Effect of cerebrolysin on neurodevelopmental outcome of high risk preterm infants: A randomized controlled trial

2021 ◽  
pp. 1-9
Author(s):  
A. Samir ◽  
N. Nasef ◽  
K. Fathy ◽  
A-H. El-Gilany ◽  
S. Yahia
Keyword(s):  
High Risk ◽  
Preterm Infants ◽  
Motor Development ◽  
Intervention Program ◽  
Controlled Trial ◽  
Intervention Group ◽  
Fine Motor ◽  
Early Intervention Program ◽  
Gross Motor ◽  
Gross Motor Development

BACKGROUND: A significant proportion of preterm infants experience developmental delay despite receiving a post discharge early interventional care. Cerebrolysin is a peptide mixture which acts similar to endogenous neurotrophic factors through promoting neurogenesis and enhancing neuronal plasticity. OBJECTIVE: To compare the effect of Cerebrolysin plus routine intervention program versus routine intervention program alone on the outcome of preterm infants at high risk for neurodevelopmental delay. METHODS: In a randomized controlled trial, high-risk preterm infants <  32 weeks’ gestation who have abnormal neurological assessment at two months corrected post-natal age were randomized at 6 months corrected post natal age to receive either early intervention program or early intervention program plus Cerebrolysin injection of 0.1 mL/kg body weight every week for 3 months as an adjuvant therapy. The primary outcome was the rate of failure of the gross motor assessment at 12 months of corrected age and secondary outcomes included fine motor, language, and personal social development at 12 months corrected post-natal age as assessed by Denver Developmental Screening Test II. RESULTS: Cerebrolysin group had a significant lower number of infants diagnosed with failed gross motor development compared to infants in the routine intervention group [10 (33%) versus 21 (70%), p = 0.009]. Cerebrolysin group had a significant lower number of infants diagnosed with failed fine motor, language and personal social development compared to infants in the routine intervention group. CONCLUSION: Cerebrolysin, as an adjuvant therapy to routine early interventional care, may improve gross motor development of high-risk preterm infants at 12 months corrected post-natal age.

scholarly journals A Case Study on Management of Rett Syndrome by Wholistic approach

2020 ◽  
Vol 11 (2) ◽  
pp. 351-357
Author(s):  
Renu Rathi ◽  
Bharat Rathi ◽  
Rakesh Khatana ◽  
Suraj Sankh
Keyword(s):  
Case Report ◽  
Rett Syndrome ◽  
Motor Development ◽  
Autism Spectrum ◽  
Severe Form ◽  
Fine Motor ◽  
Gross Motor ◽  
Gross Motor Development

Background: Rett syndrome-RS comes under Autism spectrum disorder-ASD which is a neurodevelopmental syndrome. It is diagnosed by the main differentiating features of lack of interpersonal and communication skills, poor eye contact, delayed speech with pervasive abnormal body movements. Aim and Objectives: This case report is aimed at dissemination of comprehensive role of Ayurveda in management of ASD, Rett syndrome. Material and Methods: RS is the severe form of ASD. This case study of 2.3 year’s girl presented with RS and global delay, being treated with wholistic approach. It comprises Ayurveda chikitsa and other therapies like Yoga, hydrotherapy, occupational, music, physiotherapy and many more. Observation and Result: Patient has shown promising results in all developmental milestones such as gross motor, fine motor and personal social in 6 months duration except language. Different varieties of massage therapy, diet and Basti, Nasya (Panchkarma) procedures, Omkar mantra chanting, passive Yogasana were done. Conclusion: In this case report, mainly Ayurveda interventions were implemented with wholistic approach as an adjuvant, received good result in gross motor development which is very difficult in RS, hence it is a unique case. It also opened the door of wholistic approach with the hope to deliver the good result in similar disorders.

scholarly journals Multiple Micronutrient Supplementation Using Spirulina platensis during the First 1000 Days is Positively Associated with Development in Children under Five Years: A Follow up of A Randomized Trial in Zambia

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 730 ◽  
Author(s):  
Kazuya Masuda ◽  
Maureen Chitundu
Keyword(s):  
Social Skills ◽  
Randomized Trial ◽  
Motor Development ◽  
Assessment Tool ◽  
Preschool Age ◽  
Fine Motor ◽  
Complementary Foods ◽  
Gross Motor ◽  
Gross Motor Development ◽  
Home Fortification

Early childhood development relies on various micronutrients. We recently reported that home fortification of complementary foods using spirulina reduced the time to attain motor milestones in Zambian infants. The objective of this study is to estimate the long-term associations between spirulina supplementation during the first 1000 days and child gross motor development, fine motor development, language, and personal–social skills at preschool age. We used longitudinal data from a randomized trial conducted in Zambia. In 2015, 501 infants (age, 6–18 months) were provided daily supplements of maize-soy-based porridge with spirulina (SP) and without spirulina (CON). Supplementation period lasted for 16 months. In January 2018, children who participated in the initial trial were resurveyed (CON: 182 children; SP: 188 children; now aged 36–48 months). We assessed the infants’ gross motor development, fine motor development, language, and personal–social skills using a modified version of Malawi Development Assessment Tool. The initial clinical trial registration number was NCT03523182. Children in the SP group had higher scores in gross and fine motor development, language, and social skills than those in the CON group. Home fortification of complementary foods using spirulina during the first 1000 days improved development among Zambian children at preschool age.

scholarly journals Differences in walking attainment ages between low-risk preterm and healthy full-term infants

2012 ◽  
Vol 70 (8) ◽  
pp. 593-598 ◽  
Author(s):  
Ana P. Restiffe ◽  
José Luiz D. Gherpelli
Keyword(s):  
Cerebral Palsy ◽  
Birth Weight ◽  
Prospective Study ◽  
Preterm Infants ◽  
Motor Development ◽  
Full Term ◽  
Term Infants ◽  
Gross Motor ◽  
Gross Motor Development ◽  
Predictive Variables

OBJECTIVE: To compare gross motor development of preterm infants (PT) without cerebral palsy with healthy full-term (FT) infants, according to Alberta Infant Motor Scale (AIMS); to compare the age of walking between PT and FT; and whether the age of walking in PT is affected by neonatal variables. METHODS: Prospective study compared monthly 101 PT and 52 FT, from the first visit, until all AIMS items had been observed. Results: Mean scores were similarity in their progression, except from the eighth to tenth months. FT infants were faster in walking attainment than PT. Birth weight and length and duration of neonatal nursery stay were related to walking delay. CONCLUSION: Gross motor development between PT and FT were similar, except from the eighth to tenth months of age. PT walked later than FT infants and predictive variables were birth weight and length, and duration of neonatal intensive unit stay.

scholarly journals Effect of Delayed Cord Clamping on Neurodevelopment at 3 Years: A Randomized Controlled Trial

Neonatology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Johan Henrik Martin Berg ◽  
Manuela Isacson ◽  
Omkar Basnet ◽  
Rejina Gurung ◽  
Kalpana Subedi ◽  
...  
Keyword(s):  
At Risk ◽  
Motor Development ◽  
Controlled Trial ◽  
Delayed Cord Clamping ◽  
Pronounced Difference ◽  
Gross Motor ◽  
Iron Stores ◽  
Gross Motor Development ◽  
Cord Clamping ◽  
Ages And Stages Questionnaire

<b><i>Introduction:</i></b> Iron deficiency (ID) is associated with poor neurodevelopment. We have previously shown that delayed umbilical cord clamping (CC) improves iron stores at 8 months and neurodevelopment at 1 year in term, healthy infants in Nepal. <b><i>Objective:</i></b> The aim of this study was to assess the effects of delayed CC (≥180 s) compared to early CC (≤60 s) on neurodevelopment using the Ages and Stages Questionnaire (ASQ) at age 3 years. <b><i>Methods:</i></b> In 2014, 540 healthy Nepalese infants born at term were randomized in a 1:1 ratio to delayed or early CC. At 3 years of age, ASQ assessment was performed by phone interviews with parents. A score &#x3e;1 standard deviation below the mean was defined as “at risk” for developmental impairment. <b><i>Results:</i></b> At 3 years of age, 350 children were followed up, 170 (63.0%) in the early CC group and 180 (66.7%) in the delayed CC group. No significant differences in ASQ scores in any domains between groups were found. However, more girls were “at risk” for affected gross motor development in the early CC group: 14 (18.9%) versus 6 (6.3%), <i>p</i> = 0.02. <b><i>Conclusion:</i></b> There were no significant differences in ASQ scores in any domains between groups. In the subgroup analysis, fewer girls who underwent delayed CC were “at risk” for delayed gross motor development. Due to the pronounced difference in iron stores at 8 months postpartum in this cohort, follow-up studies at an older age are motivated since neurodevelopmental impairment after early ID may be more detectable with increasing age.

scholarly journals The Role of Parenting to Increase Gross and Fine Motor Skills Development in Children Aged 5-6 Years

2020 ◽  
Vol 3 (2) ◽  
pp. 54
Author(s):  
I Gusti Ayu Putu Satya Laksmi ◽  
Ni Made Nopita Wati ◽  
R. Tri Rahyuning Lestari
Keyword(s):  
Correlation Coefficient ◽  
Motor Development ◽  
Sampling Technique ◽  
Strong Relationship ◽  
Fine Motor ◽  
Social Emotional ◽  
Cross Sectional ◽  
Gross Motor ◽  
Gross Motor Development

Children's development includes several aspects including aspects of motor development, cognitive, social-emotional, language, moral, religion. One of the factors that influence motor development is parenting. The purpose of this study was to determine the relationship between parenting parents with gross motor and fine motor development in children aged 5-6 years. This study used a quantitative non-experimental correlational type research design with a cross-sectional approach. The sample consisted of 75 respondents using a non-probability sampling technique with purposive sampling. the majority of parents applying democratic parenting, as many as 69 people (92%), most children aged 5-6 years have appropriate motor development, as many as 65 people (86.6%), most children aged 5-6 years have appropriate fine motor development, as many as 72 people (96%), there is a strong relationship between parenting parents with gross motor development in children aged 5-6 years with a correlation coefficient (r) = 0.628, there is a strong relationship between patterns foster parents with fine motor development in children aged 5-6 years with a correlation coefficient (r) = 0.672. The results of this study are expected to be used as a guide for parents who have not applied democratic parenting to their children so that the child's motor development can grow optimally.

scholarly journals Effect of a parent-provided early intervention program on infant health and development: a randomized controlled trial

2018 ◽  
Vol 5 (3) ◽  
pp. 695
Author(s):  
Basavaraj K. ◽  
Sireesha S. ◽  
Suresh J.
Keyword(s):  
Randomized Controlled Trial ◽  
Early Intervention ◽  
Problem Solving ◽  
Intervention Program ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Early Intervention Program ◽  
Problem Solving Skills ◽  
Randomized Controlled

Background: Early Intervention Program (EIP) is a unique way of providing ideal stimulation, education and care for children. EIP are designed to provide detection, treatment, prevention of handicaps, developmental delays, and environmental deprivation as early in a child's life as possible. Objective of present study were to assess the effect of parent-provided EIP on infant cognitive, psychomotor and socio- emotional behaviors at the completion of age 12 months and to evaluate whether these effects were moderated by the infant feeding practices, general health status and socio-demographic characters.Methods: The present study was randomized controlled trial conducted at villages under Vantamuri PHC area attached to J.N Medical College, Belgaum during the period May 2012 to August 2013, with a sample size of 64, full term, normal babies and weighing ≥2.5 kg. At the end of 12 months, babies were assessed by an independent evaluator using BSID-II and ASQ/SE questionnaire.Results: In the present study the mental index (MDI) scores were higher in intervention group than control group (106.63 Vs 94.45, P=0.0001). Problem solving skills were higher in intervention group compared to control group (21.33 Vs 11.56, P=0.000). Person social skills were higher for intervention compared to control (27.66 Vs 22.34, P=0.001). Children with fewer episodes of diarrhea and acute respiratory infections showed better performance.Conclusions: Early Intervention Program effectively increases the cognitive, person social, problem solving and socio-emotional skills at 12 months of age.

scholarly journals Pengaruh mikronutrien taburia terhadap perkembangan motorik anak usia 24-48 bulan yang stunting (Studi di Tanjungkarang Barat Kabupaten, Bandar Lampung)

2014 ◽  
Vol 3 (1) ◽  
pp. 52-59
Author(s):  
Arie Nugroho ◽  
Hardhono Susanto ◽  
Martha Irene Kartasurya
Keyword(s):  
Folic Acid ◽  
Treatment Group ◽  
Motor Skills ◽  
Motor Development ◽  
Developmental Delays ◽  
Fine Motor ◽  
Control Group ◽  
Gross Motor ◽  
Motor Delay ◽  
Gross Motor Development

Background: Stunting is associated to the developmental delays of gross motor and fine motor skills. Previous studiedstate that micronutrient supplementation has a positive effect on both motor skills development in children aged under24 months.Objective: The aim of this study was to analysis the effect of micronutrient sprinkle on motor development amongstunted children aged 24 to 48 months.Methods: A quasi-controlled experimental group study with a total of 63 stunting age 24-48 months are divided intotreatment group (31 children) and controls (32 children). Treatment group received micronutrient sprinklesupplementation once in two days for two months. Fine and gross motor development was measured by DDST II beforeand after intervention.Results: There was no difference in age, sex, energy intake, protein, zinc, folic acid and developmental delaypercentage before treatment. The percentage of fine motor delays before treatment was 48.4% in the treatment groupand 53.1% in the control group, while the percent of gross motor delay was 32.3% in the treatment group 34.4% in thecontrol group. After intervention, the percentage of fine motor developmental delays significant decreases 25.8%, in thetreatment group and 34.4% in the control group, while the percentage of gross motor delay in the control groupsignificant decreased to 12.5%, but not significant decreased to 16,1% in the treatment group. Confounding variablesin this study were include energy adequacy level, protein adequacy level, zinc, iron and folic acid. There was nodifferences percentage of developmental delays on fine motor (p= 0,514) and gross motor (p= 0,571) after theintervention and after controlling with confounding variables.Conclusion: Micronutrient sprinkle supplementation for two months did not influence the development of fine motorskills gross motor skills on stunting preschooler children age 24 to 48 months

scholarly journals Gerak Dasar Tari Untuk Anak Usia Dini

2020 ◽  
Vol 1 (2) ◽  
pp. 115
Author(s):  
Jauhari Kumara Dewi
Keyword(s):  
Early Childhood ◽  
Motor Skills ◽  
Motor Development ◽  
Human Life ◽  
Effective Means ◽  
Educational Process ◽  
Fine Motor ◽  
Gross Motor ◽  
Gross Motor Skills ◽  
Gross Motor Development

Early childhood education is the embryo of an educational process that seeks to develop several aspects of development, including art. Art is one that cannot be separated in human life. The movements that are carried out in children every day are very effective means of physical development, namely developing children's motor skills. As we already know that children's motor skills include gross motor development and fine motor development. So it is very important to recognize dance movements in early childhood, in developing gross motor skills. So that early childhood can express themselves and be able to appreciate the diversity of arts as a form of respect for art. This paper aims to describe the implementation of learning the basic movements of dance in developing gross motor skills for early childhood

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