Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy

1996 ◽  
Vol 10 (2) ◽  
pp. 122 ◽  
Author(s):  
Jeong Min Hwang ◽  
Hye Won Park
Keyword(s):  
Carbon Monoxide ◽  
Optic Neuropathy ◽  
Carbon Monoxide Poisoning ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Epigenetic Factor ◽  
Hereditary Optic Neuropathy

Leber's Hereditary Optic Neuropathy: Novel Views and Persisting Challenges

2018 ◽  
Vol 16 (8) ◽  
Author(s):  
Jasna Jancic ◽  
Janko Samardzic ◽  
Stevan Stojanovic ◽  
Amalija Stojanovic ◽  
Ana Marija Milanovic ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Hereditary Optic Neuropathy

scholarly journals Progress in Gene Therapy to Prevent Retinal Ganglion Cell Loss in Glaucoma and Leber’s Hereditary Optic Neuropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Sara E. Ratican ◽  
Andrew Osborne ◽  
Keith R. Martin
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Optic Nerve ◽  
Genome Editing ◽  
Optic Neuropathy ◽  
Single Gene ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Potential Use ◽  
Hereditary Optic Neuropathy

The eye is at the forefront of the application of gene therapy techniques to medicine. In the United States, a gene therapy treatment for Leber’s congenital amaurosis, a rare inherited retinal disease, recently became the first gene therapy to be approved by the FDA for the treatment of disease caused by mutations in a specific gene. Phase III clinical trials of gene therapy for other single-gene defect diseases of the retina and optic nerve are also currently underway. However, for optic nerve diseases not caused by single-gene defects, gene therapy strategies are likely to focus on slowing or preventing neuronal death through the expression of neuroprotective agents. In addition to these strategies, there has also been recent interest in the potential use of precise genome editing techniques to treat ocular disease. This review focuses on recent developments in gene therapy techniques for the treatment of glaucoma and Leber’s hereditary optic neuropathy (LHON). We discuss recent successes in clinical trials for the treatment of LHON using gene supplementation therapy, promising neuroprotective strategies that have been employed in animal models of glaucoma and the potential use of genome editing techniques in treating optic nerve disease.

Natural History of Conversion of Leber's Hereditary Optic Neuropathy

Ophthalmology ◽  
2017 ◽  
Vol 124 (6) ◽  
pp. 843-850 ◽  
Author(s):  
Tiffany Jean Hwang ◽  
Rustum Karanjia ◽  
Milton Nunes Moraes-Filho ◽  
Jesse Gale ◽  
Jeffrey Show Tran ◽  
...  
Keyword(s):  
Natural History ◽  
Optic Neuropathy ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
History Of ◽  
Hereditary Optic Neuropathy
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