scholarly journals KORELASI KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN DENGAN KADAR LOW DENSITY LIPOPROTEIN PADA PENYANDANG OBES

2020 ◽  
Vol 5 (3) ◽  
pp. 676
Author(s):  
Rama Dhanivita Djamin
Keyword(s):  
Interleukin 1 ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Low Grade ◽  
Low Density ◽  
C Reactive Protein ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Hs Crp

<p><em>Obesitas terjadi karena akumulasi lemak berlebih di dalam tubuh. Akumulasi lemak menimbulkan low grade inflammation pada jaringan adiposa, menyebabkan peningkatan sitokin inflamasi seperti tumor necrosis factor-alpha, interleukin-1 beta, dan interleukin-6 (IL-6). Peningkatan sekresi IL-6 merangsang hepar meningkatkan produksi protein fase akut. High sensitivity C-reactive protein (hs-CRP) sebagai penanda inflamasi merupakan protein fase akut. Low density lipoprotein (LDL-kolesterol) adalah lipoprotein yang paling banyak mengandung kolesterol. Peningkatan kadar hs-CRP dan kadar LDL-kolesterol pada obesitas diidentifikasi sebagai faktor risiko aterosklerosis. Penelitian ini bertujuan menganalisis hubungan hs-CRP dengan LDL-kolesterol pada penyandang obes, merupakan penelitian analitik rancangan potong lintang dilakukan  September 2018 sampai Agustus 2019. Kadar hs-CRP diperiksa dengan metode enzyme linked immunoassay (ELISA), sedangkan kadar LDL-kolesterol dengan metode kalkulasi (rumus Friedewald). Uji korelasi Spearman digunakan untuk menganalisi data, jika didapatkan nilai p&lt;0,05 korelasi dinyatakan bermakna. Subjek penelitian berjumlah 26 penyandang obes terdiri dari 6 laki-laki (23,1%) dan 20 perempuan (76,9%). Rerata umur subjek penelitian adalah 36,46(7,68) tahun. Rerata kadar hs-CRP dan kadar LDL-kolesterol adalah 5,08(1,28) mg/L dan  154,69(45,8) mg/dL. Analisis korelasi menunjukkan korelasi positif lemah dan tidak bermakna secara statistik antara kadar hs-CRP dengan kadar LDL-kolesterol (r= 0,333, p=0,096). Simpulan: Terdapat korelasi positif lemah antara kadar hs-CRP dengan kadar LDL-kolesterol pada penyandang obes.</em></p><p><strong><em>Kata kunci</em></strong><em>: </em><em>Obesitas, High Sensitivity C-Reactive, Low Density Lipoprotein</em><em></em></p>

scholarly journals HUBUNGAN KADAR KOLESTROL LOW DENSITY LIPOPROTEIN PLASMA DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Daniel Budiono
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Low Density ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Spearman Correlation Test ◽  
Hs Crp

Abstract: Atherosclerosis is the leading cause of mortality in the developed countries and in the future, it is predicted to be the leading cause of mortality in the developing countries. Low density lipoprotein, high sensitivity C-reactive protein, and obesity have been identified as risk factors of atherosclerosis. Obesity during childhood and adolescents tends to occur during adults life. The aim of this study is to know the levels of low density lipoprotein and high sensitivity C-reactive protein and the correlation between those two levels in obese adolescents. This observational cross sectional study design involved 17 obese adolescents and analyzed using Spearman Correlation Test. The results showed the mean levels of LDL was 123,0 mg/dL, and hs-CRP was 1,618 mg/L. Spearman correlation test showed significance value (p) was 0,024 and correlation significance value coefficient was 0,544. From the results can be concluded that the levels of low density lipoprotein levels in obese adolescents is in normal range, obese adolescents are associated with a moderate risk of cardiovascular disease at the future and there is a significant positive correlation between low density lipoprotein cholestrol levels and high sensitivity C-reactive protein levels in obese adolescents. Keywords : low density lipoprotein, high sensitivity c-reactive protein, obese adolescents   Abstrak: Aterosklerosis merupakan penyebab kematian utama di negara maju saat ini, dan diprediksi akan menjadi penyebab kematian utama di negara berkembang di masa mendatang. Peningkatan kadar low density lipoprotein dan kadar high sensitivity C-reactive protein (hs-CRP) serta obesitas telah diidentifikasi sebagai faktor risiko aterosklerosis. Remaja yang mengalami obesitas cenderung tetap mengalami obesitas pada saat dewasa. Tujuan dari penelitian ini untuk mengetahui gambaran kadar kolestrol low density lipoprotein dan kadar high sensitivity C-reactive protein pada remaja obes, serta hubungan kadar low density lipoprotein dengan kadar high sensitivity C-reactive protein pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross sectional terhadap 17 remaja obes. Nilai rerata kadar LDL pada remaja obes 123,00 mg/dL, dan nilai rerata kadar hs-CRP pada remaja obes 1,618 mg/L. Berdasarkan hasil penelitian, dapat disimpulkan remaja obes memiliki kadar LDL dalam rentang normal, remaja obes memiliki risiko sedang terkena penyakit kardiovaskular di masa mendatang dan terdapat hubungan positif yang signifikan antara kadar low density lipoprotein dengan kadar high sensitivity c-reactive protein pada remaja obes. Kata Kunci: low density lipoprotein, high sensitivity c-reactive protein, remaja obes

scholarly journals Roles of Achieved Levels of Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein on Cardiovascular Outcome in Statin Therapy

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Myung Han Hyun ◽  
Yuchang Lee ◽  
Byoung Geol Choi ◽  
Jin Oh Na ◽  
Cheol Ung Choi ◽  
...  
Keyword(s):  
Statin Therapy ◽  
De Novo ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Cardiovascular Outcome ◽  
Low Density ◽  
C Reactive Protein ◽  
Low Density Lipoprotein Cholesterol ◽  
Reactive Protein

In statin therapy, the prognostic role of achieved low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hsCRP) in cardiovascular outcomes has not been fully elucidated. A total of 4,803 percutaneous coronary intervention (PCI)-naïve patients who prescribed moderate intensity of statin therapy were followed up. Total and each component of major adverse cardiovascular events (MACE) according to LDL-C and hsCRP quartiles were compared. The incidence of 5-year total MACEs in the highest quartile group according to the followed-up hsCRP was higher than that in the lowest quartile (hazard ratio (HR) = 2.16, p<0.001). However, there was no difference between the highest and lowest quartiles of the achieved LDL-C (HR = 0.95, p=0.743). After adjustment of potential confounders, the incidence of total death, de novo PCI, atrial fibrillation, and heart failure in the highest quartile of followed-up hsCRP, was higher than that in the lowest quartile (all p<0.05). However, other components except for de novo PCI in the highest quartile by achieved LDL-C was not different to that in the lowest quartile. These results suggest that followed-up hsCRP can be more useful for predicting future cardiovascular outcome than achieved LDL-C in PCI-naïve patients with statin therapy.

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