Association of Plasma Retinol-Binding Protein 4, Adiponectin, and High Molecular Weight Adiponectin with Insulin Resistance in Non-Diabetic Hypertensive Patients

Abstract Background To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM). Methods Plasma RBP4 levels and insulin were measured among 135 GDM cases and 135 controls nested within the Peking University Birth Cohort in Tongzhou. Multivariable linear regression analysis was conducted to assess the influence of RBP4 levels on insulin resistance. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI) between RBP4 levels and risk of GDM. Results The GDM cases had significantly higher levels of RBP4 in the first trimester than controls (medians: 18.0 μg/L vs 14.4 μg/L; P < 0.05). Plasma RBP4 concentrations in the first and second trimester were associated with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) in the second trimester (all P < 0.001). With adjustment for diet, physical activity, and other risk factors for GDM, the risk of GDM increased with every 1-log μg/L increment of RBP4 levels, and the OR (95% CI) was 3.12 (1.08–9.04) for RBP4 in the first trimester and 3.38 (1.03–11.08) for RBP4 in the second trimester. Conclusions Plasma RBP4 levels both in the first trimester and second trimester were dose-dependently associated with increased risk of GDM.

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Plasma retinol-binding protein 4 and insulin resistance in overweight and obesity: effect of weight loss

Proceedings of The Nutrition Society ◽

10.1017/s0029665109990747 ◽

2009 ◽

Vol 68 (OCE3) ◽

Author(s):

M. Spence ◽

U. Bradley ◽

C. H. Courtney ◽

M. C. McKinley ◽

C. N. Ennis ◽

...

Keyword(s):

Insulin Resistance ◽

Weight Loss ◽

Binding Protein ◽

Overweight And Obesity ◽

Retinol Binding Protein ◽

Retinol Binding Protein 4 ◽

Plasma Retinol

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Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.116.308320 ◽

2016 ◽

Vol 36 (11) ◽

pp. 2259-2267 ◽

Cited By ~ 42

Author(s):

Gang Liu ◽

Ming Ding ◽

Stephanie E. Chiuve ◽

Eric B. Rimm ◽

Paul W. Franks ◽

...

Keyword(s):

Type 2 Diabetes ◽

Molecular Weight ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Retinol Binding Protein ◽

High Molecular Weight Adiponectin ◽

Fatty Acid Binding ◽

Retinol Binding Protein 4 ◽

Acid Binding Protein

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Letter by Menzaghi et al Regarding Article, “Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study”

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.117.309308 ◽

2017 ◽

Vol 37 (5) ◽

Author(s):

Claudia Menzaghi ◽

Massimiliano Copetti ◽

Vincenzo Trischitta

Keyword(s):

Type 2 Diabetes ◽

Molecular Weight ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Retinol Binding Protein ◽

High Molecular Weight Adiponectin ◽

Fatty Acid Binding ◽

Retinol Binding Protein 4 ◽

Acid Binding Protein

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Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients

Diabetology & Metabolic Syndrome ◽

10.1186/1758-5996-6-72 ◽

2014 ◽

Vol 6 (1) ◽

pp. 72 ◽

Cited By ~ 12

Author(s):

Wuquan Deng ◽

Yuping Zhang ◽

Yanling Zheng ◽

Youzhao Jiang ◽

Qinan Wu ◽

...

Keyword(s):

Insulin Resistance ◽

Binding Protein ◽

Retinol Binding Protein ◽

Newly Diagnosed ◽

Serum Retinol ◽

Hypertensive Patients ◽

Retinol Binding Protein 4

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Response by Liu and Sun to Letter Regarding Article, “Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study”

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.117.309320 ◽

2017 ◽

Vol 37 (5) ◽

Cited By ~ 1

Author(s):

Gang Liu ◽

Qi Sun

Keyword(s):

Type 2 Diabetes ◽

Molecular Weight ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Retinol Binding Protein ◽

High Molecular Weight Adiponectin ◽

Fatty Acid Binding ◽

Retinol Binding Protein 4 ◽

Acid Binding Protein

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Visceral adiposity in patients with psoriatic arthritis and psoriasis alone and its relationship with metabolic and cardiovascular risk

Rheumatology ◽

10.1093/rheumatology/keaa720 ◽

2020 ◽

Author(s):

Eric Toussirot ◽

François Aubin ◽

Maxime Desmarets ◽

Daniel Wendling ◽

Benoit Augé ◽

...

Keyword(s):

Molecular Weight ◽

Cardiovascular Risk ◽

High Molecular Weight ◽

Visceral Fat ◽

Fat Distribution ◽

Visceral Adiposity ◽

Retinol Binding Protein ◽

Model Assessment ◽

High Molecular Weight Adiponectin ◽

Retinol Binding Protein 4

Abstract Background Fat mass distribution, especially in the abdominal visceral region, has been rarely evaluated in patients with PsA or psoriasis (PsO). Methods Patients with PsA and patients with PsO alone were evaluated and compared with control subjects (1:1 ratio in each patient group) matched for age, sex and BMI category. Body composition and fat distribution (android and visceral fat) were evaluated by DXA. Anthropometric measurements, disease activity and the systematic coronary risk evaluation (SCORE) cardiovascular risk were assessed. Metabolic parameters (insulin, homeostasis model assessment for insulin resistance), serum adipokines [total and high-molecular-weight adiponectin, leptin, resistin and retinol-binding protein-4 (RBP4)] were measured. Results Data for 52 patients with PsA and 52 patients with PsO and their respective paired controls were analysed. Android fat and visceral fat were found to be significantly higher in patients with PsO compared with their controls, while these measurements did not differ between patients with PsA and their controls. By multivariate analysis, after adjusting for age, sex and BMI, visceral fat was higher in PsO patients compared with PsA patients (P = 0.0004) and the whole group of controls (P = 0.0013). Insulin levels and HOMA-IR were increased in both PsA and PsO groups. High-molecular-weight/total adiponectin ratio was decreased in patients with PsO. RBP4 was significantly higher in both PsA and PsO patients. In patients with PsO, visceral fat strongly correlated with SCORE (r = 0.61). Conclusion Visceral fat accumulates more in PsO alone than in PsA. Visceral adiposity may be a more pressing concern in PsO relative to PsA. Trial registration The ADIPSO study (Évaluation du tissu ADIpeux et des adipokines dans le PSOriasis et le rhumatisme psoriasique et analyse de ses relations avec le risque cardiovasculaire) is a case–control study conducted in Besançon, France, and is registered on ClinicalTrials.gov under the number NCT02849795.

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