One-step Synthesis of β-lactams Using Cyanuric Fluoride

2013 ◽  
Vol 37 (1) ◽  
pp. 25-27 ◽  
Author(s):  
Maaroof Zarei
Keyword(s):  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
One Step ◽  
Acetic Acids

Cyanuric fluoride works as an efficient acid activator reagent for the direct [2+2] ketene–imine cycloaddition of substituted acetic acids and imines in a one-pot synthesis under mild conditions. The yields are good to excellent and the reaction conditions are mild, simple and efficient.

One-step chemoselective conversion of tetrahydropyranyl ethers to silyl-protected alcohols

RSC Advances ◽  
2014 ◽  
Vol 4 (28) ◽  
pp. 14475-14479 ◽  
Author(s):  
Julián Bergueiro ◽  
Javier Montenegro ◽  
Carlos Saá ◽  
Susana López
Keyword(s):  
Single Step ◽  
Protecting Groups ◽  
Reaction Conditions ◽  
One Pot ◽  
Silyl Ethers ◽  
Triple Bonds ◽  
Mild Conditions ◽  
Silyl Groups ◽  
One Step ◽  
Optimal Reaction

A novel chemoselective one-pot transformation of acetals to silyl ethers is reported. Free hydroxyls, double bonds and triple bonds are unaffected in optimal reaction conditions. This practical, inexpensive protocol allows the selective replacement of acetal-forming protecting groups with silyl groups in a single step under mild conditions.

Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2675-2679 ◽  
Author(s):  
Chenghui Sun ◽  
Honggang Liang ◽  
Lingxiang Bao ◽  
Yao Du ◽  
Yiying Zhang ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Cyanogen Bromide ◽  
New Method ◽  
Nucleophilic Substitution Reaction ◽  
Tertiary Amines ◽  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
One Step

Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan­amides through an N-deallylation reaction and an N-cyanation reaction in one pot.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds

2020 ◽  
Vol 56 (55) ◽  
pp. 7665-7668 ◽  
Author(s):  
Lu Liu ◽  
Lei Li ◽  
Shukuan Mao ◽  
Xin Wang ◽  
Ming-Dong Zhou ◽  
...  
Keyword(s):  
Diazo Compounds ◽  
Domino Reaction ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Quinazoline Derivatives

Various o-alkenyl aromatic isocyanides were prepared from readily available reactants for their double annulation with diazo compounds for a one-pot synthesis of pyrazolo[1,5-c]quinazolines under mild reaction conditions.

scholarly journals One-Pot Synthesis of Novel Multisubstituted 1-Alkoxyindoles

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1466
Author(s):  
Ye Eun Kim ◽  
Hyunsung Cho ◽  
Yoo Jin Lim ◽  
Chorong Kim ◽  
Sang Hyup Lee
Keyword(s):  
Alkyl Halide ◽  
The Novel ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Consecutive Reactions ◽  
Intramolecular Condensation ◽  
Synthetic Sequence ◽  
Novel Target

Studies on a one-pot synthesis of novel multisubstituted 1-alkoxyindoles 1 and their mechanistic investigations are presented. The synthesis of 1 was successfully achieved through consecutive four step reactions from substrates 2. The substrates 2, prepared through a two-step synthetic sequence, underwent three consecutive reactions of nitro reduction, intramolecular condensation, and nucleophilic 1,5-addition to provide the intermediates, 1-hydroxyindoles 8, which then were alkylated in situ with alkyl halide to afford the novel target products 1. We optimized the reaction conditions for 1 focusing on the alkylation step, along with the consideration of formation of intermediates 8. The optimized condition was SnCl2·2H2O (3.3 eq) and alcohols (R1OH, 2.0 eq) for 1–2 h at 40 °C and then, base (10 eq) and alkyl halides (R2Y, 2.0 eq) for 1–4 h at 25–50 °C. Notably, all four step reactions were performed in one-pot to give 1 in good to modest yields. Furthermore, the mechanistic aspects were also discussed regarding the reaction pathways and the formation of side products. The significance lies in development of efficient one-pot reactions and in generation of new 1-alkoxyindoles.

scholarly journals One-pot synthesis of polysubstituted indoles from aliphatic nitro compounds under mild conditions

2007 ◽  
Vol 48 (10) ◽  
pp. 1809-1811 ◽  
Author(s):  
Christopher A. Simoneau ◽  
Alexis M. Strohl ◽  
Bruce Ganem
Keyword(s):  
Nitro Compounds ◽  
One Pot ◽  
Aliphatic Nitro Compounds ◽  
Mild Conditions ◽  
One Pot Synthesis

scholarly journals Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides

2016 ◽  
Vol 12 ◽  
pp. 1772-1777 ◽  
Author(s):  
Lena Huck ◽  
Juan F González ◽  
Elena de la Cuesta ◽  
J Carlos Menéndez
Keyword(s):  
Single Step ◽  
Side Chain ◽  
One Pot ◽  
Aziridine Ring ◽  
Component Process ◽  
Mild Conditions ◽  
One Step

A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of an aziridine ring. This method allows the preparation of N-unprotected, trisubstituted aziridines bearing a peptide side chain under mild conditions. Their transformation into β-trifluoroacetamido-α-ketoamide and α,β-diketoamide frameworks was also achieved in a single step.

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