Metachronous ovarian dysgerminoma after a suprasellar germ-cell tumor treated by radiation therapy

1995 ◽  
Vol 83 (1) ◽  
pp. 149-153 ◽  
Author(s):  
Takao Watanabe ◽  
Yasuhide Makiyama ◽  
Hiroshi Nishimoto ◽  
Masatomo Matsumoto ◽  
Akira Kikuchi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Clinical Course ◽  
Initial Therapy ◽  
Cell Tumor ◽  
The Other ◽  
Content Type ◽  
Intracranial Germinoma ◽  
Ovarian Dysgerminoma ◽  
Fine Print

✓ A case of suprasellar germ-cell tumor in a 9-year-old girl who later developed ovarian dysgerminoma is reported. The clinical course of the case is described and a double-primary tumor, rather than metastasis from either tumor to the other, is suggested by the authors to explain the oncogenesis in this patient. The authors strongly encourage that patients with intracranial germinoma be examined for associated extraneural lesions before, as well as after, the completion of the initial therapy.

Intrasellar mixed germ-cell tumor

1983 ◽  
Vol 58 (5) ◽  
pp. 766-770 ◽  
Author(s):  
Robert B. Page ◽  
Paul V. Plourde ◽  
Douglas Coldwell ◽  
James I. Heald ◽  
Joel Weinstein
Keyword(s):  
Germ Cell ◽  
Pituitary Gland ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Content Type ◽  
Mixed Germ Cell Tumor ◽  
Fine Print

✓ The case of a 19-year-old male with a pluripotential teratoma arising in the pituitary gland is presented. The clinical, radiological, and pathological aspects of this case are discussed. This case demonstrates that intracranial germinal tumors can arise from the pituitary gland as well as from the infundibular and pineal regions.

Extraneural metastasis of choriocarcinomatous element in pineal germ-cell tumor

1985 ◽  
Vol 63 (3) ◽  
pp. 463-466 ◽  
Author(s):  
Kazunari Yoshida ◽  
Shigeo Toya ◽  
Mitsuhiro Ohtani ◽  
Shunichi Okui ◽  
Nobuo Takenaka ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Postmortem Examination ◽  
Cell Tumor ◽  
Combined Chemotherapy ◽  
Content Type ◽  
Pulmonary Tumor ◽  
Extraneural Metastasis ◽  
Fine Print

✓ A case of pineal germ-cell tumor producing human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) is reported in a 23-year-old man. Extraneural metastasis developed during a course of combined chemotherapy after radiation therapy. Postmortem examination revealed that the metastatic pulmonary tumor was a choriocarcinoma, producing only HCG.

Control of extraneural metastasis of a primary intracranial nongerminomatous germ-cell tumor

1989 ◽  
Vol 71 (4) ◽  
pp. 601-604 ◽  
Author(s):  
Jan Watterson ◽  
John R. Priest
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Whole Brain Radiotherapy ◽  
Pineal Region ◽  
Cell Tumor ◽  
High Dose ◽  
Content Type ◽  
Extraneural Metastasis ◽  
Fine Print

✓ Primary intracranial germ-cell tumors are infrequently occurring neoplasms which most often arise in the pineal or sellar regions. Germinomas are seen more frequently than nongerminomatous germ-cell tumors; they are often curable with radiotherapeutic approaches, or with chemotherapy in the rare instance of extraneural metastasis. Nongerminomatous germ-cell tumors are relatively radioresistant and when extraneural metastasis has occurred, they have been fatal in all of the 32 previously reported cases. The case of a 14-year-old girl with a mixed malignant germ-cell tumor arising in the pineal region is reported. Extraneural metastasis to the lung developed 12 months after whole-brain radiotherapy was completed. She was treated with etoposide (VP-16), high-dose cisplatin, vinblastine, and bleomycin and is currently without evidence of disease 46 months postmetastasis.

Suprasellar germinoma in association with Klinefelter's syndrome

1983 ◽  
Vol 58 (1) ◽  
pp. 136-138 ◽  
Author(s):  
Asamitsu Ahagon ◽  
Yasuaki Yoshida ◽  
Koji Kusuno ◽  
Toshiro Uno
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Klinefelter’S Syndrome ◽  
Klinefelter's Syndrome ◽  
Intracranial Germ Cell Tumor ◽  
Content Type ◽  
Suprasellar Germinoma ◽  
Chromosomal Karyotype ◽  
Fine Print

✓ A case is presented of suprasellar germinoma in a 20-year-old man with Klinefelter's syndrome. Hypogonadism is known to be a characteristic of Klinefelter's syndrome, and has often been described in cases of suprasellar germinoma. Thus, both pathological entities may mimic one another. It is emphasized that a chromosomal karyotype should be determined in every case of intracranial germ-cell tumor associated with hypogonadism.

Reversible hearing loss associated with a malignant pineal germ cell tumor

2003 ◽  
Vol 99 (3) ◽  
pp. 587-590 ◽  
Author(s):  
Nathalie Gaspar ◽  
Arnauld Verschuur ◽  
Ghislaine Mercier ◽  
Dominique Couanet ◽  
Christian Sainte-Rose ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Clinical Symptoms ◽  
Tumor Regression ◽  
Cell Tumor ◽  
Direct Compression ◽  
Pineal Tumors ◽  
Content Type ◽  
Adjacent Structures

✓ In patients with pineal tumors, clinical symptoms are due to direct compression of adjacent structures. The most common signs include increased intracranial pressure (80%) caused by obstruction of the sylvian aqueduct, and Parinaud syndrome (50%) caused by direct compression of the superior colliculi. Hearing loss is rare in patients with tumors in this location. The authors report on the case of a 12-year-old boy in whom a malignant pineal germ cell tumor was found together with the unusual occurrence of severe hearing loss due to direct bilateral compression of the inferior colliculi. This condition resolved completely after tumor regression.

Lymphocytic infiltrates in primary glioblastomas and recidivous gliomas

1978 ◽  
Vol 49 (6) ◽  
pp. 854-861 ◽  
Author(s):  
Lucio Palma ◽  
Nicola Di Lorenzo ◽  
Beniamino Guidetti
Keyword(s):  
Immune Response ◽  
Clinical Course ◽  
Lymphocytic Infiltration ◽  
The Other ◽  
Content Type ◽  
X Ray ◽  
Group A ◽  
Group B ◽  
Lymphocytic Infiltrates ◽  
Fine Print

✓ The correlation existing in several human malignancies between lymphocytic infiltration and prolonged survival prompted this study. Two hundred selected patients who were operated on for glioblastoma were reviewed to investigate the incidence of the lymphocytic infiltration in the histological slides and its possible relevance to a better clinical course. The group that exhibited a definite lymphocytic infiltration (Group A, 11.5%) had a significantly longer preoperative history and postoperative survival (p < 0.01) than the other two groups that presented slight or no infiltration (Group B, 23%, and Group C, 65%, respectively). In addition, biopsies of 28 recidivous gliomas were reviewed to study the fate of this lymphocytic infiltration in relation to time and therapy, such as irradiation and steroids which are known to depress the immune response. The authors found that severe lymphocytic infiltration is a rare immunobiological reaction which significantly improves the prognosis of a malignant brain tumor and seems not to be influenced by time, local x-ray therapy, or steroids.

scholarly journals GERM-01. CLINICAL COURSE OF INTRACRANIAL GERM CELL TUMOR IN ONE INSTITUTE IN DEVELOPING COUNTRY

2019 ◽  
Vol 21 (Supplement_2) ◽  
pp. ii86-ii86
Author(s):  
Patcharee Komvilaisak ◽  
Piyathida Wongmas ◽  
Amnat Kitkhundee ◽  
Nipaporn Tewattanarat ◽  
Narudom Supakalin
Keyword(s):  
Germ Cell ◽  
Developing Country ◽  
Germ Cell Tumor ◽  
Clinical Course ◽  
Cell Tumor ◽  
Intracranial Germ Cell Tumor

scholarly journals Extragonadal germ cell tumor, a report of two cases presenting in the gastrointestinal tract

Rare Tumors ◽  
2021 ◽  
Vol 13 ◽  
pp. 203636132110294
Author(s):  
Mousa Elkhaldi ◽  
Ahamd Moayad Naser ◽  
Yazan AlHalaseh ◽  
Maysa Al-Hussaini
Keyword(s):  
Gastrointestinal Tract ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Clinical Course ◽  
Germ Cell Tumors ◽  
Gastrointestinal Symptoms ◽  
Young Male ◽  
Cell Tumor ◽  
Male Patients ◽  
High Index Of Suspicion

Germ cell tumors are a heterogeneous group of tumors that can present primarily as gonadal tumors in either a localized or metastatic pattern. Rarely these tumors can initially present at extra-gonadal locations, including the gastrointestinal tract. We report two young male patients who presented with nonspecific gastrointestinal symptoms caused by a mass lesion involving the duodenum. Pathologically, both were confirmed to be germ cell tumors; an unfamiliar initial presentation of germ cell tumors. In both cases, evidence of pre-existing gonadal tumor in the form of a testicular mass and a burned-out tumor with microlithiasis, in the first and second cases, respectively was detected following the confirmed diagnosis of extra-gonadal germ cell tumor. Each patient’s clinical course and outcome emphasizes the importance of a high index of suspicion, timely diagnosis, and appropriate management.

Update on Late Relapse of Germ Cell Tumor: A Clinical and Molecular Analysis

2003 ◽  
Vol 21 (1) ◽  
pp. 113-122 ◽  
Author(s):  
David W. George ◽  
Richard S. Foster ◽  
Robert A. Hromas ◽  
Kent A. Robertson ◽  
Gail H. Vance ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Initial Therapy ◽  
Cell Tumor ◽  
Late Relapse ◽  
Indiana University ◽  
Cytogenetic Analyses ◽  
Disease Free ◽  
Median Interval

Purpose: Analysis of patients with late relapse (LR) of germ cell tumor (GCT) with reports on clinical characteristics, outcomes, and molecular and cytogenetic features. Patients and Methods: Eighty-three patients evaluated at Indiana University from 1993 through 2000 for relapse of GCT more than 2 years from initial therapy were reviewed. Available specimens were investigated for expression of the transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of chromosome 12 abnormalities. Results: Median interval from initial presentation to LR was 85 months. Forty-three of 49 LR patients who underwent surgery were rendered disease free (NED), and 20 (46.5%) remain continuously NED. Thirty-two patients received chemotherapy, but only six (18.8%) obtained a complete remission. Five of these patients remain continuously NED after chemotherapy alone, including three who were chemotherapy naïve. Eighteen of these 32 patients were successfully rendered NED by postchemotherapy surgery, and 12 remain continuously NED. Two patients continue on observation with no treatment for their LR. Overall, 69 of the 81 treated patients (85.2%) ultimately achieved an NED state, and 38 (46.9%) remain continuously NED with median follow-up from LR therapy of 24.5 months (range, 1 to 83 months), whereas nine other patients are currently NED after therapy for subsequent relapses. Because of the small numbers of specimens tested, we were unable to draw any definitive conclusions from the molecular and cytogenetic analyses. Conclusion: GCT patients require lifetime follow-up. At the time of LR, surgical resection alone remains our preferred therapy.

Mixed germ-cell tumor of the pineal region

1987 ◽  
Vol 66 (2) ◽  
pp. 300-304 ◽  
Author(s):  
Stephen L. Graziano ◽  
Frank P. Paolozzi ◽  
Alfred R. Rudolph ◽  
William A. Stewart ◽  
Ahmad Elbadawi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Serum Levels ◽  
Pineal Region ◽  
Cell Tumor ◽  
Subtotal Resection ◽  
Content Type ◽  
Mixed Germ Cell Tumor ◽  
Nongerminomatous Germ Cell Tumor ◽  
Modality Approach

✓ The case is presented of a 15-year-old boy with a mixed nongerminomatous germ-cell tumor of the pineal region associated with elevated cerebrospinal fluid and serum levels of the beta subunit of human chorionic gonadotropin. Treatment consisted of initial subtotal resection followed by radiotherapy and systemic chemotherapy with cisplatin, vinblastine, and bleomycin. The patient is alive without evidence of tumor 37 months after his initial diagnosis. A literature review of intracranial embryonal carcinoma and choriocarcinoma provided the rationale for a combined-modality approach to this otherwise lethal neoplasm.

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