Kaolin-induced congenital hydrocephalus in utero in fetal lambs and rhesus monkeys

1984 ◽  
Vol 60 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Michael S. B. Edwards ◽  
Michael R. Harrison ◽  
Meredith Halks-Miller ◽  
Don K. Nakayama ◽  
Mitchell S. Berger ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Silicone Oil ◽  
Obstructive Hydrocephalus ◽  
First Trimester ◽  
In Utero ◽  
Congenital Hydrocephalus ◽  
Major Drawback ◽  
Content Type ◽  
Intracisternal Injection ◽  
First Trimester Of Pregnancy

✓ A model of congenital hydrocephalus in utero in fetal lambs and rhesus monkeys has been produced by the intracisternal injection of kaolin. Initial attempts to produce hydrocephalus using silicone oil were unrewarding. Hydrocephalus had developed by 2 weeks post-injection and could be followed by ultrasonography. The pathological findings were similar to those reported using kaolin in other species. Ventriculoamniotic shunting, when successful, was capable of partially reversing the deleterious effects of hydrocephalus. The major drawback of the present model is that hydrocephalus is produced during the second rather than the first trimester of pregnancy. However, kaolin produces mainly an obstructive hydrocephalus without other associated brain or systemic anomalies.

Chemoradiation therapy in pregnant patients treated for advanced-stage cervical carcinoma during the first trimester of pregnancy: report of two cases

2007 ◽  
Vol 17 (1) ◽  
pp. 270-274 ◽  
Author(s):  
Y. Benhaim ◽  
C. Haie-Meder ◽  
C. Lhommé ◽  
P. Pautier ◽  
P. Duvillard ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Residual Disease ◽  
First Trimester ◽  
In Utero ◽  
Chemoradiation Therapy ◽  
Advanced Stage ◽  
Tumor Spread ◽  
First Trimester Of Pregnancy ◽  
Completion Surgery ◽  
Squamous Cell Cervical Carcinoma

Two patients treated using chemoradiation therapy (CRT) (with fetus in utero) for advanced-stage squamous cell cervical carcinoma diagnosed during the first trimester of pregnancy are reported. One patient with a stage IVA disease diagnosed at 12 weeks of gestation was treated by exclusive CRT with the fetus in utero. She recurred 20 months after the end of the treatment. The second patient had a stage IIB disease diagnosed at 12 weeks of gestation and was treated by CRT with the fetus in utero followed by completion surgery (radical hysterectomy and para-aortic lymphadenectomy) due to the presence of a suspicious residual disease. No residual disease was observed during the histologic analysis of hysterectomy and nodes specimens. This patient is alive and free of disease 24 months after surgery. Our observations could suggest that CRT in pregnant patients with fetus in utero is feasible without major short-term toxicity. Such management could be proposed in patients with a bulky cervical cancer diagnosed during the first trimester of the pregnancy. Management of the uterine evacuation depends on the local tumor spread.

Correction of congenital hydrocephalus in utero I. The model: Intracisternal kaolin produces hydrocephalus in fetal lambs and rhesus monkeys

1983 ◽  
Vol 18 (4) ◽  
pp. 331-338 ◽  
Author(s):  
Don K. Nakayama ◽  
Michael R. Harrison ◽  
Mitchell S. Berger ◽  
Daryl H. Chinn ◽  
Meredith Halks-Miller ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
In Utero ◽  
Congenital Hydrocephalus

Lipoma of the quadrigeminal plate causing progressive obstructive hydrocephalus

1978 ◽  
Vol 49 (3) ◽  
pp. 453-456 ◽  
Author(s):  
G. Michael Halmagyi ◽  
William A. Evans
Keyword(s):  
Intellectual Development ◽  
Obstructive Hydrocephalus ◽  
Septum Pellucidum ◽  
Congenital Hydrocephalus ◽  
Poor Vision ◽  
Content Type ◽  
Intracranial Lipoma ◽  
Mental Deterioration ◽  
Quadrigeminal Plate ◽  
Severe Hydrocephalus

✓ A patient with congenital hydrocephalus and poor vision since early childhood, but with normal motor and intellectual development, suffered progressive mental deterioration during the last decade of life. At necropsy he was found to have severe hydrocephalus secondary to a lipoma of the midbrain tectum obstructing the aqueduct of Sylvius. In addition, the septum pellucidum was absent, the corpus callosum was thinned, and the anterior visual system was atrophic. The case emphasizes the importance of full neuroradiological investigation of congenital hydrocephalus. The possible association of intracranial lipoma with septo-optic dysplasia is discussed.

Catheter Directed Thrombolysis for Deep Vein Thrombosis during the First Trimester of Pregnancy: Two Case Reports

2008 ◽  
Vol 58 (2) ◽  
pp. 127
Author(s):  
Kum Rae Kim ◽  
Won Kyu Park ◽  
Jae Woon Kim ◽  
Woo Hyung Kwun ◽  
Bo Yang Suh ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Case Reports ◽  
First Trimester ◽  
Vein Thrombosis ◽  
Catheter Directed Thrombolysis ◽  
First Trimester Of Pregnancy ◽  
Deep Vein

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

Impact of TSH during the first trimester of pregnancy in obstetric and fetal complications: Usefulness of 2.5 mIU/l cut-off value

2018 ◽  
Author(s):  
Berta Soldevila ◽  
Marta Hernandez ◽  
Carolina Lopez ◽  
Laura Cacenarro ◽  
Maria Martinez-Barahona ◽  
...  
Keyword(s):  
First Trimester ◽  
Fetal Complications ◽  
First Trimester Of Pregnancy

Relationship between TSH values in the first trimester of pregnancy and obstetric and neonatal complications

2018 ◽  
Author(s):  
Beatriz Torres Moreno ◽  
Gabriela Castillo Carvajal ◽  
Lucrecia Vegara Fernandez ◽  
del Val Teresa Lopez ◽  
Victoria Alcazar Lazaro ◽  
...  
Keyword(s):  
First Trimester ◽  
Neonatal Complications ◽  
First Trimester Of Pregnancy
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