TMA-93 Validation by Alzheimer’s Disease Biomarkers: A Comparison with the Free and Cued Selective Reminding Test on a Biobank Sample

2021 ◽  
pp. 1-9
Author(s):  
Silvia Rodrigo-Herrero ◽  
Andrea Luque-Tirado ◽  
Carlota Méndez-Barrio ◽  
David García-Solís ◽  
María Bernal Sénchez-Arjona ◽  
...  
Keyword(s):  
Roc Curves ◽  
Stepwise Logistic Regression ◽  
Diagnostic Utility ◽  
Amyloid Pet ◽  
Spanish Validation ◽  
Selective Reminding ◽  
Diagnostic Characteristics ◽  
Stepwise Logistic Regression Model ◽  
Forward Stepwise ◽  
Selective Reminding Test

Background: The Memory Associative Test TMA-93 examines visual relational binding, characteristically affected in early-AD stages. Objective: We aim to validate the TMA-93 by biomarkers determination and compare its diagnostic characteristics with the Free and Cued Selective Reminding Test (FCSRT). Methods: Retrospective analysis of a Biobank database. Patients’ records initially consulted for memory complaints, scored MMSE≥22, had TMA-93 and FCSRT tested, and AD biomarker determination (Amyloid-PET or CSF), either positive or negative, were selected. As cutoffs, we considered the 10-percentile for TMA-93 (P10/TMA-93), and “total free recall” (TFR) 21/22, total recall (TR) 43/44, and Cued Index <  0.77 for FCSRT from previous Spanish validation and normative studies. Diagnostic utilities were calculated using ROC curves and compared by the DeLong method. We studied if one test improved the other test’s prediction, following a forward stepwise logistic regression model. Results: We selected 105 records: 64 “positive” and 41 “negative” biomarkers. TMA-93 total score diagnostic utility (AUC = 0.72; 95%CI:0.62–0.82) was higher than those of the FCSRT: TFR (AUC = 0.70; 95%CI: 0.60–0.80), TR (AUC = 0.63; 95%CI:0.53–0.74), and Cued Index (AUC = 0.62; 95%CI:0.52–0.73). The P10/TMA-93 cutoff showed 86%sensitivity, similar to that of the most sensitive FCSRT cutoff (TFR21/22, 89%) and 29%specificity, lower than that of the most specific FCSRT cutoff (Cued Index <  0.77, 57%). 32.8%of the positive-biomarker group scored above CI/0.77 but below p10TMA-93. The addition of TMA-93 total score to FCSRT variables improved significantly the biomarkers results’ prediction. Conclusion: TMA-93 demonstrated “reasonable” diagnostic utility, similar to FCSRT, for discriminating AD biomarker groups. TMA-93 total score improved the AD biomarker result prediction when added to FCSRT variables.

Comparison of Neuropsychological Assessment by Videoconference and Face to Face

2021 ◽  
pp. 1-11
Author(s):  
Richard Gnassounou ◽  
Bénédicte Defontaines ◽  
Séverine Denolle ◽  
Stéphanie Brun ◽  
Raphaël Germain ◽  
...  
Keyword(s):  
Neuropsychological Assessment ◽  
Digit Span ◽  
Cognitive Disorders ◽  
Face To Face ◽  
Complex Figure ◽  
Selective Reminding ◽  
Trail Making ◽  
Neuropsychological Assessments ◽  
Figure Test ◽  
Selective Reminding Test

Abstract Objective: To compare the administration of neuropsychological tests by teleneuropsychology (TeleNP) and face to face (F-F) in order to determine the feasibility and reliability of TeleNP. Method: At the inclusion visit, all participants underwent a traditional F-F neuropsychological assessment as part of their standard care. Four months after inclusion, they were randomized to undergo an additional neuropsychological assessment either by F-F administration or by TeleNP. Results: A total of 150 adults with cognitive complaints, but with no major cognitive or sensorial impairment were included. At 4 months, 69 participants were randomized in the F-F arm and 71 in TeleNP arm (10 lost in the follow-up). The overall satisfaction was high: 87.1% in the TeleNP arm were “very satisfied”, and 82.9% indicated no preference between F-F and TeleNP. In agreement with previous data from the literature, neuropsychological assessments gave similar results across both administration conditions for a large majority of tests [Mini-Mental State Examination (MMSE), Free and Cued Selective Reminding Test (FCSRT) French version, Mahieux gestural praxis battery, Frontal Assessment Battery (FAB), time of completion of the Trail making Test (TMT) A and B, number of errors of the TMT B, Rey complex figure test, categorical et phonological verbal fluency tests] and minor differences for others [80-picture naming test (DO-80), FAB, Digit Span forward and backward and number of errors in the TMT A]. Conclusions: TeleNP is a promising method to be able to test patients as an alternative to F-F condition. Before this procedure can be generalized, it is now necessary to standardize the adaptation of certain tests and to test them in populations with more significant cognitive disorders.

scholarly journals Texture-Based Analysis of 18F-Labeled Amyloid PET Brain Images

2021 ◽  
Vol 11 (5) ◽  
pp. 1991
Author(s):  
Alexander P. Seiffert ◽  
Adolfo Gómez-Grande ◽  
Eva Milara ◽  
Sara Llamas-Velasco ◽  
Alberto Villarejo-Galende ◽  
...  
Keyword(s):  
Area Under The Curve ◽  
Standardized Uptake Value ◽  
Texture Features ◽  
Roc Curves ◽  
Significant Feature ◽  
Study Cohort ◽  
Amyloid Pet ◽  
Reference Region ◽  
Brain Images ◽  
Positron Emission

Amyloid positron emission tomography (PET) brain imaging with radiotracers like [18F]florbetapir (FBP) or [18F]flutemetamol (FMM) is frequently used for the diagnosis of Alzheimer’s disease. Quantitative analysis is usually performed with standardized uptake value ratios (SUVR), which are calculated by normalizing to a reference region. However, the reference region could present high variability in longitudinal studies. Texture features based on the grey-level co-occurrence matrix, also called Haralick features (HF), are evaluated in this study to discriminate between amyloid-positive and negative cases. A retrospective study cohort of 66 patients with amyloid PET images (30 [18F]FBP and 36 [18F]FMM) was selected and SUVRs and 6 HFs were extracted from 13 cortical volumes of interest. Mann–Whitney U-tests were performed to analyze differences of the features between amyloid positive and negative cases. Receiver operating characteristic (ROC) curves were computed and their area under the curve (AUC) was calculated to study the discriminatory capability of the features. SUVR proved to be the most significant feature among all tests with AUCs between 0.692 and 0.989. All HFs except correlation also showed good performance. AUCs of up to 0.949 were obtained with the HFs. These results suggest the potential use of texture features for the classification of amyloid PET images.

scholarly journals Association of Crossword Puzzle Participation with Memory Decline in Persons Who Develop Dementia

2011 ◽  
Vol 17 (6) ◽  
pp. 1006-1013 ◽  
Author(s):  
Jagan A. Pillai ◽  
Charles B. Hall ◽  
Dennis W. Dickson ◽  
Herman Buschke ◽  
Richard B. Lipton ◽  
...  
Keyword(s):  
Leisure Activities ◽  
Cognitive Assessments ◽  
Crossword Puzzle ◽  
Memory Decline ◽  
Delayed Onset ◽  
Selective Reminding ◽  
Aging Study ◽  
Wide Availability ◽  
Selective Reminding Test ◽  
Crossword Puzzles

AbstractParticipation in cognitively stimulating leisure activities such as crossword puzzles may delay onset of the memory decline in the preclinical stages of dementia, possibly via its effect on improving cognitive reserve. We followed 488 initially cognitively intact community residing individuals with clinical and cognitive assessments every 12–18 months in the Bronx Aging Study. We assessed the influence of crossword puzzle participation on the onset of accelerated memory decline as measured by the Buschke Selective Reminding Test in 101 individuals who developed incident dementia using a change point model. Crossword puzzle participation at baseline delayed onset of accelerated memory decline by 2.54 years. Inclusion of education or participation in other cognitively stimulating activities did not significantly add to the fit of the model beyond the effect of puzzles. Our findings show that late life crossword puzzle participation, independent of education, was associated with delayed onset of memory decline in persons who developed dementia. Given the wide availability and accessibility of crossword puzzles, their role in preventing cognitive decline should be validated in future clinical trials. (JINS, 2011, 17, 1006–1013)

Diagnostic Validity of the Smart Aging Serious Game: An Innovative Tool for Digital Phenotyping of Mild Neurocognitive Disorder

2021 ◽  
pp. 1-13
Author(s):  
Sara Isernia ◽  
Monia Cabinio ◽  
Sonia Di Tella ◽  
Stefania Pazzi ◽  
Federica Vannetti ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Digital Health ◽  
Roc Curves ◽  
Vascular Cognitive Impairment ◽  
Serious Game ◽  
Diagnostic Validity ◽  
Early Assessment ◽  
Digital Phenotyping ◽  
Diagnostic Sensitivity And Specificity ◽  
Selective Reminding Test

Background: The Smart Aging Serious Game (SASG) is an ecologically-based digital platform used in mild neurocognitive disorders. Considering the higher risk of developing dementia for mild cognitive impairment (MCI) and vascular cognitive impairment (VCI), their digital phenotyping is crucial. A new understanding of MCI and VCI aided by digital phenotyping with SASG will challenge current differential diagnosis and open the perspective of tailoring more personalized interventions. Objective: To confirm the validity of SASG in detecting MCI from healthy controls (HC) and to evaluate its diagnostic validity in differentiating between VCI and HC. Methods: 161 subjects (74 HC: 37 males, 75.47±2.66 mean age; 60 MCI: 26 males, 74.20±5.02; 27 VCI: 13 males, 74.22±3.43) underwent a SASG session and a neuropsychological assessment (Montreal Cognitive Assessment (MoCA), Free and Cued Selective Reminding Test, Trail Making Test). A multi-modal statistical approach was used: receiver operating characteristic (ROC) curves comparison, random forest (RF), and logistic regression (LR) analysis. Results: SASG well captures the specific cognitive profiles of MCI and VCI, in line with the standard neuropsychological measures. ROC analyses revealed high diagnostic sensitivity and specificity of SASG and MoCA (AUCs >  0.800) in detecting VCI versus HC and MCI versus HC conditions. A classification accuracy acceptable-to-excellent was found for MCI and VCI (HC versus VCI; RF: 90%, LR: 91%. HC versus MCI; RF: 75%; LR: 87%). Conclusion: SASG allows the early assessment of cognitive impairment through ecological tasks and potentially in a self-administered way. These features make this platform suitable for being considered a useful digital phenotyping tool, allowing a non-invasive and valid neuropsychological evaluation, with evident implications for future digital-health trails and rehabilitation.

Selective Reminding Test

2018 ◽  
pp. 3112-3114
Author(s):  
Kate D. Randall ◽  
Kimberly A. Kerns
Keyword(s):  
Selective Reminding ◽  
Selective Reminding Test

A hybrid customer prediction system based on multiple forward stepwise logistic regression mode

2012 ◽  
Vol 16 (2) ◽  
pp. 265-278 ◽  
Author(s):  
AliReza Soroush ◽  
Ardeshir Bahreininejad ◽  
Jan van den Berg
Keyword(s):  
Logistic Regression ◽  
Stepwise Logistic Regression ◽  
Prediction System ◽  
Forward Stepwise

Demographic Factors Influencing the Initiation of Breast-Feeding in an Israeli Urban Population

PEDIATRICS ◽  
1989 ◽  
Vol 83 (4) ◽  
pp. 519-523
Author(s):  
Emanuel Birenbaum ◽  
Camil Fuchs ◽  
Brian Reichman
Keyword(s):  
Breast Feeding ◽  
Religious Belief ◽  
High Educational Level ◽  
Stepwise Logistic Regression ◽  
Prenatal Factors ◽  
Factors Influencing ◽  
Israeli Population ◽  
Breast Feed ◽  
Stepwise Logistic Regression Model ◽  
High Educational

The influence of demographic and prenatal factors on the initiation of breast-feeding in an urban Israeli population was evaluated by interviewing 1,000 parturients prior to discharge from the hospital. The mothers were all Jewish, none were single, and none were social welfare dependents. Of these mothers, 72% were breast-feeding, 6% stated an intent to breast-feed, and 22% were formula-feeding their infants. A significantly increased rate of breast-feeding was found among mothers with the following characteristics: those of orthodox religious belief, high educational level, in the academic and paraacademic professions, nonsmokers, those who worked outside of the home during the pregnancy, those who had previous breast-feeding success, and mothers whose husbands' attitude toward breast-feeding was positive. The decision to breast-feed was made prior to delivery in 85% of mothers. Participation of the mother and/or father in antenatal preparation courses did not significantly influence the initiation of breast-feeding. Multivariant analysis with a stepwise logistic regression model delineated the four factors most significantly associated with the initiation of breast-feeding: positive spousal attitude toward breast-feeding, orthodox religious belief, nonsmoking, and work outside of the home during the pregnancy. The expected probability for initiating breast-feeding was computed for the various combinations of these four categories and ranged from .94 with all factors present to .33 in the absence of these characteristics.

One-Week Free and Cued Selective Reminding Test–-Word Version

2018 ◽  
Author(s):  
Romina Manoli ◽  
Laurence Chartaux-Danjou ◽  
Halima Mecheri ◽  
Hélène Delecroix ◽  
Marion Noulhiane ◽  
...  
Keyword(s):  
Test Word ◽  
Selective Reminding ◽  
Selective Reminding Test
Sign in / Sign up

Export Citation Format

Share Document