scholarly journals Fluctuating plasma phosphorus level by changes in dietary phosphorus intake induces endothelial dysfunction

2015 ◽  
Vol 56 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Eriko Watari ◽  
Yutaka Taketani ◽  
Tomoyo Kitamura ◽  
Terumi Tanaka ◽  
Hirokazu Ohminami ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Phosphorus Level ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake ◽  
Plasma Phosphorus

Circulating phosphorus level and risk of prostate cancer: a Mendelian randomization study

2021 ◽  
Author(s):  
Linshuoshuo Lv ◽  
Ding Ye ◽  
Jie Chen ◽  
Yu Qian ◽  
Alan Nuo Fu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Observational Studies ◽  
Mendelian Randomization ◽  
Meta Analysis ◽  
Serum Phosphorus ◽  
Phosphorus Level ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake ◽  
Phosphorus Levels

Abstract Background Recent observational studies have suggested that circulating phosphorus levels are positively associated with risk of prostate cancer. However, little is known about the causal direction of the association. Objective To explore the potential causal relationship between circulating phosphorus and risk of prostate cancer, we conducted a Mendelian randomization (MR) study. Design Summary statistics of prostate cancer were obtained from a meta-analysis of genome-wide association studies (GWAS) consisting of 79,148 cases and 61,106 controls. Single nucleotide polymorphisms (SNP) associated with serum phosphorus level were selected from a GWAS of 291,408 individuals from the UK Biobank. MR analysis was performed using the inverse-variance weighted (IVW) method, supplemented with simple-median, weighted-median, maximum likelihood-based, MR-Egger regression and MR-PRESSO test. We also performed a meta-analysis of observational studies to assess the associations of dietary phosphorus intake and serum phosphorus level with risk of prostate cancer. Results In the MR analysis, a total of 125 independent SNPs associated with serum phosphorus levels were used as instrumental variables. Genetically predicted serum phosphorus levels were associated with a 19% increased risk of prostate cancer (95% confidence interval (CI): 9%, 31%) per one SD increment of serum phosphorus by IVW (P = 1.82 × 10–4). Sensitivity analyses using alternative MR methods produced similar positive associations, and no evidence of pleiotropy was detected by MR-Egger regression (P = 0.422). For meta-analysis, eight studies for dietary phosphorus intake and four for serum phosphorus levels were included involving a total of 669,080 participants. Consistently, high dietary phosphorus intake and serum phosphorus levels were associated with an 8% (95% CI: 4%, 12%) and 7% (95% CI: 1%, 14%) increase in prostate cancer risk, respectively. Conclusions Our study suggested a potential causal relationship between circulating phosphorus and risk of prostate cancer. Further studies are warranted to elucidate the underlying mechanism of phosphorus in the development of prostate cancer.

scholarly journals High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III

2013 ◽  
Vol 99 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Alex R Chang ◽  
Mariana Lazo ◽  
Lawrence J Appel ◽  
Orlando M Gutiérrez ◽  
Morgan E Grams
Keyword(s):  
Nhanes Iii ◽  
Dietary Phosphorus ◽  
All Cause Mortality ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

High dietary phosphorus intake is associated with an increased risk of type 2 diabetes in the large prospective E3N cohort study

2018 ◽  
Vol 37 (5) ◽  
pp. 1625-1630 ◽  
Author(s):  
Francesca Romana Mancini ◽  
Aurélie Affret ◽  
Courtney Dow ◽  
Beverley Balkau ◽  
Françoise Clavel-Chapelon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Dietary Phosphorus ◽  
Increased Risk ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

scholarly journals Effect of dietary phosphorus intake and age on intestinal phosphorus absorption efficiency and phosphorus balance in male rats

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207601 ◽  
Author(s):  
Colby J. Vorland ◽  
Pamela J. Lachcik ◽  
Loretta O. Aromeh ◽  
Sharon M. Moe ◽  
Neal X. Chen ◽  
...  
Keyword(s):  
Absorption Efficiency ◽  
Male Rats ◽  
Phosphorus Balance ◽  
Phosphorus Absorption ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

scholarly journals The influence of dietary phosphorus intake on the rate of bone metabolism in sheep

1966 ◽  
Vol 20 (4) ◽  
pp. 727-732 ◽  
Author(s):  
V. R. Young ◽  
J. R. Luick ◽  
G. P. Lofgreen
Keyword(s):  
Bone Metabolism ◽  
Turnover Rates ◽  
Isotope Techniques ◽  
Dietary Phosphorus ◽  
Exchangeable Ca ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Depletion ◽  
Phosphorus Intake ◽  
P Depletion ◽  
Calcium Pool

1. A combination of balance and isotope techniques was used to determine the influence of phosphorus depletion on the size of the exchangeable calcium pool and on the rates of Ca deposition in and removal from the whole skeleton of sheep. 2. The exchangeable Ca pool was reduced in size in the depleted sheep to approximately 50% of that in the controls. 3. The rates of Ca deposition in and removal from bone were reduced by P depletion and the rate of Ca transfer from the pool was reduced slightly. 4. The turnover rates of the exchangeable Ca pool and bone Ca in sheep appear to be similar to values published for man.

scholarly journals Twenty-Four-Hour Urine Phosphorus as a Biomarker of Dietary Phosphorus Intake and Absorption in CKD

2018 ◽  
Vol 13 (7) ◽  
pp. 1002-1012 ◽  
Author(s):  
Elizabeth R. Stremke ◽  
Linda D. McCabe ◽  
George P. McCabe ◽  
Berdine R. Martin ◽  
Sharon M. Moe ◽  
...  
Keyword(s):  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

scholarly journals Estimate of dietary phosphorus intake using 24-h urine collection

2014 ◽  
Vol 55 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Yuuka Morimoto ◽  
Masae Sakuma ◽  
Hiroyuki Ohta ◽  
Akitsu Suzuki ◽  
Asami Matsushita ◽  
...  
Keyword(s):  
Urine Collection ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

The flow of calcium and phosphorus in the digestive tract of the sheep

1974 ◽  
Vol 25 (1) ◽  
pp. 147 ◽  
Author(s):  
J Leibholz
Keyword(s):  
Calcium Intake ◽  
Energy Content ◽  
Calcium Content ◽  
Metabolizable Energy ◽  
Dietary Calcium Intake ◽  
Dietary Phosphorus ◽  
Calcium And Phosphorus ◽  
Dietary Phosphorus Intake ◽  
The One ◽  
Phosphorus Intake

The flow of calcium and phosphorus to the proximal duodenum was measured over 22 24-hr periods in sheep fitted with re-entrant duodenal cannulae. The sheep were offered one of six diets in a ground and pelleted form supplying 1.4–30 g of nitrogen per day from three different protein sources. The estimated metabolizable energy content of the diets was 1.9 or 1.3 Mcal/kg. The diets supplied 2.0–5.8 g of calcium per day and 2.2–3.3 g of phosphorus per day. Between 49.9% and 61.2% of the dietary calcium intake appeared at the duodenum in the sheep given all diets except the one supplying 1.4 g of nitrogen per day, where the value was 98.5%. There were highly significant correlations between the daily calcium intake and the flow of calcium to the duodenum, the excretion of calcium in the faeces, the retention of calcium and the calcium content of the rumen. Between 85.0 and 119.1% of the daily phosphorus intake appeared at the duodenum in the sheep given all six diets. The flow of phosphorus was correlated with the dietary phosphorus intake. There were significant correlations between the flow of calcium and phosphorus to the duodenum and, also, their retention.

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