scholarly journals Declining Prevalence of Helicobacter Pylori Infection- A 13C Urea Breath Test (UBT) Based Study in Symptomatic

2019 ◽  
Vol 10 (2) ◽  
pp. 121-124
Author(s):  
Mian Mashhud Ahmed ◽  
Atia Saeed ◽  
Abu Shams Md Hasan Ali Masum ◽  
Md Mohiuddin ◽  
Anisur Rahman
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Age Group ◽  
Ulcer Disease ◽  
Medical College ◽  
The World ◽  
The Mean ◽  
13C Urea Breath Test

Background: Helicobacter pylori (HP) infection is an important cause of peptic ulcer disease (PUD) in the world. This study was aimed to know the trend of H.P. infection among the symptomatic subjects Method: This was a retrospective observational study conducted from January 2015 to July 2018 in three different hospitals in Dhaka city. Patient who presented with dyspepsia underwent 13C urea breath test. Positive cases were analyzed. Results: A total 1343 patients were taken for UBT where 308 (23%) patients were found positive. The mean age group was 41.21+13.6. Male were more infected (61%) than female (39%). Conclusion: Improving sanitary and hygienic condition of this region along with significantly increasing HP eradication therapy and PPI use by the symptomatic individuals might have contributed to the decreasing trend of infection Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 121-124

Helicobacter pylori causes gastrointestinal hemorrhage in patients with congenital bleeding disorders

2003 ◽  
Vol 89 (04) ◽  
pp. 741-746 ◽  
Author(s):  
Ann-Sofie Rehnberg ◽  
Marju Hein ◽  
Olga Hegedus ◽  
Per Lindmarker ◽  
Per Hellström ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Hemorrhage ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Von Willebrand Disease ◽  
Bleeding Disorders ◽  
Ulcer Disease ◽  
H Pylori ◽  
One Year

Summary Helicobacter pylori (H. pylori) infection is associated with peptic ulcer disease and gastric cancer. The eradication of H. pylori is of special interest in patients with congenital bleeding disorders, for whom treatment of gastrointestinal hemorrhage with factor concentrates is costly. The prevalence of H. pylori varies between different populations and identification of high-risk subgroups may allow for more targeted screening and eradication of the infection. We performed a 5-year retrospective study of gastrointestinal bleeding, combined with screening and treatment for H. pylori and a long-term prospective follow-up in 168 Swedish and 23 Estonian patients with hemophilia or von Willebrand disease. The prevalence of seropositivity was lower in Sweden than in Estonia (28 versus 48%, p = 0.03), lower in native Swedes than in non-Nordic immigrants to Sweden (20 versus 76%, p = 0.0001) and lower in patients less than 40 years of age than older patients (16 versus 38%, p = 0.002). The incidence of gastrointestinal hemorrhages among the 35 Swedish patients with active H. pylori infection, confirmed by a urea breath test, was 6.0 per 100 patient-years before eradication therapy versus 1.7 during the prospective followup. A negative urea breath test one month after therapy always remained negative after one year. Screening, followed by treatment of all infected patients, yielded a reduction of direct costs over a 5-year period of 130 US-$ per screened patient. We conclude that screening and eradication therapy for infection with H. pylori in patients with congenital bleeding disorders is an effective and economic strategy.

A simplified 13C-urea breath test in children with Helicobacter pylori infection: Assessment of eradication therapy and follow-up after treatment

2001 ◽  
Vol 120 (5) ◽  
pp. A579 ◽  
Author(s):  
Atsushi Sawada ◽  
Hitoshi Tajiri ◽  
Norikazu Yoshimura ◽  
Kosuke Kozaiwa ◽  
Shinobu Ida ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
13C Urea Breath Test

13C-Urea Breath Test for Helicobacter Pylori: Cut-off Point Determination by Cluster Analysis

1997 ◽  
Vol 93 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Françcois Mion ◽  
Gaëlle Rosner ◽  
Marina Rousseau ◽  
Yves Minaire
Keyword(s):  
Cluster Analysis ◽  
Helicobacter Pylori ◽  
Breath Test ◽  
False Negative ◽  
Urea Breath Test ◽  
Large Set ◽  
Test Results ◽  
Normal Populations ◽  
The Mean ◽  
13C Urea Breath Test

1. This study was performed on a large set of 13C-urea breath test results to determine the optimal cut-off point of the test for the diagnosis of Helicobacter pylori (Hp) infection. 2. The following steps were applied to three sets of urea breath test results obtained in three groups of subjects (696 adults before anti-Hp treatment, 1056 adults after anti-Hp treatment and 173 children under 17 years of age): (1) demonstrate the distribution of urea breath test results as a mix of two normal populations (Hp negative and Hp positive) by logarithmic transformation of the results in each group of subjects; (2) apply statistical cluster analysis to determine the separation point between Hp-negative and -positive populations; (3) calculate the mean and SD of each population, and use these parameters in the equation of the normal distribution to establish the frequency curves of Hp-negative and -positive populations; and (4) determine the cut-off point of the urea breath test as the intersection of the two curves, and the risks of error related to it. 3. The optimal cut-off point was found at +3.00 δ%0/00, with a risk of false-negative or -positive response of the urea breath test of less than 3%. From this, a cut-off point of +3.00 δ%0/00 for the 13C-urea breath test is recommended, with an indetermined zone between +2.5 and +3.5 δ0/00 to account for the spontaneous variation of 13CO2 in breath and the limits of GC—isotope ratio-MS analytical precision.

scholarly journals Prevalence of Helicobacter pylori infection among dyspepsia patients in Calabar

2019 ◽  
Vol 25 (2) ◽  
pp. 145-151
Author(s):  
Kooffreh-Ada Mbang ◽  
Okonkwo Uchenna ◽  
Ugbong Emmanuel ◽  
Essien Aniekan ◽  
Chukwudike Evaristus ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Economic Status ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Sex Distribution ◽  
Ulcer Disease ◽  
Socio Economic Status ◽  
The Mean ◽  
Study Participants

Helicobacter pylori is an ubiquitous organism. It is estimated that more than 50% of the world’s population is infected with the bacteria. The infection is typically acquired in infancy and has been associated with poor living conditions and low socio-economic status. Once helicobacter pylori is acquired, it commonly persists lifelong unless treated. This pathogen has been implicated as a major aetiologic agent in the pathogenesis of peptic ulcer disease and is an established carcinogen. The aim of this study was to determine the prevalence of helicobacter pylori infection among our dyspeptic patients. This was a retrospective study conducted from April 2014 to December 2018. A total of one hundred and fifteen (115) patients who had symptoms of dyspepsia were recruited within this period of time. The presence of helicobacter pylori was determined using urea breath test. The results showed that 42.6% of the patients were positive for helicobacter pylori, while 51.3% of patients had a negative result. A borderline result was seen in 6.1% of patients. The mean age of the studied population was 45.10 years (SD= 12.55), with most patients aged between 41-60 years. This study showed no sex predilection, with an equal sex distribution of the study participants. Reports from other parts of the country also found the prevalence of helicobacter pylori to be highest in individuals between the 4th and 5th decade of life. This study concluded that the prevalence of helicobacter pylori infection is relatively high among patients with dyspepsia in South South Nigeria.Keywords: Helicobacter pylori, dyspepsia, urea breath test, South South Nigeria

scholarly journals Development of FlexSure® HP—an immunochromatographic method to detect antibodies against Helicobacter pylori

1998 ◽  
Vol 44 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Wayne H Schrier ◽  
Ronald J Schoengold ◽  
Josefina T Baker ◽  
Joyce L Norell ◽  
Corey L Jaseph ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Solid Phase ◽  
Reverse Flow ◽  
Test Strip ◽  
Urea Breath Test ◽  
Igg Antibodies ◽  
Ulcer Disease ◽  
13C Urea Breath Test ◽  
H Pylori

Abstract We describe a solid-phase immunochromatographic serologic test, FlexSure® HP, to detect IgG antibodies against Helicobacter pylori. H. pylori colonize the stomach and proximal duodenum, cause ulcer disease and mucosa-associated lymphoid tissue lymphoma, and have a role in the development of other disorders, including gastric adenocarcinoma. FlexSure HP consists of a test strip, conjugate pad, and absorbent pad, in a novel reverse-flow chromatography format. In these studies, FlexSure HP was demonstrated to be specific for IgG antibodies against H. pylori. The reactive cutoff of the test was consistent with [13C]urea breath test and commercially available ELISAs. FlexSure HP had 94% sensitivity, 88% specificity, and 91% accuracy relative to [13C]urea breath test; and 95% sensitivity, 94% specificity, and 95% overall agreement relative to high-molecular-mass cell-associated protein enzyme immunoassay (HM-CAP EIA). FlexSure HP is a simple-to-perform, visually read test requiring no specialized training, equipment, or instrumentation, and yields rapid, accurate, qualitative results.

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