The effects of pentoxifylline (Trental) on circulating platelet aggregates and platelet aggregation patterns in patients with chronic obstructive arteriosclerotic disease1

2016 ◽  
Vol 10 (2) ◽  
pp. 225-230
Author(s):  
Julian L. Ambrus ◽  
Joseph M. Anain ◽  
Shirley M. Anain ◽  
Paul M. Anain ◽  
Joseph M. Anain ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Chronic Obstructive ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates

Prevention of Platelet Hyperaggregation during Coronary Angiography

1986 ◽  
Vol 14 (4) ◽  
pp. 185-187
Author(s):  
V Ammaturo ◽  
C Perricone ◽  
B Zuccarelli ◽  
N Mininni ◽  
L Colussi ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Ventricular Fibrillation ◽  
Coronary Angiography ◽  
Cardiovascular Disorders ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates ◽  
Platelet Hyperaggregation

The authors previously reported an increase in platelet aggregation in the days after coronary angiography, accompanied at times by worrying cardiovascular disorders (ventricular fibrillation in one case, death in two others). In the present study, ten patients received a platelet antiaggregating drug (ticlopidin) 5 days before their coronary angiography. No significant changes were detected in the test for circulating platelet aggregates (CPA test) in these patients.

scholarly journals Circulating Platelet Aggregates During Emotional Stress and Cigarette Smoking

1977 ◽  
Author(s):  
G.F. Gensini ◽  
R. Abbate ◽  
D. Prisco ◽  
G.G. Neri Serneri
Keyword(s):  
Platelet Aggregation ◽  
Medical Students ◽  
Cigarette Smoking ◽  
Cigarette Smoke ◽  
Emotional Stress ◽  
Predictive Value ◽  
Normal Values ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates ◽  
Clinically Significant

Increased platelet aggregation has been observed in various hypercoagulable states, but its predictive value for thrombosis is so far uncertain. We studied the effect of emotional stress and of cigarette smoking on circulating platelets by platelet aggregates ratio (PAR) according to Wu and Hoak (1974.) in medical students aged 20-22 years. The emotional stress was undergoing a University examination.PAR was measured immediately before the examination, at the end and 15 and 30 min after the examination.PAR was significantly lowered in all the subjects at the end (P<0.0l) and after 15 min (P<0.0l) but returned toward normal values after 30 min. The decrease of PAR suggests the production of reversible circulating platelet aggregates. The effect of smo=king a cigarette has been investigated in 8 students. PAR has been determined before smoking, at the end and after 2,5 and 10 min. Smoking lasted 4 min. In 5 subjects we observed a decrease of PAR at 2 min (P< 0. 01), whereas at 5 and 10 min PAR value became normal. Lettuce cigarette smoke did not affect PAR value. Our results indicate that: 1) – Platelet aggregates are very easily produced in circulating blood; 2)- A low value of PAR does not necessarily indicate a platelet hy=peraggregability clinically significant.

Effect of Indobufen (K 3920) A New Antiplatelet Agent After Oral Administration in Patients with Vascular Diseases

1979 ◽  
Author(s):  
S. Coccheri ◽  
G.C. Fortunato
Keyword(s):  
Platelet Aggregation ◽  
Antiplatelet Agent ◽  
Vascular Diseases ◽  
Maximal Amplitude ◽  
Marked Inhibition ◽  
Lysis Time ◽  
Euglobulin Lysis Time ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates ◽  
Induced Aggregation

The antiaggregating effect of a new butyric acid derivative, indobufen (K 3920), was investigated in 30 patients with vascular diseases. A between-patient study was performed by administering 50 mg b.i.d. or 100 mg b.i.d. for 14 days to 2 groups of patients. A series of platelet function and clotting parameters were recorded at the end of the treatment period, both 2 and 24 h after the last administration.A marked inhibition of platelet aggregation was observed in both groups, as shown from the significant changes in maximal amplitude, reaction time and slope of ADP- and collagen-induced aggregation wave.Similar results were observed at the Breddin test in both groups of patients and at all experimental times.Platelet adhesiveness was also reduced and circulating platelet aggregates were normalized in all patients who had abnormal basal values.A shortening of euglobulin lysis time was observed 2 h but not 24 h after administration of both doses.Tolerability was excellent.Indobufen appears to be a promising drug for treatment of vascular diseases where platelet aggregation is involved.

Platelet Function Parameters In Diabetic Patients

1981 ◽  
Author(s):  
A I Woods ◽  
S S Meschengieser ◽  
N M Sutton ◽  
M A Lazzari
Keyword(s):  
Platelet Aggregation ◽  
Platelet Function ◽  
Diabetic Patients ◽  
Circulating Platelet Aggregates ◽  
Diabetic Population ◽  
Platelet Aggregates ◽  
Spontaneous Platelet Aggregation ◽  
Age Range ◽  
Induced Aggregation ◽  
Ristocetin Cofactor

Abnormalities in platelet function tests have already been described in diabetic patients reflecting platelet hyperreactivity. An attempt to determine which of the tests seemed to be more affected in the diabetic population was done in a group of 34 diabetic patients (20 men and 14 women, age range 15-76). The tests performed included assay of Ristocetin Cofactor (McFarlane et al.) circulating platelet aggregates (CPA) (Wu-Hoak) and platelet aggregation induced by ADP in low concentration (0.6 x 10-6M) and Bovine Factor VIII (0.001 U/ml). In matched controls only 3.5% had a positive aggregation induced by Bovine F VIII and with ADP (0.6 x 10-6M% ) the extent of maximum aggregation was 30%.In 15 of the 34 patients (44%) aggregation induced by ADP in high dilution was greater than 50% and this was the test more frequently affected. The level of Ristocetin Cofactor was increased (>160%) in 12 of 34 patients (35%) and aggregation induced by BF VIII was positive also in 12 patients (35%). The detection of CPA was positive in 9 patients (26%). Two patients had spontaneous platelet aggregation and in them all the other tests performed were also positive. Three patients had 3 of the tests altered, and 11 patients only had 2 affected tests.The assay more affected was the ADP induced aggregation followed by the Ristocetin Cofactor levels and BF VIII induced aggregation. The test less affected was the CPA. A correlation with clinical data will be mentioned.

Prevention of in vivo Platelet Aggregation by Indobufen in Angina Patients during Exercise

1981 ◽  
Vol 9 (2) ◽  
pp. 113-119 ◽  
Author(s):  
E M Pogliani ◽  
R Fantasia ◽  
C Perini ◽  
G Corvi
Keyword(s):  
Platelet Aggregation ◽  
Bicycle Ergometer ◽  
Crossover Design ◽  
Double Blind ◽  
Before And After ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates ◽  
Induced Aggregation ◽  
Platelet Functions

Platelet aggregation induced by 3 concentrations of ADP and collagen was assessed in thirty patients with stable angina, before and after exercise with a bicycle ergometer. The patients received a single oral 200 mg dose of indobufen and placebo according to a crossover design in double-blind conditions. Platelet sensitivity to both aggregating agents increased when exercise was carried out after placebo, whereas indobufen markedly inhibited ADP- and collagen-induced aggregation. Circulating platelet aggregates increased in some patients during exercise after placebo but not after indobufen. These results suggest that effort may be an important factor in activation of platelet functions and that the use of drugs blocking the arachidonate pathway and the release reaction may be appropriate in patients with angina.

Platelet Function in Childhood Migraine

Cephalalgia ◽  
1985 ◽  
Vol 5 (2_suppl) ◽  
pp. 99-101 ◽  
Author(s):  
Pietro Carrieri ◽  
Fulvio Sorge ◽  
Giuseppe Orefice ◽  
Salvatore De Feo
Keyword(s):  
Platelet Aggregation ◽  
Platelet Function ◽  
Plasma Levels ◽  
Childhood Migraine ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates

Platelet function in vitro and in vivo (ADP-induced platelet aggregation, circulating platelet aggregates, β-thromboglobulin plasma levels) has been studied in children with common migraine, in headache-free intervals. Migraine patients demonstrated increased circulating platelet aggregates when compared with controls. Moreover, two of ten patients had pathological β-thromboglobulin levels. These data indicate that in some children with migraine there is an abnormality of platelet function during headache-free periods.

Hypersensitivity of Platelets to Arachidonate /AA/ in Acute Myocardial infarction /MI/

1979 ◽  
Author(s):  
A. Szczeklik ◽  
W. Łukasiewicz ◽  
M. Serwonska ◽  
J. Musiaŀ
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Aggregation ◽  
Platelet Function ◽  
Initial Velocity ◽  
Acute Mi ◽  
Circulating Platelet Aggregates ◽  
Irreversible Aggregation ◽  
Platelet Aggregates

We studied for 17 consecutive days platelet aggregation induced by AA and compared it with that induced by ADP in 20 patients with acute MI. Within 3-7 days following MI platelets required less AA to aggregate irreversibly in vitro. They also aggregated to greater extent 3 min after addition of 2 μM ADP, although the initial velocity /Vmax/ following ADP was not increased. Threshold AA concentrations causing irreversible aggregation correlated with the extent of aggregation induced by ADP, but not with ADP-Vmax. No uniform pattern of behaviour of circulating platelet aggregates was noted. These results suggest that platelet hypersensitivity in MI might be due to the activation of AA mechanisms. Use of anti-platelet drugs in MI might prevent these changes in platelet function limiting in this way the extension of MI.

Effect of Indobufen on Platelet Functions in Angina Patitents at Rest and During Exercise

1979 ◽  
Author(s):  
E. Pogliani ◽  
R. Fantasia ◽  
E. Polli
Keyword(s):  
Platelet Aggregation ◽  
Stable Angina ◽  
Serotonin Release ◽  
Double Blind ◽  
Before And After ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates ◽  
Induced Aggregation ◽  
Platelet Functions ◽  
Stimulation Of

Platelet aggregation induced by 3 concentrations of ADP and collagen was assessed in 30 patients with stable angina before and after exercise with bicyle ergometer. The patients received a single Oral 200 mg dose of indobufen and placebo according to a cross-over design in double-blind conditions. An increase in platelet sensitivity to both aggregating agents occurred when exercise was carried out after placebo, whereas indobufen markedly inhibited ADP- and collagen-induced aggregation. Circulating platelet aggregates increased in some patients during exercise after placebo but not after indobufen. In 20 patients 14C-serotonin release induced by collagen in PRP was investigated. The release was increased when placebo was administered before exercise but it was inhibited when indobufen was given before exercise. In the same patients MDA levels after thrombin-induced stimulation of platelets in PRP increased during exercise after placebo but decreased during exercise after indobufen. These results suggest that effort may be an important factor in activation of platelet functions and that the use of drugs blocking the arachidonate pathway and the release reaction may be appropriate in patients with angina.

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