scholarly journals Association between axial length of the eye and primary angle closure glaucoma

1970 ◽  
Vol 6 (3) ◽  
pp. 361-363 ◽  
Author(s):  
D Sherpa ◽  
BP Badhu
Keyword(s):  
Risk Factor ◽  
Axial Length ◽  
Simple Random Sampling ◽  
Normal Subjects ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Control Group ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Background: Angle closure glaucoma is emerging as a leading cause of blindness in Asia. Objective: To compare the ocular axial length of normal individuals and the subjects with primary angle closure glaucoma. This study has been conducted to determine axial length of eye as a risk factor of primary angle closure glaucoma. Materials and Methods: A cross-sectional comparative study was carried out in Mechi Eye Care Centre, Jhapa, Nepal including forty eyes of 20 diagnosed cases of primary angle closure glaucoma (40 eyes) and 40 eyes of 20 normal subjects selected by simple random sampling. A complete ocular examination of all the subjects was carried out. Axial length measurement was done using ultrasound A scan. Results: Out of 80 eyes, there were 40 eyes of 20 diagnosed primary angle closure subjects and 40 eyes of 20 normal subjects. The mean axial length and standard deviation of primary angle closure glaucoma were 21.93 ± 1.16 mm (95% CI = 21.41 - 22.45) and those of control group were 23.01 ± 0.49 (95% CI = 22.79 - 23.23). The axial length of less than 23 mm was found as a risk factor for angle closure glaucoma (Relative risk =3.40; p = 0.0032). Conclusion: This study showed that patients with the axial length of less than 23 mm are at risk to develop primary angle closure glaucoma. This result can be confirmed by doing population based study in a larger sample size. Keywords: Axial length, Primary angle closure glaucoma, Nepal doi: 10.3126/kumj.v6i3.1712 Kathmandu University Medical Journal (2008), Vol. 6, No. 3, Issue 23, 361-363

scholarly journals Ocular Biometry among primary angle closure

2018 ◽  
Vol 8 (1) ◽  
pp. 5-9
Author(s):  
Dakki Sherpa
Keyword(s):  
Risk Factor ◽  
Sampling Technique ◽  
Normal Subjects ◽  
Angle Closure ◽  
Control Group ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Ocular Biometry ◽  
Lens Diameter ◽  
The Mean

Objective: To determine ocular biometry of primary angle closure. Materials and methods: A cross-sectional compara­tive study was carried out in Nepal Eye Hospital including thirty-six eyes of 29 diagnosed cases of primary angle closure and 44 eyes of 22 normal subjects selected by convenience sampling technique. A complete ocular examination of all the subjects was carried out. AL, ACD and LD measurement was done using ultrasound A scan. Result: Out of 80 eyes, there were 36 eyes of 29 diagnosed primary angle closure subjects and 44 eyes of 22 normal subjects. The mean age of primary angle closure patients were 61. 65+/- 10.44. The mean AL of PAC was 22.15mm +/-0.76. The mean AL of control group was 22.98 mm with SD of 0.63. The mean ACD of PAC patients were 2.85mm and SD of 0.46 and the mean ACD of control group was 3.59 with SD of .40. The mean lens diameter of PAC group was 4.57 mm +/- 0.58 and the mean LD of control group was 4.43mm +/- 0.54. The Sig (2-tailed) test showed: Age: 0.268, AL: 0.001, ACD: 0.000 and LD: 0.466. Conclusion: This study reveals that short AL and shallow ACD is a strong risk factor of primary angle closure. Though LD more than 4.5 mm is a risk factor of primary angle closure it is not statistically significant.

scholarly journals Evaluation of spontaneous retinal venous pulsation in primary open-angle and primary angle-closure glaucoma patients

2020 ◽  
Vol 2 (1) ◽  
pp. 27-41
Author(s):  
Sylves Patrick ◽  
Chan Hui Tze ◽  
Rasdi Abdul Rashid ◽  
Liza Sharmini Ahmad Tajudin
Keyword(s):  
Cross Sectional Study ◽  
Angle Closure ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Venous Pulsation ◽  
Primary Glaucoma

Introduction: Spontaneous retinal venous pulsation (SRVP) is a rhythmic variation in the calibre of one or more retinal veins. The incidence of SRVP was reduced in glaucoma patients. It was also reduced in people with raised intracranial pressure compared to a healthy population. Purpose: The main objective was to report the frequency and rate of SRVP in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) patients and to associate these with the severity of glaucoma in Malay patients. Design of study: A comparative cross-sectional study. Materials and methods: A comparative cross-sectional study involving primary glaucoma patients attending the eye clinic at Hospital Universiti Sains Malaysia (HUSM), Kelantan, Malaysia, was performed between December 2015 and June 2017. The main outcomes measured were the presence and rate of SRVP using a confocalscanning laser ophthalmoscope (Spectralis High-Resolution Optical Coherence Tomography Angiography, Heidelberg Engineering GmbH, Heidelberg, Germany). In the presence of SRVP, the rate of SRVP in one minute was counted manually based on the real-time fundus movie recorded using the confocal scanning laser ophthalmoscope. Results: Thirty-eight POAG, 14 PACG, and 51 control group subjects were included. There was a significantly lower incidence of SRVP in primary glaucoma patients than in the control group (p = 0.003). The presence of SRVP was significantly lower in POAG than PACG (p = 0.04). There was no significant difference in the rate ofSRVP between primary glaucoma patients and the control group (p = 0.873) or between the POAG group and PACG group (p = 0.511). There was no association of incidence (p = 0.574) and rate (p = 0.167) of SRVP according to the severity of glaucoma. Systolic blood pressure (95% CI: 0.95–1.00, p = 0.038) and retinal nervefibre layer thickness (95% CI: 1.01–1.09, p = 0.008) showed a significant association with the presence of SRVP. Conclusions: SRVP is a potential predictive factor for detection of primary glaucoma. The role of SRVP in the severity of glaucoma is still unclear. The role of SRVP in PACG patients warrants further studies in the future.

scholarly journals Development of a new algorithm for treatment of primary angle closure glaucoma

2018 ◽  
Vol 9 (2) ◽  
pp. 20-29
Author(s):  
N. I. Kurysheva ◽  
V. N. Trubilin ◽  
S. G. Kapkova ◽  
L. V. Lepeshkina
Keyword(s):  
Diabetes Mellitus ◽  
Corneal Endothelium ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Control Group ◽  
Lens Thickness ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Pigment Deposition

Purpose – to develop a new algorithm for treatment of primary angle closure glaucoma (PACG) based on laser peripheral iridotomy (PI) and selective laser trabeculoplasty (SLT) and to determine its indications and contraindications. 68 eyes with PACG were observed for 6 years. These patients had undergone PI and then SLT. The control group included 74 POAG eyes of the same age and stage of glaucoma. The effectiveness of SLT was assessed using the Kaplan-Meier survival analysis. The risk factors for SLT failure in the long-term period were studied to determine the indications and contraindications for this treatment algorithm, and the condition of corneal endothelium in dynamics was investigated using confocal microscopy. The hypotensive effect of SLT in PACG was worse than in POAG: 90 and 93% respectively one year after SLT, and 16 and 21% six years after SLT (log rank test, p=0.195). The following factors of SLT failure were common for both forms of glaucoma: IOP >24 mm Hg, corneal thickness ≤540 µm, corneal hysteresis <7 mm Hg and age of patients >68 years. The extension of laser action <1800 and lens thickness >4.8 mm were additional predictors of SLT failure in PACG. In both forms of glaucoma, diabetes mellitus, age of patients and duration of the disease before SLT had a negative effect on the condition of corneal endothelium. The anterior-posterior axis and the presence of pigment deposition on the endothelium were significant in PACG. The proposed algorithm for PACG treatment, including the initial performance of PI and then SLT, is an effective method of treating this form of glaucoma, provided that the opening of the anterior chamber angle is sufficient (at least half) and the lens thickness is no more than 4.8 mm. The initially high IOP, the age of patients over 68 and a thin cornea (<540 μm) worsen the SLT prognosis. Moreover, diabetes mellitus and the presence of pigment deposition on the endothelium along with long-term glaucoma history increase the risk of corneal endothelium damage after SLT.

scholarly journals Long-Term Outcomes of Primary Trabeculectomy in Diabetic Patients without Retinopathy with Primary Angle-Closure Glaucoma

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Jian Liu ◽  
Miaomiao Zhang ◽  
Bin Li ◽  
Jianrong Wang
Keyword(s):  
Case Series ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Control Group ◽  
Diabetic Patients ◽  
Surgical Success ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Purpose. To evaluate primary trabeculectomy with adjunctive mitomycin-C (MMC) in diabetic patients without retinopathy with primary angle-closure glaucoma (PACG). Design. This is a retrospective case series comparison. Participants. This retrospective trial compared outcomes of 88 eyes that underwent trabeculectomy in patients with diabetes mellitus (DM) without retinopathy and in 97 patients without DM. Methods. In this study, the intraocular pressure (IOP), visual acuity, visual field, and postoperative complications were compared between the two groups. Qualified surgical success is defined as an IOP between 6 and 18 mmHg with or without topical antiglaucoma medication. Results. After a follow-up of 5 years, the IOP decreased from a mean basal IOP of 27.8±7.3 mmHg to 15.0±5.6 mmHg in the DM group and from 27.3±6.0 mmHg to 12.4±5.3 mmHg in the control group. The mean number of antiglaucoma medications was 3.4±1.3 and 3.3±1.2 preoperatively (P=0.587) whereas it was 1.7±1.5 and 1.1±1.4 at the 5-year follow-up (P=0.049). The 5-year qualified surgical success rates were 42.9% and 65.4% for both groups (P=0.046; log-rank test). Encysted blebs were seen in 21 (23.9%) patients in the DM group and in 12 (12.4%) patients in the control group (P=0.041). Conclusion. PACG patients with DM without retinopathy undergoing primary trabeculectomy with MMC may have a lower long-term surgical survival rate compared with patients without DM.

scholarly journals Features Local Interlacing Status of Elderly Patients with Primary Angle-Closure Glaucoma

2021 ◽  
Vol 18 (1) ◽  
pp. 123-128
Author(s):  
A. M. Chukhraev ◽  
N. M. Agarkov ◽  
K. I. Proschayev ◽  
A. N. Ilnitskiy ◽  
A. S. Kulabukhov ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Local Level ◽  
The Elderly ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Anti Inflammatory

An increased share of the elderly in the structure of modern society, along with other causes and risk factors, is accompanied by the growing the incidence of glaucoma. According to international research in the world by 2020 it is predicted that glaucoma patients will increase to 80 million. Among the elderly, glaucoma is a common pathology, the development of which is associated with local disorders of the interleukin profile. However, the features of the latter in patients with primary closed-angle glaucoma in the elderly have not been studied. The purpose of this work is to identify the features and informativeness of local interleukin profile indicators in elderly patients with primary angle — closure glaucoma. The study included 58 patients with primary angle-closure glaucoma of stage II, who made up the main group, aged 60–74 years with a median of 70.1 ± 2.5 years. All patients underwent a comprehensive ophthalmological examination. The diagnosis of primary angle-closure glaucoma was established in accordance with the requirements of the National glaucoma guidelines. The control group consisted of 27 elderly people aged 60 to 74 years with a median of 68.7 ± 2.1 years without signs and manifestations of primary angle-closure glaucoma, who also underwent a comprehensive ophthalmological examination. Changes in proinflammatory interleukins at the local level in the development of primary angle-closure glaucoma are accompanied by a significant increase in their content in all cases. On the contrary, changes in anti-inflammatory interleukins in the lacrimal fluid in patients with the considered ophthalmological pathology are characterized by a significant inhibition of their production. IL-10 are characterized by the most significant decrease at the local level and it is less related to IL-4. Local interlacing profile of patients with primary angle-closure glaucoma elderly are characterized by increased level in the tear fluid of anti-inflammatory IL-2, IL-17, IL-8 and lower production of anti-inflammatory IL-10. These local interleukins have the greatest informative value, which is of scientific and practical significance for identifying new mechanisms of development, diagnostics and justification of selective immunotropic therapy of the pathology in question.

scholarly journals A Rare Case of Chronic Primary Angle-Closure Glaucoma in a Young Woman with Coexisting Pathologic Myopia

2021 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Ni Putu Ayu Reza Dhiyantari ◽  
Nurwasis Nurwasis ◽  
Evelyn Komaratih ◽  
Yulia Primitasari
Keyword(s):  
Anterior Chamber ◽  
Axial Length ◽  
Rare Case ◽  
Retinal Pigment ◽  
Anterior Chamber Depth ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Pathologic Myopia ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Introduction: Primary Angle-Closure Glaucoma (PACG) is usually present in adults older than forty and is more common in hyperopic eyes. Angle-closure is usually related to structural or developmental ocular abnormalities in young individuals. Case presentation: We presented a rare case of PACG in a 32 years old woman with pathologic myopia of -23.0 RLE. The chief complaint was blurring of the right eye three months before the visit. Right eye Intraocular Pressure (IOP) was 30mmHg-38mmHg despite treatment with three intra-ocular pressure-lowering agents. Axial length was 32.36 mm and 31.19 mm RLE. Anterior chamber depth was 2.36 mm and 2.60 mm RLE. Lens thickness was 5.07 mm and 5.40 mm RLE. Signs of GON and pathologic myopia were found in both eyes. GON was present asymmetrically (0.9 and 0.6 RLE), with the myopic crescent as well as baring and peripapillary atrophy. The optic disc was slightly tilted with the myopic crescent. There was also a marked sign of retinal pigment epithelium thinning and attenuation along with myopic chorioretinal atrophy. Conclusions: PACG in a young myopic individual is challenging to diagnose because myopia and glaucoma share similar optic nerve head pathology. Comprehensive examinations including gonioscopy, biometry, and OCT may confirm the diagnosis. In the presented case, angle-closure was caused by thick lenses and a shallow anterior chamber, along with excessively long axial length. Primary angle-closure at a young individual with myopic eyes is highly uncommon. Nonetheless, clinicians should always consider glaucoma even in the presence of high axial length and myopic fundus.

scholarly journals Inflammatory cytokine profiles in eyes with primary angle-closure glaucoma

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Yayi Wang ◽  
Shida Chen ◽  
Yaoming Liu ◽  
Wenbin Huang ◽  
Xinyi Li ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Aqueous Humor ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Inflammatory Protein

Acute primary angle-closure (APAC) eyes show an early ‘acute inflammatory’ condition, while the inflammation condition has not been fully elucidated in the development of primary angle-closure glaucoma (PACG). To evaluate the roles of inflammatory cytokines in the pathogenesis of PACG, this cross-sectional study involved 40 eyes of 32 PACG patients who required trabeculectomy and 24 eyes of 24 patients who required cataract surgery. The aqueous humor samples were collected at the time of surgery. Fifteen inflammatory cytokines were detected using the multiplex bead immunoassay technique, and the clinical information was recorded for the correlation analysis. Eight of the 15 cytokines were all detectable in both groups, including granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), macrophage inflammatory protein (MIP)-1β, and vascular endothelial growth factor (VEGF). When compared with the cataract patients, the MCP-3, MDC, and VEGF levels were elevated in the PACG patients, while the MCP-1 and MIP-1β levels were decreased. However, the G-CSF, IL-6, and IL-8 levels were similar between the two groups. The MCP-1 concentration was elevated accordingly as the disease progressed in the PACG patients. Our results suggest the PACG eyes retained a ‘mild inflammation’ condition in the aqueous humor, and MCP-1 may play an important role in the progression of this disease.

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