scholarly journals Fabrication and Characterization of Chitosan/Poly(Lactic-Co-glycolic Acid) Core-Shell Nanoparticles by Coaxial Electrospray Technology for Dual Delivery of Natamycin and Clotrimazole

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiaoming Cui ◽  
Xiaoli Li ◽  
Zhilu Xu ◽  
Xiuwen Guan ◽  
Jinlong Ma ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Fungal Growth ◽  
Plga Nanoparticles ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Drug Of Choice ◽  
Fungal Growth Inhibition ◽  
Coaxial Electrospray

Natamycin (NAT) is the drug of choice for the treatment of fungal keratitis (FK). However, its inherent shortcomings, such as poor solubility, high dosing frequency, and long treatment cycle, need to be urgently addressed by designing a new delivery to widen its clinical utility. Growing research has confirmed that clotrimazole (CLZ) plays a significant role in fungal growth inhibition. Hence, coaxial electrospray (CO-ES) technology is used herein to prepare nano-systems with an average hydrodynamic particle size of 309-406 nm for the co-delivery of NAT and CLZ in chitosan (CTS) and poly(lactic-co-glycolic acid) (PLGA). The resulting NAT/CLZ@CTS/PLGA formulations were characterized by a transmission electron microscope (TEM) and in vitro release test. The results show that the formulations had obvious core-shell structures, uniform particle distribution, and also can sustain the release of drugs over 36 h. Furthermore, in vitro hemolysis, in vivo corneal irritation test, local allergenic test, and antifungal activity analyses are performed to evaluate the safety and efficiency of the formulations. Thus, good biosafety along with a significant anti-candidiasis effect are found in the NAT/CLZ@CTS/PLGA nanoparticles (NPs). Taken together, the results suggest that this design may provide a promising drug delivery system and a new option for the treatment of FK.

scholarly journals Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 193 ◽  
Author(s):  
Ana Luiza C. de S. L. Oliveira ◽  
Raimundo Fernandes de Araújo Júnior ◽  
Thaís Gomes de Carvalho ◽  
Alan B. Chan ◽  
Timo Schomann ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Retinoic Acid ◽  
Antitumor Activity ◽  
Glycolic Acid ◽  
Plga Nanoparticles ◽  
Ki 67 ◽  
Apoptotic Proteins

Apoptosis signaling pathways, drug resistance, and metastasis are important targets to develop new cancer treatments. We developed cholesterol-coated Poly(d,l-Lactide-co-Glycolic Acid) (PLGA) nanoparticles for effective encapsulation and delivery of retinoic acid and oxaliplatin to analyze their antitumor activity in colorectal cancer. The cell viability and proliferation of tumoral cells lines (CT-26 and SW-480) decreased when compared to control in vitro after treatment with the nanoparticles. In addition, apoptosis of CT-26 cells increased. Importantly, cytoprotection of nontumor cells was detected. Expression of pro-apoptotic proteins was upregulated, while anti-apoptotic proteins were downregulated either in vitro or in vivo. In addition, drug resistance and metastasis factors were downregulated in vivo. Human colorectal tumors that highly expressed BCL-2 and Ki-67 had a greater tendency towards death within 60 months. Our results show that loading oxaliplatin combined with retinoic acid and cholesterol in a nanoparticle formulation enables determination of optimal antitumor activity and subsequent treatment efficacy.

scholarly journals An in vitro and in vivo bio-interaction responses and biosafety evaluation of novel Au–ZnTe core–shell nanoparticles

2016 ◽  
Vol 5 (4) ◽  
pp. 1078-1089 ◽  
Author(s):  
R. Dunpall ◽  
N. Revaprasadu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapeutics ◽  
Surface Modifications ◽  
Core Shell ◽  
Support Surface ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Biosafety Evaluation

Novel gold–zinc telluride (Au–ZnTe) core–shell nanoparticles were synthesized to support surface modifications for enhanced drug delivery in cancer therapeutics.

ZnO@Gd2O3 core/shell nanoparticles for biomedical applications: Physicochemical, in vitro and in vivo characterization

2017 ◽  
Vol 80 ◽  
pp. 603-615 ◽  
Author(s):  
Anna Woźniak ◽  
Bartosz F. Grześkowiak ◽  
Nataliya Babayevska ◽  
Tomasz Zalewski ◽  
Monika Drobna ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
In Vivo Characterization

Isoniazid loaded core shell nanoparticles derived from PLGA–PEG–PLGA tri-block copolymers: In vitro and in vivo drug release

2013 ◽  
Vol 104 ◽  
pp. 107-115 ◽  
Author(s):  
Mani Gajendiran ◽  
Venkatachalam Gopi ◽  
Vellaichamy Elangovan ◽  
Rajagopalan Venkatakrishna Murali ◽  
Sengottuvelan Balasubramanian
Keyword(s):  
Block Copolymers ◽  
Drug Release ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Polymer-controlled core–shell nanoparticles: a novel strategy for sequential drug release

RSC Advances ◽  
2014 ◽  
Vol 4 (57) ◽  
pp. 30430-30439 ◽  
Author(s):  
Yang Cao ◽  
Bochu Wang ◽  
Yazhou Wang ◽  
Deshuai Lou
Keyword(s):  
Drug Release ◽  
Plga Nanoparticles ◽  
Therapeutic Agents ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Miscible Liquids ◽  
Novel Strategy ◽  
Core Shell Nanoparticles ◽  
Sequential Drug Release ◽  
Coaxial Electrospray

Immiscible and miscible liquids were utilized to fabricate PVP/PLGA and PCL/PLGA nanoparticles with a distinct core–shell structure by coaxial electrospray. Two different sequential drug release profiles from different nanoparticles were observed. The melanoma cells and endothelial cells can be sequentially targeted and killed by therapeutic agents released from nanoparticles.

Alginate coated chitosan core-shell nanoparticles for efficient oral delivery of naringenin in diabetic animals—An in vitro and in vivo approach

2017 ◽  
Vol 170 ◽  
pp. 124-132 ◽  
Author(s):  
Subhajit Maity ◽  
Piyasi Mukhopadhyay ◽  
Patit Paban Kundu ◽  
Abhay Sankar Chakraborti
Keyword(s):  
Oral Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles
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