scholarly journals IMPACT OF THE TREATMENT WITH COMBINATION OF TIOTROPIUM/OLODATEROL ON THE QUALITY OF LIFE IN PATIENTS WITH COPD

2021 ◽  
Vol 2021 (3) ◽  
pp. 36-42
Author(s):  
K. D. Dmytriiev

IMPACT OF THE TREATMENT WITH COMBINATION OF TIOTROPIUM/OLODATEROL ON THE QUALITY OF LIFE IN PATIENTS WITH COPD K. D. Dmytriiev Vinnytsia National Pirogov Memorial Medical University Vinnytsia, Ukraine Abstract. Materials and methods. 100 patients with the diagnosis of COPD were included into the study, their average age was (64.09 ± 1.94) years, there were 66 men (66 %) and 34 women (34 %). The average duration of COPD was (9.35 ± 2.42) years. Clinical course of COPD was assessed based on the clinical documentation of the patients. All patients filled out questionnaires for the assessment of the COPD severity — mMRC and CAT; and quality of life — SF-36, SGRQ at visit 1, visit 2 (4-6 weeks) and visit 3 (1 year). Results. Treatment with combination of tiotropium/olodaterol reliably improve COPD course, by decrease in the amount of exacerbations from (2.63 ± 0.29) to (1.63 ± 0.21) and hospital admissions from (1.2 ± 0.2) to (0.37 ± 0.11); dyspnea severity according to mMRC questionnaire from (2.3 ± 0.14) to (1.87 ± 0.15); САТfrom (23.28 ± 1.71) to (15.77 ± 1.58). Treatment with combination of tiotropium/olodaterol reliably improve quality of life according to SF-36 questionnaire, specifically physical and emotional role functioning from (16 ± 5.57) % to (35.10 ± 7.15) % and from (27.35 ± 7.83) % to (50.29 ± 7.99) %, exerted vitality from (38.26 ± 3.86) % to (49.49 ± 3.7) %, mental health from (51.56 ± 3.76) % to (61.49 ± 3.59) %, social functioning from (57.61 ± 5.93) % to (69.22 ± 5.08) % and pain intensity from (66.92 ± 5.99) % tо (81.00 ± 4.17) %. Treatment with combination of tiotropium/olodaterol reliably improve quality of life according to SGRQ questionnaire, specifically «Symptoms» scale from (76.72 ± 3.85) tо (61.37 ± 4.59), «Activity» from (65.26 ± 4.18) to (51.97 ± 3.86), «Impact» from (52.36 ± 4.65) to (35.19 ± 4.25) and Total score from(60.31 ± 3.95) tо (44.62 ± 3.89). Conclusions. Combination of tiotropium/olodaterol showed its efficacy in real clinical practice. This combination is effective in the improvement of the clinical course of COPD and decrease of symptoms intensity, which is also accompanied by the improvement of the quality of life. Key words: COPD, quality of life, tiotropium/olodaterol. K. D. Dmytriiev Vinnytsia National Pirogov Memorial University Department of the Propedeutics of Internal Medicine PhD student str. Khmelnytske highway 96, 20129, Vinnytsia, Ukraine e-mail: [email protected] Аsthma and Allergy, 2021, 3, P. 36–42.

2006 ◽  
Vol 64 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Mara Renata Fernandes ◽  
Luciane B.C. Carvalho ◽  
Gilmar F. Prado

CONTEXT: Hemiparesia changes quality of life of patients with stroke making difficult a normal life. OBJECTIVE: To evaluate the effect of Functional Eletric Orthesis (FEO) applied over the paretic leg in the quality of life of stroke patients. METHOD: The quality of life of 50 stroke patients of Associacao de Assistencia a Crianca Deficiente (AACD) was evaluated with SF-36 questionnaire before and after the treatment with a FEO for rehabilitation of walking. We analyzed data according to gender and affected hemisphere. RESULTS: The average values from all domains of SF-36 improved significantly (p<0.001). Female patients improved more than male in Emotional Domain (p=0.04) and presented a trend to be better regarding Bodily Pain and Social Functioning. Patients with right hemiparesia improved more than those with left hemiparesia (p=0.02). CONCLUSION: FEO over a paretic leg is efficient to improve quality of life of stroke patients, mainly Physical Functioning.


Author(s):  
Amaryah Yaeger ◽  
Nancy R Cash ◽  
Tara Parham ◽  
Rajeev Pathak ◽  
David S Frankel ◽  
...  

Objective: The desired goal of atrial fibrillation (AF) management is maintenance of sinus rhythm in order to improve quality of life (QoL) and arrhythmia symptoms (AS). Although obesity and obstructive sleep apnea (OSA) are known risk factors for development of AF, these remain inadequately treated. We report the impact of prospectively modifying these risk factors on QoL and AS in AF patients (pts). Methods: AF pts with obesity (body mass index (BMI) ≥30kg/m 2 ) and/or the need for OSA management (high-risk as per Berlin Questionnaire or untreated OSA) were voluntarily enrolled in a nurse-led risk factor modification (RFM) program at their arrhythmia clinic visit. RFM entailed patient education, lifestyle modification counseling, coordination of care with appropriate specialists, and longitudinal care management. Progress with weight loss (WL) and OSA treatment was monitored via monthly follow-up calls and/or downloads from continuous positive airway pressure (CPAP) units for up to 12 months. QoL and AS were determined with the SF-36 and AF Severity Scale (AFSS) respectively, and were assessed at baseline, 6 months, and 12 months. Student t-test and chi-square tests were used to compare continuous and dichotomous variables. Results: From 11/1/16 to 10/31/17, 252 pts (age 63±11 years; male=179; paroxysmal AF=126) were enrolled as follows: 189 for obesity and 93 for OSA. The mean WL was 2.7±3.8% from baseline and 78% (n=126 of 162 pts with available data) of enrolled obese patients achieved WL. Among 93 pts at risk for OSA, 70 completed sleep studies and 50 were identified with OSA. Majority of these patients (76%; n=38 of 50) started CPAP therapy and have remained full (57%; n=17 of 30 pts with available CPAP data) and partial (13%; n=4 of 30) users. Table shows that SF-36 and AFSS scores improved for most measures of QoL and AS from baseline to 6 months. Conclusion: Participation in a risk factor modification program targeting obesity and obstructive sleep apnea can improve quality of life and arrhythmia symptoms in patients with atrial fibrillation. The impact of this strategy on long-term maintenance of sinus rhythm remains to be determined.


2010 ◽  
Vol 9 (4) ◽  
pp. 63-69
Author(s):  
V. N. Karnaukh ◽  
Yu. A. Lugovtsova ◽  
I. A. Barabash

The study explored the life quality of 94 multiple sclerosis patients in comparison to healthy respondents and in dependence to different parameters of the disease with the use of SF-36 questionnaire. The study has discovered a decline of all the factors of life quality and their dependence on disablement intensity, clinical course and duration of the disease. Immunomodulatory therapy contributed to the improvement of life quality factors.


Author(s):  
Nofel Ahmet Binicier ◽  
Atıf Yolgösteren ◽  
Murat Biçer

Objective: In this study, we aimed to compare the effects between on-pump and off-pump coronary artery bypass surgery on the effect of quality of life. Methods: Fifty patients who underwent isolated coronary artery bypass (CABG) between 01.08.2012 - 31.01.2013 were divided into two equal groups (group 1: off-pump CABG; group 2: on-pump CABG). The quality of life of all patients was evaluated using the SF-36 questionnaire in the postoperative first week and first month (8 basic parameters in SF-36 questionnaire form: Physical function, pain, physical role, mental health, emotional role, social function, fitness / fatigue, general health) Results: One week after CABG surgery, physical function, physical role, social function and emotional role were significantly better in group 1 than group 2 (p <0.05). There was no statistically significant difference between the two groups in terms of quality of life, one month after CABG surgery (p> 0.05). Physical function was significantly better in female gender one week after CABG (p <0.05). There was no difference between the two genders in terms of quality of life after one month (p> 0.05). Conclusion: We think that CABG performed off-pump in order to avoid from negative effects of cardiopulmonary bypass has no significant effect on the quality of life of the patients in the postoperative period. Nevertheless, in order to get a clearer idea on this issue, we think that large series studies should be conducted with a higher number of patients.


2019 ◽  
Vol 1 (6) ◽  
pp. 56-60
Author(s):  
N. B. Gubergrits ◽  
E. A. Krylova ◽  
E. Yu. Plotnikova

In 72 patients with chronic pancreatitis were studied quality of life indicators using a common questionnaire the SF-36 (Short Form-36, Healt Status Survey) in the dynamics of treatment. It was established that the disease affects the quality of life of patients, affecting all levels of life:physical, emotional, role, psychological, social functioning. After treatment, the quality of life of patients significantly improved both indicators of physical and social health of patients increased the overall tone and physical activity during the day, improves sleep at night.


Author(s):  
N V Gonchar ◽  
E O Kalinicheva ◽  
E H Mustafaev ◽  
V A Dobrenko ◽  
M I Sokolova

Objective. Nutritional peculiarities and their relationship with the quality of life’s (QoL) values were estimated in 38 students. Materials and methods. We evaluated the dietary peculiarities according to the results of our special questionnaire. The students used ten-point scale for answer questions. We have formed the two subgroups of the respondents according to the results of their answers: subgroup A (students whose answers were 5 points or less) and subgroup B (students whose answers were more than 5). We estimated QoL according to the SF-36 questionnaire. Results. Most of the respondents eat regularly the food containing plant fibers (76.3%) and the food with animal proteins (81.6%). Above mentioned dietary peculiarities correlates reliably with such QoL values as SF and BP in men and VT in women. 36,8% of respondents have breakfast irregularly, this nutritional peculiarity reduces reliably such QoL values as PF, GH and VT. The regularity of breakfasts correlates reliably with VT in men, and PF and GH in women. Dietary restriction of spicy, fatty, fried, smoked foods is observed in 36.8% of respondents; a negative reliable correlation of this nutritional peculiarity with RP has been revealed in women; possible positive effect of such kind of food on the QoL can be suggested. Conclusion. It is shown that there is a correlation between students’ eating habits and the quality of life. (For citation: Gonchar NV, Kalinicheva EO, Mustafaev EH, et al. Gender peculiarities of nutrition in students and their relationship with quality of life. Herald of North-Western State Medical University named after I.I. Mechnikov. 2018;10(2):73-78. doi: 10.17816/mechnikov201810273-78).


2013 ◽  
Vol 94 (4) ◽  
pp. 483-487
Author(s):  
D Kh Chetukova ◽  
A A Savin

Aim. To investigate the health-related quality of life among the patients with hand-arm vibration syndrome in the Kabardino-Balkar Republic. Methods. The study included 198 patients aged 36-65 years. The health-related quality of life (HRQoL) was assessed using the SF-36 questionnaire before and after recreation treatment. Patients were divided to 3 groups according to disease severity: hand-arm vibration syndrome stage 1 - 54 (27.3%) patients, stage 2 - 75 (37.9%) patients, stage 3 - 69 (34.8%) patients. Results. Marked decrease in all HRQoL parameters measured by SF-36 was observed at the baseline. After the recreation treatment there was a significant improvement in all HRQoL parameters in all groups (particularly on «vitality» and «emotional role functioning»). The most prominent improvement was observed in patients with early stages of hand-arm vibration syndrome. Conclusion. Patients with hand-arm vibration syndrome suffer from severe decrease of HRQoL. Recreation therapy improves the HRQoL, especially on early stages of hand-arm vibration syndrome.


2010 ◽  
Vol 63 (9-10) ◽  
pp. 701-704
Author(s):  
Marija Zdravkovic ◽  
Mirjana Krotin ◽  
Marina Deljanin-Ilic ◽  
Darko Zdravkovic

Definition of quality of life. In recent years, quality of life has become a very important measure of treatment of disease and successful therapy, regarding not only general health of an individual patient but also of the whole population In 1993 the WHO proclaimed 'Vision of health for all', as 'Add years to life' but also 'Add life to years', emphasizing quality of life to be as important as life duration. Although the remaining life expectancy in patients with cardiovascular disease is prolonged, there is still medical challenge: 'How to improve quality of life in these patients?'. Measurement of quality of life. Quality of life can be defined as the patient's perception of impact of disease and concomitant therapy and procedures on his physical and working capacity, emotional role, social communication and general health. Different types of standardized questionnaires for quality of life evaluation It can be measured by general health questionnaires and specified questionnaires for disease. Questionnaire SF-36 is regarded as one of the most reliable, considering the great number of publications. Conclusion. The most important step in complicated evaluation of quality of life is the adequate selection of questionnaire with a high confidence.


2021 ◽  
Author(s):  
Lilian Nascimento Rosa ◽  
Nora Manoukian Forones

Abstract Purpose: The caregivers of cancer patients may experience changes in their routine and environment that affect their quality of life. The aim of the study was to identify the domains that compromise the quality of life of the caregivers of patients with gastrointestinal cancer (GIC). Methods: A descriptive, observational study with caregivers of patients diagnosed with GIC during chemotherapy therapy was done. The caregivers answered 2 questionnaires, SF-36 (Short Form Health Survey 36) and CBS (Caregiver Burden Scale). Results: 100 caregivers of 100 patients with GIC were included. The mean age of the patients was 62.2±13 years. Most of them had colorectal cancer (66%), ECOG 0-1 (87%) and stage II/III (81%) disease. Among caregivers, 81% had less than 60 years old and 76% were female. According to the SF-36, lower levels were observed in the emotional, physical aspects and vitality and the best average in functional capacity. Regarding the CBS instrument, the general strain domain and disappointment was the more affected. Stage or ECOG was not associated to the caregivers QOL or burden. High schooling level of the patients was associated with a better quality of life and less burden of the caregivers. Ageing caregivers had a worst QoL and an increased burden.Conclusion: Most of caregivers were women and youngers and had a worst quality of life in emotional role, physical aspects and vitality and an increased burden in general strain and disappointment.


2016 ◽  
Vol 97 (5) ◽  
pp. 681-686
Author(s):  
S A Kozhevnikova ◽  
A V Budnevskiy

Aim. To study the clinical course of chronic obstructive pulmonary disease in patients with metabolic syndrome and analyze the degree of influence of the metabolic syndrome components on chronic obstructive pulmonary disease and patients’ quality of life.Methods. 100 patients with chronic obstructive pulmonary disease were examined: 30 patients without metabolic syndrome (the first group) and 70 patients with metabolic syndrome (the second group). Anthropometric measurements (weight, height, body mass index, waist circumference), laboratory tests (levels of triglycerides, cholesterol, low- and high-density lipoproteins, fasting blood glucose, the oral glucose tolerance test), physical examination, quality of life assessment were performed.Results.Patients of the second group had statistically significant differences in the studied parameters in comparison with the first group. The number of exacerbations, calls to ambulance service, hospital admissions were 1.4; 1.3 and 1.5 times higher, respectively. Dyspnea intensity, cough and sputum score were 1.6; 1.7 and 1.6 times higher respectively as compared with the first group (pConclusion. Metabolic syndrome is associated with a more severe course of chronic obstructive pulmonary disease, which results in a higher frequency of exacerbations, hospital admissions, more severe clinical manifestations, greater influence of dyspnea on the physical activity limitation of patients, more severe airflow obstruction, low exercise tolerance with worse performance of everyday activities, emotional perception of the disease, worse psychosocial adaptation of patients.


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