scholarly journals Kyoto consensus — a new etiological classification of chronic gastritis and its discussion

2017 ◽  
Vol 37 (3) ◽  
pp. 57-63
Author(s):  
Y. S. Tsimmerman
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Detailed Analysis ◽  
Chronic Gastritis ◽  
Critical Assessment ◽  
Etiological Role ◽  
Development Of Gastric Cancer

The article provides a detailed analysis of the provisions of the Kyoto consensus on the classification of chronic gastritis. Particular attention is paid to the etiological role of Helicobacter pylori. The authors presented the results of their own study of the microbial “landscape” of the gastric mucosa. The role of Helicobacter pylori, atrophy and metaplasia of the gastric mucosa in the development of gastric cancer, as well as other etiological variants of chronic gastritis: alcoholic, medicinal, etc. are discussed. Critical assessment of the main provisions of the Kyoto consensus was made.

scholarly journals Kyoto consensus - the new etiological classification of chronic gastritis and its discussion

2017 ◽  
Vol 95 (2) ◽  
pp. 181-188
Author(s):  
Yakov S. Tsimmerman ◽  
Yu. A. Zakharova
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Evidence Based Medicine ◽  
Urease Activity ◽  
Evidence Based ◽  
Based Medicine ◽  
Gastric Microflora

The main provisions and headings of the new etiological classification of chronic gastritis are discussed in the context of recent data on the true role of Helicobacter pylori infection in the development of this pathology. The methods and results of the authors ’ investigations into gastric microflora are presented along with information about the frequency of detection of its different forms, concentration of microbial forms in gastric mucosa, their pathogenic properties including urease activity, and possible contribution to chronic gastritis etiology. The possibility of alcoholic and chemical chronic gastritis is discussed along with the role of these conditions in the development of stomach cancer. Special emphasis is laid on the disagreement between the adopted consensuses and principles of evidence-based medicine.

scholarly journals Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Fasciana Teresa ◽  
Nicola Serra ◽  
Giuseppina Capra ◽  
Chiara Mascarella ◽  
Cesare Gagliardi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Epstein Barr Virus ◽  
Normal Gastric Mucosa ◽  
Gastric Diseases ◽  
Barr Virus ◽  
Genes Encoding ◽  
Epstein Barr

Introduction. Helicobacter pylori and Epstein–Barr virus (EBV) infection have recently been shown to be associated with gastric diseases. Polymorphisms in genes encoding cytokines such as interleukin 10 (IL-10) and interleukin 1 Receptor (IL-1RN) influence cytokine secretion levels and appear to contribute to the risk of developing gastroduodenal diseases. To our knowledge, this is the first preliminary study to address the association of coinfection with H. pylori and EBV and their correlation with genetic predisposition in the development of gastric diseases. Methods. Gastric biopsy samples of 96 patients with different gastric diseases were used. Results. Our results showed that the rate of coinfection was higher in patients with gastric cancer than in patients with normal gastric mucosa, active chronic gastritis, and MALT lymphoma. As regards the characterization of H. pilory strains, the polymorphism s1m1i1 of vacA gene was more frequent in patients with MALT Lymphoma in comparison to others, while the polymorphism s2m2i2 was most frequent in patients with normal gastric mucosa. In addition, patients who tested positive for the cagA gene were more frequently those affected with gastric cancer than those with inactive chronic gastritis. Similarly, the patients with oipA gene ON were more frequently those with gastric cancer than those with inactive chronic gastritis. Conclusion. According to our analysis, there was no correlation between coinfection and polymorphisms in genes encoding IL-10 and IL-1RN. We conclude that various factors can be involved in the development of gastric diseases.

scholarly journals The Prevalence ofHelicobacter pyloriVirulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Tran Thi Huyen Trang ◽  
Seiji Shiota ◽  
Miyuki Matsuda ◽  
Tran Thanh Binh ◽  
Rumiko Suzuki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Virulence Factors ◽  
Cancer Incidence ◽  
The Status ◽  
The Difference ◽  
H Pylori ◽  
Significant Health ◽  
Development Of Gastric Cancer

Gastric cancer is a significant health problem in Asia. Although the prevalence ofHelicobacter pyloriinfection is similar in Bhutan, Vietnam, and Myanmar, the incidence of gastric cancer is highest in Bhutan, followed by Vietnam and Myanmar. We hypothesized thatH. pylorivirulence factors contribute to the differences. The status ofcagA,vacA,jhp0562, andβ-(1,3)galT(jhp0563)was examined in 371H. pylori-infected patients from Bhutan, Vietnam, and Myanmar. Each virulence factor could not explain the difference of the incidence of gastric cancer. However, the prevalence of quadruple-positive forcagA,vacAs1,vacAm1, andjhp0562-positive/β-(1,3)galT-negative was significantly higher in Bhutan than in Vietnam and Myanmar and correlated with gastric cancer incidence. Moreover, gastritis-staging scores measured by histology of gastric mucosa were significantly higher in quadruple-positive strains. We suggest that thecagA,vacAs1,vacAm1, andjhp0562-positive/β-(1,3)galT-negative genotype may play a role in the development of gastric cancer.

Difference of p53AIP1 mRNA Expression in Gastric Mucosa Between Patients With Gastric Cancer and Chronic Gastritis Infected With Helicobacter pylori

2008 ◽  
Vol 42 (4) ◽  
pp. 351-355 ◽  
Author(s):  
Manabu Sawaya ◽  
Tetsuro Yoshimura ◽  
Tadashi Shimoyama ◽  
Akihiro Munakata ◽  
Shinsaku Fukuda
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Mrna Expression ◽  
Chronic Gastritis

scholarly journals Functional dyspepsia and chronic gastritis

2018 ◽  
Vol 9 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Yury P. Uspenskiy ◽  
Natalia V. Baryshnikova
Keyword(s):  
Helicobacter Pylori ◽  
Digestive Tract ◽  
Functional Dyspepsia ◽  
Chronic Gastritis ◽  
Eradication Therapy ◽  
Point Of View ◽  
Etiological Role ◽  
Working Age ◽  
Social Importance

Diseases of upper parts of digestive tract are extremely widespread pathology and have not only the medical, but also social importance since often occur at young working-age people. It is actual to separate the items: functional dyspepsia (FD) and a dyspepsia associated with Helicobacter pylori because it is important for optimization of patient’s treatment. The review of modern foreign and Russian references about treatment of dyspeptic patients depending on existence or absence of an infection of Helicobacter pylori is presented in article (recommendation of V Maastricht consensus, Kyoto consensus, Russian gastroenterological association, Science society of Russian gastroenterologists). At diagnosis of a functional dyspepsia, it is recommended to be guided by the Roman criteria of the IV revision. In with document not only importance of an exception of organic pathology of digestive tract as the reasons of a secondary dyspepsia, but also need of inspection for the purpose of verification of Helicobacter pylori for an exception of an etiological role of a microorganism in development of a dyspepsia is emphasized. Allocation of two clinical options of a functional dyspepsia is also proved from the point of view of approaches to therapy of this disease. Algorithms of treatment of patients with various options of a dyspepsia are presented in article. These algorithms include different schemes of eradication therapy in case of dyspepsia associated with Helicobacter pylori and prokinetics/acid suppressors in case of functional dyspepsia.

scholarly journals Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Gonzalo Carrasco ◽  
Alejandro H. Corvalan
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Promoter Region ◽  
Staging System ◽  
Normal Gastric Mucosa ◽  
Cycle Arrest ◽  
Systems Pathology ◽  
Risk Areas

Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced byHelicobacter pylori(HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the role of HP in the multistep cascade of GC. We attempt to define the role of the Operative Link for Gastritis Assessment (OLGA) staging system in assessing the risk of GC. The epigenetic bases of chronic gastritis, mainly DNA methylation, are presented through examples such as (i) the methylation of the promoter region of E-cadherin in HP-induced chronic gastritis and its reversion after HP eradication and (ii) the association of methylation of the promoter region of Reprimo, a p53-mediated cell cycle arrest gene, with aggressive HP strains in high risk areas for GC. In addition, we discuss the finding of RPRM as a circulating cell-free DNA, offering the opportunity for noninvasive risk assessment of GC. Finally, the integration of OLGA and tissue biomarkers, by systems pathology approach, suggests that severe atrophy has a greater risk for GC development if, in addition, overexpressed p73. This trial is registered with ClinicalTrials.govNCT01774266.

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