scholarly journals Assessment of role of serum uric acid as a predictor of gestational diabetes mellitus

2021 ◽  
Vol 5 (5) ◽  
pp. 33-35
Author(s):  
Dr. Lavee Mehrotra ◽  
Dr. Seema Mishra
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Uric Acid

scholarly journals Correlation between first trimester uric acid level and subsequent development of gestational diabetes mellitus

2017 ◽  
Vol 6 (2) ◽  
pp. 606
Author(s):  
Amudha P. ◽  
Nithya D. ◽  
Pradeeba S. ◽  
Manochithra B.
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Subsequent Development ◽  
First Trimester

Background: The aim of the study was to correlate between first trimester uric acid level and its association with subsequent development of gestational diabetes mellitus.Methods: This is a prospective study conducted at Govt. Raja Mirasudar Hospital attached to Thanjavur Medical College, Thanjavur over a period of one year from September 2015. A total of one hundred and eighty seven ante natal women less than 14 weeks of gestational age who attended the outpatient antenatal department were included in this study. Serum uric acid estimation was done in women with <14 weeks of gestation and they were subsequently screened for GDM between 24 to 28 weeks by oral glucose tolerance test (OGTT) with 75 gms glucose according to IADPSG criteria.Results: In our study, among 178 antenatal pregnant women 13 with uric acid >3.6 mg/dl and 2 with serum uric acid <3.6 mg/dl developed GDM. This shows development of GDM increases with increase in uric acid concentration.Conclusions: Though our study results suggest that serum uric acid level estimation in first trimester can be used as a marker to predict GDM in pregnant women, large scale studies are required before it can be recommended as a routine first trimester screening test for prediction of gestational diabetes mellitus.

scholarly journals Prediction of Gestational Diabetes Mellitus by Serum Uric Acid Levels: Prospective Analysis at a Rural Tertiary Care Center

2021 ◽  
Vol 6 (2) ◽  
pp. 283-285
Author(s):  
Deepika Kapil ◽  
Uday Mahajan
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Uric Acid ◽  
Care Center ◽  
Tertiary Care ◽  
Medical College ◽  
One Year ◽  
Period Of Gestation

Serum uric acid has been recommended to screen gestational diabetes during pregnancy. Objective: Prediction of gestational diabetes by serum uric acid levels at 17-20 weeks. Methods: Eighty pregnant women who reported to the antenatal OPD at 17-20 weeks of period of gestation were enrolled in the study over the period of one year from Jan 2018 to Dec 2018 at Department of Obstetrics & Gynaecology Dr Rajendra Prasad Govt. Medical College, Kangra at Tanda, Himachal Pradesh, India. Results: Out of 8 patients, who developed GDM 4 (50%) had serum uric acid >3.5 mg/dl and 4 (50%) had serum uric levels <3.5 mg/dl. And the sensitivity of serum uric acid was 50% and specificity was 67%. Out of 8 patients, who developed GDM 4 (50%) had serum uric acid >3.5 mg/dl and 4 (50%) had serum uric levels <3.5 mg/dl. And the sensitivity of serum uric acid was 50% and specificity was 67%. Conclusion: Serum uric acid can be used to predict gestational diabetes. Keywords: Serum uric acid, gestational diabetes mellitus.

scholarly journals Association of first trimester serum uric acid levels gestational diabetes mellitus development

2016 ◽  
Vol 13 (2) ◽  
pp. 71-74 ◽  
Author(s):  
Seda Şahin Aker ◽  
Tuncay Yüce ◽  
Erkan Kalafat ◽  
Murat Seval ◽  
Feride Söylemez
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Uric Acid ◽  
First Trimester

scholarly journals Serum Uric Acid: A Novel Risk Factor for Gestational Diabetes Mellitus

2015 ◽  
Vol 3 (1) ◽  
pp. 10-15
Author(s):  
Dr. Urmila Singh ◽  
◽  
Dr Seema Mehrotra ◽  
Dr Renu Singh ◽  
Dr Sujata Sujata ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Uric Acid

Relationship between serum uric acid, creatinine, albumin and gestational diabetes mellitus

2006 ◽  
Vol 44 (8) ◽  
Author(s):  
Emre Sinan Güngör ◽  
Nuri Danişman ◽  
Leyla Mollamahmutoğlu
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Uric Acid

AbstractClin Chem Lab Med 2006;44:974–7.

scholarly journals Predictive significance of first trimester serum uric acid as risk factor for the gestational diabetes mellitus.

2021 ◽  
Vol 28 (7) ◽  
pp. 967-972
Author(s):  
Anjum Rehman ◽  
◽  
Sadia Saeed ◽  
Syeda Fariha Hasny ◽  
Nathumal Maheshwari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
First Trimester ◽  
Gynecology And Obstetrics ◽  
Diagnostic Threshold

Objective: Determining the predictive significance of first trimester serum uric acid for the development of gestational diabetes mellitus (GDM) in pregnant women. Study Design: Case Control study. Setting: Department Gynecology and Obstetrics, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi. Period: March 2017 to December 2018. Material & Methods: Sample of 172 pregnant women in first trimester (<14 weeks gestation) were divided into; 72 controls and 72 cases through purposive sampling. Pregnant women with fasting blood glucose (FBG) ≥100 mg/dl were defined as GDM. FBG was estimated by hexokinase and uric acid by enzymatic method (uricase) using commercial colorimetric assay (Nikken Seal Co., Ltd, Japan). Data was analyzed on SPSS software 21.0 (IBM, Inc USA) at 95% CI. Results: Maternal age of control and cases was noted 30.23±1.47 and 30.14±1.41 years. Gestational age in controls was 9.80±2.23 weeks compared to 10.37±2.34 weeks in cases. Serum Uric acid in control was 3.19±0.49 mg/dl compared to 3.73±0.43 mg/dl in cases (P=0.0001). Logistic regression analysis model generated ROC curve shows excellent area under the curve (AUC) of 0.92 [95% CI (0.87-0.97)] with a diagnostic threshold of 3.91 mg/dl for uric acid. At this Uric acid threshold, the specificity and sensitivity was 96.4% and 69.7% respectively (P=0.0001). Conclusion: It is concluded first trimester serum uric acid may be used for predicting the future development of gestational diabetes mellitus.

scholarly journals First trimester uric acid level: a reliable marker for gestational diabetes mellitus

2019 ◽  
Vol 8 (6) ◽  
pp. 2358
Author(s):  
Suvarna Jyothi Ganta ◽  
Sunanda R. Kulkarni
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
First Trimester ◽  
Family History Of Diabetes ◽  
Increased Risk ◽  
In Pregnancy

Background: The prevalence of diabetes mellitus (DM) is increasing worldwide and more in developing countries like India. The diabetic epidemic experienced in India can be due to strong genetic factors coupled with increasing urbanization, sedentary lifestyle, changes in the dietary patterns and increasing obesity. Indians are at an 11-fold increased risk of developing gestational glucose intolerance and hence universal screening is essential. Uric acid is a known marker of oxidative stress. Hyperuricemia in early pregnancy may be an indicator of the existing metabolic disturbance which can hinder the maternal physiological adaptations generally seen in pregnancy thus making the pregnant women more vulnerable to the development of gestational diabetes mellitus. The objective of this study was to investigate the association between elevated uric acid levels in the first trimester of pregnancy with gestational diabetes.Methods: This prospective observational study was conducted in Chinmaya mission hospital, Bangalore from June 2016 to March 2017 (10 months). Three hundred and twelve (312) pregnant women of gestational age less than 12 weeks who attended the OBG outpatient department within this time of period for regular antenatal check-up were enrolled in the study. Along with the other antenatal investigations serum uric acid levels were estimated before 12 weeks and also between 24-28 weeks. At 24-28 weeks screening for GDM was done by OGCT using 75 gms of glucose (IADPISG criteria). Other parameters like age, parity, BMI, family history of diabetes was noted and compared.Results: In our study, among the 312 pregnant women, 88 (28%) developed GDM. Of these 74 Women (84%) with GDM had uric acid levels above 3.5 mg/dl and 14 women (15.9%) with GDM had uric acid levels below 3.5 mg/dl. Women with higher BMI showed high uric acid levels.Conclusions: Elevated serum uric acid in the first trimester has a significant correlation with development of GDM. In present study; the cut-off level of maternal serum uric acid of 3.5 mg/dl in the first trimester appears to have a good sensitivity and specificity in identifying those patients who are most likely to develop GDM later in pregnancy.

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