scholarly journals Hand function in patients with Dupuytren’s disease : Assessment, results & patients’ perspectives

2016 ◽  
Author(s):  
Christina Engstrand
Keyword(s):  
Hand Function ◽  
Dupuytren’S Disease ◽  
Disease Assessment ◽  
Dupuytren's Disease ◽  
Assessment Results

scholarly journals Recent advances in the understanding of Dupuytren’s disease

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 231 ◽  
Author(s):  
Thomas Layton ◽  
Jagdeep Nanchahal
Keyword(s):  
Hand Function ◽  
Therapeutic Targets ◽  
Therapeutic Options ◽  
Dupuytren’S Disease ◽  
Treatment Modalities ◽  
Dupuytren's Disease ◽  
Recent Advances ◽  
Cellular Factors ◽  
Fibrotic Disorder ◽  
Novel Therapeutic

Dupuytren’s disease (DD) is a common fibrotic disorder of the hand and can significantly impair hand function. Although the exact pathogenesis of this disorder remains to be elucidated, immunological, genetic and cellular factors likely interact. In this review, we summarise recent advances in the understanding of DD pathogenesis and look to the future for potential novel therapeutic targets. In addition, we discuss the therapeutic options in DD with a focus on the need for more rigorous evidence to allow a meaningful comparison of different treatment modalities.

Dupuytren's Contracture. The Safety and Efficacy of Collagenase Treatment

2016 ◽  
Vol 21 (02) ◽  
pp. 187-192 ◽  
Author(s):  
Adalsteinn Odinsson ◽  
Lars Erik Brenne ◽  
Tone Bøyesen Lurie ◽  
Vilhjalmur Finsen
Keyword(s):  
Patient Satisfaction ◽  
Hand Function ◽  
Primary Treatment ◽  
Dupuytren’S Disease ◽  
Successful Outcome ◽  
Extension Deficit ◽  
Serious Adverse Events ◽  
Dupuytren's Disease ◽  
Collagenase Injection ◽  
New Treatment

Background: Our main goal was to see if treatment with collagenase injection is safe and effective and to assess patient satisfaction with this new treatment. Methods: We prospectively followed 77 consecutive patients, treated for contracture in 91 fingers and 142 joints that received total of 109 collagenase injections. The patients were reviewed on the first and second day and at 4 and 12 months. A contracture reduced to five degrees or less at 12 months after the last injection, was considered to be a successful outcome. Results: A mean of 1.2 injections were used per patient and 0.8 injections per joint. There was a significant improvement in mean passive extension deficit. Out of the 142 joints treated, 84 (59%) met our criterion for a successful outcome; 56 (80%) out of 70 MCP joints and 28 (39%) out of 72 PIP joints. There were also significant improvements in both hand function and pain. No serious adverse events were observed. The mean patient satisfaction with the treatment at the 12-month follow up was a VAS score of 78 (0 = none; 100 = complete) and only 11% stated that they would not have consented to the treatment if they had known the outcome in advance. Conclusions: Treatment of Dupuytren's disease with collagenase injection is both safe and effective. It is now our primary treatment for Dupuytren's disease.

scholarly journals Hand function 5 years after treatment with collagenase Clostridium histolyticum injection for Dupuytren’s disease

2021 ◽  
pp. 175319342110023
Author(s):  
Ingrid Göransson ◽  
Lars Brudin ◽  
Andra Irbe ◽  
Christina Turesson
Keyword(s):  
Range Of Motion ◽  
Hand Function ◽  
Treatment Method ◽  
Dupuytren’S Disease ◽  
Collagenase Clostridium Histolyticum ◽  
Extension Deficit ◽  
Level Of Evidence ◽  
Dupuytren's Disease ◽  
Clostridium Histolyticum ◽  
New Treatment

The aim of this study was to report hand function, disability and satisfaction and patients’ perception of functionally troublesome contractures 5 years after injection with collagenase Clostridium histolyticum and hand therapy for Dupuytren's disease. Data from 79 patients were collected before and at 3, 12 and 60 months after treatment. Hand function was significantly improved, and 70% achieved a functional range of motion in the treated hand. QuickDASH scores and range of motion were best at 3 months follow-up. At 60 months, mean total extension deficit was 48°, which was 57% of the deficit before treatment. Thirty-seven patients (47%) had developed recurrent contractures in treated finger(s) meeting the criteria for new treatment. The threshold for functionally troublesome contractures was found to be 30°–60° in the finger joints. Treatment was experienced as painful, but few hand function problems occurred. Most patients would choose this treatment method again. Level of evidence: IV

scholarly journals Measurement properties of the Dutch Unité Rhumatologique des Affections de la Main and its ability to measure change due to Dupuytren’s disease progression compared with the Michigan Hand outcomes Questionnaire

2018 ◽  
Vol 43 (8) ◽  
pp. 855-863 ◽  
Author(s):  
Dieuwke C. Broekstra ◽  
Edwin R. van den Heuvel ◽  
Rosanne Lanting ◽  
Paul M. N. Werker
Keyword(s):  
Disease Progression ◽  
Hand Function ◽  
Dupuytren’S Disease ◽  
Receiver Operating Curve ◽  
Measurement Properties ◽  
Minimal Important Change ◽  
Level Of Evidence ◽  
Dupuytren's Disease ◽  
Smallest Detectable Change ◽  
Prospective Longitudinal

Data of a prospective longitudinal cohort study including 233 Dupuytren’s patients was used to determine: (1) whether the Unité Rhumatologique des Affections de la Main scale and Michigan Hand outcomes Questionnaire can detect change in hand function due to Dupuytren’s disease progression and to compare their abilities; (2) the concurrent validity, reliability, responsiveness and interpretability of the Dutch Unité Rhumatologique des Affections de la Main. The Unité Rhumatologique des Affections de la Main and Michigan Hand outcomes Questionnaire had comparable measurement properties, and were both able to distinguish participants with disease progression from those without progression (resp. U = 1252.5, p = 0.008, and U = 1086.0, p < 0.001), but only at a group level. Individual cases of progression could not be detected using these outcome measures, as indicated by the fact that the smallest detectable change was larger than the minimal important change, and area under the receiver operating curve (AUC) values of 0.75 for Michigan Hand outcomes Questionnaire and 0.67 for Unité Rhumatologique des Affections de la Main. Level of evidence: II

Functional Benefit of Dupuytren’s Surgery

2002 ◽  
Vol 27 (4) ◽  
pp. 378-381 ◽  
Author(s):  
R. SINHA ◽  
T. R. CRESSWELL ◽  
R. MASON ◽  
I. CHAKRABARTI
Keyword(s):  
Hand Function ◽  
Dupuytren’S Disease ◽  
Flexion Deformity ◽  
Dupuytren's Disease ◽  
Functional Benefit ◽  
Operative Result ◽  
The Mean ◽  
Results Of Surgery

The results of surgery for Dupuytren’s disease were prospectively assessed to see if there is a correlation between hand function, the degree of deformity and the post-operative result. A total of 42 patients were followed-up for 6 months. The mean flexion deformity was 81° pre-operatively and 32° post-operatively. The mean Sollerman score improved from 71 (out of 80) pre-operatively to 77 post-operatively. There was a significant correlation between the degree of deformity and the Sollerman score, and also between the improvement in deformity after surgery, and the Sollerman score. We conclude that hand function is worsened by increasing deformity in Dupuytren’s disease and improved by correction of the deformity.

Out-Patient Surgery for Dupuytren’s Disease Under Intravenous Regional Anaesthesia

1988 ◽  
Vol 13 (3) ◽  
pp. 257-258
Author(s):  
I. KJELDAL ◽  
H. P. NYGAARD
Keyword(s):  
Regional Anaesthesia ◽  
Hand Function ◽  
Dupuytren’S Disease ◽  
Dupuytren’S Contracture ◽  
Dupuytren's Disease ◽  
Dupuytren's Contracture ◽  
Intravenous Regional Anaesthesia

During a six-month period, 55 operations for Dupuytren’s contracture were performed on an out-patient basis. Intravenous regional anaesthesia was used in all cases, and the skin was closed primarily by Z-plasties. This method, which has not been published earlier, does not allow the surgeon to release the tourniquet before securing haemostasis. It is left to the patients to manage the post-operative elevation. No cases of post-operative haematoma occurred, and recovery of hand function was good in all cases. The method saves resources and is well-tolerated by patients.

Dermofasciectomy and Proximal Interphalangeal Joint Replacement in Dupuytren’s Disease

1985 ◽  
Vol 10 (3) ◽  
pp. 351-352
Author(s):  
M. A. TONKIN ◽  
W. P. LENNON
Keyword(s):  
Joint Replacement ◽  
Hand Function ◽  
Proximal Interphalangeal Joint ◽  
Interphalangeal Joint ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease

A case of Dupuytren’s Disease is presented in which a combination of dermofasciectomy and proximal interphalangeal joint replacement using a Swanson’s prosthesis improved hand function and avoided further digit amputation.

scholarly journals Actual Aspects of Surgical Treatment of Dupuytren's Disease (Literature Review)

2021 ◽  
pp. 63-72
Author(s):  
L.Yu. Naumenko ◽  
I.A. Kondrashova
Keyword(s):  
Surgical Treatment ◽  
Hand Function ◽  
Surgical Techniques ◽  
Proximal Interphalangeal Joint ◽  
Dupuytren’S Disease ◽  
Professional Activity ◽  
Dupuytren's Disease ◽  
Surgical Tactics ◽  
Severity Of The Disease ◽  
Definition Of

Relevance. The variety of manifestations of Dupuytren's disease, caused by the degree of lesions of the palmar aponeurosis, the duration of the disease, the nature of professional activity, and concomitant pathology of patients, has led to the development of numerous surgical techniques with different levels of effectiveness in the acute and long-term periods. A wide discussion of the issues of Dupuytren's disease in the domestic and foreign periodicals, the analysis of treatment methods, complications and rehabilitation indicate the urgency of the problem and the expediency of further research. Objective: a retrospective analysis of the leading literary sources devoted to the surgical treatment of Dupuytren's disease; the definition of modern approaches to surgical tactics and restoration of hand function. Results. The analysis of literature sources showed the advantages of differentiated approaches to the surgical treatment of Dupuytren's disease, depending on the severity of the disease. With mild and moderate lesions, there is a significant increase in needle aponeurectomy. In severe forms, the segmental aponeurectomy technique is preferred over the total one. There is some discrepancy in carrying out surgical mobilization of the proximal interphalangeal joint and the need to achieve a functional position as a result of treatment. The tactics of surgical treatment and rehabilitation of Dupuytren's disease requires an individual approach, taking into account the age and severity of the disease, and tends to spread minimally invasive fasciotomy techniques.

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