Pancreatic Neuroendocrine Tumor Pathologic Distant Metastasis TNM Finding v8

2020 ◽  
Author(s):  
Keyword(s):  
Neuroendocrine Tumor ◽  
Distant Metastasis ◽  
Pancreatic Neuroendocrine Tumor

Case report: Refractory hypercalcemia due to a pancreatic neuroendocrine tumor misdiagnosed as adenocarcinoma

2020 ◽  
Author(s):  
Mirella Hage ◽  
Ségolène Hescot ◽  
Amani Asnacios ◽  
Sophia Bakopoulou ◽  
Laure Cazabat ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor

scholarly journals Heterogeneity of the Clinical Presentation of the MEN1 LRG_509 c.781C>T (p.Leu261Phe) Variant Within a Three-Generation Family

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 512
Author(s):  
Aleksandra Gilis-Januszewska ◽  
Anna Bogusławska ◽  
Kornelia Hasse-Lazar ◽  
Beata Jurecka-Lubieniecka ◽  
Barbara Jarząb ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Clinical Presentation ◽  
Age Of Onset ◽  
Malignant Tumors ◽  
Genetic Disorder ◽  
Family Members ◽  
Pancreatic Neuroendocrine Tumor ◽  
Index Patient ◽  
Generation Family

Multiple neuroendocrine neoplasia type 1 (MEN1) is a rare genetic disorder with an autosomal dominant inheritance, predisposing carriers to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localization, age of onset, and clinical aggressiveness, even between affected members within the same family. We describe a heterogenic phenotype of the MEN1 variant c.781C>T (LRG_509t1), which was previously reported only once in a family with isolated hyperparathyroidism. A heterozygous missense variant in exon 4 of the gene was identified in the sequence of the MEN1 gene, i.e., c.781C>T, leading to the amino acid change p.Leu261Phe in a three-generation family. In the screened family, 5/6 affected members had already developed hyperparathyroidism. In the index patient and two other family members, an aggressive course of pancreatic neuroendocrine tumor (insulinoma and non-functioning neuroendocrine tumors) with dissemination was diagnosed. In the index patient, late diagnosis and slow progression of the disseminated neuroendocrine tumor have been observed (24 years of follow-up). The very rare variant of MEN1, LRG_509t1 c.781C>T /p.Leu261Phe (LRG_509p1), diagnosed within a three-generation family has a heterogenic clinical presentation. Further follow-up of the family members should be carried out to confirm the spectrum and exact time of clinical presentation.

Management of the primary tumor in patients with metastatic pancreatic neuroendocrine tumor: a contemporary single-institution review

2009 ◽  
Vol 197 (3) ◽  
pp. 376-381 ◽  
Author(s):  
Matias Bruzoni ◽  
Purvi Parikh ◽  
Rolando Celis ◽  
Chandrakanth Are ◽  
Quan P. Ly ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Primary Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Single Institution

Novel recurrence risk stratification of resected pancreatic neuroendocrine tumor

2018 ◽  
Vol 412 ◽  
pp. 188-193 ◽  
Author(s):  
Heli Gao ◽  
Liang Liu ◽  
Wenquan Wang ◽  
Huaxiang Xu ◽  
Kaizhou Jin ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Neuroendocrine Tumor ◽  
Pancreatic Neuroendocrine Tumor ◽  
Recurrence Risk
Sign in / Sign up

Export Citation Format

Share Document