Role of Percutaneous Septal Ablation in Hypertrophic Obstructive Cardiomyopathy

2013 ◽  
Vol 8 (2) ◽  
pp. 110-112
Author(s):  
ATM Iqbal Hasan ◽  
SA Ahsan ◽  
AKM F Rahman ◽  
CM Ahmed ◽  
M Safiuddin ◽  
...  
Keyword(s):  
Cardiac Disease ◽  
Therapeutic Option ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
Successful Outcome ◽  
Outflow Obstruction ◽  
Septal Thickness ◽  
Percutaneous Septal Ablation ◽  
Selection Of Patients ◽  
Selection Of

HCM is a relatively common genetic mediated primary cardiac disease which may cause sudden death in the young including competative athlets.PTSMA is an alternative therapeutic option for surgical septal myomectomy who are high risk for surgery and presented with severe disabling symptoms due to marked LV outflow obstruction. PTSMA is performed by injection of 1 to 4 ml of 96% to 98% ethanol into the target artery in 0.5 to 1.0 ml aliquots at 1 ml/min. Selection of patients for PTSMA includes those with severe symptoms refractory to maximum medical management associated with LV outflow gradient > 50 mm Hg and basal septal thickness > 18 mm. Successful outcome following septal ablation by LV outflow gradient often reduced to < 20 mm of Hg and improved from symptomatic standpoint. DOI: http://dx.doi.org/10.3329/uhj.v8i2.16083 University Heart Journal Vol. 8, No. 2, July 2012

Role of MR Imaging in the Selection of Patients with Early Cervical Carcinoma for Fertility-preserving Surgery: Initial Experience

Radiology ◽  
1999 ◽  
Vol 212 (2) ◽  
pp. 395-399 ◽  
Author(s):  
P. Delia Peppercorn ◽  
Arjun R. Jeyarajah ◽  
Robert Woolas ◽  
John H. Shepherd ◽  
David H. Oram ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Cervical Carcinoma ◽  
Initial Experience ◽  
Selection Of Patients ◽  
Selection Of

The Role of a Vibration Response Imaging Device in the Selection of Patients for Lung Resection Surgery

2011 ◽  
Author(s):  
Fatma Comce ◽  
Zuleyha Bingol ◽  
Esen Kiyan ◽  
Serhan Tanju ◽  
Alper Toker ◽  
...  
Keyword(s):  
Lung Resection ◽  
Vibration Response ◽  
Imaging Device ◽  
Selection Of Patients ◽  
Vibration Response Imaging ◽  
Selection Of

The role of multimodality imaging in the selection of patients for aortic valve repair

2015 ◽  
Vol 14 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Madelien V. Regeer ◽  
Michel I.M. Versteegh ◽  
Nina Ajmone Marsan ◽  
Jeroen J. Bax ◽  
Victoria Delgado
Keyword(s):  
Aortic Valve ◽  
Multimodality Imaging ◽  
Aortic Valve Repair ◽  
Valve Repair ◽  
Selection Of Patients ◽  
Selection Of

Predictors of Successful Outcome for Lumbar Chemonucleolysis: Analysis of 3000 Cases during the Past 14 Years

Neurosurgery ◽  
2002 ◽  
Vol 51 (suppl_2) ◽  
pp. S2-123-S2-128 ◽  
Author(s):  
Young-Soo Kim ◽  
Dong-Kyu Chin ◽  
Yong-Eun Cho ◽  
Byung-Ho Jin ◽  
Do-Heum Yoon
Keyword(s):  
Back Pain ◽  
Clinical Outcome ◽  
Patient Group ◽  
Chief Complaint ◽  
Leg Pain ◽  
Successful Outcome ◽  
Duration Of Symptoms ◽  
Straight Leg Raising ◽  
Selection Of Patients ◽  
Selection Of

Abstract OBJECTIVE Among numerous minimally invasive procedures for the treatment of herniated lumbar disc disease (HLD), chymopapain chemonucleolysis has the longest history of clinical usage. Long-term studies indicated good clinical results with a low risk for patients. However, much confusion still remains about the indications. This study was conducted to evaluate the predictors of successful outcome for chemonucleolysis and to firmly establish the proper indications for this procedure. METHODS Three thousand patients with HLD were treated with chemonucleolysis between 1984 and 1999. The clinical success rate in our series was 85%. The medical history and physical and radiological findings, including the type and direction of disc herniation, were analyzed retrospectively. RESULTS The patient group with the chief complaint of leg pain achieved a better clinical outcome than the patient group with low back pain (88% versus 59%, P &lt; 0.05). A positive straight-leg-raising test was strongly correlated with good clinical outcome (&lt; P &lt; 0.05). Patients manifesting a soft, protruded disc had a better outcome than those manifesting diffuse bulging disc (&lt; P &lt; 0.05). Other prognostic factors favoring a good outcome were as follows: young age, short duration of symptoms, and no bony spur or calcification on radiological study. CONCLUSION Chymopapain chemonucleolysis is a safe and effective procedure. Proper selection of patients is important for the success of treatment. We propose the following three clinical criteria (Kim's triad) for selection of patients: chief complaint of leg pain rather than back pain, positive straight-leg-raising test, and soft protruded disc.

scholarly journals The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer

2017 ◽  
Author(s):  
Aurelio Bartolome Castrellon ◽  
Ihor Pidhorecky ◽  
Vicente Valero ◽  
Luis Estuardo Raez
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Triple Negative ◽  
Response Rate ◽  
Pathologic Response ◽  
Chemotherapy Treatment ◽  
Improved Outcomes ◽  
Selection Of Patients ◽  
Selection Of ◽  
Made In

Triple negative breast (TNBC) cancer constitutes a heterogeneous group of disease with histologic and molecular differences. Complete pathologic response to neoadjuvant chemotherapy (NACT) in TNBC is associated with improved outcomes. Efforts have been made in identifying drug combinations that will increase the response rate to preoperative chemotherapy. In this review we present recent studies that have incorporated carboplatin (Cb) in the NACT of TNBC. We discuss the homologous recombination deficiency score and the somatic or germline mutation for BRCA as potential biomarkers for future selection of patients that could benefit from the addition of Cb to NACT.

Cardioversion of Atrial Fibrillation: How Important is a Long Arrhythmia Duration?

1994 ◽  
Vol 39 (3) ◽  
pp. 78-79
Author(s):  
G.Y.H. Lip ◽  
K.J. Hogg
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Successful Outcome ◽  
Proper Selection ◽  
Long Duration ◽  
Selection Of Patients ◽  
Selection Of

A long duration of atrial fibrillation is usually considered as an adverse feature for successful cardioversion of atrial fibrillation and the maintenance of sinus rhythm. This often leads to the exclusion of such patients from being considered for this procedure. We report three patients in whom atrial fibrillation was present for a long duration (one for 2 years, two for 10 years), and successful cardioversion to sinus rhythm was achieved. Proper selection of patients with atrial fibrillation with an understanding of all features predicting a successful outcome will often allow a good result.

The role of duplex scanning in the selection of patients for transluminal angioplasty

1991 ◽  
Vol 13 (1) ◽  
pp. 69-74 ◽  
Author(s):  
James M. Edwards ◽  
Douglas M. Coldwell ◽  
Martin L. Goldman ◽  
D.Eugene Strandness
Keyword(s):  
Transluminal Angioplasty ◽  
Duplex Scanning ◽  
Selection Of Patients ◽  
Selection Of

The Role of Complement Inhibition in PNH

Hematology ◽  
2008 ◽  
Vol 2008 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Peter Hillmen
Keyword(s):  
Early Adulthood ◽  
European Medicines Agency ◽  
Intravascular Hemolysis ◽  
Specific Therapy ◽  
The Us ◽  
Impact On Survival ◽  
Thrombotic Complications ◽  
Selection Of Patients ◽  
Selection Of

AbstractParoxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, debilitating, acquired disorder that most frequently presents in early adulthood and usually continues throughout the life of a patient. PNH results in the death of approximately half of affected individuals, mainly through thrombotic complications, and until recently had no specific therapy. In 2007 eculizumab, an anti-complement antibody targeting the C5 complement component was approved for PNH by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMEA). Eculizumab is very effective in the treatment of intravascular hemolysis and all its sequelae, which include most of the symptoms and complications of PNH. Eculizumab has revolutionized our approach to hemolytic PNH and as it markedly reduces the principal complications of PNH, namely thrombosis and renal failure, should have a significant impact on survival. However, the development of eculizumab presents new challenges in PNH, such as how to avoid complications of therapy, how to overcome some of the problems associated with treatment and who to select for treatment, as only a proportion of patients with a PNH clone will benefit. This article will review the evidence behind the use of eculizumab in PNH, the effect it will have on the complications of the disease, the most appropriate selection of patients for therapy, the optimal management and the potential complications of the therapy.

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