scholarly journals Effectiveness of Ureteric Reimplantation on Non-Refluxing Obstructive Congenital Megaureter

2020 ◽  
Vol 21 (1) ◽  
pp. 20-24
Author(s):  
Shafiqur Rahman ◽  
Mohammad Abdul Aziz ◽  
MM Hasan ◽  
Nurun Nahar Happy ◽  
Tasneem Mahjabeen
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Structural Changes ◽  
Intravenous Urography ◽  
Definitive Treatment ◽  
Voiding Cystourethrogram ◽  
Cross Sectional ◽  
Poor Renal Function ◽  
Ureteric Reimplantation ◽  
Split Function

Background: One in ten thousand children born with megaureter. A significant portion of this groups are of obstructed variety and the rest are refluxing ureter. It can cause obstructions and back pressure renal damage. Early diagnosis and treatment can stop deterioration of renal function and prevent complications like renal failure. Definitive treatment is uretero-neocystostomy with or without tailoring the ureter. Objective: Objective of this study was to observe the effectiveness of ureteric reimplantation on non-refluxing obstructive congenital megaureter. To achieve this objective we had observed serum creatinine level pre and postoperatively and assessed structural changes in kidney by ultrasonogram, IVU, MCU and RGP pre and postoperatively. We also observed the split renal function and split GFR of the affected kidney both pre and post operatively. Methods: This was a cross-sectional observational study. This study comprise of 35 cases of congenital non-refluxing obstructed megaureter, who were admitted in BIRDEM General Hospital and multiple other hospitals in Dhaka city from July 2013 to December 2014. Diagnosis was made by intravenous urography (IVU) reveling a dilated lower third or entire ureter with narrow tapering lower end. Obstruction was also confirmed by diuretic Tc99m DTPA scan. A voiding cystourethrogram was obtained to exclude VUR. Those with poor renal function were evaluated by ultrasonography, DTPA scan and retrograde ureteropyelography. Results: Of 35 patients, 20 were male and 15 were female. Age range 2 to 19 years. All patients underwent ureteric reimplantation, with tailoring in 15 cases. Post-operative mean serum creatinine was 0.99±0.34 which showed improvement. Split function in DTPA renogram and split GFR of patient with POM in the affected right side also showed improvement (29.49±4.02 and 29.64±4.86) as well as affected in left side (27.77±4.18 and 28.02±5.31). Conclusion: Ureteral tailoring with an extravesical ureteral reimplantation can be performed safely and effectively for primary obstructive megaureter. It is found that, ureteroneocystostomy ensured free renal drainage and preserved renal function as well as prevented complications and further deterioration. Bangladesh Journal of Urology, Vol. 21, No. 1, January 2018 p 20-24

scholarly journals Evaluation of renal function in subclinical hypothyroidism

2018 ◽  
Vol 10 (01) ◽  
pp. 050-055 ◽  
Author(s):  
Vijayetha P. Patil ◽  
Alagilwada S. Shilpasree ◽  
Vidya S. Patil ◽  
Kangokar R. Pravinchandra ◽  
Deepti G. Ingleshwar ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Subclinical Hypothyroidism ◽  
Linear Regression Analysis ◽  
Laboratory Diagnosis ◽  
Thyroid Stimulating Hormone ◽  
Function Parameter ◽  
Overt Hypothyroidism ◽  
Free Triiodothyronine ◽  
Cross Sectional

Abstract INTRODUCTION: Patients with subclinical hypothyroidism (SCH) have a few or no symptoms or signs of thyroid dysfunction and thus by its very nature, SCH is a laboratory diagnosis. Serum creatinine is elevated and glomerular filtration rate (GFR) values are reversibly reduced in overt hypothyroid patients. We hypothesize that SCH also may be associated with low GFR. AIMS AND OBJECTIVES: The objective of this study was (1) to know the effect of SCH on kidney function, (2) to find the correlation between the renal function parameter creatinine, estimated GFR (eGFR), and thyroid-stimulating hormone (TSH), and (3) to know if creatinine values can be predicted by TSH values in SCH cases. MATERIALS AND METHODS: This is a hospital-based cross-sectional study for 1 year. A total of 608 subjects of either sex were included in the study and were divided into 3 groups: (1) SCH, (2) overt hypothyroidism (OHT), and (3) euthyroidism (ET). TSH, free triiodothyronine, free thyroxine, and serum creatinine were estimated and eGFR was calculated using modification of diet in renal disease study equation and the chronic kidney disease epidemiology collaboration equations. RESULTS: Serum creatinine levels were higher and eGFR was lower significantly in the subclinical hypothyroid group when compared to the control ET group (P < 0.001). The overtly hypothyroid group had significantly higher levels of serum creatinine and lower eGFR when compared to both the groups (P < 0.001). Significant correlation between TSH, creatinine, and eGFR was found in OHT group only. Linear regression analysis showed the regression in creatinine upon TSH is attributable to 44.5% among OHT group, 48.2% in SCH group. CONCLUSION: It can be concluded that the SCH group behaves biochemically similar to OHT group and changes in serum creatinine reflect tissue hypothyroidism in SCH cases.

scholarly journals Correlation of serum uric acid with renal function parameters in preeclampsia.

2020 ◽  
Vol 27 (12) ◽  
pp. 2703-2707
Author(s):  
Muddasir Zia ◽  
Rukhshan Khurshid ◽  
Uzma Jabbar ◽  
Adnan Riaz ◽  
Roohi Jabbar ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Urinary Protein ◽  
Estimation Of Parameters ◽  
Cross Sectional ◽  
Significant Difference ◽  
Relationship Of

Objectives: Study was designed to find out the Correlation of serum uric acid with renal function parameters in Preeclampsia. Study Design: Cross Sectional study. Setting: Sir Ganga Ram Hospital Lahore. Period: July 2016 to July 2017. Material & Methods: Level of serum uric acid, serum creatinine and blood urea of 40 Preeclamptic women and 30 gestation-matched normotensive controls were estimated. Their Demographic and clinical characteristics were noted. The blood sample was analyzed for biochemical parameters, blood urea, serum uric acid, serum creatinine and urinary protein. Result: Mean age and gestational age of women was 25 weeks with BMI 29 Kg/m2. Level of serum uric acid and blood urea and serum creatinine were increased, but significant difference only observed with serum uric acid and blood urea with marked proteinuria. An inverse relationship of serum uric acid with urinary protein was observed. A direct relationship, of serum uric acid with serum creatinine was observed. Conclusion: it is concluded that estimation of parameters of renal function of preeclamptic women are important along with hyperuicaemia.

scholarly journals Fatigability: An Early Marker of Diminished Renal Function?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 208-208
Author(s):  
Ann Moore ◽  
Michelle Shardell ◽  
Pei-Lun Kuo ◽  
Ajoy Karikkineth ◽  
Luigi Ferrucci ◽  
...  
Keyword(s):  
Renal Function ◽  
Perceived Exertion ◽  
Fatigue Threshold ◽  
P Value ◽  
Cross Sectional ◽  
Men And Women ◽  
Multiple Systems ◽  
Poor Renal Function ◽  
Baltimore Longitudinal Study ◽  
Using Data

Abstract Renal function declines markedly with age due to normal aging and/or disease processes and impacts multiple systems. Diminished renal function may manifest as low exercise tolerance and fatigue threshold. Using data on 951 well-functioning (usual gait speed &gt;.67m/s and no difficulty walking ¼ mile) men and women (51%) aged 60-89 years in the Baltimore Longitudinal Study of Aging, we evaluated the cross-sectional association between perceived fatigability (Rating Perceived Exertion after 5-minute treadmill walk at 1.5mph) categorized as 6-7, 8-9, 10-11 and 12+ and GFR using Cockcroft-Gault. For each fatigability increment, likelihood of suboptimal (GFR=75-89, 21%), diminished (GFR=60-74, 26%) and poor renal function (GFR=15-59, 30%) relative to GFR≥90 was respectively OR(95%CI)p-value 1.51(1.16-1.96).002, 1.38(1.04-1.83).027 and 1.68(1.22-2.31).002 adjusted for demographics, weight, height, smoking, exercise and anemia. Findings were similar for men and women. Perceived fatigability may facilitate identification of apparently well-functioning older adults on the precipice of suboptimal to poor renal function.

submitted manuscript

2018 ◽  
Author(s):  
Janet Alexander ◽  
Richard Butterwick ◽  
Jonathan Stockman ◽  
Jujhar Atwal ◽  
Alison Colyer ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Structural Changes ◽  
Test Group ◽  
Abdominal Ultrasound ◽  
Data Interpretation ◽  
Renal Ultrasound ◽  
Dietary Phosphorus ◽  
The Impact ◽  
Total P

To evaluate the impact of dietary phosphorus (P) intake on renal function in healthy adult cats, two independent studies were completed. Study 1: 48 cats, 1.7 - 9.1 y, were stratified into control or test diets providing 1.2 or 4.8 g/1000 kcal P (Ca:P 1.2 and 0.6) for 36 weeks. Study 2: 50 cats, 1.4 - 7.8 y, were stratified into control or test diets, providing 1.3 or 3.6 g/1000 kcal P (Ca:P 1.2 and 0.9) for 29 weeks. Health markers, glomerular filtration rate (GFR) and mineral balance were measured at regular intervals, with abdominal ultrasound at baseline and completion. Study 1; after 4 weeks the study was halted as test group GFR reduced by 0.4 (0.3, 0.4) ml/min/kg (p&lt;0.001), serum creatinine increased by 24.9 (24.4, 25.5) mol/L (p&lt;0.001) and renal ultrasound revealed changes in echogenicity. Study 2; at week 28, no differences in GFR were observed (p&gt;0.05) and serum creatinine did not change from baseline in the test group (p&gt;0.05). Ultrasound revealed new renoliths in 27% of control and 60% of test cats, with changes in renal echogenicity in 36% of test cats. Feeding a diet containing 4.8 g/1000 kcal total P; inorganic P 3.6 g/1000 kcal; Ca:P 0.6 resulted in a loss of renal function and marked changes in ultrasound suggestive of renal pathology. Intake of a diet containing 3.6 g/1000 kcal total P, Ca:P 0.9, led to more subtle structural changes in a third of test cats, however nephrolithiasis occurred in both groups complicating data interpretation

scholarly journals Assessing glomerular filtration rate in patients with severe heart failure: comparison between creatinine-based formulas

2012 ◽  
Vol 130 (5) ◽  
pp. 289-293 ◽  
Author(s):  
Alexandre Libório ◽  
Russian Uchoa ◽  
João Neto ◽  
Juan Valdivia ◽  
Elizabeth De Francesco Daher ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Serum Creatinine ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Severe Heart Failure ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Gfr Estimation

CONTEXT AND OBJECTIVE: Severe heart failure is highly associated with chronic kidney disease (CKD). Serum creatinine is a poor indicator of renal function and glomerular filtration rate (GFR) estimation is an accessible method for assessing renal function. The most popular formulas for GFR estimation are the Cockcroft-Gault (CG), the four-variable Simplified Modification of Diet in Renal Disease (sMDRD) and the recently introduced CKD-Epidemiology Collaboration (CKD-EPI). The objective of the study was to analyze the correlation between these three equations for estimating GFR in patients with severe heart failure. DESIGN AND SETTING: Cross-sectional observational study at a university reference center. METHODS: GFR was estimated in patients with severe heart failure who were awaiting heart transplantation, using the CG, sMDRD and CKD-EPI formulas. These estimates were analyzed using Pearson's correlation and Bland-Altman analysis. RESULTS: This study included 157 patients, of whom 32 (20.3%) were female. Normal serum creatinine concentration was observed in 21.6%. The mean GFR according to CG, sMDRD and CKD-EPI was 70.1 ± 29.5, 70.7 ± 37.5 and 73.7 ± 30.1 ml/min/1.73 m²; P > 0.05. Pearson's coefficient demonstrated good correlations between all the formulas, as did Bland-Altman. However, the patients presented GFR < 60 ml/min more frequently with the sMDRD formula (54.1% versus 40.2% for CG and 43.2% for CKD-EPI; P = 0.02). CONCLUSION: Despite the good correlation and agreement between the three methods, the sMDRD formula classified more patients as presenting GFR less than 60 ml/min.

Assessment of renal function based on cystatin C in elderly with dementia

2017 ◽  
Vol 41 (S1) ◽  
pp. S178-S178
Author(s):  
M.V. Zamfir ◽  
A.A. Talașman
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Correlation Coefficients ◽  
Clinical Problem ◽  
Cross Sectional Study ◽  
Dementia Diagnosis ◽  
Serum Cystatin C ◽  
Cross Sectional ◽  
Diagnosis Of Dementia

IntroductionAssessment of renal function in elderly with dementia is a difficult clinical problem due to the high prevalence of malnutrition and creatinine limits as a marker of glomerular filtration in this context.ObjectivesTo assess the correlation between renal function and dementia diagnosis.AimsTo highlight differences between methods of assessment of renal function based on creatinine and cystatin C.MethodsCross-sectional study. Patients institutionalized at Bucharest City-Center of Socio-Medical Services (a nursing home) from 04/2014 to 11/2014 were included in the study. Dementia diagnosis was established by a psychiatrist. We determined serum creatinine by Jaffe method and serum cystatin C by nephelometry. Renal function was determined using several formulas based on serum creatinine/cystatin C: Cockcroft–Gault, MDRD, creatinine CKDEPI/cystatin/creatinine + cystatin, Berlin Initiative Study (BIS1, BIS2), Lund-Malmo LM-LBM. To highlight a link between dementia and renal function, we determined Spearman correlation coefficients.ResultsThirty-one patients were included in the study, mean age 78.6 (63–97) years, 64% women. The diagnosis of dementia (1 = positive, 0 = negative) had the following statistically significant correlations: CKDEPIcystatin: rho = –0.390, P = 0.015; CKDEPI creatinine-cystatin: rho = –0.332, P = 0.032; BIS2: rho = –0.346, P = 0.02. We did not find statistically significant correlations between the diagnosis of dementia and formulas for assessing renal function based on creatinine only.ConclusionsElderly patients with dementia present decreased kidney function as determined by formulas based on cystatin/cystatin + creatinine, but not on creatinine alone. Assessment of renal function using cystatin C might represent a useful method for detection of renal dysfunction in these patients and for proper dosage of medication.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Changes in Renal Function Among Women With Preeclampsia in a Tertiary Health Institution in Nigeria

2020 ◽  
Vol 8 (3) ◽  
pp. 272-275
Author(s):  
Njoku Charles ◽  
Njoku Amarachukwu ◽  
Edet Ekpo ◽  
Emechebe Cajethan
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Disease Severity ◽  
Serum Potassium ◽  
Age Groups ◽  
Inverse Correlation ◽  
Third Trimester ◽  
Cross Sectional ◽  
Sodium Potassium ◽  
Singleton Pregnancies

Objectives: Preeclampsia is a pregnancy-related multisystem medical disorder which adversely affects the health of the mother and fetus. Studies have shown varied changes in biochemical renal function indices in preeclampsia. These changes vary in different environments and affect renal health and pregnancy outcomes. Accordingly, this study aimed to determine changes in serum electrolytes, urea, and creatinine in women with preeclampsia in Calabar. Materials and Methods: A cross-sectional comparative study was conducted on 144 pregnant women including 72 normotensive and 72 preeclamptic cases of similar age groups, with singleton pregnancies, and in the third trimester. The serum sodium, potassium, bicarbonate, chloride, urea, and creatinine were assayed in the two groups. Finally, statistical analysis was done using SPSS, version 22. Results: Based on the results, the preeclamptic group had significantly higher mean blood pressure (BP) and body mass index (BMI) compared to the normotensives. In addition, women with preeclampsia had a significant decrease in serum potassium and an increase in the serum creatinine compared to the normotensive group. The results further revealed that serum potassium, as well as systolic BP and diastolic BP had a significant inverse correlation in preeclampsia (P < 0.01 and P < 0.05, respectively). Eventually, the serum creatinine had a significant positive relationship with systolic and diastolic BP (P < 0.01) Conclusions: In general, serum potassium and creatinine levels significantly altered in preeclampsia and were associated with increased disease severity. Therefore, it is suggested the serial electrolyte and creatinine profile should be used in the monitoring disease severity, which informs a timely intervention and reduces complications associated with preeclampsia.

Estimated glomerular filtration rate from serum creatinine in Brazil/changing in CKD

2017 ◽  
Vol 5 (4) ◽  
pp. 315-322
Author(s):  
Mark Fernandez Bedoya ◽  
Maria A. Hegeman
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Developed Countries ◽  
Cross Sectional ◽  
Progression Of Kidney Disease

Continued progression of kidney disease will lead to renal function too low to sustain healthy life. In developed countries, such people will be offered renal replacement therapy in the form of dialysis or renal transplantation. Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease. The purpose of this study is to evaluate the glomerular filtration rate from serum creatinine in Brazil patients with chronic kidney disease (CKD). Multiple equations exist to estimate glomerular filtration rate (GFR); however, there is no consensus on which is superior for risk classification in patients with chronic kidney disease (CKD). Renal function was analyzed through serum creatinine and glomerular filtration rate (GFR) estimated according to the CG, MDRD and CKD-EPI equations, available on the websites of the Brazilian Nephrology Society (SBN) and the (NKF) by using cross-sectional analyses in diverse populations totaling 3949 participants.

scholarly journals Glycemic Status and Renal Function among Type 2 Diabetics

2014 ◽  
Vol 13 (4) ◽  
pp. 406-410
Author(s):  
Priti Singh ◽  
Salman Khan ◽  
Rabindra Kumar Mittal
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Clinical Chemistry ◽  
Medical Science ◽  
High Serum ◽  
Cross Sectional ◽  
Male And Female ◽  
Type 2 Diabetics ◽  
Significant Difference

Background: Diabetes mellitus (DM) is characterized by some specific complications including diabetic nephropathy. Urea & creatinine are useful parameters to diagnose the renal function, despite some limitations. Objective: This study aimed to analyze the effect of hyperglycemic condition on the renal function parameters like serum urea and serum creatinine. Methods: It was a cross sectional study. To determine the incidence of kidney dysfunction in type 2 diabetics in Nepalgunj Medical College and Hospital, Nepalgunj, Nepal. Random blood samples were taken from 100 diabetic subjects and 100 non-diabetic controls between the period 1st February, 2012 to 31st January, 2013 for investigation of fasting plasma glucose (FPG), blood urea and serum creatinine. These biochemical parameters were determined by using a fully automated clinical chemistry analyzer. The comparison was done by using Student ‘t’ test. Results: Our findings showed that the level of blood urea (P<0.0128 Diabetic male and P?0.0082 Diabetic female) and serum creatinine (P<0.0001 Diabetic male and P?0.0187 Diabetic female) were significantly higher in type 2 diabetics as compared to non-diabetics in both male and female. There was no significant difference between diabetic male and female. High serum creatinine level was seen in males than females. Conclusion: In our study there was an increase of blood urea level in type 2 DM. Good control of blood glucose level is absolute requirement to prevent progressive renal impairment. DOI: http://dx.doi.org/10.3329/bjms.v13i4.20586 Bangladesh Journal of Medical Science Vol.13(4) 2014 p.406-410

scholarly journals EVALUATION OF IMPROVEMENT IN RENAL FUNCTION AFTER FIRST-LINE CHEMOTHERAPY IN MULTIPLE MYELOMA PATIENTS PRESENTING WITH RENAL IMPAIRMENT

2021 ◽  
Vol 71 (4) ◽  
pp. 1431-35
Author(s):  
Syed Abdul Mannan Hamdani ◽  
Abdul Wahab ◽  
Musa Azhar ◽  
Faiza Iftikhar ◽  
Bushra Ahsan ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Renal Function ◽  
Renal Impairment ◽  
Serum Creatinine ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
First Line ◽  
Cross Sectional ◽  
Kaplan Meier ◽  
Line Chemotherapy

Objective: To evaluate the effect of response to first-line chemotherapy on renal functions in multiple myeloma (MM) patients. Study Design: Cross-sectional study. Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital, Lahore, from Jan 2013 to Dec 2017. Methodology: Multiple myeloma patients with renal impairment (RI) at baseline were included. Data was collected from the hospital registry.The variables assessed pre and post first-line chemotherapywere age, gender, initial estimated glomerular filteration rate and serum creatinine levels. Progression-free survivaland overall survival (OS) was calculated for both groups of patients i.e those who had improvement in renal funtions and those who did not show improvement. Kaplan-Meier curves were drawn, and SPSS-20 was used for data analysis. Results: Mean age was 48 ± 7 years. Out of 139 myeloma patients, 35 (25.1%) had RI at baseline. Males were 23 (65.7%), while females were 12 (34.3%). Cyclophosphamide, thalidomide and deamethsone (CTD)were used in the majority 30 (85.7%) followed by boretzomib, thalidomide and dexamethasone (VTD) in 2 (5.7%) patients. Boretezomib and dexamethasone (BorDex), lenalidomide and dexamethasone (Len Dex), lenalidomde, cyclophosphamide and dexamethasone (LCD) were given to 1 (2.8%) patient each. Serum creatinine levels normalized in 19 (54.3%). Dialysis was required in 11 (31.4%) patients out of which 3 (8.6%) got dialysis-independent while 8 (22.9%) patients remained dialysis-dependent. The medianoverall survival in whomcreatinine levels normalized was 35 months while it was 15 months in those in whom it did not normalize. Conclusion: Prompt administration of chemotherapy regimens can lead to an improvement in renal function....................

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