scholarly journals Is it possible to eliminate the number of inappropriate thyroid surgeries combining scintigraphy and cytology?

2021 ◽  
Vol 3 (5) ◽  
pp. 01-03
Author(s):  
Smaroula Divani
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Nodules ◽  
Follicular Carcinoma ◽  
Accurate Method ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Indeterminate Cytology

Objective: Although fine needle aspiration cytology (FNAC) is the most reliable, safe and accurate method for the clinical management of abnormal thyroid nodules, 5%-15% of cases lead to indeterminate diagnoses and surgery is the recommended practice for them as they may be malignant. Nevertheless, the majority of cases with indeterminate cytology are benign, so the risk of unnecessary surgery is significant. In our study we combined FNAC and scintigraphy in order to reduce the number of inappropriate surgeries. Subjects and Methods: From 219 patients with thyroid fine needle aspiration cytology 33(9 males and 24 females) aged 18-73 years, had indeterminate FNAC diagnoses and were referred for scintigraphy. Surgery was performed in all cases. The results of FNAC, scintigraphy and histology were collected and compared. Results: From 33 cases with indeterminate cytology 32 had a benign histological diagnosis and only one was malignant (follicular Ca). That case had a positive scan. All cases with negative thyroid scans (29/33) were benign. False positive scans were 3, whereas one scan was true positive with final diagnosis follicular carcinoma. Conclusion: This study showed that combining the FNAC with the thyroid scintigraphy in cases of thyroid nodules with indeterminate cytology it is possible to reduce the number of inappropriate surgeries from 32 to 3.

scholarly journals Correlation between fine needle aspiration cytology and histopathological examination in thyroid swellings-a pilot study

2020 ◽  
Vol 7 (11) ◽  
pp. 4381
Author(s):  
Sanjay V. Gupta ◽  
Manish Munjal ◽  
Devyani Gupta ◽  
Siddharth Gupta ◽  
Shubham Munjal ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Nodules ◽  
Follicular Adenoma ◽  
Follicular Carcinoma ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: Thyroid swellings are an enigma that necessitates either, a partial thyroidectomy and a tissue diagnosis to be followed by completion surgery or straightaway a radical intervention. A preoperative presumptive diagnosis of a thyroid swelling, solitary or otherwise is correlated with the post-surgical histopathological finding in the present study.Methods: 30 patients of thyroid nodules were selected from the head-neck tumour clinic of Dayanand medical college hospital, Ludhiana. Pre-operative fine needle aspiration cytology (FNAC) was performed and subjects taken for thyroidectomy, partial or total as the case maybe.Results: There were 20 (66.6%) females in the age group 25-65 years and 10 males (33.3%) 19-50 years with thyroid nodules. 86.6%, 26 patients were of follicular adenoma, 10% 3 patients of papillary carcinoma and 3.33% 1 patient of follicular carcinoma. No case in this study was reported as medullary carcinoma. In the cytological diagnosis of follicular neoplasm in 5 cases, 3 were diagnosed as thyroid adenoma, 2 were finally found to be papillary carcinoma. Overall sensitivity of fine needle aspiration was 40%. There was 84.6% agreement in follicular adenoma; 33% in papillary carcinoma and 100% in follicular carcinoma, and overall accuracy was 85.7%.Conclusion: FNAC is an ideal preoperative investigative modality in thyroid swellings with overall accuracy of 85 % and can differentiate preoperatively a benign from a   malignant thyromegaly; and thereby plan extent of surgery, with or without a neck dissection, Maximum cases of follicular adenoma could be easily diagnosed with this aspiration modality.                                               

The diagnostic accuracy of fine-needle aspiration cytology for thyroid nodules is not affected by coexistent chronic autoimmune thyroiditis: Results from a cyto-histological series of patients with indeterminate cytology.

2021 ◽  
Author(s):  
Mario Rotondi ◽  
Martina Molteni ◽  
Carlo Cappelli ◽  
Laura Croce ◽  
Alessandro Caputo ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Chronic Autoimmune Thyroiditis ◽  
Needle Aspiration Cytology ◽  
Indeterminate Cytology

Objective Indeterminate cytological result at Fine-needle-aspiration-cytology (FNAC) remains a clinical challenge for endocrinologists. Aim of the present study was to evaluate whether a coexistent Chronic-Autoimmune-Thyroiditis (CAT) might affect the diagnostic accuracy of fine-needle aspiration cytology for thyroid nodules. Design and Methods A retrospective cohort study was designed including all nodules receiving an indeterminate cytology result (TIR3A or TIR3B) undergoing thyroid surgery and subsequent histological confirmation. Patients were stratified in two groups according to the presence or absence of CAT. The hypothesis to be tested was whether follicular cell alterations induced by CAT might increase the rate of indeterminate cytological results in histologically benign thyroid nodules. Additional control groups were represented by nodules with determinate cytology, either benign (TIR 2) or malignant (TIR5). Results: One-hundred-eighty-nine indeterminate thyroid nodules were included (67 TIR3A and 122 TIR3B). At post-surgical histology 46 nodules (24.3%) were malignant. No significant differences were observed in the rate of histologically proven malignancy between patients without CAT and patients with CAT in the TIR3B (29.4% vs 32.4%; p=0.843) nor TIR3A (13.0% vs 11.4%; p=1.000) nodules. The rate of coexistent CAT was similar between TIR3B and TIR5 nodules harboring PTC at histology (30.4% vs 39.4%, p=0.491) and between indeterminate nodules and a control group of TIR2 nodules (39.2% vs 37.0%; p=0.720). Conclusions: The similar rates of histologically proven malignancy found in cytologically indeterminate nodules in the presence or absence of concomitant CAT, would not support that CAT itself affects the diagnostic accuracy of fine-needle aspiration cytology.

Utility of intraoperative frozen sections for thyroid nodules with prior fine needle aspiration cytology diagnosis

2017 ◽  
Vol 45 (9) ◽  
pp. 789-794 ◽  
Author(s):  
Sudarshana Roychoudhury ◽  
Fabiola Souza ◽  
Cecilia Gimenez ◽  
Ryan Glass ◽  
Rubina Cocker ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Frozen Sections ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Value of Clinical Examination, Scintigraphy and Fine-Needle Aspiration Cytology in the Diagnosis of Solitary Thyroid Nodules

1990 ◽  
Vol 2 (3-4) ◽  
pp. 167-171
Author(s):  
Adel Zaki Al-Taweel ◽  
Hussein Dashti ◽  
Abdulla Behbehani ◽  
W. Olszewski ◽  
Shafik O. Atia ◽  
...  
Keyword(s):  
Clinical Examination ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology
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