scholarly journals Relationship between type 2 diabetes mellitus and coronary artery lesion characteristics: a single center study

2014 ◽  
Vol 10 (1) ◽  
pp. 20-22 ◽  
Author(s):  
Laxman Dubey ◽  
Sogunuru Guruprasad ◽  
Gangapatnam Subramanyam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Artery ◽  
Small Vessel Disease ◽  
Significant Coronary Artery Disease ◽  
Diabetic Patients ◽  
Atherosclerotic Burden ◽  
Coronary Lesions ◽  
Artery Disease

Background: Coronary atherosclerotic burden is excessive in diabetic patients. The aim of present study was to assess the relationship between diabetes mellitus and plaque characteristics in patients with coronary artery disease.Methods: The coronary angiograms of 223 patients with significant obstructive lesions during April 2011 to May 2013 in College of Medical Sciences and Teaching Hospital were analyzed. The coronary lesions of patients with and without type 2 diabetes were compared. Results: 81 diabetic and 142 non-diabetic patients had significant coronary artery disease. Diabetic patients had more multivessel (64.2% versus 55.6%, p<0.05), and small vessel disease (74.1% versus 54.9%, p<0.05) than nondiabetic patients. Moreover, complex Type C lesion was significantly higher in the diabetic patients as compared to the nondiabetic patients (55.5% versus 29.6%, p<0.01). Conclusions: Complex coronary lesions were significantly more common in diabetic patients than in nondiabetic patients. Nepalese Heart Journal | Volume 10 | No.1 | November 2013| Pages 20-22 DOI: http://dx.doi.org/10.3126/njh.v10i1.9742

scholarly journals A study of prevalence of silent coronary artery disease in asymptomatic type II diabetes mellitus

2021 ◽  
Vol 9 (1) ◽  
pp. 1-4
Author(s):  
Moogaambiga S ◽  
Kirubhakaran K ◽  
Devi PL ◽  
Santhosh P
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diabetic Patients ◽  
Treadmill Test ◽  
Silent Coronary Artery Disease ◽  
Artery Disease

Background: Cardiovascular disease is a major cause of morbidity and mortality in diabetics. However diabetic patients do not present with typical anginal symptoms or may be even asymptomatic and silent coronary artery disease (CAD) is prevalent in diabetics. Moreover silent CAD is not different from symptomatic CAD with respect to prognosis and adverse effects. Aim: The study was done to demonstrate the prevalence of silent myocardial ischemic changes in asymptomatic type 2 diabetes mellitus patients with normal resting ECG by doing a stress exercise test. Methodology: This descriptive study was done in 100 patients with type 2 diabetes more than 2 years who did not have any history of cardiovascular disease or symptoms. Detailed history was taken and investigations such as HbA1c, fasting and postprandial blood sugar, serum creatinine, urine examination were done. Resting ECG, Echocardiogram was found to be normal and they were subjected to a treadmill test. Results: Among the 100 participants 18 persons (18%) had positive ECG findings in treadmill test. A positive association was found between the duration of diabetes and prevalence of positive treadmill test. Conclusion: There is significant prevalence of silent CAD in diabetic patients and they tend to present with advanced disease at presentation and have poorer prognosis compared to non diabetic population. Hence it is necessary to screen early for silent CAD in diabetics to improve disease outcomes.

scholarly journals Association of Plasma Myeloperoxidase Level with Risk of Coronary Artery Disease in Patients with Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Ping Song ◽  
Jin Xu ◽  
Yongfeng Song ◽  
Shiliang Jiang ◽  
Haitao Yuan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Logistic Analysis ◽  
Artery Disease

Aims. This study aimed to investigate whether the change of plasma myeloperoxidase (MPO) level would be associated with the incidence of coronary artery disease (CAD) among diabetic patients.Methods. 339 patients with type 2 diabetes mellitus (DM) underwent coronary angiography. Of them, 204 cases had CAD and were assigned to CAD group and 135 cases without CAD were assigned to non-CAD group.Results. Compared to non-CAD group, CAD group had higher level of plasma MPO (p<0.01). Multiple linear regression analysis showed that plasma MPO level was correlated with Gensini score. Multiple logistic analysis showed that the odds ratios for CAD across increasing tertiles of MPO level were 1.191 (0.971–1.547) and 1.488 (1.115–2.228) (p=0.048,p=0.009versus 1st tertile of MPO level, resp.) by adjusting for age, sex, and other conventional risk factors for CAD. The subjects were stratified into nine groups according to tertiles of MPO and HbA1c. The odds ratio for CAD was significantly higher in group with highest levels of MPO and HbA1c (OR = 4.08,p<0.01).Conclusion. Plasma MPO level was positively correlated with the degree of coronary artery stenosis in type 2 diabetic patients, and increasing blood glucose might amplify the association between MPO and CAD.

Does exercise training impact clock genes in patients with coronary artery disease and type 2 diabetes mellitus?

2016 ◽  
Vol 23 (13) ◽  
pp. 1375-1382 ◽  
Author(s):  
Eva Steidle-Kloc ◽  
Martin Schönfelder ◽  
Edith Müller ◽  
Sebastian Sixt ◽  
Gerhard Schuler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Type 2 Diabetes Mellitus ◽  
Coronary Artery ◽  
Exercise Training ◽  
Clock Genes ◽  
Artery Disease ◽  
Training Impact
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