Apocrine Metaplasia of Breast

2020 ◽  
Author(s):  
Keyword(s):  
Apocrine Metaplasia

Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy

1994 ◽  
Vol 1 (2) ◽  
pp. 49-55 ◽  
Author(s):  
I Számel ◽  
B Budai ◽  
K Daubner ◽  
J Kralovánszky ◽  
Sz Ottó ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sex Steroids ◽  
Linear Regression Analysis ◽  
Cyst Fluid ◽  
Type I ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Apocrine Metaplasia ◽  
Endocrine Parameters

ABSTRACT Gross cystic disease (GCD) of the breast may be associated with a higher risk for the development of breast cancer. High levels of sex steroids, steroid hormone precursors, prolactin and cations have been found in breast cyst fluid (BCF) by several investigators. Accordingly, endocrine parameters and the cationic composition of BCF may be considered as useful characteristics to follow patients bearing macrocysts. In this study we have investigated the concentrations of estradiol (E2), progesterone, testosterone, dehydroepiandrosterone (DHA) and DHA-3-sulfate (DHA-S), prolactin, potassium (K+) and sodium (Na+) in BCF aspirated from 99 women. The mean age of the patients was 49.8 years (range 32-58). The hormone levels were measured by RIA methods; K+ and Na+ were determined by flame photometry. Estradiol, progesterone, testosterone, DHA, DHA-S, prolactin and K+ showed significant accumulation in the BCF compared with their respective serum values. The K+/Na+ ratio proved to be useful in dividing cysts into type I (≥1), type II (<1 but ≥0.1) and type III (<0.1) subgroups. For type I BCF, higher DHA, DHA-S and prolactin concentrations were detected. Linear regression analysis established a highly significant (P<0.001) correlation between the concentrations of E2 and DHA-S (r=0.686), and also between testosterone and DHA-S (r=0.711). These findings indicate that type I BCF might be a marker for 'active' GCD of the breast, and suggest that it may be associated with an increased breast cancer risk, since this group of patients is supposed to have cysts with apocrine metaplasia. It is suggested therefore that when BCF is aspirated, sex steroids, steroid precursors and cations should be routinely measured, and women with type I cysts should be regularly examined.

Cell turnover in apocrine metaplasia and apocrine adenosis of the breast

2010 ◽  
Vol 14 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Ghada Elayat ◽  
Abdel-Ghani A Selim ◽  
Clive A Wells
Keyword(s):  
Cell Turnover ◽  
Apocrine Metaplasia

Significance of Apocrine Metaplasia in Mammary Carcinogenesis.

1990 ◽  
Vol 586 (1 Biochemistry) ◽  
pp. 238-251 ◽  
Author(s):  
J. TÖTH ◽  
I. SZÁMEL ◽  
E. SVASTICS ◽  
E. R. DeSOMBRE
Keyword(s):  
Mammary Carcinogenesis ◽  
Apocrine Metaplasia

scholarly journals Apocrine Carcinoma of Breast: A Case Report with Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Jyotsna V. Wader ◽  
Akash Jain ◽  
Suresh J. Bhosale ◽  
Pandurang G. Chougale ◽  
Sujata S. Kumbhar
Keyword(s):  
Case Report ◽  
Androgen Receptor ◽  
Breast Carcinoma ◽  
Invasive Breast Carcinoma ◽  
Apocrine Carcinoma ◽  
Review Of The Literature ◽  
Rare Form ◽  
Breast Malignancy ◽  
Apocrine Metaplasia

Apocrine carcinoma is a very rare form of breast malignancy with an incidence of <1% of female invasive breast carcinoma. We report a case of apocrine carcinoma in a 42-year female with marked adenosis showing apocrine metaplasia and discuss the criteria to diagnose apocrine carcinoma with the emerging concept of androgen receptor positivity with its implication on treatment and management of the patient.

Apocrine metaplasia in phyllodes tumours of the breast

1986 ◽  
Vol 10 (11) ◽  
pp. 1211-1211 ◽  
Author(s):  
J.R. Salisbury ◽  
L.N. Singh
Keyword(s):  
Apocrine Metaplasia ◽  
Phyllodes Tumours

Apocrine Metaplasia Found at MR Biopsy: Is There Something to be Learned?

2017 ◽  
Vol 23 (4) ◽  
pp. 429-435 ◽  
Author(s):  
Yiming Gao ◽  
Vandana Dialani ◽  
Carolynn DeBenedectis ◽  
Nicole Johnson ◽  
Elena Brachtel ◽  
...  
Keyword(s):  
Apocrine Metaplasia
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