scholarly journals Sirenomelia in Dicephalic parapagus twins discordant for anencephaly and spina bifida.

2020 ◽  
Vol 15 (1) ◽  
pp. 81-83
Author(s):  
Tripti Shrestha ◽  
Gehanath Baral ◽  
Nesuma Sedhain
Keyword(s):  
Spina Bifida ◽  
Key Words ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Congenital Anomalies ◽  
Rare Case ◽  
In Utero ◽  
Termination Of Pregnancy ◽  
High Incidence

An extremely rare case of sirenomelia in dicephalic parapagus twins discordant for anencephaly and spina bifida that was diagnosed after birth is presented. High incidence of congenital anomalies both with sirenomelia and parapagus twins independently make the prognosis much worse, with additional neural tube defect rendering it almost incompatible with life. Termination of pregnancy is advised when diagnosed in utero. Key words: anencephaly, dicephalic parapagus, spina bifida, sirenomelia

scholarly journals Prenatal diagnosis of a rare case of iniencephaly apertus

2018 ◽  
Vol 7 (4) ◽  
pp. 1635
Author(s):  
Mahy Mohsen ◽  
Ahmed El Sheikhah ◽  
Lamees Mohamed ◽  
Sief El-Eslam Ali ◽  
Armia Michael ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Prenatal Diagnosis ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Rare Case ◽  
Termination Of Pregnancy ◽  
Cervical Region ◽  
Common Features ◽  
History Of ◽  
Medical Induction

Iniencephaly is a rare neural tube defect that was firstly reported by Saint-Hilaire in 1836. Its incidence ranges from 0.1 to 10 in 10,000 deliveries with higher incidence in females. The most common features present iniencephaly are bifida at the cervical region, defect in the occipital bone and retroflexion of the head on the cervical spine. Here we report a case of a 24 years old second gravida with a history of consanguinity. She presented with a malformed fetus at 22 weeks gestation diagnosed by detailed ultrasonographic anatomy scan as iniencephaly apparatus. Termination of pregnancy was performed vaginally through medical induction by prostaglandins.

Prenatal diagnosis of rare form of chromosomal abnormality: double trisomy 48,XXX,+18 in the first trimester in association with spina bifida

2020 ◽  
Author(s):  
K.K. Otaryan , M.A. Kolyshkina , Y.B. Aninyan et all
Keyword(s):  
Prenatal Diagnosis ◽  
Spina Bifida ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Chromosomal Abnormality ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Rare Form ◽  
Double Trisomy ◽  
Chorion Villus

The case of prenatal diagnosis of neural tube defect at 11+5 weeks of gestation is presented. Chorion villus sampling performed. Karyotyping revealed double trisomy (48,XXX,+18). Termination of pregnancy was performed at 13 weeks of gestation.

Detection of spina bifida in the first trimester of gestation in association with triploidy

2017 ◽  
Author(s):  
K.K. Otaryan , C.G. Gagaev
Keyword(s):  
Spina Bifida ◽  
Early Detection ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Diagnostic Tools ◽  
Prenatal Detection ◽  
Post Abortion

The case of prenatal detection of spina bifida at 12+3 weeks of gestation is described. Termination of pregnancy was performed at 13+3 weeks. Post-abortion karyotyping revealed triploidy (69XXX). Diagnostic tools for early detection of neural tube defects in the 1st trimester of gestation and subsequent appropriate management of pregnancy are discussed.

Outcome in Infants Born to Mothers With Unexplained Elevations of Maternal Serum α-Fetoprotein

PEDIATRICS ◽  
1986 ◽  
Vol 77 (4) ◽  
pp. 582-586
Author(s):  
Barbara K. Burton ◽  
Robert G. Dillard
Keyword(s):  
Adverse Events ◽  
Amniotic Fluid ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Growth Retardation ◽  
Congenital Anomalies ◽  
Intrauterine Growth Retardation ◽  
Maternal Serum ◽  
Placental Barrier ◽  
Intrauterine Growth

The outcome in infants without fetal neural tube defect born to mothers with elevated maternal serum α-fetoprotein was studied. Elevated maternal serum α-fetoprotein with normal amniotic fluid α-fetoprotein was found to be associated with an increased incidence of intrauterine growth retardation and nonneural tube congenital anomalies. There was no increased incidence of developmental disabilities in infants born to mothers with elevated maternal serum α-fetoprotein. It is speculated that adverse events occurring early in gestation may simultaneously result in congenital anomalies and subsequently elevated maternal serum α-fetoprotein, perhaps through disruption of the normal placental barrier between the fetal and maternal circulations.

Profile of Neurological Congenital Anomalies in the Two Teaching Hospitals in Enugu, Nigeria

2021 ◽  
Vol 8 (6) ◽  
pp. 01-05
Author(s):  
Chukwubuike Emeka
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Teaching Hospital ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Congenital Anomalies ◽  
Physical Structure ◽  
University Teaching ◽  
Teaching Hospitals ◽  
The Central Nervous System

Background: Congenital anomalies of the central nervous system (CACNS) are birth defects of the physical structure of the brain or spinal cord that occur during intrauterine growth. The purpose of study was to obtain the incidence, types and risk factors of congenital anomalies of the central nervous system in the 2 teaching hospitals in Enugu, Nigeria. Materials and Methods: This was a hospital based observational study carried out on infants delivered at University of Nigeria Teaching Hospital (UNTH) and Enugu State University Teaching Hospital (ESUTH), Enugu during the periods of January 2013 and December 2018. Diagnosis of neurological congenital anomaly was made through clinical examination by a pediatrician and a neurosurgeon. Stillborns were excluded. Results: During the study period, 15,820 were delivered in the 2 teaching hospitals, out of which 79 infants had CACNS, which gave an incidence of 0.5%. Neural tube defect was the most common neurological anomaly. A significant number of the mothers took herbal concoctions during pregnancy. About one-fifth of the neurological anomalies were diagnosed prenatally. Conclusion: This study showed an incidence of CACNS of 0.5% in the two teaching hospitals in Enugu, South East Nigeria. Neural tube defect was the most common anomaly.

scholarly journals Perinatal and Neonatal Outcomes of Patients Who Were Diagnosed with Neural Tube Defect in Midtrimester Fetal Ultrasound Scan and Refused Request for Termination of Pregnancy

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Rauf Melekoglu ◽  
Sevil Eraslan ◽  
Ebru Celik ◽  
Yavuz Simsek
Keyword(s):  
Neural Tube ◽  
Neural Tube Defect ◽  
Treatment Options ◽  
Postnatal Period ◽  
Termination Of Pregnancy ◽  
Neonatal Outcomes ◽  
Ultrasound Scan ◽  
Fetal Ultrasound ◽  
Neonatal Deaths ◽  
History Of

Objectives. In this study, we aimed to demonstrate the perinatal and neonatal outcomes of patients who were diagnosed with neural tube defect (NTD) in the midtrimester fetal ultrasound scan and refused the request for termination of pregnancy. Material and Methods. The records of 69 patients, for whom NTD was detected in the midtrimester fetal ultrasound scan and who preferred the continuation of the pregnancy after comprehensive counselling about the possible prognosis and treatment options during the period between January 2011 and February 2016, were reviewed retrospectively. Results. Of these patients, 66.7% were 25–35 years old; 95.7% were multiparous; and 1.4% had a history of a fetus having NTD in previous pregnancies. There were 7 (10.1%) neonatal deaths in these patients. Meningomyelocele closure procedure was the most performed surgery in the postnatal period (92%). Of these patients, 30.7% had paraplegia; 51.6% had neurogenic bladder; and 6.4% had infections due to surgery. Conclusion. The results of this study demonstrated perinatal and neonatal outcomes of fetuses with NTD who were not terminated by the preference of the family in midtrimester. The experience of our centre would be beneficial as a tool for nondirective counselling of these patients when considering the antenatal/postnatal care options and postnatal prognosis.

In utero Repair of an Experimental Neural Tube Defect in a Chronic Sheep Model Using Biomatrices

2005 ◽  
Vol 20 (5) ◽  
pp. 335-340 ◽  
Author(s):  
A.J. Eggink ◽  
L.A.J. Roelofs ◽  
W.F.J. Feitz ◽  
R.M.H. Wijnen ◽  
R.A. Mullaart ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defect ◽  
In Utero ◽  
Sheep Model

Congenital Anomalies in Twins in Northern Ireland. II: Neural Tube Defects, 1974-1979

1989 ◽  
Vol 38 (1-2) ◽  
pp. 17-25 ◽  
Author(s):  
J. Little ◽  
N.C. Nevin
Keyword(s):  
Northern Ireland ◽  
Spina Bifida ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Anomalies ◽  
Large Population ◽  
Great Majority ◽  
Population Based ◽  
Population Based Study ◽  
Male Preponderance

AbstractIn a large population-based study in Northern Ireland during the period 1974-1979, the rate of anencephalus in twins (9.1/10,000) was found to be less than that in singletons (24.3/10,000). This finding is in contrast with most other studies and the possibility of underascertainment of twin cases is considered, but it is concluded that chance is the likeliest explanation. The rate of spina bifida in twins (36.4/10,000) was similar to that in singletons (31.9/10,000). All of the twins with anencephalus were female and from pairs of like sex. Rates of spina bifida in twins from pairs of the two sex types were similar but, unusually, there was a male preponderance. As in previous studies, the great majority of twins with NTDs had unaffected cotwins.

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