) ◽  
pp. 433-437 ◽  
Author(s):  
V. Rewari ◽  
R. Madan ◽  
H. L. Kaul ◽  
L. Kumar
Keyword(s):  
Adverse Effects ◽  
Respiratory Depression ◽  
Study Groups ◽  
Group Iv ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Retrobulbar Block ◽  
Significant Movement ◽  
Group Ii

We studied remifentanil and propofol for analgesia and sedation during the placement of an ophthalmic block. Eighty ASA I or II patients undergoing elective cataract surgery under a retrobulbar block in a rural camp setting were included in the study. Patients were randomly divided into four groups and received different drug combinations as follows: Group I—remifentanil 1 μg/kg, Group II—remifentanil 0.5 μg/kg and propofol 0.5 mg/kg, Group III— remifentanil 1 μg/kg with propofol 0.5 mg/kg and Group IV—saline 0.1 ml/kg. Patients were observed for degree of movement, sedation, pain, recall and respiratory depression. No patient in the study groups reported pain or displayed movement whereas most of the patients in the control group had significant pain during the placement of the block. Also, seven (35%) patients in the control group showed significant movement which may have led to failure of block in two patients and retrobulbar haemorrhage in one patient. Incidence of significant respiratory depression was maximum in Group III patients (60%), followed by Group I (20%) and least in Group II (5%). All patients in the study groups remained cooperative and obeyed commands except four patients in group III (OAA/S-4). Postoperatively, other than the control group, recall was maximum in Group I (55%) and least in Group II (5%). Hence, a combination of remifentanil 0.5 μg/kg with propofol 0.5 mg/kg as a bolus was considered to provide excellent relief of pain and anxiety with least adverse effects for the placement of ophthalmic blocks.

Use of superphosphate as a phosphorus supplement for lambs – effect of calcination or supplementation with oral cobalt or parenteral vitamin B12

1971 ◽  
Vol 77 (3) ◽  
pp. 467-471 ◽  
Author(s):  
O. N. Agarwala ◽  
K. Nath ◽  
V. Mahadevan
Keyword(s):  
Adverse Effects ◽  
Vitamin B12 ◽  
Fluorine Content ◽  
Control Group ◽  
Common Salt ◽  
Vitamin B ◽  
Mineral Supplement ◽  
Group I ◽  
Group Ii ◽  
Basal Ration

SUMMARYA feeding and balance trial was conducted for 15 weeks on 25 lambs (aged 3–5 months) divided into five groups of 5 animals each on a basal ration consisting of oats, groundnut cake, barley, common salt, green grass and wheat straw. The five groups were fed a mineral supplement as follows:Group I. Basal ration plus ‘Supermindiff’ mineral mixture (control group).Group II. Basal ration plus calcined superphosphate.Group III. Basal ration plus superphosphate.Group IV. Basal ration plus superphosphate plus oral cobalt chloride (3 mg Co/10 kg body weight).Group V. Basal ration plus superphosphate plus parenteral vitamin B12 (50 μg/week/ animal).Calcination of fertilizer-grade superphosphate at 600°C for 2 h reduced the fluorine content from 23350ppm to 1600 ppm. The results show that high fluorine or superphosphate significantly reduced growth rate and retention of calcium and phosphorus and significantly increased blood inorganic phosphorus. Calcination of superphosphate in Group II gave comparable results to the control group (Group I). The oral Co or parenteral vitamin B12 supplementation (Groups IV and V) did not ameliorate the adverse effects of high fluorine in superphosphate.It is concluded that calcination of superphosphate at 600°C for 2 h yields a suitable defluorinated product which can be used as a phosphorus supplement in the feeding of animals. Fertilizer-grade superphosphate is unsuitable due to its high fluorine content, the adverse effects of which are not mitigated by oral Co or parenteral vitamin B12 supplementation.

scholarly journals Evaluation of the Safety and the Influence of a W Whole Body Cryotherapy on the Level of Pain Perception and Functional Capacity of Patients at Different Age

2019 ◽  
Vol 61 (3) ◽  
pp. 182-188
Author(s):  
Katarzyna Pietrzak ◽  
Łukasz Kikowski ◽  
Adrianna Zwolińska ◽  
Joanna Kostka
Keyword(s):  
Adverse Effects ◽  
Pain Perception ◽  
Whole Body ◽  
Functional Tests ◽  
Everyday Functioning ◽  
Pain Syndromes ◽  
Group I ◽  
Pain Scales ◽  
Group Ii ◽  
Whole Body Cryotherapy

Introduction: Whole body cryotherapy with kinesitherapy can potentially improve the everyday functioning of patients. The aim of the study was to assess the influence of whole body cryotherapy on the pain perception and functional efficiency of patients with pain syndromes in a different age and to assess the occurrence of adverse effects during treatment. Material and Methods: The study involved 40 patients with pain syndromes aged between 24 and 73 divided into 2 groups: group I (younger) up to 55 years old and group II (older) over 55 years old. The subjects underwent a series of 10 treatments of cryotherapy. The following tests were used to assess functional performance and pain: FTSST (Five Times Sit- to- Stand Test), TUG (Timed Up and Go Test), VAS (Visual Analogue Scale) Modified Pain Questionnaire according to Laitinen. Results: In the group I: the intensity of pain on the VAS scale was reduced after the first treatment (p=0.003); after a series of 10 treatments improvement in pain scales (VAS: p = 0.001, Laitinen Questionnaire: p = 0.002) and functional tests (TUG: p = 0.002, FTSST: p <0.001) was obtained. In the group II: improvement in pain perception at VAS scale after first treatment (p = 0.01) was achieved and after a series of 10 treatments, functional improvement (TUG: p = 0.006, FTSST: p <0.001) and in results in pain scales (VAS: p = 0.04, Laitinen questionnaire: p = 0.05) was obtained. Conclusions: Whole body cryotherapy with kinesitherapy contribute to the reduction of pain after only a single exposure, and after a series of 10 treatments occur to improve performance of functional tests. Cryotherapy may be associated with adverse effects, which are relatively rare, disappear quickly and do not endanger the life or health of patients. The age of patients has no significant effect on the final outcomes of therapy and on the occurrence of adverse effects.

scholarly journals A comparative study of hemodynamic changes and adverse effects of intrathecal bupivacaine with fentanyl and intrathecal bupivacaine with clonidine in infra-umbilical abdominal and lower limb surgery

2019 ◽  
Vol 6 (11) ◽  
pp. 4048
Author(s):  
Krishna Prasad G. V. ◽  
Vipin Jaishree Sharma
Keyword(s):  
Adverse Effects ◽  
Lower Limb ◽  
Analgesic Effects ◽  
Anesthetic Agents ◽  
Group I ◽  
Significant Difference ◽  
Lower Limb Surgery ◽  
Hemodynamic Profile ◽  
Group Ii ◽  
Intrathecal Clonidine

Background: Adjuvants prolong the action of intrathecal local anesthetic agents. They have shown to have significant analgesic effects in the postoperative period much after the regression of the sensory and motor blockade. Our objective of the current study was to compared the hemodynamic profile and adverse effects (nausea, pruritus, sedation and respiratory depression) in two groups of adult patients undergoing infra-umbilical and lower limb surgery under spinal anaesthesia using either intrathecal clonidine or intrathecal fentanyl as an adjuvant to intrathecal bupivacaine (0.5% heavy).Methods: This randomized, prospective and observational study was undertaken in the Department of Anaesthesiology and Critical Care, 5 Airforce Hospital, Kanpur from the period of January 2014 to February 2016 on 120 patients fulfilling the inclusion criteria. Study patients were randomly allocated to the two groups Group I: Cases who received intrathecal 0.5% heavy bupivacaine (2.5 ml) + fentanyl (50 mcg/ml) (0.5 ml) (n=60 patients) and Group II: cases who received intrathecal 0.5% heavy bupivacaine (2.5 ml) + clonidine (60 mcg/ml) (0.5 ml) (n=60 patients).Results: Mean age of patients in Group I and Group II was 42.60±5.93 and 42.03±7.16 years, respectively. Mean BMI of patients in Group I and Group II was 22.0±1.92 and 21.54±2.14 kg/m2, respectively. Comparison of baseline hemodynamic parameters (heart rate (bpm), mean arterial pressure (mmhg), respiratory rate (/min) and oxygen saturation (%) did not show a significant difference between two groups.Conclusions: With respect to the side effects like nausea and pruritus, these are significantly more in fentanyl group as compared to clonidine group.

scholarly journals Indicators of humoral immunity of patients with neonatal sepsis under different conditions of environmental pollution of parents' places of residence

2020 ◽  
pp. 66-69
Author(s):  
O.V. Vlasova ◽  
Keyword(s):  
Adverse Effects ◽  
Environmental Pollution ◽  
Humoral Immunity ◽  
Neonatal Sepsis ◽  
The Body ◽  
Group I ◽  
Regional Centers ◽  
Group Ii ◽  
Water And Soil Pollution

The aim is to determine the indicators of humoral immunity of patients with neonatal sepsis under different conditions of environmental pollution of their parents' places of residence. Materials and methods. 260 patients with neonatal sepsis born to parents who lived in different environmental conditions were examined. An environmental risk factor (CER) was proposed as a group-forming feature of a comprehensive assessment of the long+term load of anthropogenic air, water and soil pollution in the regions of the region on the body of parents of newborns, taking into account the environmental situation in regional centers. Results. The level of IgA in the serum of patients with neonatal sepsis in group I was 0.82±0.11 g/l against 1.54±0.23 g/l (p<0.05) in group II, the level of IgG in children I groups — 4.27±0.45 g/l against 6.67±0.77 g/l (p<0.05) of group II. The decrease in IgM content had no significant differences, but there was a tendency to reduce its level in children of group I. Conclusions. The constant residence of parents in areas with a high risk of adverse effects of these environmental factors on their body (ERF<2.0) contributed to a decrease in the level of immunoglobulins A, M, G in the serum of patients with neonatal sepsis, compared with newborns whose parents lived in areas with a low risk of adverse effects (ERF<2.0), and were more likely to have severe neonatal sepsis. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: neonatal sepsis, pollution, immunoglobulins.

scholarly journals Evaluation of outcome of early appendectomy in appendicular lump

2020 ◽  
Vol 8 (1) ◽  
pp. 7
Author(s):  
A. S. M. Rezbanul Haque ◽  
Bablu Kumar Saha ◽  
M. Mahfuzul Haque ◽  
M. Abdus Sattar ◽  
Upendra Nath Ray ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Recovery Period ◽  
Medical College ◽  
Group I ◽  
Perforated Appendix ◽  
Early Exploration ◽  
The Mean ◽  
Group Ii ◽  
Surgery Department ◽  
The Cost

Background: Appendicular lump is a well-known sequalae of acute appendicitis encountered in 2-6% of patients. Successful management of appendicular lump is controversial with different approaches. This study aims to evaluate the outcome of early appendectomy in an appendicular lump.Methods: A total of 210 patients were admitted in surgery and pediatric surgery department of Rangpur medical college and hospital with the diagnosis of acute appendicitis and its sequalae over two years.Results: In this study, sixty patients were included who were presented with an appendicular lump. Maximum patients (50%) were found in the age group of 21-30 years. Males (66.67%) were more affected. Eighty percent of patients were coming from below-average socio-economic conditions. In group I, early appendicectomy had done and outcomes were satisfactory and favorable. In group II, eighteen patients were operated who were admitted at 6 to 8 days after an attack of acute appendicitis, and twelve patients were continued the conservative treatment. In group II, who had done surgery, among them, fourteen patients (77.78%) were found an appendicular abscess, and four patients (22.22%) were found perforated appendix per-operatively. In group I, the mean recovery period was less and they had minimum complications. In group II, the mean recovery period was more and they had more complications.Conclusions: Based on these findings, it can be concluded that early exploration in appendicular lump patients confirm the diagnosis, cures the problem, reduces the cost of management, and shortens the convalescence period and hospital stay with reasonably satisfactory outcomes.

scholarly journals Comparison Intra Articular Steroid vs. Hydraulic Distention for the Treatment of Frozen Shoulder

2013 ◽  
Vol 1 (1) ◽  
pp. 3-9 ◽  
Author(s):  
GP Singh
Keyword(s):  
Pain Relief ◽  
Teaching Hospital ◽  
Frozen Shoulder ◽  
College Teaching ◽  
Muscle Relaxants ◽  
Medical College ◽  
Group I ◽  
Normal Sleep ◽  
Group Ii

Background Frozen shoulder is a chronic fibrosing condition of the capsule of the shoulder joint. OBJECTIVE The objective of the study was to compare the result of treatment of frozen shoulder by Hydraulic Distention under local anesthesia with steroid and intra articular steroid alone. Sample Size: 60 patients were taken in this study and were divided into two groups. Duration and Setting: The study was conducted in 2005-2006 treated in the department of orthopaedic, Janaki medical college Teaching Hospital, Janakpur. Materials and Methods: It was a prospective, observational, comparative and clinical study. Sixty patients were selected from Dhanusha District of Janakpur, Nepal. They were divided into two groups. Since January 2005 to January 2006 periods in the department of orthopedics surgery, Janaki Medical College & Teaching Hospital, Janakpur. The Group I was treated by hydraulic distention of glenohumeral joint with 50ml normal saline with steroid, oral medicines (analgesics and muscle relaxants) and exercises. Patients in group II were treated by intra-articular steroid followed by oral medicines (analgesics and muscle relaxants) and exercises. Results: The average age of patients in group I was 52 ± 2.16 years and 50 ± 2.03 in group II. There were 37 (63%) females and 23 (37%) males in our study. Female to male ratio was 1.7:1. All patients in group noted immediate pain relief with excellent return of range of motion (ROM) and resumption of normal sleep. At the end of 45 days of follow up all patients had returned to their normal daily activities. Most of them got excellent ROM and pain relief. All patients in group II noted immediate pain relief and resumption of almost normal sleep. At the end of 45 days of follow up most of the patient presented with good relief of pain but could not return to most of their normal activities because of less improvement in ROM. Conclusions: Hydraulic distension technique is quick, safe and gives early results, so it should be considered first for the treatment of frozen shoulder. DOI: http://dx.doi.org/10.3126/jucms.v1i1.8415   Journal of Universal College of Medical Sciences Vol.1(1) 2013: 3-9

scholarly journals A comparative study in between tropical honey and povidone dressing in diabetic wounds in a medical college of Northern India

2018 ◽  
Vol 5 (10) ◽  
pp. 3391
Author(s):  
Akhilesh Kumar Yadav ◽  
Sankalp Dwivedi ◽  
Siddharth Desai
Keyword(s):  
Hospital Stay ◽  
Diabetic Foot ◽  
Povidone Iodine ◽  
Subsequent Treatment ◽  
Medical College ◽  
Northern India ◽  
Group I ◽  
Stay Time ◽  
Group Ii ◽  
Age Range

Background: The study was done to compare outcomes with dressings of honey to povidone iodine in the management of diabetic foot ulcers.Methods: The present study was carried out for a period of three years from June 2016 to July 2018 in a medical college of northern India. About 200 patients who presented with features of diabetic foot were selected randomly and included in this study and divided into two groups based upon the subsequent treatment of raw area with honey and povidone- iodine respectively.Results: A total of 200 patients were studied. Group I consist of 100 patients out of which 58 were males and 42 females while in Group II there were 56 males and 44 females. The age range in group I was 46 to 75 years while the age range in group II was 48 to 82 years.  In case of group I time of healing was 7- 75 days with median of 28 while in group II time of healing was 7- 60 days with median of 18 days. In case of group II time of healing was 7-60 days with median of 18 days, hospital stay was 7- 34 days with median of 12 days.Conclusions: In terms of hospital stay, time of healing, allergy to material and need for amputation honey was found to be better than povidone iodine solution for dressing of diabetic foot ulcers.

scholarly journals Impact of temporal bone dissection on the understanding anatomy of the ear among medical students

2018 ◽  
Vol 4 (6) ◽  
pp. 1489
Author(s):  
K. C. Prasad ◽  
Prathyusha K. ◽  
Shreeharsha Maruvala ◽  
Harshita T. R. ◽  
Indu Varsha Gopi ◽  
...  
Keyword(s):  
Medical Students ◽  
Temporal Bone ◽  
Three Dimensional ◽  
Operative Procedures ◽  
Research Centre ◽  
Medical College ◽  
Group I ◽  
Group Ii ◽  
Temporal Bones ◽  
The Impact

<p class="abstract">The aim was to study the impact of temporal bone dissection demonstrations on understanding anatomy of the ear among medical students. During a period of six months from October 2017 to March 2018, 10 cadaveric temporal bones dissections were demonstrated using ZEISS microscope and in the presence of medical students headed by a Consultant Otolaryngologist in the department of ENT, Sri Devaraj URS Medical College and Research Centre, Kolar. Anatomy of the middle ear and inner ear and various operative procedures were demonstrated. The students were divided into 2 groups. Group I comprised students who attended the temporal bone dissection and Group II included those who didn’t attend dissection. After the session both the groups were assessed by the consultant. Scores were given to the group individuals based on the ability to answer the questions. 10 Temporal bone dissections were demonstrated in 6 months period to medical students who were divided into 2 groups based on their attendance of the demonstration. The students of both groups were assessed. Scores were given by Likert scale-5point scale question. The results of our study proved that those students who attended the temporal bone dissection (Group-I) had better understanding of the anatomy and operative procedures of the ear as compared to students in group II. Demonstration of temporal bone dissection to the medical students had a good impact on their understanding of the three dimensional anatomy of the ear.</p>

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