The Effect of High-Intensity Interval Training on GLP-1, Appetite, and Weight in Obese Rats

2021 ◽  
Vol 20 (3) ◽  
pp. 290-299
Author(s):  
Mohammad Hosein Sepehri ◽  
Javad Nemati ◽  
Maryam Koushkie Jahromi ◽  
Mohammad Hadi Eskandari ◽  
Farhad Daryanoosh ◽  
...  

Background and Objectives: Appetite is an essential factor in obesity. The present study aimed to evaluate the effect of High-Intensity Interval Training (HIIT) on GLP-1, appetite, and weight of obese mice while maintaining a high caloric diet. Subjects and Methods A total of 24 C57BL/6 mice with a Mean±SD weight of 20.7±1 g were selected. After implementing a high caloric dieting and making them fat (Mean±SD weight: 30.95±3.23 g), they were divided into two groups of training and control. A high caloric diet was maintained for both groups (training and control) until the end of the experiment, while the training group performed HIIT for 8 weeks. Every session of HIIT included 30 minutes of exercise with a progressive intensity of 50% to 60% in low-intensity intervals and 80% to 90% in high-intensity intervals. The independent t test and analysis of variance with repeated measures were used for data analysis. Results Findings of the study indicated that GLP-1 increased significantly in the HIIT training group compared to the control group (P<0.05). In the HIIT group, body weight was significantly higher (P<0.001), and food intake was significantly lower (P<0.001) than those in the control group. Conclusion When consuming high-calorie food, HIIT training can probably cause weight loss through reducing appetite mediated by increasing GLP-1

2017 ◽  
Vol 18 (2) ◽  
Author(s):  
Mari Stenman ◽  
Arto J. Pesola ◽  
Arto Laukkanen ◽  
Eero A. Haapala

AbstractWe investigated the effects of a two-week high-intensity interval training (HIT) on cognition in adolescents.The participants were recruited from local high schools with an electronic messaging system. The HIT group participated in 4 high-intensity interval running sessions and 2 circuit training sessions. The control group (CG) continued their usual habits. Reaction time, choose reaction time, working memory, visual memory, and learning were assessed by computerized CogState test battery. The intervention effect was investigated with repeated measures ANOVA and the effect size by Morris dppc2.The total of 25 participants aged 17–20 years participated in the baseline measurements and were randomized into the intervention (The study on HIT produced mixed effects on cognition in adolescents. Studies with a longer intervention period and larger sample sizes are warranted to further explore HIT effects on cognition.


Author(s):  
Mohammadreza Zarali ◽  
Zaher Etemad ◽  
Kamal Azizbeigi ◽  
Pouran Karimi

Background: Apoptosis is the physiological cell death that in natural conditions leads to the elimination of old, damaged, waste, and harmful cells. The aim of this study was the effect of eight weeks of high-intensity interval training (HIIT) with and without caloric restriction on gene expression of myocardial Bax and Bcl2 in mice. Methods: Present study was an experimental multi-group design with a control group conducted on 30 two-month old male mice. Subjects were divided into five homogenous groups including base control, control, caloric restriction, interval exercise training, and caloric restriction + interval exercise training. Training groups participated in interval exercise training five sessions per week for 8 weeks. The level of gene expression of myocardial Bax and Bcl2 was evaluated by real-time PCR. Data were analyzed using the one-way ANOVA at the level of (P<0.05). Results: The results showed that the training group had a significant increase in gene expression of myocardial Bcl2 in comparison with caloric restriction + exercise training (P<0.05) and a significant decrease in gene expression of myocardial Bax compared to the caloric restriction group (P<0.05). Also, exercise training and exercise training + caloric restriction significantly increased the gene expression of myocardial Bcl2 and significantly decreased Bax/Bcl2 ratio compared to caloric restriction, base control, and control (P< 0.05). Conclusion: It seems that high-intensity interval training without caloric restriction would provide a suitable environment for increasing the integrity of the mitochondrial membrane of myocardial cells and possibly apoptosis.


2019 ◽  
Vol 40 (08) ◽  
pp. 503-510 ◽  
Author(s):  
Myong-Won Seo ◽  
Jung-Min Lee ◽  
Hyun Chul Jung ◽  
Sung Woo Jung ◽  
Jong Kook Song

AbstractTo examine the effect of high-intensity interval training (HIIT) with different work-to-rest ratios on athletic performance in athletes. Forty-seven male Taekwondo athletes (aged 15–18 yrs) were randomly assigned into 3 HIIT groups and a control group. Each group performed 6 and 8 bouts of HIIT: 1) 1:2 (30:60 s), 2) 1:4 (30:120 s), and 3) 1:8 (30:240 s) groups while the control group performed only Taekwondo training program. All HIIT groups completed 10 sessions over 4 weeks. Athletic performance tests including VO2max test, Wingate anaerobic test, vertical jump, and agility T-test were measured at both pre- and post-tests. Two-way repeated measures ANOVA were applied to examine the performance changes between protocols. VO2max improved significantly in all HIIT groups (p<0.01), and the post-hoc test indicated that the only 1:4 group showed significant improvement compared to the control group. The HIIT with 1:4 ratio showed the effective protocol for enhancing anaerobic capacity including relative peak and mean power compared to control (p<0.01). Ten sessions of HIIT involving the 1:4 group, lasting over a brief 4-week period revealed the effective protocol for enhancing both aerobic and anaerobic capacity. Our findings provide practical implications to develop a performance-enhancing program specialized for adolescent Taekwondo athletes.


Author(s):  
Sirvan Atashak ◽  
Stephen R. Stannard ◽  
Ali Daraei ◽  
Mohammad Soltani ◽  
Ayoub Saeidi ◽  
...  

We investigated the effects of 12 weeks of high-intensity interval training (HIIT) on selected circulating adipokines and other cardiovascular diseases risks factors in men with obesity. Thirty men with obesity (age: 24.96 ± 3.11 year, BMI: 30.92 ± 1.04 kg/m2) were randomly assigned to HIIT and control groups. The HIIT group participated in a 12-week HIIT program (5×2 min interval bout at an intensity of 85-95% HRmax interspersed by 1 min passive recovery, three times per week), while the control group maintained their usual lifestyles. Blood lipids, insulin resistance, and select serum adipokines were assessed before and after 12 weeks of the intervention period. HIIT improved body composition and lipid profiles (p<0.05) and also decreased fasting insulin levels (p=0.001) and HOMA-IR (p=0.002) levels. Furthermore, HIIT increased levels of lipocalin-2 (p=0.002) while decreasing omentin-1 levels (p=0.001) in men with obesity. Changes in lcn2 and omentin-1 concentrations correlated with the changes in risk factors in the HIIT group (p<0.05). The results indicate that 12 weeks of supervised HIIT significantly improves both circulating concentrations of lcn2 and omentin-1, two recently described adipokines, and risk markers of cardiovascular diseases in men with obesity. Further research is necessary to understand the molecular mechanisms involved with these changes.


2021 ◽  
Author(s):  
Menglu Shen ◽  
Suyong Yang ◽  
Songting Lu ◽  
Dong Zhu

Abstract IntroductionCognitive deficit is a common syndrome of methamphetamine (MA) dependence, it relates to decision-making, control ability, and social functioning. High-Intensity Interval Training (HIIT) is a training technique that requests people to work out at full intensity during a short period. A number of studies have already shown the potential effects of HIIT on cognitive roles. A number of studies have already shown the potential effects of HIIT on cognitive function. The purpose of this trial is to evaluate the cognitive effects of HIIT on the individuals of MA dependent. Methods and analysis240 individuals of MA dependent are randomly assigned to High-intensity Interval Training group (HIIT), Moderate-intensity Continuous Training group (MICT) and Control group (CON) respectively. HIIT consists of a 24-minute exercise of high-intensity interval training on a treadmill. MICT consists of a 1-hour body-mind exercise. CON remains their traditional intervention. The experimental period will be 12 months, with 3 interventions weekly for the first 6 months and follow-up for the next 6 months. All subjects will be given both physical and cognitive tests at baseline, after intervention and follow-up. The cognitive performances will be compared by a mixed-model analysis for repeated-measures.DiscussionHIIT training may reduce illicit drug cravings among individuals of MA dependent, it indicates that HIIT has better effect on cognitive functions such as memory and executive function for individuals of MA dependent.Trial RegistrationChiCTR, ChiCTR2000032492, Registered on Aril 30, 2020, Prospective registration, http://www.chictr.org.cn/edit.aspx?pid=52127&htm=4.


2017 ◽  
Vol 14 (4) ◽  
pp. 4088 ◽  
Author(s):  
Kadir Baynaz ◽  
Kursat Acar ◽  
Engin Çinibulak ◽  
Taner Atasoy ◽  
Ahmet Mor ◽  
...  

The aim of this study is to examine the effect of high intensity training with their own body weight on flexibility and anaerobic capacity. A total of 20 sedentary women (10 control and 10 experimental groups) participated in the study voluntary, with a mean age of 18.37 ± 1.43 years. The experimental group completed high intensity interval training 3 times weekly for 6 weeks. Between the 1st and 3rd weeks burpees, plank, jumping jacks, push-up movements and between 4th and 6th weeks box jump, crunches, step ups, mountain climber movements were applied to experimental group according to  20 sec loading and 10 sec resting principle.  The control group did not participate any exercise during this time. Body weight, flexibility and anaerobic power measurements were taken before and after 6 weeks of high intensity interval training. The data were analyzed using the two way repeated measures of ANOVA. The level of significance was determined as p<0.05. At the end of the study, there was no significant difference in the control group parameters. In the experimental group, significant differences were found in the flexibility, body weight and anaerobic power values after the high intensity interval training (p<0.05). For sedentary women who are exercising for health purposes, the Tabata Protocol applied with their own body weight, can be recommended as a high intensity interval training method in terms of improving the parameters mentioned in the study.Extended English abstract is in the end of Full Text PDF (TURKISH) file. ÖzetÇalışmanın amacı, 6 hafta süresince kendi vücut ağırlığıyla yapılan yüksek yoğunluklu antrenmanların esneklik ve anaerobik kapasite üzerine etkisinin incelenmesidir. Çalışmaya yaş ortalaması 18,37± 1,43 yıl olan 10’u kontrol, 10’u deney grubu olmak üzere toplam 20 gönüllü sedanter kadın katılmıştır. Deney grubuna,  6 hafta süresince haftada 3 gün yüksek şiddetli interval antrenman yaptırılmıştır.  1. ve 3. haftalar arasında ikişer kez sırayla burpees, plank, jumping jacks, push-up hareketleri,   4. ve 6. haftalar arasında da ikişer kez sırayla box jump, crunches, step ups, mountain climber hareketleri 20 saniye yüklenme 10 saniye dinlenme prensibiyle uygulanmıştır. Kontrol gurubu bu süre içerisinde herhangi bir egzersiz yapmamıştır. 6 haftalık antrenmana başlamadan önce ve 6 haftanın bitiminden sonra deneklerin vücut ağırlığı, esneklik ve anaerobik güç ölçümleri alınmıştır. Esneklik, anaerobik kapasite ve vücut ağırlığı skorlarındaki değişim iki yönlü varyans analizi (two way repeated measures of ANOVA) ile yapılmıştır. Çalışmanın istatistiksel anlamlılık seviyesi p<0,05 olarak belirlenmiştir. Çalışma sonunda kontrol grubu parametrelerinde anlamlı fark yokken, yüksek şiddetli interval antrenman yapan sedanter kadınların esneklik, vücut ağırlığı ve anaerobik güç değerlerinde anlamlı fark bulunmuştur (p<0.05). Sağlık amaçlı egzersiz yapan sedanterlere, çalışmada belirtilen parametreleri geliştirmeleri açısından yüksek şiddetli interval antrenman yöntemi olarak kendi vücut ağırlığı ile yapılan Tabata Protokolü önerilebilir.


2019 ◽  
Vol 8 (2) ◽  
pp. 169-176
Author(s):  
Yoga Handita Windiastoni ◽  
Nurul Fithriati Haritsah

Background: Cardiorespiratory fitness in adolescence affects the level of fitness and determinants of health levels in old age. School adolescents who have low physical activity need easy, efficient and effective physical training to increase cardiorespiratry fitness, namely high intensity interval training. Objective: to determine the effect of high intensity interval training on cardiorespitatory fitness training in adolescents. Subjects: 60 high school students (men n = 21, women n = 39) aged 15-19 years who met the study criteria and were divided into 2 groups, a high intensity interval training group and a control group by jogging. Method: quasi experimental with pre-test and post-test one group design with control group. The instrument used in this study was a 20m shuttle run test. Analysis: normality test with Kolmogorov-Smirnov, then parametric test with paired sample t-test and parametric difference test with independent sample t-test. Results: VO2max pre-test and post-test high intensity interval training group obtained p value = 0,000 (p <0.05) which showed there were significant differences before and after treatment. The results of the post-test different test between the control and treatment groups showed that the value of p = 0,000 (p <0.05) showed that there was a significant difference between the high intensity interval training group and the control group and the results of the different mean mean were greater in the high intensity interval training group. after and before treatment. Conclusion: high intensity interval training can increase cardiorespiratory fitness in adolescents according to the results of VO2max values.


Author(s):  
Jinshu Zeng ◽  
Jing Xu ◽  
Yuanhong Xu ◽  
Wu Zhou ◽  
Fei Xu

The aim of the study was to investigate the effects of 4-week small-sided games (SSG) and high-intensity interval training with changes of direction (HIT-COD) on physical performance and specific technical skills in female collegiate basketball players. Nineteen players were divided into SSG (n = 9) and HIT-COD (n = 10) groups, that performed either SSG or HIT-COD three times per week for 4 weeks during the pre-season. Players’ heart rate (HR) and perceived exertion responses (RPE) were assessed during the intervention. Before and after the intervention period, performances were assessed with 30-15 intermittent fitness test (30-15IFT), repeated sprint ability (RSA) test, modified agility T-test (MAT), countermovement jump (CMJ), 20-m sprint, shooting accuracy test, 1 min shooting test, passing test, defensive movement test and control dribble test. Both training interventions led to similar physiological and perceived exertion responses, showing no significant differences in HR ( P = .49, d = 0.2) and RPE ( P = .77, d = 0.1) between groups. Significant improvements were observed in 30-15IFT (SSG: 4.1%, d = 1.5; HIT-COD: 4.2%, d = 1.7), RSAmean (SSG: −2.2%, d = 1.0; HIT-COD: −1.9%, d = 1.0), RSAbest (SSG: −2.0%, d = 0.9; HIT-COD: −2.1%, d = 1.1), MAT (SSG: −7.2%, d = 1.7; HIT-COD: 5.7%, d = 1.5), defensive movement test (SSG: −5.1%, d = 2.1; HIT-COD: −5.8%, d = 1.8) and control dribble test (SSG: −3.4%, d = 1.0; HIT-COD: −2.6%, d = 1.0). The only significant group × time interaction was found ( P = .032, [Formula: see text] = 0.24), with SSG improving 1 min shooting (22.4%, d = 1.0) and HIT-COD performing slightly worse (−2.6%, d = 0.1) after a 4-week intervention. The current study suggests that using SSG is more effective than HIT-COD for female collegiate basketball players in pre-season, since SSG improves physical performance and basketball-specific movements as well as shooting abilities after a 4-week intervention.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y.C Huang ◽  
J.S Wang

Abstract Background Interventricular interactions in increased RV afterload such as hypoxia stress, which affects both synchrony and function in an in-series effect as well as a parallel effect arising from leftward septal shift. Improved myocardial contractility is a critical circulatory adaptation to exercise training, however, the types of exercise that can improve interventricular synchrony under hypoxic environment have not yet been established. Purpose This study investigates how high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) influence on the interventricular synchrony in response to normobaric hypoxia in sedentary men. Methods Fifty-four sedentary males were randomized to perform HIIT (3-minute intervals at 40% and 80% VO2peak, n=18), MICT (sustained 60% VO2peak, n=18) for 30 minutes/day, 5 days/week for 6 weeks and the control group (CTL, n=18). Synchrony measurements at apical 4-chamber view including (1) intra-delay, the difference in time to peak strain (TS) between segmental septal-to-lateral ventricular or atrial walls, and (2) inter-delay, the difference in TS between RV or RA free wall and LV or LA lateral wall. The data were acquired by 2-dimensional speckle tracking echocardiography at rest under hypoxic condition (12% FIO2, simulated an altitude of 4,500 m) before and after the interventions. Results HIIT had significantly elevated radial and longitudinal strains in both LA and LV (p&lt;0.05). As the results showed, HIIT was superior than MICT in improvement of longitudinal intra-delay of LV; furthermore, only HIIT simultaneously ameliorated both radial and longitudinal synchrony at apex. Although the HIIT enhanced intraventricular synchrony in both motions, whereas the interventricular synchrony deteriorated at radial motion. In atrium synchrony, although both groups augmented the intra-LA synchrony, however, only HIIT reduced the inter-delay between LA and RA at the roof motion. LV end-systolic volume (ESV) significantly correlated with the longitudinal inter-delay of ventricle (r=−0.53, p&lt;0.05), whereas the LV end-diastolic volume (EDV) correlated with the inter-delay of atrium in roof motion (r=0.40, p&lt;0.05). Conclusion We found differences between HIIT and MICT in segmental intra- and inter- synchrony. HIIT enhanced both ventricular or atrial synchrony, and further increased the EDV coupled with decreased ESV. These findings give new insight into cardiac adaptation to difference endurance training and the long-term impact of such changes warrants future study in cardiac diseases. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National Science Council of Taiwan


Author(s):  
Soo-Yong Park ◽  
Thomas Jürgen Klotzbier ◽  
Nadja Schott

The ability to process goal-related visual information while ignoring goal-irrelevant information is essential for the human attention system. The study aimed to investigate how perceptual–cognitive performance was affected during high-intensity interval training (HIIT) using a 3D-multiple object tracking (3D-MOT) task called Neurotracker (NT). In an experimental design, 42 healthy adults (age M = 23.3 SD = 2.94, VO2max 52.8 ± 5.66 mL·kg−1·min−1) were randomly assigned to an intervention (HIIT + NT, NT, HIIT) or control group. NT performance (20 trials per session) was measured pre-and post-test (at 5, 15, and 25 min while running on the treadmill). The participants trained twice a week for a 4-week intervention period. There was a significant interaction effect between pre/post-test and groups regarding perceptual-cognitive performance, indicating similar enhancements in the HIIT + NT and the NT group during exercise. HIIT influences physical fitness but did not show any impact on perceptual–cognitive performance. Due to the specific NT task characteristics, improved physical abilities may not directly impact sport-specific perceptual-cognitive performance. Our findings suggest that training resulted in substantial task-specific gains. Therefore, combination training may be proposed as a training program to improve perceptual–cognitive, and physical performance in a time-efficient way.


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