scholarly journals Obstructive Sleep Apnea is Associated with Longitudinal Increases in Amyloid Burden in Elderly Mild Cognitive Impairment Individuals

2019 ◽  
Vol 15 (4) ◽  
pp. 71-77 ◽  
Author(s):  
Megan Hogan ◽  
Amanda Shim ◽  
Ogie Queen Umasabor-Bubu ◽  
Mukhtar Fahad ◽  
Omonigho Michael Bubu
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Rate Of Change ◽  
Amyloid Pet ◽  
Amyloid Burden ◽  
Obstructive Sleep ◽  
History Of ◽  
Over Time

Cross sectional analysis has shown an association between Obstructive Sleep Apnea (OSA) severity and Aβ burden using amyloid-PET among Mild Cognitive Impairment (MCI) patients. However, whether OSA accelerates longitudinal increases in amyloid beta (Aβ) burden in MCI patients is presently unclear. Study participants included a total of 798 subjects with a diagnosis of MCI and were a subset of the ADNI cohort (adni.loni.usc.edu). OSA was self-reported and participants were labeled either as OSA+ or OSA−. Aβ burden was determined by florbetapir SUVRs. To test whether OSA is associated with the rate of change in Aβ data longitudinally, multilevel mixed effects linear regression was used to fit the models with randomly varying intercepts and slopes allowing dependence on OSA status. The final model was adjusted for age, sex, body mass index, education, CPAP use status, history of respiratory disease, hypertension, diabetes, and history of cardiovascular disease. A significant variation in the change (slope) in Aβ volumes over time was seen (p<.0001). The covariance between the baseline Aβ level and Aβ volume change over time indicated that OSA subjects experienced greater mean change differences in brain Aβ volumes over time (p < .0001). The rate of change in Aβ deposition also varied significantly across OSA groups over the follow-up period. Obstructive Sleep Apnea possibly facilitates longitudinal increases in amyloid burden in elderly Mild Cognitive Impairment individuals. Further research examining mechanisms underlying effects of OSA on the longitudinal increases in Aβ burden is needed.

scholarly journals IC-P-118: βETA-AMYLOID BURDEN MODIFIES CONVERSION RISK IN CLINICALLY NORMAL AND MILD COGNITIVE IMPAIRMENT OBSTRUCTIVE SLEEP APNEA ELDERLY INDIVIDUALS

2019 ◽  
Vol 15 ◽  
pp. P100-P100
Author(s):  
Omonigho M. Bubu ◽  
Ogie Queen Umasabor-Bubu ◽  
Andreia G. Andrade ◽  
Maddie Birckbichler ◽  
Ram A. Sharma ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Amyloid Burden ◽  
Elderly Individuals ◽  
Clinically Normal ◽  
Obstructive Sleep

[IC-P-009]: OBSTRUCTIVE SLEEP APNEA IS ASSOCIATED WITH LONGITUDINAL INCREASES IN AMYLOID BURDEN IN ELDERLY MILD COGNITIVE IMPAIRMENT INDIVIDUALS

2017 ◽  
Vol 13 (7S_Part_1) ◽  
pp. P15-P16 ◽  
Author(s):  
Megan Hogan ◽  
Amanda Shim ◽  
Kathryn Halldin ◽  
Hannah Clark ◽  
Beka Behrens ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Amyloid Burden ◽  
Obstructive Sleep

[P3-414]: OBSTRUCTIVE SLEEP APNEA IS ASSOCIATED WITH LONGITUDINAL INCREASES IN AMYLOID BURDEN IN ELDERLY MILD COGNITIVE IMPAIRMENT INDIVIDUALS

2017 ◽  
Vol 13 (7S_Part_23) ◽  
pp. P1124-P1124
Author(s):  
Megan Hogan ◽  
Amanda Shim ◽  
Kathryn Halldin ◽  
Hannah Clark ◽  
Beka Behrens ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Amyloid Burden ◽  
Obstructive Sleep

scholarly journals Obstructive sleep apnea and longitudinal Alzheimer’s disease biomarker changes

SLEEP ◽  
2019 ◽  
Vol 42 (6) ◽  
Author(s):  
Omonigho M Bubu ◽  
Elizabeth Pirraglia ◽  
Andreia G Andrade ◽  
Ram A Sharma ◽  
Sandra Gimenez-Badia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Sleep Apnea ◽  
Rate Of Change ◽  
Csf Biomarkers ◽  
Amyloid Pet ◽  
Obstructive Sleep ◽  
T Tau

Abstract Study Objectives To determine the effect of self-reported clinical diagnosis of obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers (Aβ42, T-tau, and P-tau) in cognitively normal (NL), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) elderly. Methods Longitudinal study with mean follow-up time of 2.52 ± 0.51 years. Data were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Participants included 516 NL, 798 MCI, and 325 AD elderly. Main outcomes were annual rate of change in brain amyloid burden (i.e. longitudinal increases in florbetapir PET uptake or decreases in CSF Aβ42 levels); and tau protein aggregation (i.e. longitudinal increases in CSF total tau [T-tau] and phosphorylated tau [P-tau]). Adjusted multilevel mixed effects linear regression models with randomly varying intercepts and slopes was used to test whether the rate of biomarker change differed between participants with and without OSA. Results In NL and MCI groups, OSA+ subjects experienced faster annual increase in florbetapir uptake (B = .06, 95% CI = .02, .11 and B = .08, 95% CI = .05, .12, respectively) and decrease in CSF Aβ42 levels (B = −2.71, 95% CI = −3.11, −2.35 and B = −2.62, 95% CI = −3.23, −2.03, respectively); as well as increases in CSF T-tau (B = 3.68, 95% CI = 3.31, 4.07 and B = 2.21, 95% CI = 1.58, 2.86, respectively) and P-tau (B = 1.221, 95% CI = 1.02, 1.42 and B = 1.74, 95% CI = 1.22, 2.27, respectively); compared with OSA− participants. No significant variations in the biomarker changes over time were seen in the AD group. Conclusions In both NL and MCI, elderly, clinical interventions aimed to treat OSA are needed to test if OSA treatment may affect the progression of cognitive impairment due to AD.

scholarly journals P3-585: βETA-AMYLOID BURDEN MODIFIES CONVERSION RISK IN CLINICALLY NORMAL AND MILD COGNITIVE IMPAIRMENT OBSTRUCTIVE SLEEP APNEA ELDERLY INDIVIDUALS

2019 ◽  
Vol 15 ◽  
pp. P1199-P1200
Author(s):  
Omonigho M. Bubu ◽  
Ogie Queen Umasabor-Bubu ◽  
Andreia G. Andrade ◽  
Maddie Birckbichler ◽  
Fahad Mukhtar ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Amyloid Burden ◽  
Elderly Individuals ◽  
Clinically Normal ◽  
Obstructive Sleep

scholarly journals The Prevalence of Obstructive Sleep Apnea in Mild Cognitive Impairment: A Systematic Review

2019 ◽  
Author(s):  
Talha Mubashir ◽  
Lusine Abrahamyan ◽  
Ayan Niazi ◽  
Deween Piyasena ◽  
Abdul A. Arif ◽  
...  
Keyword(s):  
Systematic Review ◽  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Diagnostic Methods ◽  
Patient Recruitment ◽  
Prevalence Rates ◽  
Community Based ◽  
Obstructive Sleep

Abstract Background: Previous studies have shown that obstructive sleep apnea (OSA) is associated with a higher risk of cognitive impairment or dementia in the elderly, leading to deleterious health effects and decreasing quality of life. This systematic review aims to determine the prevalence of OSA in patients with mild cognitive impairment (MCI) and examine whether an association between OSA and MCI exists. Methods: We searched Medline, PubMed, Embase, Cochrane Central, Cochrane Database of Systematic Reviews, PsychINFO, Scopus, the Web of Science, ClinicalTrials.gov and the International Clinical Trials Registry Platform for published and unpublished studies. We included studies in adults with a diagnosis of MCI that reported on the prevalence of OSA. Two independent reviewers performed the abstract and full-text screening, data extraction and the study quality critical appraisal. Results: Five studies were included in the systematic review. Overall, OSA prevalence rates in patients with MCI varied between 11−71% and were influenced by OSA diagnostic methods and patient recruitment locations (community or clinic based). Among studies using the following OSA diagnostic measures– self-report, ApneaLink, Berlin Questionnaire and polysomnography– the OSA prevalence rates in MCI were 11%, 27%, 59% and 70%, respectively. In a community-based sample, the prevalence of OSA in patients with and without MCI was 27% and 26%, respectively. Conclusions: Based on limited evidence, the prevalence of OSA in patients with MCI is 27% and varies based upon OSA diagnostic methods and patient recruitment locations. Our findings provide an important framework for future studies to prospectively investigate the association between OSA and MCI among larger community-based cohorts and implement a standardized approach to diagnose OSA in memory clinics. PROSPERO registration: CRD42018096577

scholarly journals 0538 Effect of CPAP Adherence on Cognition in Older Adults with Mild Cognitive Impairment and Obstructive Sleep Apnea

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A215-A215
Author(s):  
Kathy Richards ◽  
Nalaka Gooneratne ◽  
Barry Dicicco ◽  
Alexandra Hanlon ◽  
Stephen Moelter ◽  
...  
Keyword(s):  
Older Adults ◽  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Cpap Adherence ◽  
Obstructive Sleep

scholarly journals The prevalence of obstructive sleep apnea in mild cognitive impairment: a systematic review

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Talha Mubashir ◽  
Lusine Abrahamyan ◽  
Ayan Niazi ◽  
Deween Piyasena ◽  
Abdul A. Arif ◽  
...  
Keyword(s):  
Systematic Review ◽  
Obstructive Sleep Apnea ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sleep Apnea ◽  
Obstructive Sleep
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