scholarly journals Diagnostic Dilemma in Metaplastic Chondroid Breast Carcinoma

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Farina MY ◽  
Shahrun Niza AS ◽  
Saladina JJ ◽  
Nani Harlina ML ◽  
Zaireen MN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Treatment Strategies ◽  
Rare Condition ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Metaplastic Carcinoma ◽  
Metaplastic Breast Cancer ◽  
Diagnostic Dilemma ◽  
Year 2000

Metaplastic breast cancer is a rare form of primary breast cancer. It contains a mixture of adenocarcinoma with metaplastic elements. It is important to differentiate with primary sarcoma of the breast which carries different treatment strategies and prognosis. A 55-year-old lady previously diagnosed to have a left breast cancer in the year 2000 and carcinoma of the endometrium in 2009, presented with a right breast lump. A trucut biopsy reported as an infiltrating ductal carcinoma with background of chondromyxoid and cartilagenous matrix, most probably metaplastic carcinoma. A wide local excision with sentinel lymph node biopsy was performed, and the final histology was consistent with metaplastic chondroid carcinoma of the breast with no evidence of metastsis. The surgery was followed by adjuvant radiotherapy and currently free from any recurrence. The diagnostic dilemma on this very rare condition is reviewed.

scholarly journals METAPLASTIC CARCINOMA OF BREAST : A CASE REPORT

2021 ◽  
pp. 39-40
Author(s):  
Manju Singh ◽  
S N Gole ◽  
S L Nirala ◽  
T Narasimha Murty
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptors ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Metaplastic Breast Cancer ◽  
Biopsy Report ◽  
Simple Mastectomy ◽  
Cell Variant

Metaplastic breast cancer constitute nearly 1 % of all breast carcinoma cases. There is metaplasia of normal epithelial components of the breast into other types. They are highly aggressive with very poor prognosis. Here we present a case of 30 year old female who presented with a breast lump in her left breast associated with dull aching pain. It was 10 x 10 cm in size involving upper inner, upper outer, lower outer quadrants and retroareolar area of left breast. USG was suugestive of BIRADS VI lesion. Axillary lymph nodes were not found enlarged clinically or radiologically. Core biopsy report showed Phylloides tumor of breast. The patient underwent simple mastectomy of left breast and histopathology revealed spindle cell variant of metaplastic breast cancer. The cell blocks sent for immunohistochemistry were negative for estrogen, progesterone receptors and Her2neu receptor. The post surgical treatment of this type of breast cancer is still under study.

scholarly journals Is It Contralateral Axillary Metastasis or Occult Breast Cancer: A Confusing Case Report

2015 ◽  
Vol 8 (3) ◽  
pp. 498-502 ◽  
Author(s):  
Yong Gi Son ◽  
Woon Won Kim ◽  
Ki Hoon Kim ◽  
Jin Soo Kim
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Growth Factor Receptor ◽  
Immunohistochemical Analysis ◽  
Breast Conserving Surgery ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Adjuvant Radiation ◽  
Axillary Lymph ◽  
Axillary Metastasis

We report the case of a 43-year-old woman with primary left breast cancer presenting metastatic lymphadenopathy in the contralateral axilla. This patient represents a diagnostic and therapeutic challenge because primary breast cancer, occult contralateral breast cancer, and extra-mammary primary lesion can all be the source of the contralateral axillary metastasis. Left breast-conserving surgery, left sentinel lymph node biopsy, right breast mass excision, and right axillary lymph node dissection were performed. Immunohistochemical analysis revealed that the left breast cancer specimen was positive for estrogen receptor (ER) and progesterone receptor (PR), but negative for human epidermal growth factor receptor 2 (HER2). In contrast, the right axillary lymphadenopathy specimen was negative for ER and PR, but positive for HER2. Further investigation revealed no evidence of occult primary cancers or extra-mammary tumors. After surgical intervention, the patient was treated with adjuvant chemotherapy, adjuvant radiation therapy, and targeted therapy with trastuzumab. Two years after diagnosis, she is free of disease and presently being treated with tamoxifen.

scholarly journals Pectoralis muscle metastases from breast cancer in a young patient detected by automated breast ultrasound

2019 ◽  
Vol 21 (2) ◽  
pp. 200
Author(s):  
Anca Ileana Ciurea ◽  
Ioana Boca ◽  
Liliana Rogojan ◽  
Larisa Dorina Ciule ◽  
Cristiana Augusta Ciortea
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Rare Condition ◽  
Left Breast ◽  
Breast Ultrasound ◽  
Pectoralis Muscle ◽  
Resonance Imaging ◽  
Ultrasound Guided ◽  
Screening Ultrasound ◽  
Automated Breast Ultrasound

Metastases to the skeletal muscle from breast cancer represent an unusual and rare condition. We present the case of a 27-year-old female with left breast cancer (IDC NST G3) who underwent neoadjuvant chemotherapy followed by conservativesurgery (sectorectomy and lymphadenectomy) and radiation therapy. Two months after the end of radiotherapy she presented with a 2 mm skin lesion and she was referred for a screening ultrasound. The screening automated breast ultrasound (ABUS) revealed local recurrence and pectoralis metastases, lesions evaluated also by magnetic resonance imaging. The diagnosis was confirmed by the ultrasound-guided biopsy.

scholarly journals Right Breast Metaplastic Carcinoma with Chondroid Diff erentiation (Chondrosarcoma)

2018 ◽  
Vol 22 (4) ◽  
pp. 45-51
Author(s):  
Alya S. Binmahfouz
Keyword(s):  
Breast Cancer ◽  
Metaplastic Carcinoma ◽  
Adjuvant Radiation ◽  
Resonance Imaging ◽  
Metaplastic Breast Cancer ◽  
Diagnostic Features ◽  
Palpable Mass ◽  
Adjuvant Radiation Therapy ◽  
The Right ◽  
Metaplastic Breast Carcinoma

Metaplastic breast cancer is rare, representing < 5% of breast cancer (only eight cases have been reported so far). We present here a 42-year-old female complaining of a painless lump in the right breast for the previous two months. Physical examination revealed a palpable mass. Lumpectomy was performed and histopathologic examination revealed metaplastic breast carcinoma with foci of chondrosarcoma. The patient received adjuvant radiation therapy and chemotherapy and is currently following up as an outpatient. We also discuss diff erentimaging diagnostic features of this specifi c type of breast cancer using mammography, ultrasonography, and magnetic resonance imaging.

Metaplastic Breast Cancer: Clinical Features and Outcomes

2005 ◽  
Vol 71 (9) ◽  
pp. 725-730 ◽  
Author(s):  
Glen R. Gibson ◽  
Dajun Qian ◽  
Joseph K. Ku ◽  
Lily L. Lai
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Local Recurrence ◽  
Menopausal Status ◽  
Axillary Node ◽  
Metaplastic Carcinoma ◽  
Metaplastic Breast Cancer ◽  
Histologic Subtype ◽  
Hormone Receptor Positive ◽  
Node Involvement

Metaplastic carcinoma of the breast, a neoplasm with both epithelial and mesenchymal elements, represents less than 1 per cent of all breast cancer. We reviewed the records of all patients diagnosed with localized metaplastic breast cancer from 1991 to 2003 at our institution. We identified 21 patients. Mean primary tumor size was 4.62 cm. Eight patients (38%) had axillary node involvement at presentation. All the tumors were high grade. Only two (10%) of the tumors were hormone receptor positive. Seventeen (81%) of the patients received adjuvant chemotherapy, and 12 (57%) of the patients received radiation. Ten (29%) patients suffered a local recurrence. With a mean follow-up of 46 months, the 5-year disease-free and overall survival was 42 per cent (95% CI: 20% to 65%) and 71 per cent (95% CI: 46% to 96%), respectively. Stage-specific overall survival was 100 per cent, 83 per cent, and 53 per cent for stages I, II, and III, respectively. By multivariate analysis, there was no impact on recurrence or survival with regard to size, age, menopausal status, nodal status, histologic subtype, adjuvant therapy, or extent of surgery. Metaplastic breast cancer is a unique neoplasm that tends to present at an advanced stage and has a propensity for local recurrence. When stratified by stage, however, survival appears similar to that of adenocarcinoma of the breast, and these tumors should be treated as such.

Imaging characteristics of metaplastic breast cancer with osteoblastic differentiation

2020 ◽  
Vol 13 (8) ◽  
pp. e235050
Author(s):  
Sara Twadell ◽  
Kathy Schilling ◽  
Aaron Gleckman ◽  
Kerry-Ann McDonald
Keyword(s):  
Giant Cells ◽  
Left Breast ◽  
Osteoblastic Differentiation ◽  
Metaplastic Carcinoma ◽  
Pathology Report ◽  
Tissue Stiffness ◽  
Metaplastic Breast Cancer ◽  
Imaging Characteristics ◽  
Hypoechoic Mass

An 82-year-old female presented to her breast surgeon with a hard, painful mass in the left breast. Mammography demonstrated a new hyperdense mass with pleomorphic calcifications of trabeculated appearance. Ultrasound-guided biopsy demonstrated a hypoechoic mass with significantly increased vascularity and tissue stiffness as well as additional irregular, hypoechoic masses in the same area. Together these findings suggested multifocal malignancy. The pathology report from the biopsy demonstrated fragments of solid sheets of epithelioid and focally spindled cells with multinucleated osteoclast giant cells. This was found to be most consistent with metaplastic carcinoma showing osteoblastic differentiation. The patient received a left-sided mastectomy. During follow-up with the patient, adjuvant chemotherapy was not advised given the relatively unknown survival advantage in this elderly patient.

scholarly journals Nodular Scleritis Revealing Metastasis of Breast Cancer: Diagnosis Not to Be Neglected

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Belghmaidi Sarah ◽  
Ghazza Ahmed ◽  
Boutgayout Saloua ◽  
Hajji Ibtissam ◽  
Moutaouakil Abdeljalil ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Breast Cancer Diagnosis ◽  
Left Breast ◽  
Histopathological Study ◽  
Ophthalmological Examination ◽  
Secondary Tumor ◽  
Systemic Corticosteroids ◽  
Anterior Scleritis ◽  
History Of

We report the case of ocular metastasis in a 48-year-old woman presenting left eye redness and pain. The patient was followed in another health institution for nodular scleritis and received systemic corticosteroids with moderate improvement. Medical history revealed that she was diagnosed three years ago with invasive ductal carcinoma of the left breast treated by tumorectomy with ganglion dissection. An ophthalmological examination found a hard scleral nodule with vascular architectural disorganization. A biopsy was performed, and the histopathological study revealed the presence of secondary tumor proliferation of poorly differentiated carcinoma of mammary cancer. This case report shows the fact that any unusual ocular presentation, even one simulating anterior scleritis, in a patient with a history of breast cancer should raise suspicion of metastasis.

A case of extensive ductal carcinoma in situ and sclerosing adenosis with metastasis on sentinel lymph node

2019 ◽  
Vol 105 (6) ◽  
pp. NP63-NP66
Author(s):  
Selin Narter ◽  
Secil Hasdemir ◽  
Sahsine Tolunay ◽  
Sehsuvar Gokgoz
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Sclerosing Adenosis

Introduction: Sclerosing adenosis is a form of adenosis characterized by lobulocentric architecture, glandular and stromal proliferation in which the stromal component compresses and distorts the glandular structures. Atypical epithelial proliferations such as atypical lobular hyperplasia, lobular carcinoma in situ, and ductal carcinoma in situ may accompany areas of sclerosing adenosis. We present a case of ductal carcinoma in situ and sclerosing adenosis with metastatic carcinoma on sentinel lymph node. Case description: A 40-year-old woman presented with a palpable mass in her left breast. Radiologic studies showed a lesion suggesting malignancy in the left breast and atypical lymph node in the left axillary region. Left lumpectomy and sentinel lymph node biopsy was performed. Histopathologic examination revealed lobulocentric lesions with glandular proliferation and hyalinizing stroma in between. Foci of high-grade cribriform and solid type ductal carcinoma in situ were observed. Sentinel lymph node biopsy showed micrometastasis in one lymph node section. Based on these findings, the patient was diagnosed with high-grade ductal carcinoma in situ with sclerosing adenosis. However, the presence of micrometastasis in the lymph node suggested occult invasion that we were not able to detect. Conclusion: Ductal carcinoma in situ with sclerosing adenosis can mimic invasive carcinoma both radiologically and histologically. It should be kept in mind that there may be occult invasive carcinoma in patients with ductal carcinoma in situ whether the lesion is accompanied by sclerosing adenosis or not. Multiple sections and immunohistochemical studies can be of help.

Indication of sentinel lymph node biopsy with breast-conserving surgery for ductal carcinoma in situ considering lymphatic flow.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 192-192
Author(s):  
Ayane Yamaguchi ◽  
Shigeru Tsuyuki ◽  
Miru Okamura ◽  
Yukiko Kawata ◽  
Kosuke Kawaguchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Breast Conserving Surgery ◽  
Lymph Node Biopsy ◽  
Outer Quadrant ◽  
Lymphatic Flow ◽  
Node Biopsy

192 Background: Ductal carcinoma in situ (DCIS) has been regarded as curable with resection, but axillary lymph node metastases have been reported in 2% of DCIS patients. Even when DCIS has been diagnosed by preoperative core needle biopsy (CNB), 8% to 38% of the patients have been found to have invasive ductal carcinoma (IDC) on the basis of pathological diagnosis after surgical treatment. The indication of sentinel lymph node biopsy (SLNB) and breast-conserving surgery (BCS) for DCIS is still controversial. Methods: SLNB is a standard surgical technique for early breast cancer treatment, and indocyanine green (ICG) fluorescence method is remarkable in terms of the visualization of lymphatic flow. We analyzed the variation in lymphatic drainage routes from the nipple to the SLN (sentinel lymphatic routes) by using the ICG florescence method in early breast cancer patients and investigated the effects on the localization of the tumor to the sentinel lymphatic routes after BCS. Results: From November 2010 to April 2012, we recorded the sentinel lymphatic routes in 118 patients. All the routes passed through the upper outer quadrant (UOQ) area, and there were more than 2 routes in 53 cases. Of these routes, 73% passed through only the UOQ area and 27% passed through the UOQ via the upper inner, lower inner, and/or lower outer quadrant area. Conclusions: We should confirm the sentinel lymphatic routes by using the ICG florescence method before BCS for preoperatively diagnosed DCIS. If the lymphatic routes do not pass over the extent of resection of BCS, we can omit SLNB in the first surgical treatment and await the final pathological result. However, we should perform SLNB in addition to BCS in cases in which the lymphatic routes pass over the tumor in the region except the UOQ area.

scholarly journals Tuberculosis axillary lymph node coexistent breast cancer in adjuvant treatment: case report

2015 ◽  
Vol 13 (3) ◽  
pp. 423-425 ◽  
Author(s):  
Silvio Eduardo Bromberg ◽  
Paulo Gustavo Tenório do Amaral
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Adjuvant Treatment ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Lymph Node Biopsy ◽  
Accurate Diagnosis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Biopsy

Coexistence of breast cancer and tuberculosis is rare. In most cases, involvement by tuberculosis occurs in axillary lymph nodes. We report a case of a 43-years-old patient who had undergone adenomastectomy and left sentinel lymph node biopsy due to a triple negative ductal carcinoma. At the end of adjuvant treatment, the patient had an atypical lymph node in the left axilla. Lymph node was excised, and after laboratory analysis, the diagnosis was ganglion tuberculosis. The patient underwent treatment for primary tuberculosis. The development of these two pathologies can lead to problems in diagnosis and treatment. An accurate diagnosis is important to avoid unnecessary surgical procedures.

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