scholarly journals Underweight Indian Women at a Risk for Developing Breast Cancer: A Retrospective Study

2021 ◽  
Vol 6 (3) ◽  
pp. 305-309
Author(s):  
Mrunal Ketkar ◽  
Amrita Ulhe ◽  
Minal Mahajan ◽  
Karamchand Patil ◽  
Ruchika Kaul-Ghanekar

Background: Breast cancer is the leading cancer diagnosed in Indian women. Lifestyle related factors such as high body mass index (BMI) and obesity have been recognized as major risk factors for the development of breast cancer. However, India has higher proportion of underweight population and recently positive correlation has been reported between underweight and increased risk of breast cancer. We have attempted to study an association between low BMI and total body fat percentage with breast cancer risk by performing retrospective analysis on a small sample size of 41 female patients diagnosed with breast cancer. The data was collected from Department of Oncology, Bharati Vidyapeeth Hospital and Research Centre (BVHRC), Pune, India. Methods: Binary logistic regression was performed to estimate odds ratios (ORs) and to examine the predictive effect of each factor on the breast cancer risk. Results: It was observed that underweight population displayed higher risk of breast cancer development based on BMI (OR-15.40) and body fat % (OR-1.33). Conclusion: This pilot study suggests that low body mass index may be related to poor prognosis in breast cancer and thus warrants further studies on a larger sample size to establish a positive correlation.

2014 ◽  
Vol 25 (2) ◽  
pp. 519-524 ◽  
Author(s):  
K. Wada ◽  
C. Nagata ◽  
A. Tamakoshi ◽  
K. Matsuo ◽  
I. Oze ◽  
...  

2018 ◽  
Vol 111 (4) ◽  
pp. 350-364 ◽  
Author(s):  
Frank Qian ◽  
Shengfeng Wang ◽  
Jonathan Mitchell ◽  
Lesley McGuffog ◽  
Daniel Barrowdale ◽  
...  

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Daniele Campa ◽  
Anika Hüsing ◽  
James D McKay ◽  
Olga Sinilnikova ◽  
Ulla Vogel ◽  
...  

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Sherko Abdullah Molah Karim ◽  
Hawar Hasan Ali Ghalib ◽  
Fattah Hama Rahim Fattah ◽  
Mohammed Ibrahim Mohialdeen Gubari ◽  
Aween Baiz Majeed

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Yiwey Shieh ◽  
Christopher G. Scott ◽  
Matthew R. Jensen ◽  
Aaron D. Norman ◽  
Kimberly A. Bertrand ◽  
...  

2017 ◽  
Vol 168 (1) ◽  
pp. 241-248 ◽  
Author(s):  
Arielle S. Gillman ◽  
Casey K. Gardiner ◽  
Claire E. Koljack ◽  
Angela D. Bryan

2016 ◽  
Vol 156 (1) ◽  
pp. 163-170 ◽  
Author(s):  
John L. Hopper ◽  
Tuong L. Nguyen ◽  
Jennifer Stone ◽  
Kelly Aujard ◽  
Melanie C. Matheson ◽  
...  

2014 ◽  
Vol 99 (2) ◽  
pp. 625-632 ◽  
Author(s):  
Adana A. Llanos ◽  
Juan Peng ◽  
Michael L. Pennell ◽  
Jessica L. Krok ◽  
Mara Z. Vitolins ◽  
...  

Context: Breast cancer risk among postmenopausal women increases as body mass index increases. Practical preventive methods to reduce risk of breast cancer are lacking. Few studies have investigated the effects of carotenoids and isoflavones on circulating adipokines in postmenopausal women. Objective: The aim was to examine the effects of lycopene- and isoflavone-rich diets on serum adipokines. Design: This was a 26-week, two-arm, longitudinal crossover trial. Setting: Participants were recruited from clinics at The Ohio State University Comprehensive Cancer Center. Participants: Seventy postmenopausal women at increased breast cancer risk participated in the study. The mean age and body mass index of participants was 57.2 years and 30.0 kg/m2, respectively; the study was comprised of 81.4% whites. Interventions: The interventions included 10 weeks of consumption of a tomato-based diet (≥25 mg lycopene daily) and 10 weeks of consumption of a soy-based diet (≥40 g of soy protein daily), with a 2-week washout in between. Main Outcome Measures: Changes in serum adiponectin, leptin, and the adiponectin to leptin ratio were examined for each intervention through linear mixed models, with ratio estimates corresponding to postintervention adipokine concentrations relative to preintervention concentrations. Results: After the tomato intervention, among all women, adiponectin concentration increased (ratio 1.09, 95% confidence interval (CI) 1.00–1.18), with a stronger effect observed among nonobese women (ratio 1.13, 95% CI 1.02–1.25). After the soy intervention, adiponectin decreased overall (ratio 0.91, 95% CI 0.84–0.97), with a larger reduction observed among nonobese women (ratio 0.89, 95% CI 0.81–0.98). Overall, no significant changes in leptin or the adiponectin to leptin ratio were observed after either intervention. Conclusions: Increasing dietary consumption of tomato-based foods may beneficially increase serum adiponectin concentrations among postmenopausal women at increased breast cancer risk, especially those who are not obese. Additional studies are essential to confirm these effects and to elucidate the specific mechanisms that may make phytonutrients found in tomatoes practical as breast cancer chemopreventive agents.


2010 ◽  
Vol 28 (4) ◽  
pp. 1296-1301 ◽  
Author(s):  
K. O. Hajian-Tilaki ◽  
A. R. Gholizadehpasha ◽  
S. Bozorgzadeh ◽  
E. Hajian-Tilaki

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