scholarly journals High Sensitivity CReactive Protein (hsCRP) Level on Premature Rupture of Membrane (PROM) at Term Pregnancy

2017 ◽  
pp. 12-15
Author(s):  
Meily Manoppo ◽  
Hermie MM Tendean ◽  
Joice MM Sondakh
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Hs Crp ◽  
Cross Sectional Design ◽  
Parametric Statistical Test

Objective: To compare the level of high sensitivity C-Reactive Protein (hs-CRP) on patients with premature rupture of membranes (PROM) at term pregnancy. Methods: The study was cross-sectional design. The data collection included age, parity, gestational age, birth weight, and APGAR score on 28 pregnant women at term pregnancy consisting of 14 subjects of Premature Rupture of Membrane (PROM) less than 12 hours and the remaining one was equal or more than 12 hours. We took blood samples from the subjects for the examination of hs-CRP level. Data were analyzed using non-parametric statistical test and processed using Statistical Package for Social Sciences (SPSS) version 20. Results: The mean hs-CRP level on PROM <12-hour and 12-hour group was 12.9 and 17.8 mg/l. There was not significant difference on hs-CRP level between both of group at term pregnancy (p=0.734). Conclusion: The level of hs-CRP does not have association with the incidence of PROM. [Indones J Obstet Gynecol 2017; 5-1: 12-15] Keywords: high sensitivity C-Reactive Protein, premature ruptures of membranes, term pregnancy

scholarly journals High sensitivity C-reactive protein level in various manifestations of tuberculosis in children

2021 ◽  
Vol 61 (5) ◽  
pp. 253-60
Author(s):  
Radita Kusumaningrum ◽  
Moh Syarofil Anam ◽  
Dwi Wastoro Dadiyanto ◽  
Maria Mexitalia ◽  
Magdalena Sidhartani
Keyword(s):  
Community Health Center ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Reactive Protein ◽  
Significant Difference ◽  
Extra Pulmonary ◽  
Hs Crp

Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Of all TB patients, 40-50% are children. C-reactive protein (CRP) is produced during the inflammation process and is an indicator of active TB disease. High sensitivity CRP (hs-CRP) test has higher accuracy and sensitivity to detect CRP at lower levels. Objective To compare hs-CRP in children with TB infection, pulmonary TB, and extra-pulmonary TB. Methods This cross-sectional study of children with tuberculosis was conducted at Dr. Kariadi Hospital and the Semarang Community Health Center, Semarang, Central Java, from January 2020–February 2021. Inclusion criteria were patients aged 1–18 years with suspected TB (contact with adult TB patient or clinically suspected to have TB). Results From 95 study subjects, 19 had TB infection, 51 had pulmonary TB, and 25 had extra-pulmonary TB. There was a significant increase in hs-CRP level based on prolonged fever (P<0.001), enlarged lymph glands (P=0.004), joint swelling (P=0.006), low WHZ or BMI for age (P=0.048), positive bacteriological evidence (P<0.001), and negative/not done tuberculin skin test (P=0.001). There was a significant difference of hs-CRP level based on TB status, with the highest hs-CRP level in extra-pulmonary TB [14.3 mg/l (0.16–321.5)], followed by pulmonary TB [0.8 mg/l (0.3–129.1)], and TB infection [0.7 mg/l (0.3–20.2)]. The highest hs-CRP level for extra-pulmonary TB was found in abdominal TB [84.5 mg/l (0.6–321.5)]. Conclusion  Children with extra-pulmonary TB have significantly higher hs-CRP than children with TB infection or pulmonary TB.

scholarly journals Kadar High Sensitivity C-Reactive Protein Berkaitan dengan Lingkar Pinggang pada Lansia

2021 ◽  
Vol 8 (1) ◽  
pp. 21
Author(s):  
Deny Yudi Fitranti ◽  
Bunga Syifarahmi ◽  
Martha Ardiaria ◽  
Nurmasari Widyastuti
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
International Physical Activity Questionnaire ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Consecutive Sampling ◽  
Hs Crp ◽  
Activity Questionnaire

<p>Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum <em>high-sensitivity C-reactive Protein</em> (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian <em>cross sectional</em> pada 53 subjek dipilih secara <em>consecutive sampling</em>. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode <em>enyme-linked immunosorbent assay</em> (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode <em>food recall</em> 3x24 jam. Aktivitas fisik diperoleh menggunakan <em>International Physical Activity Questionnaire</em> (IPAQ). Analisis data digunakan uji korelasi <em>Spearman</em>. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP</p>

Abstract 346: Platelet Reactivity to Aspirin and Clopidogrel in Patients with Acute ST Elevation Myocardial Infarction and its Correlation with High Sensitivity C- Reactive Protein

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Archana Rajdev ◽  
Oana Penciu ◽  
Jacqueline Bradley ◽  
Cristina Mihu ◽  
Alan Siqueros ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Platelet Reactivity ◽  
High Sensitivity ◽  
St Elevation Myocardial Infarction ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
St Elevation ◽  
Hs Crp

INTRODUCTION Implantation of bare metal or drug eluting stents supported by dual antiplatelet therapy (DAPT) is standard treatment for the management of patients with ST elevation myocardial infarction (STEMI). Individual response to aspirin and clopidogrel is heterogeneous, and decreased response is associated with thrombotic events following stenting. We postulated that systemic inflammation at the time of STEMI would diminish responsiveness to DAPT. The aim of this study is to evaluate the correlation between elevated high-sensitivity C-reactive protein (hs-CRP) as a marker of inflammation and decreased platelet sensitivity to DAPT in STEMI. METHODS We recruited patients with STEMI undergoing percutaneous coronary intervention (PCI) who received oral clopidogrel 600 mg loading dose followed by 75 mg daily maintenance dose and aspirin 325 mg daily. Platelet reactivity and hs-CRP were measured within 72 hours of PCI and at 6 weeks. For patients receiving eptifibatide, blood samples were taken 48 hours after discontinuation. Platelet reactivity was assessed using the VerifyNow platelet function analyzer. A cut-off value of 208 platelet reaction units (PRU) was used to define high on-clopidogrel platelet reactivity (HCPR) and a value of 454 aspirin reaction units (ARU) was used to define high on-aspirin platelet reactivity (HAPR). RESULTS In 20 patients aged 31 to 85, in hospital and 6 weeks after STEMI, hs-CRP was 6.7 (SD 4.0) and 2.6 (SD 3.2) respectively, p< 0.01. Changes in ARU from 408.3 (SD 54.3) to 425.2 (SD 68.2) and PRU from 157.8 (SD 74.7) to 164.2 (SD 75) were not statistically significant. 2 patients had HAPR in hospital; 1 became sensitive at follow up. 2 patients developed HAPR and HCPR. We saw a trend towards higher PRU in diabetic patients and those prescribed statins. CONCLUSIONS Although we found a significant difference in hs-CRP levels between the first and second time point, no significant difference was found in on-aspirin and on-clopidogrel platelet reactivity between the time points.Thus, in this small series, the acute inflammatory state associated with STEMI did not appear to influence the on-DAPT reactivity at the dosages used. Trends among those with diabetics and prescribed statins will be discussed

A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

2021 ◽  
pp. 71-73
Author(s):  
Amit Kumar Tiwari ◽  
Umesh Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Cerebrovascular Accident ◽  
High Sensitivity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Abrupt Onset ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

scholarly journals Association between weekend catch-up sleep and high-sensitivity C-reactive protein levels in adults: a population-based study

SLEEP ◽  
2020 ◽  
Vol 43 (8) ◽  
Author(s):  
Kyu-Man Han ◽  
Heon-Jeong Lee ◽  
Leen Kim ◽  
Ho-Kyoung Yoon
Keyword(s):  
Sleep Duration ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Obese People ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Catch Up

Abstract Study Objectives To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)—a serum inflammatory maker—in adults Methods Data of 5,506 adults aged 19 years or older were obtained from the nationwide cross-sectional Korea National Health and Nutrition Examination Surveys conducted in 2016. Serum hsCRP level, weekday and weekend sleep durations, and sociodemographic and health-related characteristics were assessed. Participants whose weekend sleep duration was more than 1 h longer than their weekday sleep duration were included in the WCS group. hsCRP level was categorized into quartiles (i.e. highest, middle-high, middle-low, and lowest). Obesity was defined by body mass index ≥ 25.0 kg/m2. Results The WCS group included 1,901 participants (34.5%). In the logistic regression analysis controlling for all variables, adults in the WCS group were significantly less likely to show the highest hsCRP level (versus the lowest level) compared with those without WCS in the complete sample (adjusted odds ratio = 0.795, 95% confidence interval [CI] = 0.662 to 0.955). In a subgroup analysis, this association was significant only for those with weekday sleep duration of 6 h or lower. Longer WCS (≥3 h) was not associated with hsCRP levels. Non-obese people with WCS demonstrated a lower risk for high hsCRP levels, while there was no significant difference in obese people with WCS. Conclusions Our findings indicate that WCS may be beneficial for low-grade systemic inflammation in adults, particularly among those with shorter weekday sleep durations. WCS may also interact with obesity.

scholarly journals Serum high sensitivity C reactive protein levels in patients with diabetic retinopathy: a cross sectional study

2020 ◽  
Vol 7 (3) ◽  
pp. 391
Author(s):  
Harishchandra R. Chaudhari ◽  
Gaurav A. Chaudhari
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Glucose ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Postprandial Blood Glucose ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Hs Crp

Background: Diabetic retinopathy (DR) is one of the major visual morbidities associated with diabetes. This study determined the levels of serum high-sensitivity C-reactive protein (hs-CRP) in patients with DR and to correlate the estimated levels of serum hs-CRP with the severity of DR and other coexisting factors.Methods: This was a cross-sectional study conducted between March 2009 and August 2010 and included patients with type 2 diabetes mellitus (T2DM) with or without DR. A detailed fundus evaluation was performed using direct and indirect ophthalmoscopy. The retinopathies were observed and documented in accordance with the Kanski's system of classification as background DR (BDR), pre-proliferative DR (PPDR), and proliferative DR (PDR). Laboratory investigations determined the levels of fasting blood glucose (FBG), postprandial blood glucose (PPBG), glycosylated hemoglobin, urine albumin excretion, and serum hs-CRP levels.Results: In total, 80 patients with T2DM were included (DR group, n=40 [BDR, n=22; PDR, n=11; PPDR, n=7]; control group, n=40). Highest serum hs-CRP levels were found in PDR group (6.68 mg/L), followed by PPDR and BDR group (3.2 mg/L and 1.56 mg/L, respectively). The PDR group showed the longest duration of diabetes (16 years), highest FBG (221.8 mg/dL) and HbA1c (6.68 mg/L). The incidence of albuminuria and maculopathy was higher in PDR group (72.7% and 54.54%, respectively). A significant association of hs-CRP levels with DR in patients with T2DM was observed. A significantly (<0.005) positive correlation of hs-CRP was also observed with age, duration of disease, FBG, PPBG, and HbA1c.Conclusions: Patients with severe grades of retinopathy had significantly higher hs-CRP levels than patients with the milder grades.

scholarly journals HUBUNGAN KADAR TRIASILGLISEROL DARAH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Melda Melatunan
Keyword(s):  
Cardiovascular Disease ◽  
High Sensitivity ◽  
Nonparametric Test ◽  
Inflammatory Factors ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Triacylglycerol Level ◽  
Hs Crp

Abstract: Obesity is one of the health problem in the world, also in Indonesia. Obesity is caused by an increased amount of fat that stored in the form triacylglycerol ( TAG ) which is acquired from food. Increase of triacylglycerol level may cause higher risk of cardiovascular disease. High Sensitivity C-Reactive Protein (hs-CRP) is a marker of inflammatory factors that can be used as a marker for cardiovascular disease. This study aimed to determine the correlations between TAG levels on blood and hs-CRP levels on obese adolescents. This study performed by observational analytic study design with the cross-sectional approach. The number of sample in this study were 17 sample who was willing to join. Analysis of bivariate using Spearman nonparametric test. The results showed a significance value ( p ) 0.272 which indicates that the correlation between TAG levels and hs-CRP levels were not significant. Spearman value showed 0.282 that indicates that the direction of a positive correlation with the strength of the correlation is weak. It can be concluded that there is no correlations between TAG levels in blood with hs-CRP levels on obese adolescents. Keyword: Obesity, TAG, hs-CRP, Adolescents    Abstrak: Obesitas merupakan masalah kesehatan di seluruh dunia, termasuk di Indonesia. Obesitas disebabkan akibat peningkatan jumlah lemak yang disimpan dalam bentuk triasilgliserol (TAG) yang diperoleh dari makanan. Peningkatan triasilgliserol ini akan meningkatkan risiko penyakit kardiovaskuler. High Sensitivity C-Reactive Protein (hs-CRP) merupakan faktor penanda inflamasi yang dapat digunakan sebagai penanda risiko penyakit kardiovaskuler. Penelitian ini bertujuan untuk mengetahui hubungan kadar TAG darah dengan kadar hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Sampel pada penelitian ini berjumlah 17 sampel yang diambil dari seluruh populasi yang bersedia. Analisis bivariat menggunakan uji nonparametrik Spearman. Hasil penelitian didapatkan nilai signifikansi (p) 0,272 yang menunjukkan bahwa korelasi antara kadar TAG dan kadar hs-CRP tidak signifikan. Nilai Spearman sebesar 0,282 menunjukkan bahwa arah korelasi positif dengan kekuatan korelasi yang lemah. Dapat disimpulkan bahwa tidak terdapat hubungan antara kadar TAG darah dengan kadar hs-CRP pada remaja obes. Kata Kunci : Obesitas, TAG, hs-CRP, Remaja

scholarly journals Controlled Clinical Trial Effect of Noni Fruit Extract (Morinda citrifolia) Toward Overactive Bladder Women through Observation of High-Sensitivity C-reactive Protein in Urine Levels

2020 ◽  
Vol 8 (A) ◽  
pp. 706-710
Author(s):  
Edy Ardiansyah ◽  
M. F. G. Siregar ◽  
R. A. Ganie ◽  
I. B. Utra
Keyword(s):  
Oxidative Stress ◽  
High Sensitivity ◽  
Morinda Citrifolia ◽  
C Reactive Protein ◽  
Urine Level ◽  
Fruit Extract ◽  
Reactive Protein ◽  
Significant Difference ◽  
Hs Crp ◽  
Urine Levels

BACKGROUND: The prevalence of overactive bladder (OAB) appears to increase with age (aging), and free radicals most contribute to an increase in the aging process. But now, some researchers have found the efficacy of Morinda citrifolia in inhibiting the oxidative stress process so that it is expected to be beneficial for the treatment of OAB. AIM: The aim of this study was to find out the effect of M. citrifolia extract on overactive women bladder (OAB) through observation of high-sensitivity C-reactive protein (hs-CRP) urine level. METHODS: This research is an experimental study using double-blind randomized controlled trial design conducted at General Hospital H. Adam Malik Medan, USU Pharmacy Laboratory for extraction of noni fruit (M. citrifolia) and the Integrated Laboratory of Biochemical-Biomolecular USU Faculty of Medicine for the examination of hs-CRP urine levels. A t-dependent test is performed if data distribution is normally distributed or if not normally distributed, the median values are compared with the Mann–Whitney U-test. The effect of noni in hs-CRP levels performed by wilcoxon signed-Ranks Test. The statistical significance test with CI 95% and significant difference value p<0,05. RESULTS: These results indicate that the noni fruit extract has weak antioxidant activity (IC50 >150 ppm). From the statistical analysis, a significant difference (p < 0.05) was obtained in hs-CRP urine level after compared to before treatment. These results indicate that after treatment, there was an improvement in the degree of OAB symptom scores in Group A and Group B. CONCLUSIONS: Noni fruit extract (M. citrifolia) is proven to be able to inhibit oxidative stress in urothelium through observation of hs-CRP urine levels in overactive women bladder (OAB).  

scholarly journals High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan

2020 ◽  
Vol 17 (16) ◽  
pp. 5878
Author(s):  
Hai-Hua Chuang ◽  
Rong-Ho Lin ◽  
Wen-Cheng Li ◽  
Wei-Chung Yeh ◽  
Yen-An Lin ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Impairment ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Community Based ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Hs Crp ◽  
Northern Taiwan

This cross-sectional study aimed to investigate the associations between high-sensitivity C-reactive protein (hs-CRP) and renal impairment (RI) among middle-aged and elderly people. We collected and analyzed demographic, anthropometric, metabolic, and renal function data in a community-based population in Northern Taiwan. We excluded subjects with acute inflammation from this study and defined RI as the presence of urinary albumin–creatinine ratio 30–300 mg/g or an estimated glomerular filtration rate of <60 mL/min/1.73 m2. There were 131, 125, and 125 participants in the low (≤0.80 mg/L), middle (0.81–1.76 mg/L), and high (>1.77 mg/L) hs-CRP tertiles, respectively. hs-CRP exhibited significantly positive correlations with body mass index, waist circumference, systolic blood pressure, triglyceride, and fasting plasma glucose, and a negative correlation with high-density lipoprotein. The prevalence and odds ratio of RI significantly increased across hs-CRP tertiles from low to high, and this trend remained significant after adjusting for the conventional cardiometabolic risk factors. hs-CRP ≥ 1.61 mg/L in the total group and ≥2.03 mg/L in the elderly group accurately predicted RI (p = 0.01 and 0.03, respectively). These findings suggest that we should carefully evaluate the renal function for at-risk individuals with hs-CRP elevation.

scholarly journals HUBUNGAN ANTARA WHR DENGAN KADAR Hs-CRP SERUM PADA MAHASISWA OBES DAN TIDAK OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Ezra Toreh ◽  
Shirley E. S. Kawengian ◽  
Alexander S. L. Bolang
Keyword(s):  
Statistical Analysis ◽  
High Sensitivity ◽  
Medical Faculty ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Waist To Hip Ratio ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp ◽  
Spearman Test

Abstract: Central obesity is recognized as a major factor that associated with increased risk for some chronic diseases. Waist to hip ratio described the increase in visceral adipose tissue and subcutaneous fat on waist circumference and hip circumference.C-reactive protein is the detection of cardiovascular disease risk in conventional but not sensitive enough to detect cardiovascular risk so  beused the new method is of high sensitivity C-reactive protein.The research have purpose to know the difference and relationship of waist to hip ratio and high sensitivity c-reactive protein level between obese and non-obese students at Medical Faculty of Sam Ratulangi University Manado. This research was an observational analytic cross-sectional approach. The results of statistical analysis using the Mann-Whitney U test revealed that there were significant differences (p = 0.000 <0.05) both WHR and hs-CRP level in both groups of students are. Conclusion: The results of statistical analysis using the Spearman test showed that there is a positive very weak relationship (r = 0309) and significant (p = 0017 <0.05) between the values ​​of WHR with hs-CRP level in obese and non-obese students at Medical Faculty of Sam Ratulangi University Manado. Key Words: WHR, hs-CRP     Abstrak: Obesitas sentral diakui sebagai factor utama yang dikaitkan dengan peningkatan resiko untuk beberapa penyakit kronis. Waist to hip ratio (WHR) menggambarkan peningkatan jaringan adiposa visceral dan lemak subkutan pada lingkar pinggang dan lingkar pinggul. C-reactive protein (CRP) merupakan deteksi risiko penyakit kardiovaskular tapi secara konvensional tidak cukup sensitif untuk mendeteksi risiko kardiovaskular sehingga digunakan metode baru yaitu high sensitivity C-reactive protein (hsCRP). Penelitian bertujuan untuk mengetahui perbedaan dan hubungan waist to hip ratio (WHR) dengan kadar high sensitivity c-reactive protein (hs-CRP) serum pada mahasiswa obes dan tidak-obes di Fakultas Kedokteran Universitas Sam Ratulangi Manado. Penelitian ini bersifat observasional analitik dengan menggunakan pendekatan cross-sectional. Hasil analisis statistic dengan menggunakan uji Mann-Whitney U menunjukan terdapat perbedaan yang bermakna (p=0.000<0.05) baik WHR maupun kadar hs-CRP serum pada kedua kelompok mahasiswa tersebut. Simpulan: Hasil analisis statistic dengan mengguna-kan uji Spearman menunjukan bahwa terdapat hubungan yang positif sangat lemah (r=0.309) dan bermakna (p=0.017<0.05) antara nilai WHR dengan kadar hs-CRP serum mahasiswa obes dan tidak-obes pada Fakultas Kedokteran Universitas Sam Ratulangi Manado. Kata Kunci: WHR, hs-CRP

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