scholarly journals Therapeutic Potential of Wharton’s Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges

2020 ◽  
Vol 8 ◽  
Author(s):  
Mohamed M. Kamal ◽  
Dina H. Kassem
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Wharton’S Jelly ◽  
Wharton's Jelly

scholarly journals The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis

2009 ◽  
Vol 15 (5) ◽  
pp. 484-495 ◽  
Author(s):  
Pei-Chun Tsai ◽  
Tz-Win Fu ◽  
Yi-Ming Arthur Chen ◽  
Tsui-Ling Ko ◽  
Tien-Hua Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Fibrosis ◽  
Rat Liver ◽  
Therapeutic Potential ◽  
Wharton’S Jelly ◽  
Wharton's Jelly ◽  
Rat Liver Fibrosis ◽  
Umbilical Mesenchymal Stem Cells

scholarly journals Perinatal sources of mesenchymal stem cells: Wharton’s jelly, amnion and chorion

2011 ◽  
Vol 16 (3) ◽  
Author(s):  
Malgorzata Witkowska-Zimny ◽  
Edyta Wrobel
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Biology ◽  
Adult Stem Cells ◽  
Therapeutic Potential ◽  
Autologous Transplantation ◽  
Embryonic Stem ◽  
Wharton’S Jelly ◽  
Wharton's Jelly

AbstractRecently, stem cell biology has become an interesting topic, especially in the context of treating diseases and injuries using transplantation therapy. Several varieties of human stem cells have been isolated and identified in vivo and in vitro. Ideally, stem cells for regenerative medical application should be found in abundant quantities, harvestable in a minimally invasive procedure, then safely and effectively transplanted to either an autologous or allogenic host. The two main groups of stem cells, embryonic stem cells and adult stem cells, have been expanded to include perinatal stem cells. Mesenchymal stem cells from perinatal tissue may be particularly useful in the clinic for autologous transplantation for fetuses and newborns, and after banking in later stages of life, as well as for in utero transplantation in case of genetic disorders.This review highlights the characteristics and therapeutic potential of three human mesenchymal stem cell types obtained from perinatal sources: Wharton’s jelly, the amnion, and the chorion.

scholarly journals Comparative Proteomic Analysis of the Mesenchymal Stem Cells Secretome from Adipose, Bone Marrow, Placenta and Wharton’s Jelly

2021 ◽  
Vol 22 (2) ◽  
pp. 845
Author(s):  
Sungho Shin ◽  
Jeongmin Lee ◽  
Yumi Kwon ◽  
Kang-Sik Park ◽  
Jae-Hoon Jeong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Wharton’S Jelly ◽  
Therapeutic Effects ◽  
Human Mscs ◽  
Paracrine Effects ◽  
Wharton's Jelly ◽  
Different Sources

Mesenchymal stem cells (MSCs) have the potential to be a viable therapy against various diseases due to their paracrine effects, such as secretion of immunomodulatory, trophic and protective factors. These cells are known to be distributed within various organs and tissues. Although they possess the same characteristics, MSCs from different sources are believed to have different secretion potentials and patterns, which may influence their therapeutic effects in disease environments. We characterized the protein secretome of adipose (AD), bone marrow (BM), placenta (PL), and Wharton’s jelly (WJ)-derived human MSCs by using conditioned media and analyzing the secretome by mass spectrometry and follow-up bioinformatics. Each MSC secretome profile had distinct characteristics depending on the source. However, the functional analyses of the secretome from different sources showed that they share similar characteristics, such as cell migration and negative regulation of programmed cell death, even though differences in the composition of the secretome exist. This study shows that the secretome of fetal-derived MSCs, such as PL and WJ, had a more diverse composition than that of AD and BM-derived MSCs, and it was assumed that their therapeutic potential was greater because of these properties.

scholarly journals Mesenchymal Stem Cells from the Wharton’s Jelly of the Human Umbilical Cord: Biological Properties and Therapeutic Potential

2019 ◽  
Vol 12 (2) ◽  
pp. 218-226 ◽  
Author(s):  
Luigi Marino ◽  
Maria Antonietta Castaldi ◽  
Rosa Rosamilio ◽  
Enrico Ragni ◽  
Rosa Vitolo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Wharton’S Jelly ◽  
Human Umbilical Cord ◽  
Wharton's Jelly

scholarly journals Increased Expression of BIRC2, BIRC3, and BIRC5 from the IAP Family in Mesenchymal Stem Cells of the Umbilical Cord Wharton’s Jelly (WJSC) in Younger Women Giving Birth Naturally

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Paulina Gil-Kulik ◽  
Małgorzata Świstowska ◽  
Adrianna Kondracka ◽  
Piotr Chomik ◽  
Arkadiusz Krzyżanowski ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Therapeutic Potential ◽  
Wharton’S Jelly ◽  
Biophysical Parameters ◽  
Younger Women ◽  
Wharton's Jelly ◽  
Umbilical Blood ◽  
The Relationship

The knowledge of factors affecting the viability as well as proliferation and therapeutic potential of perinatal stem cells is of great importance for the decisions concerning their collection, multiplication, and storing. The aim of this work is to evaluate the expression of the BIRC2, BIRC3, and BIRC5 genes at the level of transcription in mesenchymal stem cells derived from the umbilical cord Wharton’s jelly. The study examined the relationship between the expression level of the studied genes and selected biophysical parameters of umbilical blood: pH, pCO2, pO2, and cHCO3. Moreover, the relationship between the pregnant age, the type of delivery (natural delivery or cesarean section), and the level of expression of the BIRC2, BIRC3, and BIRC5 genes was assessed. The research was carried out on mesenchymal stem cells derived from the umbilical cord Wharton’s jelly (WJSC) taken from 55 women immediately after delivery. Expression of the examined genes was assessed with the qPCR method using commercially available reagent kits. On the basis of the conducted research, it was demonstrated that WJSCs collected from younger women giving birth naturally, and in the acidic environment of the umbilical cord blood, are characterized by a higher expression of the BIRC2, BIRC3, and BIRC5 genes. It was shown that the expression of the BIRC2 and BIRC3 genes in Wharton’s jelly mesenchymal stem cells declines with the mother’s age. Our research suggests that stem cells collected from younger women giving birth naturally can be more resistant to apoptosis and show a more stem cell-like character, which can increase their therapeutic potential and clinical utility, but this conclusion needs to be approved in the next studies.

Enhanced neuro-therapeutic potential of Wharton's Jelly–derived mesenchymal stem cells in comparison with bone marrow mesenchymal stem cells culture

Cytotherapy ◽  
2016 ◽  
Vol 18 (4) ◽  
pp. 497-509 ◽  
Author(s):  
Katarzyna Drela ◽  
Wioletta Lech ◽  
Anna Figiel-Dabrowska ◽  
Marzena Zychowicz ◽  
Michał Mikula ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Wharton’S Jelly ◽  
Wharton's Jelly ◽  
Marrow Mesenchymal Stem Cells
Sign in / Sign up

Export Citation Format

Share Document